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Leishmaniavirus
''Leishmaniavirus'' (also known as ''Leishmania'' RNA virus or LRV) is a genus of double-stranded RNA virus, in the family ''Totiviridae''. Protozoa serve as natural hosts, and Leishmaniaviruses are present in several species of the human protozoan parasite '' Leishmania''. There are two species in this genus. History The presence of virus-like particles in ''Leishmania hertigi'' was first reported in 1974. Various molecular descriptions of ''Leishmaniavirus'' were revealed over the subsequent decade, and mostly performed on members of the South American ''L. (Viannia)'' subgenus of parasites (which carries the LRV1 species) such as ''L. guyanensis'' (''L.g'') and then later in '' L. braziliensis'' (''L.b''). Recently, interest in these microbial viruses has been renewed by a finding that they may play a role in leishmanial pathology. Prevalence The prevalence of LRV1 in human parasites is still largely unknown. So far, no LRV1 has been detected in other key ''L. (Viannia)'' s ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Totiviridae
''Totiviridae'' is a family of double-stranded RNA viruses. Giardia lamblia, leishmania, trichomonas vaginalis, and fungi serve as natural hosts. The name of the group derives from Latin ''toti'' which means undivided or whole. There are 28 species in this family, assigned to 5 genera. Structure Viruses in the family ''Totiviridae'' are non-enveloped, double-stranded RNA viruses with icosahedral geometries, and T=2 symmetry. The virion consists of a single capsid protein and is about 40 nanometers in diameter. Genome The genome is composed of a monopartite, linear double-stranded RNA molecule of 4.6–6.7 kilobases. It contains two overlapping open reading frames (ORF) – ''gag'' and ''pol –'' which respectively encode the capsid protein and the RNA-dependent RNA polymerase. Some totiviruses contain a third small potential ORF. Life cycle Viral replication is cytoplasmic. Replication follows the double-stranded RNA virus replication model. Double-stranded RNA virus tran ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Double-stranded RNA Virus
Double-stranded RNA viruses (dsRNA viruses) are a polyphyletic group of viruses that have double-stranded genomes made of ribonucleic acid. The double-stranded genome is used to transcribe a positive-strand RNA by the viral RNA-dependent RNA polymerase (RdRp). The positive-strand RNA may be used as messenger RNA (mRNA) which can be translated into viral proteins by the host cell's ribosomes. The positive-strand RNA can also be replicated by the RdRp to create a new double-stranded viral genome. Double-stranded RNA viruses are classified in two separate phyla ''Duplornaviricota'' and ''Pisuviricota'' (specifically class ''Duplopiviricetes''), which are in the kingdom ''Orthornavirae'' and realm ''Riboviria''. The two groups do not share a common dsRNA virus ancestor. Double-stranded RNA viruses evolved two separate times from positive-strand RNA viruses. In the Baltimore classification system, dsRNA viruses belong to Group III. Virus group members vary widely in host range (anim ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Protozoan
Protozoa (singular: protozoan or protozoon; alternative plural: protozoans) are a group of single-celled eukaryotes, either free-living or parasitic, that feed on organic matter such as other microorganisms or organic tissues and debris. Historically, protozoans were regarded as "one-celled animals", because they often possess animal-like behaviours, such as motility and predation, and lack a cell wall, as found in plants and many algae. When first introduced by Georg Goldfuss (originally spelled Goldfuß) in 1818, the taxon Protozoa was erected as a class within the Animalia, with the word 'protozoa' meaning "first animals". In later classification schemes it was elevated to a variety of higher ranks, including phylum, subkingdom and kingdom, and sometimes included within Protoctista or Protista. The approach of classifying Protozoa within the context of Animalia was widespread in the 19th and early 20th century, but not universal. By the 1970s, it became usual to require th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Leishmania
