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Lapachol
Lapachol is a natural phenolic compound isolated from the bark of the lapacho tree.Record, Samuel J.. "Lapachol" pages 17-19. In: ''Tropical Woods'' (1925). This tree is known botanically as ''Handroanthus impetiginosus'', but was formerly known by various other botanical names such as ''Tabebuia avellanedae''. Lapachol is also found in other species of ''Handroanthus''. Lapachol is usually encountered as a yellow, skin-irritating powder from wood. Chemically, it is a derivative of vitamin K Vitamin K refers to structurally similar, fat-soluble vitamers found in foods and marketed as dietary supplements. The human body requires vitamin K for post-synthesis modification of certain proteins that are required for blood coagulation ....Louis F.Fieser. ''The Scientific Method'' pages 163-191. Reinhold Publishing Corporation, New York, 1964 Once studied as a possible treatment for some types of cancer, it is now considered too toxic for use. See also * Hooker reaction R ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Handroanthus Impetiginosus
''Handroanthus impetiginosus'', the pink ipê, pink lapacho or pink trumpet tree, is a tree in the family Bignoniaceae, distributed throughout North, Central and South America, from northern Mexico south to northern Argentina. It is the national tree of Paraguay. Description It is a rather large deciduous tree, with trunks sometimes reaching in width and in height. Usually a third of that height is trunk, and two thirds are its longer branches. It has a large, globous, but often sparse canopy. The tree has a slow growth rate. Leaves are opposite and petiolate, 2 to 3 inches long, elliptic and lanceolate, with lightly serrated margins and pinnate venation. The leaves are palmately compound with usually 5 leaflets. Its bark is brownish grey, tough and hard to peel. The wood is of a pleasant yellowish colour, barely knotted and very tough and heavy (0,935 kg/dm³). It's rich in tannins and therefore very resistant to weather and sun.López ''et al.'' (1987) It is not ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hooker Reaction
In the Hooker reaction (1936) an alkyl chain in a certain naphthoquinone (phenomenon first observed in the compound lapachol) is reduced by one methylene unit as carbon dioxide in each potassium permanganate oxidation.''On the Oxidation of 2-Hydroxy-1,4-naphthoquinone Derivatives with Alkaline Potassium Permanganate. Part II. Compounds with Unsaturated Side'' Chains Samuel C. Hooker and Al Steyermark J. Am. Chem. Soc. 1936; 58(7); pp 1179–81; : :Mechanistically oxidation causes ring-cleavage at the alkene group, extrusion of carbon dioxide in decarboxylation Decarboxylation is a chemical reaction that removes a carboxyl group and releases carbon dioxide (CO2). Usually, decarboxylation refers to a reaction of carboxylic acids, removing a carbon atom from a carbon chain. The reverse process, which is t ... with subsequent ring-closure. : References {{reflist Organic reactions Name reactions Degradation reactions Homologation reactions ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nature
Nature, in the broadest sense, is the physics, physical world or universe. "Nature" can refer to the phenomenon, phenomena of the physical world, and also to life in general. The study of nature is a large, if not the only, part of science. Although humans are part of nature, human activity is often understood as a separate category from other natural phenomena. The word ''nature'' is borrowed from the Old French ''nature'' and is derived from the Latin word ''natura'', or "essential qualities, innate disposition", and in ancient times, literally meant "birth". In ancient philosophy, ''natura'' is mostly used as the Latin translation of the Greek word ''physis'' (φύσις), which originally related to the intrinsic characteristics of plants, animals, and other features of the world to develop of their own accord. The concept of nature as a whole, the physical universe, is one of several expansions of the original notion; it began with certain core applications of the word ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Phenolic Compound
In organic chemistry, phenols, sometimes called phenolics, are a class of chemical compounds consisting of one or more hydroxyl groups (— O H) bonded directly to an aromatic hydrocarbon group. The simplest is phenol, . Phenolic compounds are classified as simple phenols or polyphenols based on the number of phenol units in the molecule. Phenols are both synthesized industrially and produced by plants and microorganisms. Properties Acidity Phenols are more acidic than typical alcohols. The acidity of the hydroxyl group in phenols is commonly intermediate between that of aliphatic alcohols and carboxylic acids (their pKa is usually between 10 and 12). Deprotonation of a phenol forms a corresponding negative phenolate ion or phenoxide ion, and the corresponding salts are called phenolates or phenoxides (aryloxides according to the IUPAC Gold Book). Condensation with aldehydes and ketones Phenols are susceptible to Electrophilic aromatic substitutions. Condensation with formald ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bark Isolate
Bark isolates are chemicals which have been extracted from bark. Prominent medical examples are salicylic acid (active metabolite of aspirin) and paclitaxel (Taxol). The pharmacology Pharmacology is a branch of medicine, biology and pharmaceutical sciences concerned with drug or medication action, where a drug may be defined as any artificial, natural, or endogenous (from within the body) molecule which exerts a biochemica ... of bark isolates is an ongoing topic of medical research. See also Notes {{Reflist Trees Pharmaceutical isolates ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Scientific Name
In taxonomy, binomial nomenclature ("two-term naming system"), also called nomenclature ("two-name naming system") or binary nomenclature, is a formal system of naming species of living things by giving each a name composed of two parts, both of which use Latin grammatical forms, although they can be based on words from other languages. Such a name is called a binomial name (which may be shortened to just "binomial"), a binomen, name or a scientific name; more informally it is also historically called a Latin name. The first part of the name – the '' generic name'' – identifies the genus to which the species belongs, whereas the second part – the specific name or specific epithet – distinguishes the species within the genus. For example, modern humans belong to the genus ''Homo'' and within this genus to the species ''Homo sapiens''. ''Tyrannosaurus rex'' is likely the most widely known binomial. The ''formal'' introduction of this system of naming species is credit ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Botanical Name
A botanical name is a formal scientific name conforming to the '' International Code of Nomenclature for algae, fungi, and plants'' (ICN) and, if it concerns a plant cultigen, the additional cultivar or Group epithets must conform to the ''International Code of Nomenclature for Cultivated Plants'' (ICNCP). The code of nomenclature covers "all organisms traditionally treated as algae, fungi, or plants, whether fossil or non-fossil, including blue-green algae ( Cyanobacteria), chytrids, oomycetes, slime moulds and photosynthetic protists with their taxonomically related non-photosynthetic groups (but excluding Microsporidia)." The purpose of a formal name is to have a single name that is accepted and used worldwide for a particular plant or plant group. For example, the botanical name ''Bellis perennis'' denotes a plant species which is native to most of the countries of Europe and the Middle East, where it has accumulated various names in many languages. Later, the plant was intro ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Vitamin K
Vitamin K refers to structurally similar, fat-soluble vitamers found in foods and marketed as dietary supplements. The human body requires vitamin K for post-synthesis modification of certain proteins that are required for blood coagulation (K from ''Koagulation'', German for "coagulation") or for controlling binding of calcium in bones and other tissues. The complete synthesis involves final modification of these so-called "Gla proteins" by the enzyme gamma-glutamyl carboxylase that uses vitamin K as a cofactor. Vitamin K is used in the liver as the intermediate VKH2 to deprotonate a glutamate residue and then is reprocessed into vitamin K through a vitamin K oxide intermediate. The presence of uncarboxylated proteins indicates a vitamin K deficiency. Carboxylation allows them to bind (chelate) calcium ions, which they cannot do otherwise. Without vitamin K, blood coagulation is seriously impaired, and uncontrolled bleeding occurs. Research suggests that deficiency of v ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Toxicology And Applied Pharmacology
''Toxicology and Applied Pharmacology'' is a scientific journal for original research pertaining to action of chemicals, drugs, or natural products to animals or humans. The journal covers mechanistic approaches to physiological, biochemical, cellular, or molecular understanding of toxicologic/pathologic lesions and to methods used to describe these responses. Indexing The journal is included in the Index Medicus and in MEDLINE. According to the ''Journal Citation Reports'', ''Toxicology and Applied Pharmacology'' has a 2020 impact factor The impact factor (IF) or journal impact factor (JIF) of an academic journal is a scientometric index calculated by Clarivate that reflects the yearly mean number of citations of articles published in the last two years in a given journal, as ... of 4.219, ranking it 29 out of 93 in the category ''Toxicology''. References External links Elsevier {{DEFAULTSORT:Toxicology And Applied Pharmacology Monthly journals Elsevier academic ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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