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Lupus Vulgaris
Lupus vulgaris (also known as tuberculosis luposa) are painful cutaneous tuberculosis skin lesions with nodular appearance, most often on the face around the nose, eyelids, lips, cheeks, ears and neck. It is the most common ''Mycobacterium tuberculosis'' skin infection. The lesions may ultimately develop into disfiguring skin ulcers if left untreated. Signs and symptoms It begins as painless reddish-brown nodules which slowly enlarge to form irregularly shaped red plaque. File:Lupus vulgaris.jpg, Lupus vulgaris, changes in skin in hyperkeratotic forms File:Lupus vulgaris 2.jpg, Lupus vulgaris in a woman in 19th century Cause Lupus vulgaris often develops due to inadequately treated pre-existing tuberculosis. It may also develop at site of BCG vaccination. Rarely, it has been shown to be associated with tattoo marks. Histopathology Histologically, it shows presence of epithelioid cell granulomas with Langhans giant cells with or without central caseation necrosis in the derm ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Infectious Disease (medical Speciality)
Infectious diseases or ID, also known as infectiology, is a medical specialty dealing with the diagnosis and treatment of infections. An infectious diseases specialist's practice consists of managing nosocomial ( healthcare-acquired) infections or community-acquired infections and is historically associated with hygiene, epidemiology, clinical microbiology, travel medicine and tropical medicine. Scope Infectious diseases specialists typically serve as consultants to other physicians in cases of complex infections, and often manage patients with HIV/AIDS and other forms of immunodeficiency. Although many common infections are treated by physicians without formal expertise in infectious diseases, specialists may be consulted for cases where an infection is difficult to diagnose or manage. They may also be asked to help determine the cause of a fever of unknown origin. Specialists in infectious diseases can practice both in hospitals (inpatient) and clinics (outpatient). In hospitals ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sarcoidosis
Sarcoidosis (also known as ''Besnier-Boeck-Schaumann disease'') is a disease involving abnormal collections of inflammatory cells that form lumps known as granulomata. The disease usually begins in the lungs, skin, or lymph nodes. Less commonly affected are the eyes, liver, heart, and brain. Any organ can be affected though. The signs and symptoms depend on the organ involved. Often, no, or only mild, symptoms are seen. When it affects the lungs, wheezing, coughing, shortness of breath, or chest pain may occur. Some may have Löfgren syndrome with fever, large lymph nodes, arthritis, and a rash known as erythema nodosum. The cause of sarcoidosis is unknown. Some believe it may be due to an immune reaction to a trigger such as an infection or chemicals in those who are genetically predisposed. Those with affected family members are at greater risk. Diagnosis is partly based on signs and symptoms, which may be supported by biopsy. Findings that make it likely include large lymph n ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Edward VII
Edward VII (Albert Edward; 9 November 1841 – 6 May 1910) was King of the United Kingdom of Great Britain and Ireland and Emperor of India, from 22 January 1901 until his death in 1910. The second child and eldest son of Queen Victoria and Prince Albert of Saxe-Coburg and Gotha, and nicknamed "Bertie", Edward was related to royalty throughout Europe. He was Prince of Wales and heir apparent to the British throne for almost 60 years. During the long reign of his mother, he was largely excluded from political influence and came to personify the fashionable, leisured elite. He travelled throughout Britain performing ceremonial public duties and represented Britain on visits abroad. His tours of North America in 1860 and of the Indian subcontinent in 1875 proved popular successes, but despite public approval, his reputation as a playboy prince soured his relationship with his mother. As king, Edward played a role in the modernisation of the British Home Fleet and the reorganis ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Alexandra Of Denmark
