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Kevan Shokat
Kevan Michael Shokat (born August 26, 1964) is an American chemical biologist. He is a Professor and Chair in the Department of Cellular and Molecular Pharmacology at University of California, San Francisco, a Professor in the Department of Chemistry at University of California, Berkeley, and an Investigator with the Howard Hughes Medical Institute. Biography Shokat received his B.A, in chemistry from Reed College in 1986, completing his thesis, "Synthesis of a precursor of PRCPCP, a non-hydrolyzable analog of phosphoribosylpyrophosphate (PRPP)," with Ron McClard, and his Ph.D. from University of California, Berkeley in 1991, under Peter G. Schultz. Research Shokat is one of the leading figures in the field of chemical genetics. He uses methods of bioorganic chemistry to elucidate signal transduction pathways at the single cell and whole organism levels, and is particularly interested in protein kinases, and developing methods to elucidate the particular targets of each kinase ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Boulder City, Nevada
Boulder City is a city in Clark County, Nevada, United States. It is approximately southeast of Las Vegas. As of the 2020 United States Census, 2020 census, the population of Boulder City was 14,885. The city took its name from Boulder Canyon (Colorado River), Boulder Canyon. Boulder City is one of only two places in Nevada that prohibits gambling, the other being the town of Panaca, Nevada, Panaca. History Beginnings as federal company town The land upon which Boulder City was founded was a harsh, desert environment. Its sole reason for existence was the need to house workers contracted to build the Hoover Dam on the Colorado River (known commonly as Boulder Dam from 1933 to 1947, when it was officially renamed Hoover Dam by a joint resolution of Congress). Men hoping for work on the dam project had begun settling along the river in tents soon after the precise site for the dam had been chosen by the Bureau of Reclamation in 1930. Their ramshackle edifices were collectively kno ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bump And Hole
The bump-and-hole method is a tool in chemical genetics for studying a specific Protein isoform, isoform in a protein family without perturbing the other members of the family. The unattainability of isoform-selective inhibition due to structural homology in protein families is a major challenge of chemical genetics. With the bump-and-hole approach, a Protein–ligand complex, protein–ligand interface is engineered to achieve selectivity through Steric effects, steric complementarity while maintaining biochemical competence and orthogonality to the wild type pair. Typically, a "bumped" ligand/inhibitor analog is designed to bind a corresponding "hole-modified" protein. Bumped ligands are commonly bulkier derivatives of a Cofactor (biochemistry), cofactor of the target protein. Hole-modified proteins are Protein production, recombinantly expressed with an amino acid substitution from a larger to smaller residue, e.g. glycine or alanine, at the cofactor binding site. The designed li ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
