Kleiber's Law
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Kleiber's Law
Kleiber's law, named after Max Kleiber for his biology work in the early 1930s, is the observation that, for the vast majority of animals, an animal's metabolic rate scales to the power of the animal's mass. Symbolically: if is the animal's metabolic rate, and is the animal's mass, then Kleiber's law states that . Thus, over the same time span, a cat having a mass 100 times that of a mouse will consume only about 32 times the energy the mouse uses. The exact value of the exponent in Kleiber's law is unclear, in part because the law currently lacks a single theoretical explanation that is ''entirely'' satisfactory. 400px, Kleiber's plot comparing body size to metabolic rate for a variety of species. Proposed explanations for the law Kleiber's law, as many other biological allometric laws, is a consequence of the physics and/or geometry of animal circulatory systems. Max Kleiber first discovered the law when analyzing a large number of independent studies on respiration ...
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Max Kleiber
Max Kleiber (4 January 1893 – 5 January 1976)
was a Swiss agricultural biologist, born and educated in Zurich, Switzerland. Kleiber graduated from the as an Agricultural Chemist in 1920, earned the ScD degree in 1924, and became a private '''' after publishing his thesis ''The Energy Concept in the Science of Nutrition''. Kleiber joined the Animal Husbandry Department of

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Fractal
In mathematics, a fractal is a geometric shape containing detailed structure at arbitrarily small scales, usually having a fractal dimension strictly exceeding the topological dimension. Many fractals appear similar at various scales, as illustrated in successive magnifications of the Mandelbrot set. This exhibition of similar patterns at increasingly smaller scales is called self-similarity, also known as expanding symmetry or unfolding symmetry; if this replication is exactly the same at every scale, as in the Menger sponge, the shape is called affine self-similar. Fractal geometry lies within the mathematical branch of measure theory. One way that fractals are different from finite geometric figures is how they scale. Doubling the edge lengths of a filled polygon multiplies its area by four, which is two (the ratio of the new to the old side length) raised to the power of two (the conventional dimension of the filled polygon). Likewise, if the radius of a filled sphere i ...
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Brady Haran
Brady John Haran (born 18 June 1976) is an Australian-British independent filmmaker and video journalist who produces educational videos and documentary films for his YouTube channels, the most notable being ''Periodic Videos'' and ''Numberphile''. Haran is also the co-host of the'' Hello Internet'' podcast along with fellow educational YouTuber CGP Grey. On 22 August 2017, Haran launched his second podcast, called ''The Unmade Podcast'', and on 11 November 2018, he launched his third podcast, '' The Numberphile Podcast'', based on his mathematics-centered channel of the same name. Reporter and filmmaker Brady Haran studied journalism for a year before being hired by ''The Adelaide Advertiser''. In 2002, he moved from Australia to Nottingham, United Kingdom. In Nottingham, he worked for the BBC, began to work with film, and reported for ''East Midlands Today'', BBC News Online and BBC radio stations. In 2007, Haran worked as a filmmaker-in-residence for Nottingham Science ...
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Rate-of-living Theory
The rate of living theory postulates that the faster an organism’s metabolism, the shorter its lifespan. The theory was originally created by Max Rubner in 1908 after his observation that larger animals outlived smaller ones, and that the larger animals had slower metabolisms. After its inception by Rubner, it was further expanded upon through the work of Raymond Pearl. Outlined in his book, ''The Rate of Living'' published in 1928, Pearl conducted a series of experiments in drosophila and cantaloupe seeds that corroborated Rubner’s initial observation that a slowing of metabolism increased lifespan. Further strength was given to these observations by the discovery of Max Kleiber’s law in 1932. Colloquially called the “mouse-to-elephant” curve, Kleiber’s conclusion was that basal metabolic rate could accurately be predicted by taking 3/4 the power of body weight. This conclusion was especially noteworthy because the inversion of its scaling exponent, between 0.2 and 0 ...
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Scaling Law
In statistics, a power law is a functional relationship between two quantities, where a relative change in one quantity results in a proportional relative change in the other quantity, independent of the initial size of those quantities: one quantity varies as a power of another. For instance, considering the area of a square in terms of the length of its side, if the length is doubled, the area is multiplied by a factor of four. Empirical examples The distributions of a wide variety of physical, biological, and man-made phenomena approximately follow a power law over a wide range of magnitudes: these include the sizes of craters on the moon and of solar flares, the foraging pattern of various species, the sizes of activity patterns of neuronal populations, the frequencies of words in most languages, frequencies of family names, the species richness in clades of organisms, the sizes of power outages, volcanic eruptions, human judgments of stimulus intensity and many other quantit ...
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Metabolic Theory Of Ecology
The metabolic theory of ecology (MTE) is the ecological component of the more general Metabolic Scaling Theory and Kleiber's law. It posits that the metabolic rate of organisms is the fundamental biological rate that governs most observed patterns in ecology. MTE is part of a larger set of theory known as metabolic scaling theory that attempts to provide a unified theory for the importance of metabolism in driving pattern and process in biology from the level of cells all the way to the biosphere. MTE is based on an interpretation of the relationships between body size, body temperature, and metabolic rate across all organisms. Small-bodied organisms tend to have higher mass-specific metabolic rates than larger-bodied organisms. Furthermore, organisms that operate at warm temperatures through endothermy or by living in warm environments tend towards higher metabolic rates than organisms that operate at colder temperatures. This pattern is consistent from the unicellular level up ...