''Leishmania'' is a parasitic protozoan, a single-celled organism of the genus '' Leishmania'' that are responsible for the disease leishmaniasis. They are spread by sandflies of the genus ''Phlebotomus'' in the Old World, and of the genus ''Lutzomyia'' in the New World. At least 93 sandfly species are proven or probable vectors worldwide.WHO (2010) Annual report. Geneva Their primary hosts are vertebrates; ''Leishmania'' commonly infects hyraxes, canids, rodents, and humans. History Members of an ancient genus of the ''Leishmania'' parasite, ''Paleoleishmania'', have been detected in fossilized sand flies dating back to the early Cretaceous period. The first written reference to the conspicuous symptoms of cutaneous leishmaniasis surfaced in the Paleotropics within oriental texts dating back to the 7th century BC (allegedly transcribed from sources several hundred years older, between 1500 and 2000 BC). Due to its broad and persistent prevalence throughout antiquity as a mys ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Leishmania Braziliensis
''Leishmania braziliensis'' is a ''Leishmania'' species. It is associated with leishmaniasis. Geographical distribution : countries of South and central America. forms (stages): amastigote in the human cells body and animals. Signs and symptoms Within a few months of infection, an ulcer forms. After healing there is an asymptomatic phase for three to twenty years. At this time, the parasite causes oral and nasal lesions causing severe damage to the mucus membranes. Visceral Leishmaniasis causes the infected to have a fever, skin lesions, skin tumors, loss in weight, spleen and liver enlargement, and if left untreated, death. Treatment Pentostam, Liposomal and lipid complex preparations of Amphotericin B, or paromomycin can be given. In Brazil, Currently, the most common treatment for humans to cure Leishmaniasis is the drug pentavalent antimony. The treatment is expensive, toxic, and only “variably effective.” Although 80 percent of patients respond successfully to the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pathology
Pathology is the study of the causes and effects of disease or injury. The word ''pathology'' also refers to the study of disease in general, incorporating a wide range of biology research fields and medical practices. However, when used in the context of modern medical treatment, the term is often used in a narrower fashion to refer to processes and tests that fall within the contemporary medical field of "general pathology", an area which includes a number of distinct but inter-related medical specialties that diagnose disease, mostly through analysis of tissue, cell, and body fluid samples. Idiomatically, "a pathology" may also refer to the predicted or actual progression of particular diseases (as in the statement "the many different forms of cancer have diverse pathologies", in which case a more proper choice of word would be " pathophysiologies"), and the affix ''pathy'' is sometimes used to indicate a state of disease in cases of both physical ailment (as in cardiomy ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Neotropics
The Neotropical realm is one of the eight biogeographic realms constituting Earth's land surface. Physically, it includes the tropics, tropical Ecoregion#Terrestrial, terrestrial ecoregions of the Americas and the entire South American temperate climate, temperate zone. Definition In biogeography, the Neotropic or Neotropical realm is one of the eight terrestrial realms. This realm includes South America, Central America, the Caribbean islands, and southern North America. In Mexico, the Yucatán Peninsula and southern lowlands, and most of the east and west coastlines, including the southern tip of the Baja California Peninsula are Neotropical. In the United States southern Florida and coastal Central Florida are considered Neotropical. The realm also includes temperate southern South America. In contrast, the Neotropical Phytochorion, Floristic Kingdom excludes southernmost South America, which instead is placed in the Antarctic Floristic Kingdom, Antarctic kingdom. The ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Paleotropic
The Paleotropical Kingdom (Paleotropis) is a floristic kingdom comprising tropical areas of Africa, Asia and Oceania (excluding Australia and New Zealand), as proposed by Ronald Good and Armen Takhtajan. Part of its flora, inherited from the ancient supercontinent of Gondwana or exchanged later (e.g. Piperaceae with pantropical distribution and but few warm temperate representatives), is shared with the Neotropical Kingdom, comprising tropical areas of Central and South America. Moreover, the Paleotropical flora influenced the tropical flora of the Australian Kingdom. The Paleotropical Kingdom is subdivided into five floristic subkingdoms according to Takhtajan (or three, according to Good) and about 13 floristic regions. In this article the floristic subkingdoms and regions are given as delineated by Takhtajan. Origin A distinct community of vascular plants evolved millions of years ago, and are now found on several separate areas. Millions of years ago, the warmer and wetter areas ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cutaneous Leishmaniasis
