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Keith Burridge
Keith Burridge (born 1 July 1950) is a British researcher and Kenan distinguished Professor at the University of North Carolina at Chapel Hill.ISI Highly Cited ResearcheAn essay by: Professor Keith Burridgein-cites.com His research on focal adhesions includes the discovery of many adhesion proteins including vinculin, talin and paxillin, and ranks him in top 1% of the most cited scientist in the field of molecular biology and genetics. Burridge has published more than 200 peer reviewed articles. Early life and education He was born in 1950 in Dorset, England. He obtained his undergraduate degree in 1971 from the University of Cambridge, and then completed his Ph.D. in Dennis Bray’s laboratory in the MRC Laboratory of Molecular Biology (LMB), also in Cambridge, in 1975. Using biochemical techniques, he showed that at least two distinct types of myosin II exist in non-muscle cells and that some cells expressed both types. Focal adhesion research He went as a postdoc to James D. W ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Keith Burridge Picture
Keith may refer to: People and fictional characters * Keith (given name), includes a list of people and fictional characters * Keith (surname) * Keith (singer), American singer James Keefer (born 1949) * Baron Keith, a line of Scottish barons in the late 18th century * Clan Keith, a Scottish clan associated with lands in northeastern and northwestern Scotland Places Australia * Keith, South Australia, a town and locality Scotland * Keith, Moray, a town ** Keith railway station * Keith Marischal, East Lothian United States * Keith, Georgia, an unincorporated community * Keith, Ohio, an unincorporated community * Keith, West Virginia, an unincorporated community * Keith, Wisconsin, a ghost town * Keith County, Nebraska Other uses * Keith F.C., a football team based in Keith, Scotland * , a ship of the British Royal Navy * Hurricane Keith, a 2000 hurricane that caused extensive damage in Central America * ''Keith'' (film), a 2008 independent film directed by Todd Kessler * ' ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Zyxin
Zyxin is a protein that in humans is encoded by the ''ZYX'' gene. Function Focal adhesions are actin-rich structures that enable cells to adhere to the extracellular matrix and at which protein complexes involved in signal transduction assemble. Zyxin is a zinc-binding phosphoprotein that concentrates at focal adhesions and along the actin cytoskeleton. Zyxin has an N-terminal proline-rich domain and three LIM domains in its C-terminal half. The proline-rich domain may interact with SH3 domains of proteins involved in signal transduction pathways while the LIM domains are likely involved in protein-protein binding. Zyxin may function as a messenger in the signal transduction pathway that mediates adhesion-stimulated changes in gene expression and may modulate the cytoskeletal organization of actin bundles. