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Lemont Kier
Lemont Kier (born September 13, 1930) is an American chemist and researcher in the field of drug design and medicinal chemistry. He is the recipient of the American Association of Pharmaceutical Scientists 2008 Research Achievement Award in Drug Development and Discovery. He obtained his PhD in Medicinal Chemistry at the University of Minnesota in 1958 and is currently a Professor Emeritus of Medicinal Chemistry and Nurse Anesthesia at the Virginia Commonwealth University in Richmond, Virginia. Kier participated in the founding of the Center for the Study of Biological Complexity at Virginia Commonwealth University. Work Kier built one of the first models in which molecular orbital theory In chemistry, molecular orbital theory (MO theory or MOT) is a method for describing the electronic structure of molecules using quantum mechanics. It was proposed early in the 20th century. In molecular orbital theory, electrons in a molec ... was applied successfully to drug design and d ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Drug Design
Drug design, often referred to as rational drug design or simply rational design, is the inventive process of finding new medications based on the knowledge of a biological target. The drug is most commonly an organic small molecule that activates or inhibits the function of a biomolecule such as a protein, which in turn results in a therapeutic benefit to the patient. In the most basic sense, drug design involves the design of molecules that are complementary in shape and charge to the biomolecular target with which they interact and therefore will bind to it. Drug design frequently but not necessarily relies on computer modeling techniques. This type of modeling is sometimes referred to as computer-aided drug design. Finally, drug design that relies on the knowledge of the three-dimensional structure of the biomolecular target is known as structure-based drug design. In addition to small molecules, biopharmaceuticals including peptides and especially therapeutic antibodi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
