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Leser–Trélat Sign
The Leser–Trélat sign is the explosive onset of multiple seborrheic keratoses (many pigmented skin lesions), often with an inflammatory base. This can be a sign of internal malignancy as part of a paraneoplastic syndrome. In addition to the development of new lesions, preexisting ones frequently increase in size and become symptomatic. Associations Although most associated neoplasms are gastrointestinal adenocarcinomas (stomach, liver, colorectal and pancreas), malignancies of the breast, lung, and urinary tract, as well as lymphoid tissue, have been associated with this impressive rash. It is likely that various cytokines and other growth factors produced by the neoplasm are responsible for the abrupt appearance of the seborrheic keratoses. In some cases, paraneoplastic acanthosis nigricans (35% of patients), florid cutaneous papillomatosis, ichthyosis acquisita (acquired hypertrichosis lanuginosa), Cowden syndrome, tylosis, acrokeratosis paraneoplastica of Bazex or t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Seborrheic Keratosis On Human Back
Seborrhoeic dermatitis, sometimes inaccurately referred to as seborrhoea, is a long-term skin disorder. Symptoms include red, scaly, greasy, itchy, and inflamed skin. Areas of the skin rich in oil-producing glands are often affected including the scalp, face, and chest. It can result in social or self-esteem problems. In babies, when the scalp is primarily involved, it is called cradle cap. Dandruff is a milder form of the condition without inflammation. The cause is unclear but believed to involve a number of genetic and environmental factors. Risk factors include poor immune function, Parkinson's disease, and alcoholic pancreatitis. The condition may worsen with stress or during the winter. The ''Malassezia'' yeast is believed to play a role. It is not a result of poor hygiene. Diagnosis is typically based on the symptoms. The condition is not contagious. The typical treatment is antifungal cream and anti-inflammatory agents. Specifically, ketoconazole or ciclopirox are effe ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Lymphoma
Lymphoma is a group of blood and lymph tumors that develop from lymphocytes (a type of white blood cell). In current usage the name usually refers to just the cancerous versions rather than all such tumours. Signs and symptoms may include enlarged lymph nodes, fever, drenching sweats, unintended weight loss, itching, and constantly feeling tired. The enlarged lymph nodes are usually painless. The sweats are most common at night. Many subtypes of lymphomas are known. The two main categories of lymphomas are the non-Hodgkin lymphoma (NHL) (90% of cases) and Hodgkin lymphoma (HL) (10%). The World Health Organization (WHO) includes two other categories as types of lymphoma – multiple myeloma and immunoproliferative diseases. Lymphomas and leukemias are a part of the broader group of tumors of the hematopoietic and lymphoid tissues. Risk factors for Hodgkin lymphoma include infection with Epstein–Barr virus and a history of the disease in the family. Risk factors for common ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Angioma
Angiomas are benign tumors derived from cells of the vascular or lymphatic vessel walls (endothelium) or derived from cells of the tissues surrounding these vessels. Angiomas are a frequent occurrence as patients age, but they might be an indicator of systemic problems such as liver disease. They are not commonly associated with cancer. Signs and symptoms Angiomas usually appear at or near the surface of the skin anywhere on the body, and may be considered bothersome depending on their location. However, they may be present as symptoms of another more serious disorder, such as cirrhosis. When they are removed, it is generally for cosmetic reasons. Types * Hemangiomas # Capillary: Cherry hemangioma, Infantile haemangioma # Cavernous # Pyogenic granuloma * Lymphangiomas # Capillary (simple) # Cavernous (cystic) * Glomus tumor * Vascular ectasias # Naevus flammeus # Telangiectasia - Spider, Hereditary hemorrhagic * Reactive vascular proliferations # Bacillary angiomatosis S ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ulysse Trélat