Alexandra of Denmark (Alexandra Caroline Marie Charlotte Louise Julia; 1 December 1844 – 20 November 1925) was Queen of the United Kingdom and the British Dominions, and Empress of India, from 22 January 1901 to 6 May 1910 as the wife of King-Emperor Edward VII. Alexandra's family had been relatively obscure until 1852, when her father, Prince Christian of Schleswig-Holstein-Sonderburg-Glücksburg, was chosen with the consent of the major European powers to succeed his second cousin Frederick VII as king of Denmark. At the age of sixteen Alexandra was chosen as the future wife of Albert Edward, Prince of Wales, the son and heir apparent of Queen Victoria. The couple married eighteen months later in 1863, the year in which her father became king of Denmark as Christian IX and her brother was appointed king of Greece as George I. Alexandra was Princess of Wales from 1863 to 1901, the longest anyone has ever held that title, and became generally popular; her style of dress ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Light Therapy
Light therapy, also called phototherapy or bright light therapy is intentional daily exposure to direct sunlight or similar-intensity artificial light in order to treat medical disorders, especially seasonal affective disorder (SAD) and circadian rhythm sleep-wake disorders. Treating skin conditions such as neurodermatitis, psoriasis, acne vulgaris, and eczema with ultraviolet light is called ultraviolet light therapy. Medical uses Nutrient deficiency Vitamin D deficiency Exposure to light at specific wavelengths of Ultraviolet B (abbreviated as UV-B or UVB) enables the body to produce vitamin D to treat vitamin D deficiency. Skin conditions Light therapy treatments for the skin usually involve exposure to ultraviolet light. The exposures can be to a small area of the skin or over the whole body surface, as in a tanning bed. The most common treatment is with narrowband UVB, which has a wavelength of approximately 311–313 nanometers. Full body phototherapy can be d ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Niels Ryberg Finsen
Niels Ryberg Finsen (15 December 1860 – 24 September 1904) was a Faroese- Icelandic physician and scientist. In 1903, he was awarded the Nobel Prize in Medicine and Physiology "in recognition of his contribution to the treatment of diseases, especially lupus vulgaris, with concentrated light radiation, whereby he has opened a new avenue for medical science." Biography Niels Finsen was born in Tórshavn, Faroe Islands, as the second-oldest of four children. His father was , who belonged to an Icelandic family with traditions reaching back to the 10th century, and his mother was Johanne Formann from Falster, Denmark. The family moved to Tórshavn from Iceland in 1858 when his father was given the position of Landfoged. When Niels was four years old his mother died, and his father married her cousin Birgitte Kirstine Formann, with whom he had six children. In 1871 his father was made ''Amtmand'' of the Faroe Islands. His father was a member of the Faroese parliament for 12 yea ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Squamous Cell Carcinoma
Squamous-cell carcinomas (SCCs), also known as epidermoid carcinomas, comprise a number of different types of cancer that begin in squamous cells. These cells form on the surface of the skin, on the lining of hollow organs in the body, and on the lining of the respiratory and digestive tracts. Common types include: * Squamous-cell skin cancer: A type of skin cancer * Squamous-cell carcinoma of the lung: A type of lung cancer * Squamous-cell thyroid carcinoma: A type of thyroid cancer * Esophageal squamous-cell carcinoma: A type of esophageal cancer * Squamous-cell carcinoma of the vagina: A type of vaginal cancer Despite sharing the name "squamous-cell carcinoma", the SCCs of different body sites can show differences in their presented symptoms, natural history, prognosis, and response to treatment. By body location Human papillomavirus infection has been associated with SCCs of the oropharynx, lung, fingers, and anogenital region. Head and neck cancer About 90% of cases ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ethambutol
Ethambutol (EMB, E) is a medication primarily used to treat tuberculosis. It is usually given in combination with other tuberculosis medications, such as isoniazid, rifampicin and pyrazinamide. It may also be used to treat ''Mycobacterium avium'' complex, and ''Mycobacterium kansasii''. It is taken by mouth. Common side effects include problems with vision, joint pain, nausea, headaches, and feeling tired. Other side effects include liver problems and allergic reactions. It is not recommended in people with optic neuritis, significant kidney problems, or under the age of five. Use during pregnancy or breastfeeding has not been found to cause harm. In the United States the FDA has raised concerns about eye issues in the baby if used during pregnancy. Ethambutol is believed to work by interfering with the bacteria's metabolism. Ethambutol was discovered in 1961. It is on the World Health Organization's List of Essential Medicines and is available as a generic medication. Chir ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Streptomycin
