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List Of Cutaneous Neoplasms Associated With Systemic Syndromes
Many cutaneous neoplasms occur in the setting of systemic syndromes. See also *List of cutaneous conditions *List of contact allergens *List of cutaneous conditions associated with increased risk of nonmelanoma skin cancer *List of cutaneous conditions associated with internal malignancy *List of cutaneous conditions caused by mutations in keratins *List of cutaneous conditions caused by problems with junctional proteins *List of dental abnormalities associated with cutaneous conditions *List of genes mutated in cutaneous conditions *List of genes mutated in pigmented cutaneous lesions *List of histologic stains that aid in diagnosis of cutaneous conditions *List of immunofluorescence findings for autoimmune bullous conditions *List of inclusion bodies that aid in diagnosis of cutaneous conditions *List of keratins expressed in the human integumentary system *List of radiographic findings associated with cutaneous conditions *List of specialized glands within the human integum ...
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Neoplasms
A neoplasm () is a type of abnormal and excessive growth of tissue. The process that occurs to form or produce a neoplasm is called neoplasia. The growth of a neoplasm is uncoordinated with that of the normal surrounding tissue, and persists in growing abnormally, even if the original trigger is removed. This abnormal growth usually forms a mass, when it may be called a tumor. ICD-10 classifies neoplasms into four main groups: benign neoplasms, in situ neoplasms, malignant neoplasms, and neoplasms of uncertain or unknown behavior. Malignant neoplasms are also simply known as cancers and are the focus of oncology. Prior to the abnormal growth of tissue, as neoplasia, cells often undergo an abnormal pattern of growth, such as metaplasia or dysplasia. However, metaplasia or dysplasia does not always progress to neoplasia and can occur in other conditions as well. The word is from Ancient Greek 'new' and 'formation, creation'. Types A neoplasm can be benign, potentially ma ...
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Syringofibroadenoma
Syringofibroadenoma is a cutaneous condition characterized by a hyperkeratotic nodule or plaque involving the extremities. It is considered of eccrine origin. See also * Syringadenoma papilliferum * Skin lesion A skin condition, also known as cutaneous condition, is any medical condition that affects the integumentary system—the organ system that encloses the body and includes skin, nails, and related muscle and glands. The major function of this s ... References External links Epidermal nevi, neoplasms, and cysts {{Epidermal-growth-stub ...
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Fibrofolliculoma
Fibrofolliculomas are 2 to 4 mm in diameter, dome-shaped, yellowish or skin-colored papules usually located on the head, neck, and upper trunk. They are characteristically seen in Birt–Hogg–Dubé syndrome.Freedberg, et al. (2003). ''Fitzpatrick's Dermatology in General Medicine''. (6th ed.). Page 994. McGraw-Hill. . See also * List of cutaneous conditions * List of cutaneous neoplasms associated with systemic syndromes Many cutaneous neoplasms occur in the setting of systemic syndromes. See also * List of cutaneous conditions * List of contact allergens * List of cutaneous conditions associated with increased risk of nonmelanoma skin cancer *List of cutane ... * Trichodiscoma References Epidermal nevi, neoplasms, and cysts {{Epidermal-growth-stub ...
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Spiradenoma
Spiradenomas (SA) are rare, benign cutaneous adnexal tumors that may progress to become their malignant counterparts, i.e. spiradenocarcinomas (SAC). Cutaneous adnexal tumors are a group of skin tumors consisting of tissues that have differentiated (i.e. matured from stem cells) towards one of the four primary adnexal structures found in normal skin: hair follicles, sebaceous sweat glands, apocrine sweat glands, and eccrine sweat glands. SA and SAC tumors were regarded as eccrine gland tumors and termed eccrine spiradenomas and eccrine spiradenocarcinomas, respectively. However, more recent studies have found them to be hair follicle tumors and commonly term them spiradenomas and spiradenocarcinomas, respectively. Further confusing the situation, SA-like and SAC-like tumors are also 1) manifestations of the inherited disorder, CYLD cutaneous syndrome (CCS), and 2) have repeatedly been confused with an entirely different tumor, adenoid cystic carcinomas of the salivary gland. Her ...
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Poroma
Poromas are rare, benign, cutaneous adnexal tumors. Cutaneous adnexal tumors are a group of skin tumors consisting of tissues that have differentiated (i.e. matured from stem cells) towards one or more of the four primary adnexal structures found in normal skin: hair follicles, sebaceous sweat glands, apocrine sweat glands, and eccrine sweat glands. Poromas are eccrine or apocrine sweat gland tumors derived from the cells in the terminal portion of these glands' ducts. This part of the sweat gland duct is termed the acrosyringium and had led to grouping poromas in the acrospiroma class of skin tumors ( syringofibroadenomas and syringoacanthomas are classified as acrospiromas). Here, poromas are regarded as distinct sweat gland tumors that differ from other sweat gland tumors by their characteristic clinical presentations, microscopic histopathology, and the genetic mutations that their neoplastic cells have recently been found to carry. As currently viewed, there are 4 por ...