Cutaneous leishmaniasis is the most common form of leishmaniasis affecting humans. It is a skin infection caused by a single-celled parasite that is transmitted by the bite of a phlebotomine sand fly. There are about thirty species of ''Leishmania'' that may cause cutaneous leishmaniasis. This disease is considered to be a zoonosis (an infectious disease that is naturally transmissible from animals to humans), with the exception of ''Leishmania tropica'' — which is often an anthroponotic disease (an infectious disease that is naturally transmissible from humans to vertebrate animals). Signs and symptoms Post kala-azar dermal leishmaniasis Post-kala-azar dermal leishmaniasis (PKDL) is a recurrence of kala-azar that may appear on the skin of affected individuals months and up to 20 years after being partially treated, untreated or even in those considered adequately treated. In Sudan, they can be demonstrated in up to 60% of treated cases. They manifest as hypopigmented ski ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ethiopian Highlands
The Ethiopian Highlands is a rugged mass of mountains in Ethiopia in Northeast Africa. It forms the largest continuous area of its elevation in the continent, with little of its surface falling below , while the summits reach heights of up to . It is sometimes called the Roof of Africa due to its height and large area. Most of the Ethiopian Highlands are part of central and northern Ethiopia, and its northernmost portion reaches into Eritrea. History In the southern parts of the Ethiopian Highlands once was located the Kingdom of Kaffa, a medieval early modern state, whence the coffee plant was exported to the Arabian Peninsula. The land of the former kingdom is mountainous with stretches of forest. The land is very fertile, capable of three harvests a year. The term ''coffee'' derives from the ar, قهوة, italic=no ()''Oxford English Dictionary'', 1st ed. "coffee, ''n.''" Oxford University Press (Oxford), 1891. and is traced to Kaffa. Physical geography The Highl ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Leishmania RNA Virus 1
''Leishmania'' is a parasitic protozoan, a single-celled organism of the genus ''Leishmania'' that are responsible for the disease leishmaniasis. They are spread by sandflies of the genus ''Phlebotomus'' in the Old World, and of the genus ''Lutzomyia'' in the New World. At least 93 sandfly species are proven or probable vectors worldwide.WHO (2010) Annual report. Geneva Their primary hosts are vertebrates; ''Leishmania'' commonly infects hyraxes, canids, rodents, and humans. History Members of an ancient genus of the ''Leishmania'' parasite, ''Paleoleishmania'', have been detected in fossilized sand flies dating back to the early Cretaceous period. The first written reference to the conspicuous symptoms of cutaneous leishmaniasis surfaced in the Paleotropics within oriental texts dating back to the 7th century BC (allegedly transcribed from sources several hundred years older, between 1500 and 2000 BC). Due to its broad and persistent prevalence throughout antiquity as a myste ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Leishmania RNA Virus 2
''Leishmania'' is a parasitic protozoan, a single-celled organism of the genus ''Leishmania'' that are responsible for the disease leishmaniasis. They are spread by sandflies of the genus ''Phlebotomus'' in the Old World, and of the genus ''Lutzomyia'' in the New World. At least 93 sandfly species are proven or probable vectors worldwide.WHO (2010) Annual report. Geneva Their primary hosts are vertebrates; ''Leishmania'' commonly infects hyraxes, canids, rodents, and humans. History Members of an ancient genus of the ''Leishmania'' parasite, ''Paleoleishmania'', have been detected in fossilized sand flies dating back to the early Cretaceous period. The first written reference to the conspicuous symptoms of cutaneous leishmaniasis surfaced in the Paleotropics within oriental texts dating back to the 7th century BC (allegedly transcribed from sources several hundred years older, between 1500 and 2000 BC). Due to its broad and persistent prevalence throughout antiquity as a myste ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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