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Luciano Marraffini
Luciano Marraffini (born July 17, 1974) is an Argentinian-American microbiologist. He is currently professor and head of the laboratory of bacteriology at The Rockefeller University. He is recognized for his work on CRISPR-Cas systems, being one of the first scientists to elucidate how these systems work at the molecular level. Early life and education Marraffini was born and raised in Rosario, Argentina. He had two passions growing up: following his hometown soccer team Club Atlético Newell's Old Boys, and reading about science. Marraffini attended the Escuela Dante Alighieri high school and then entered the Facultad de Ciencias Bioquimicas y Farmaceuticas at the Universidad Nacional de Rosario to pursue a degree in Biotechnology. As an undergraduate he studied the biochemistry of plant ferredoxin-NADP⁺ reductases under the guidance of Dr. Eduardo Ceccarelli. Marraffini moved to Chicago for his doctoral studies. He earned a PhD from the University of Chicago investigating t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Rosario
Rosario () is the largest city in the central provinces of Argentina, Argentine province of Santa Fe Province, Santa Fe. The city is located northwest of Buenos Aires, on the west bank of the Paraná River. Rosario is the third-most populous city in the country, and is also the most populous city in Argentina that is not a capital (provincial or national). With a growing and important metropolitan area, Greater Rosario has an estimated population of 1,750,000 . One of its main attractions includes the neoclassical architecture, neoclassical, Art Nouveau, and Art Deco architecture that has been retained over the centuries in hundreds of residences, houses and public buildings. Rosario is the head city of the Rosario Department and is located at the heart of the major industrial corridor in Argentina. The city is a major rail transport, railroad terminal and the shipping center for north-eastern Argentina. Ships reach the city via the Paraná River, which allows the existence of a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of Chicago
The University of Chicago (UChicago, Chicago, U of C, or UChi) is a private research university in Chicago, Illinois. Its main campus is located in Chicago's Hyde Park neighborhood. The University of Chicago is consistently ranked among the best universities in the world and it is among the most selective in the United States. The university is composed of an undergraduate college and five graduate research divisions, which contain all of the university's graduate programs and interdisciplinary committees. Chicago has eight professional schools: the Law School, the Booth School of Business, the Pritzker School of Medicine, the Crown Family School of Social Work, Policy, and Practice, the Harris School of Public Policy, the Divinity School, the Graham School of Continuing Liberal and Professional Studies, and the Pritzker School of Molecular Engineering. The university has additional campuses and centers in London, Paris, Beijing, Delhi, and Hong Kong, as well as in downtown ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
American Society For Biochemistry And Molecular Biology
The American Society for Biochemistry and Molecular Biology (ASBMB) is a learned society that was founded on December 26, 1906, at a meeting organized by John Jacob Abel (Johns Hopkins University). The roots of the society were in the American Physiological Society, which had been formed some 20 years earlier. ASBMB is the US member of the International Union of Biochemistry and Molecular Biology. The ASBMB was originally called the American Society of Biological Chemists, before obtaining its current name in 1987. The society is based in Rockville, Maryland. ASBMB's mission is to advance the science of biochemistry and molecular biology through publication of scientific and educational journals, the organization of scientific meetings, advocacy for funding of basic research and education, support of science education at all levels, and by promoting the diversity of individuals entering the scientific workforce. The organization currently has over 12,000 members. Publications Th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of Bern
The University of Bern (german: Universität Bern, french: Université de Berne, la, Universitas Bernensis) is a university in the Switzerland, Swiss capital of Bern and was founded in 1834. It is regulated and financed by the Canton of Bern. It is a comprehensive university offering a broad choice of courses and programs in eight faculty (division), faculties and some 150 institutes. With around 18,576 students, the University of Bern is the third largest university in Switzerland. Organization The University of Bern operates at three levels: university, faculties and institutes. Other organizational units include interfaculty and general university units. The university's highest governing body is the Senate, which is responsible for issuing statutes, rules and regulations. Directly answerable to the Senate is the University Board of Directors, the governing body for university management and coordination. The board comprises the rector, the vice-rectors and the administrati ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hans Sigrist Prize
The Hans Sigrist Prize is awarded by the Hans Sigrist Foundation, at the University of Bern in Switzerland. The Foundation's benefactor Hans Sigrist died on December 30, 1982. The Foundation was founded in 1993. The Foundation's first award was presented in 1994. The Hans Sigrist Prize is for mid-career researchers in order to boost those researcher's potential impact. Every year, the Foundation asks faculty members at the University of Bern to propose a prize field. The Foundation board chooses a field from those proposals and selects a chair for the prize search committee. Two former Hans Sigrist prize winners have gone on to win Nobel prizes The Nobel Prizes ( ; sv, Nobelpriset ; no, Nobelprisen ) are five separate prizes that, according to Alfred Nobel's will of 1895, are awarded to "those who, during the preceding year, have conferred the greatest benefit to humankind." Alfre ... later in their careers. The Hans Sigrist Doctoral Fellowship is an up to three year Fellow ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
NIH Director's New Innovator Award