Streptomycin is an antibiotic medication used to treat a number of bacterial infections, including tuberculosis, ''Mycobacterium avium'' complex, endocarditis, brucellosis, ''Burkholderia'' infection, plague, tularemia, and rat bite fever. For active tuberculosis it is often given together with isoniazid, rifampicin, and pyrazinamide. It is administered by injection into a vein or muscle. Common side effects include vertigo, vomiting, numbness of the face, fever, and rash. Use during pregnancy may result in permanent deafness in the developing baby. Use appears to be safe while breastfeeding. It is not recommended in people with myasthenia gravis or other neuromuscular disorders. Streptomycin is an aminoglycoside. It works by blocking the ability of 30S ribosomal subunits to make proteins, which results in bacterial death. Albert Schatz first isolated streptomycin in 1943 from ''Streptomyces griseus''. It is on the World Health Organization's List of Essential Medicine ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pyrazinamide
Pyrazinamide is a medication used to treat tuberculosis. For active tuberculosis, it is often used with rifampicin, isoniazid, and either streptomycin or ethambutol. It is not generally recommended for the treatment of latent tuberculosis. It is taken by mouth. Common side effects include nausea, loss of appetite, muscle and joint pains, and rash. More serious side effects include gout, liver toxicity, and sensitivity to sunlight. It is not recommended in those with significant liver disease or porphyria. It is unclear if use during pregnancy is safe but it is likely okay during breastfeeding. Pyrazinamide is in the antimycobacterial class of medications. How it works is not entirely clear. Pyrazinamide was first made in 1936, but did not come into wide use until 1972. It is on the World Health Organization's List of Essential Medicines. Pyrazinamide is available as a generic medication. Medical uses Pyrazinamide is only used in combination with other drugs such as isonia ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Isoniazid
Isoniazid, also known as isonicotinic acid hydrazide (INH), is an antibiotic used for the treatment of tuberculosis. For active tuberculosis it is often used together with rifampicin, pyrazinamide, and either streptomycin or ethambutol. For latent tuberculosis it is often used by itself. It may also be used for atypical types of mycobacteria, such as '' M. avium'', '' M. kansasii'', and '' M. xenopi''. It is usually taken by mouth but may be used by injection into muscle. Common side effects include increased blood levels of liver enzymes and numbness in the hands and feet. Serious side effects may include liver inflammation and acute liver failure. It is unclear if use during pregnancy is safe for the baby. Use during breastfeeding is likely safe. Pyridoxine may be given to reduce the risk of side effects. Isoniazid works in part by disrupting the formation of the bacteria's cell wall which results in cell death. Isoniazid was first made in 1952. It is on the World ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Rifampicin
Rifampicin, also known as rifampin, is an ansamycin antibiotic used to treat several types of bacterial infections, including tuberculosis (TB), mycobacterium avium complex, ''Mycobacterium avium'' complex, leprosy, and Legionnaires’ disease. It is almost always used together with other antibiotics with two notable exceptions: when given as a "preferred treatment that is strongly recommended" for latent TB infection; and when used as post-exposure prophylaxis to prevent Haemophilus influenzae type b, ''Haemophilus influenzae'' type b and meningococcal disease in people who have been exposed to those bacteria. Before treating a person for a long period of time, measurements of liver enzymes and blood counts are recommended. Rifampicin may be given either Oral administration, by mouth or intravenously. Common side effects include nausea, vomiting, diarrhea, and loss of appetite. It often turns urine, sweat, and tears a red or orange color. Liver problems or allergic reactions ma ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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