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Evolutionary Physiology
Evolutionary physiology is the study of the biological evolution of physiological structures and processes; that is, the manner in which the functional characteristics of individuals in a population of organisms have responded to natural selection across multiple generations during the history of the population. It is a sub-discipline of both physiology and evolutionary biology. Practitioners in the field come from a variety of backgrounds, including physiology, evolutionary biology, ecology, and genetics. Accordingly, the range of phenotypes studied by evolutionary physiologists is broad, including life history, behavior, whole-organism performance, functional morphology, biomechanics, anatomy, classical physiology, endocrinology, biochemistry, and molecular evolution. The field is closely related to comparative physiology and environmental physiology, and its findings are a major concern of evolutionary medicine. One definition that has been offered is "the study of the physio ...
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Allometric Law
Allometry is the study of the relationship of body size to shape, anatomy, physiology and finally behaviour, first outlined by Otto Snell in 1892, by D'Arcy Thompson in 1917 in ''On Growth and Form'' and by Julian Huxley in 1932. Overview Allometry is a well-known study, particularly in statistical shape analysis for its theoretical developments, as well as in biology for practical applications to the differential growth rates of the parts of a living organism's body. One application is in the study of various insect species (e.g., Hercules beetles), where a small change in overall body size can lead to an enormous and disproportionate increase in the dimensions of appendages such as legs, antennae, or horns The relationship between the two measured quantities is often expressed as a power law equation (Allometric equation) which expresses a remarkable scale symmetry: : y = kx^a \,\! or in a logarithmic form: : \log y = a \log x + \log k\,\! or similarly \ln y = a \ln x ...
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Adipocytes
Adipocytes, also known as lipocytes and fat cells, are the cells that primarily compose adipose tissue, specialized in storing energy as fat. Adipocytes are derived from mesenchymal stem cells which give rise to adipocytes through adipogenesis. In cell culture, adipocyte progenitors can also form osteoblasts, myocytes and other cell types. There are two types of adipose tissue, white adipose tissue (WAT) and brown adipose tissue (BAT), which are also known as white and brown fat, respectively, and comprise two types of fat cells. Structure White fat cells White fat cells contain a single large lipid droplet surrounded by a layer of cytoplasm, and are known as unilocular. The nucleus is flattened and pushed to the periphery. A typical fat cell is 0.1 mm in diameter with some being twice that size, and others half that size. However, these numerical estimates of fat cell size depend largely on the measurement method and the location of the adipose tissue. The fat stored is ...
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Neuron
A neuron, neurone, or nerve cell is an electrically excitable cell that communicates with other cells via specialized connections called synapses. The neuron is the main component of nervous tissue in all animals except sponges and placozoa. Non-animals like plants and fungi do not have nerve cells. Neurons are typically classified into three types based on their function. Sensory neurons respond to stimuli such as touch, sound, or light that affect the cells of the sensory organs, and they send signals to the spinal cord or brain. Motor neurons receive signals from the brain and spinal cord to control everything from muscle contractions to glandular output. Interneurons connect neurons to other neurons within the same region of the brain or spinal cord. When multiple neurons are connected together, they form what is called a neural circuit. A typical neuron consists of a cell body (soma), dendrites, and a single axon. The soma is a compact structure, and the axon and dend ...
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Analysis Of Variance
Analysis of variance (ANOVA) is a collection of statistical models and their associated estimation procedures (such as the "variation" among and between groups) used to analyze the differences among means. ANOVA was developed by the statistician Ronald Fisher. ANOVA is based on the law of total variance, where the observed variance in a particular variable is partitioned into components attributable to different sources of variation. In its simplest form, ANOVA provides a statistical test of whether two or more population means are equal, and therefore generalizes the ''t''-test beyond two means. In other words, the ANOVA is used to test the difference between two or more means. History While the analysis of variance reached fruition in the 20th century, antecedents extend centuries into the past according to Stigler. These include hypothesis testing, the partitioning of sums of squares, experimental techniques and the additive model. Laplace was performing hypothesis testing ...
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Adenosine Triphosphate
Adenosine triphosphate (ATP) is an organic compound that provides energy to drive many processes in living cells, such as muscle contraction, nerve impulse propagation, condensate dissolution, and chemical synthesis. Found in all known forms of life, ATP is often referred to as the "molecular unit of currency" of intracellular energy transfer. When consumed in metabolic processes, it converts either to adenosine diphosphate (ADP) or to adenosine monophosphate (AMP). Other processes regenerate ATP. The human body recycles its own body weight equivalent in ATP each day. It is also a precursor to DNA and RNA, and is used as a coenzyme. From the perspective of biochemistry, ATP is classified as a nucleoside triphosphate, which indicates that it consists of three components: a nitrogenous base (adenine), the sugar ribose, and the Polyphosphate, triphosphate. Structure ATP consists of an adenine attached by the 9-nitrogen atom to the 1′ carbon atom of a sugar (ribose), which i ...
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