Ulysse Trélat (13 August 1828, Paris – 28 March 1890) was a French surgeon remembered for describing the Leser–Trélat sign. He was the son of an Army physician, also named Ulysse Trélat (1795–1879). He received his education from his father, from Philippe-Frédéric Blandin, Auguste Nélaton and Philibert Joseph Roux. He graduated Doctor of Medicine in 1854, became prosector in 1855 and agrégé in 1857. He became surgeon in 1860, chief of surgery at ''Paris Maternité'' in 1864 and professor of clinical surgery at the Hôpital Necker. With military physician Anacharsis Baizeau (1821–1910), the eponymous "Baizeau and Trélat's method" is named, which is a surgical procedure for repair of a clefted soft palate. With surgeon Pierre Delbet (1861–1925), he published ''Clinique chirurgicale'' (1891). [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Edmund Leser
Edmund Leser (1 May 1853, in Münster – 11 December 1916, in Frankfurt am Main) was a German surgeon remembered for describing the Leser-Trélat sign (named with Ulysse Trélat, 1828–1890). He studied law in Berlin and served in the Franco-Prussian War as an artillery officer before studying medicine in Leipzig Leipzig ( , ; Upper Saxon: ) is the most populous city in the German state of Saxony. Leipzig's population of 605,407 inhabitants (1.1 million in the larger urban zone) as of 2021 places the city as Germany's eighth most populous, as wel .... He received his doctorate in 1880 and worked as Richard von Volkmann's assistant in Halle. He qualified as a surgeon in 1884, and became a professor in 1894, practicing in Halle and Frankfurt. He was the author of ''Lehrbuch der speciellen Chirurgie in 50 Vorlesungen'' (Textbook of special surgery in 50 lectures), published in several editions. [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tripe Palms
Tripe palms, is a cutaneous condition characterized by ridged velvety lesions on the palms resembling the lining of a cow's stomach (tripe). It is a paraneoplastic syndrome in gastric cancer. See also * Acrokeratosis paraneoplastica of Bazex * List of cutaneous conditions * List of cutaneous conditions associated with internal malignancy There are many skin conditions that may occur which are associated with cancers, as well as some benign tumors, inside the human body. Footnotes See also * List of target antigens in pemphigus * List of cutaneous conditions * List of g ... References Papulosquamous hyperkeratotic cutaneous conditions {{Dermatology-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Acrokeratosis Paraneoplastica Of Bazex
Paraneoplastic acrokeratosis, or Bazex syndrome is a cutaneous condition characterized by psoriasiform changes of hands, feet, ears, and nose, with involvement of the nails and periungual tissues being characteristic and indistinguishable from psoriatic nails. The condition is associated with carcinomas of the upper aerodigestive tract.Freedberg, et al. (2003). ''Fitzpatrick's Dermatology in General Medicine''. (6th ed.). McGraw-Hill. . History This was first reported by the French dermatologist, Andre Bazex (1911–1988), in 1945. Contrary to some publications, he did not die in 1944, as a victim of the Battle for France, but instead, was alive and well and continued his research on skin diseases up until his retirement in 1980. See also * List of cutaneous conditions * Nail anatomy * List of cutaneous conditions associated with increased risk of nonmelanoma skin cancer There are several conditions of or affecting the human integumentary system that are associated wi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Diffuse Nonepidermolytic Palmoplantar Keratoderma
Palmoplantar keratodermas are a heterogeneous group of disorders characterized by abnormal thickening of the stratum corneum of the palms and soles. Autosomal recessive, dominant, X-linked, and acquired forms have all been described. Types Clinically, three distinct patterns of palmoplantar keratoderma may be identified: diffuse, focal, and punctate. Diffuse Diffuse palmoplantar keratoderma is a type of palmoplantar keratoderma that is characterized by an even, thick, symmetric hyperkeratosis over the whole of the palm and sole, usually evident at birth or in the first few months of life. Restated, diffuse palmoplantar keratoderma is an autosomal dominant disorder in which hyperkeratosis is confined to the palms and soles. The two major types can have a similar clinical appearance: *''Diffuse epidermolytic palmoplantar keratoderma'' (also known as "Palmoplantar keratoderma cum degeneratione granulosa Vörner," "Vörner's epidermolytic palmoplantar keratoderma", and "Và ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cowden Syndrome