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Turner Syndrome
Turner syndrome (TS), also known as 45,X, or 45,X0, is a genetic condition in which a female is partially or completely missing an X chromosome. Signs and symptoms vary among those affected. Often, a short and webbed neck, low-set ears, low hairline at the back of the neck, short stature, and swollen hands and feet are seen at birth. Typically, those affected do not develop menstrual periods, or breasts without hormone treatment and are unable to have children without reproductive technology. Heart defects, diabetes, and low thyroid hormone occur in the disorder more frequently than average. Most people with Turner syndrome have normal intelligence; however, many have problems with spatial visualization that may be needed in order to learn mathematics. Vision and hearing problems also occur more often than average. Turner syndrome is not usually inherited; rather, it occurs during formation of the reproductive cells in a parent or in early cell division during development. ...
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Pilomatricoma
Pilomatricoma, is a benign skin tumor derived from the hair matrix. These neoplasms are relatively uncommon and typically occur on the scalp, face, and upper extremities. Clinically, pilomatricomas present as a subcutaneous nodule or cyst with unremarkable overlying epidermis that can range in size from 0.5 to 3.0 cm, but the largest reported case was 24 cm. Presentation Associations Pilomatricomas have been observed in a variety of genetic disorders including Turner syndrome, myotonic dystrophy, Rubinstein-Taybi syndrome, Trisomy 9, and Gardner syndrome. It has been reported that the prevalence of pilomatricomas in Turner syndrome is 2.6%. Hybrid cysts that are composed of epidermal inclusion cysts and pilomatricoma-like changes have been repeatedly observed in Gardner syndrome. This association has prognostic import, since cutaneous findings in children with Gardner Syndrome generally precede colonic polyposis. Histologic features The characteristic components of ...
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Hidrocystoma
Hidrocystoma (also known as cystadenoma, a Moll's gland cyst, and a sudoriferous cyst) is an adenoma of the sweat glands.Freedberg, et al. (2003). ''Fitzpatrick's Dermatology in General Medicine''. (6th ed.). McGraw-Hill. . Hidrocystomas are cysts of sweat ducts, usually on the eyelids. They are not tumours (a similar-sounding lesion called hidroadenoma is a benign tumour). The three types of "sweat" glands are: True sweat glands or eccrine glands, sebaceous glands, which have an oily secretion around hair follicles, and apocrine glands, which have more oily product than eccrine glands and are found on the face, armpit, and groin. Hidrocystomas usually arise from apocrine glands. They are also called cysts of Moll or sudoriferous cysts. A type of hidroadenoma that arises from eccrine glands is uncommon. Other related conditions on the eyelids include chalazion (a granulomatous reaction to sebaceous glands on the eyelid), lacrimal duct cysts (cysts related to tear ducts), and nas ...
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Birt–Hogg–Dubé Syndrome
Birt–Hogg–Dubé syndrome (BHD), also Hornstein–Birt–Hogg–Dubé syndrome, Hornstein–Knickenberg syndrome, and fibrofolliculomas with trichodiscomas and acrochordons is a human autosomal dominant genetic disorder that can cause susceptibility to kidney cancer, renal and pulmonary cysts, and noncancerous tumors of the hair follicles, called fibrofolliculomas. The symptoms seen in each family are unique, and can include any combination of the three symptoms. Fibrofolliculomas are the most common manifestation, found on the face and upper trunk in over 80% of people with BHD over the age of 40. Pulmonary cysts are equally common (84%), but only 24% of people with BHD eventually experience a collapsed lung (spontaneous pneumothorax). Kidney tumors, both cancerous and benign, occur in 14–34% of people with BHD; the associated kidney cancers are often rare hybrid tumors. Any of these conditions that occurs in a family can indicate a diagnosis of Birt–Hogg–Dubé syndr ...
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Trichodiscoma
A trichodiscoma is a cutaneous condition, a benign, usually skin-colored tumor most often affecting the face and upper trunk. See also * Birt–Hogg–Dubé syndrome * Fibrofolliculoma * List of cutaneous conditions * List of cutaneous neoplasms associated with systemic syndromes Many cutaneous neoplasms occur in the setting of systemic syndromes. See also * List of cutaneous conditions * List of contact allergens * List of cutaneous conditions associated with increased risk of nonmelanoma skin cancer *List of cutane ... References External links Epidermal nevi, neoplasms, and cysts {{Epidermal-growth-stub ...
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Nicolau–Balus Syndrome
Nicolau–Balus syndrome is a cutaneous condition characterized by syringomas and milia. See also * Parry–Romberg syndrome * List of cutaneous conditions * List of cutaneous neoplasms associated with systemic syndromes Many cutaneous neoplasms occur in the setting of systemic syndromes. See also * List of cutaneous conditions * List of contact allergens * List of cutaneous conditions associated with increased risk of nonmelanoma skin cancer *List of cutane ... References Connective tissue diseases Syndromes {{Dermatology-stub ...
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Down Syndrome
Down syndrome or Down's syndrome, also known as trisomy 21, is a genetic disorder caused by the presence of all or part of a third copy of chromosome 21. It is usually associated with physical growth delays, mild to moderate intellectual disability, and characteristic facial features. The average IQ of a young adult with Down syndrome is 50, equivalent to the mental ability of an eight- or nine-year-old child, but this can vary widely. The parents of the affected individual are usually genetically normal. The probability increases from less than 0.1% in 20-year-old mothers to 3% in those of age 45. The extra chromosome is believed to occur by chance, with no known behavioral activity or environmental factor that changes the probability. Down syndrome can be identified during pregnancy by prenatal screening followed by diagnostic testing or after birth by direct observation and genetic testing. Since the introduction of screening, Down syndrome pregnancies are often abor ...
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