National Institutes of Health Director's New Innovator Award is a research initiative first announced in 2007 designed to supports exceptionally creative, early-career investigators who propose innovative, high-impact projects. The focus is specifically on "innovative" research that has a potential to produce paradigm shifting results. The Award is for $300,000 (direct cost) per year for five years. The NIH Director's New Innovator Award has one of the lowest "success rates" of all NIH funding mechanism. In 2014 only the National Institutes of Health Director's Pioneer Award had a lower "success rate." During the evaluation process each New Innovator application is reviewed and scored independently by three external reviewers. NIA program leadership then rank the applications by averaging the Overall Scores, and the highest scored applications are considered finalists. The finalist applications are then scored by a second set of reviewers, and are ranked once more by program lead ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Genomes
In the fields of molecular biology and genetics, a genome is all the genetic information of an organism. It consists of nucleotide sequences of DNA (or RNA in RNA viruses). The nuclear genome includes protein-coding genes and non-coding genes, other functional regions of the genome such as regulatory sequences (see non-coding DNA), and often a substantial fraction of 'junk' DNA with no evident function. Almost all eukaryotes have mitochondria and a small mitochondrial genome. Algae and plants also contain chloroplasts with a chloroplast genome. The study of the genome is called genomics. The genomes of many organisms have been sequenced and various regions have been annotated. The International Human Genome Project reported the sequence of the genome for ''Homo sapiens'' in 200The Human Genome Project although the initial "finished" sequence was missing 8% of the genome consisting mostly of repetitive sequences. With advancements in technology that could handle sequencing ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
CRISPR-Cas9
Cas9 (CRISPR associated protein 9, formerly called Cas5, Csn1, or Csx12) is a 160 kilodalton protein which plays a vital role in the immunological defense of certain bacteria against DNA viruses and plasmids, and is heavily utilized in genetic engineering applications. Its main function is to cut DNA and thereby alter a cell's genome. The CRISPR-Cas9 genome editing technique was a significant contributor to the Nobel Prize in Chemistry in 2020 being awarded to Emmanuelle Charpentier and Jennifer Doudna. More technically, Cas9 is a dual RNA-guided DNA endonuclease enzyme associated with the Clustered Regularly Interspaced Short Palindromic Repeats ( CRISPR) adaptive immune system in ''Streptococcus pyogenes''. ''S. pyogenes'' utilizes CRISPR to memorize and Cas9 to later interrogate and cleave foreign DNA, such as invading bacteriophage DNA or plasmid DNA. Cas9 performs this interrogation by unwinding foreign DNA and checking for sites complementary to the 20 nucleotide sp ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Harvard
Harvard University is a private Ivy League research university in Cambridge, Massachusetts. Founded in 1636 as Harvard College and named for its first benefactor, the Puritan clergyman John Harvard, it is the oldest institution of higher learning in the United States and one of the most prestigious and highly ranked universities in the world. The university is composed of ten academic faculties plus Harvard Radcliffe Institute. The Faculty of Arts and Sciences offers study in a wide range of undergraduate and graduate academic disciplines, and other faculties offer only graduate degrees, including professional degrees. Harvard has three main campuses: the Cambridge campus centered on Harvard Yard; an adjoining campus immediately across Charles River in the Allston neighborhood of Boston; and the medical campus in Boston's Longwood Medical Area. Harvard's endowment is valued at $50.9 billion, making it the wealthiest academic institution in the world. Endowment inco ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Broad Institute
The Eli and Edythe L. Broad Institute of MIT and Harvard (IPA: , pronunciation respelling: ), often referred to as the Broad Institute, is a biomedical and genomic research center located in Cambridge, Massachusetts, Cambridge, Massachusetts, United States. The institute is independently governed and supported as a 501(c)(3) nonprofit research organization under the name Broad Institute Inc., and it partners with the Massachusetts Institute of Technology, Harvard University, and the five Harvard teaching hospitals. History The Broad Institute evolved from a decade of research collaborations among MIT and Harvard scientists. One cornerstone was the Center for Genome Research of Whitehead Institute at MIT. Founded in 1982, the Whitehead became a major center for genomics and the Human Genome Project. As early as 1995, scientists at the Whitehead started pilot projects in genomic medicine, forming an unofficial collaborative network among young scientists interested in genomic a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Feng Zhang
Feng Zhang (; born October 22, 1981) is a Chinese-American biochemist. Zhang currently holds the James and Patricia Poitras Professorship in Neuroscience at the McGovern Institute for Brain Research and in the departments of Brain and Cognitive Sciences and Biological Engineering at the Massachusetts Institute of Technology. He also has appointments with the Broad Institute of MIT and Harvard (where he is a core member). He is most well known for his central role in the development of optogenetics and CRISPR technologies. Early life and education Zhang was born in China in 1981 and given the name 锋 (which means "point of a spear; edge of a tool; vanguard"). Both of his parents were computer programmers in China. At age 11, he moved to Iowa with his mother (his father was not able to join them for several years). He attended Theodore Roosevelt High School and Central Academy in Des Moines, graduating in 2000. In 1999 he attended the acclaimed Research Science Institute at M ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Olaf Schneewind
Olaf Schneewind was a German-born American microbiologist who made important contributions to the study of bacterial cell wall composition and assembly as well as the pathogenesis of the microbial species '' S. aureus''. Republished as: He was elected to the National Academy of Sciences in 2018. Career Schneewind was born in Germany and attended the University of Cologne. He completed postdoctoral training with Vincent Fischetti at Rockefeller University. Schneewind subsequently joined the faculty of the University of California, Los Angeles in 1992. His first major discovery as an independent investigator was the finding that the surface proteins of gram-positive bacteria are cleaved between the T and G residue in the LPXTG sortase signal by the enzyme sortase (the enzyme was not discovered yet, but was later shown by him to be responsible for the cleavage) in order to be anchored to the cell wall. In 2001, Schneewind began teaching at the University of Chicago The Uni ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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