Cowden syndrome (also known as Cowden's disease and multiple hamartoma syndrome) is an autosomal dominant inherited condition characterized by benign overgrowths called hamartomas as well as an increased lifetime risk of breast, thyroid, uterine, and other cancers. It is often underdiagnosed due to variability in disease presentation, but 99% of patients report mucocutaneous symptoms by age 20–29. Despite some considering it a primarily dermatologic condition, Cowden's syndrome is a multi-system disorder that also includes neurodevelopmental disorders such as macrocephaly. The incidence of Cowden's disease is about 1 in 200,000, making it quite rare. Furthermore, early and continuous screening is essential in the management of this disorder to prevent malignancies. It is associated with mutations in PTEN on 10q23.3, a tumor suppressor gene otherwise known as phosphatase and tensin homolog, that results in dysregulation of the mTOR pathway leading to errors in cell proliferation, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ichthyosis Acquisita
Ichthyosis acquisita is a skin condition clinically and histologically similar to ichthyosis vulgaris.James, William; Berger, Timothy; Elston, Dirk (2005). ''Andrews' Diseases of the Skin: Clinical Dermatology''. (10th ed.). Saunders. . Presentation Associated conditions The development of ichthyosis in adulthood can be a manifestation of systemic disease, and it has been described in association with malignancies, drugs, endocrine and metabolic disease, HIV, infection, and autoimmune conditions.Freedberg, et al. (2003). ''Fitzpatrick's Dermatology in General Medicine''. (6th ed.). McGraw-Hill. . It usually is associated with people who have Hodgkin's disease but it is also occurs in people with mycosis fungoides, other malignant sarcomas, Kaposi's sarcoma and visceral carcinomas. It can occur in people with leprosy, AIDS, tuberculosis, and typhoid fever. See also * Ichthyosis * Confluent and reticulated papillomatosis of Gougerot and Carteaud * List of cutaneous conditions ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Florid Cutaneous Papillomatosis
Florid cutaneous papillomatosis (FCP), is an obligate paraneoplastic syndrome. FCP begins as the sudden onset of numerous cutaneous papillomas that are clinically indistinguishable from viral warts. The papillomas range from 1 to 3 mm in diameter may spread to involve the entire body, including the face. Pruritus, which may sometimes precede the onset of FCP, is evident in the affected regions in about half of patients. Evaluation of a skin biopsy clearly distinguishes FCP from viral warts. FCP is associated with underlying cancer of the breast, bladder, ovary, uterus, prostate, and lung. Other associated underlying malignancies include squamous cell carcinomas and lymphomas such as non-Hodgkin's lymphoma. FCP is sometimes seen together with other signs of internal cancer, especially malignant acanthosis nigricans, tripe palms, Leser–Trélat sign, and hypertrichosis lanuginosa acquisita. FCP tends to improve in association with surgical or chemotherapeutic therapy of t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Acanthosis Nigricans
Acanthosis nigricans is a medical sign characterised by brown-to-black, poorly defined, velvety hyperpigmentation of the skin. It is usually found in body folds, such as the posterior and lateral folds of the neck, the armpits, groin, navel, forehead and other areas. It is associated with endocrine dysfunction, especially insulin resistance and hyperinsulinaemia, as seen in diabetes mellitus. This activates the insulin-like growth factor receptors, which leads to proliferation of keratinocytes, fibroblasts and other cells in the skin. Activation of other growth factor receptors such as fibroblast growth factor receptors or epidermal growth factor receptor can also be responsible. Signs and symptoms Acanthosis nigricans may present with thickened, velvety, relatively darker areas of skin on the neck, armpit and in skin folds. Causes It typically occurs in individuals younger than age 40, is associated with insulin resistance, Type 2 diabetes, obesity or endocrinopathies, s ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
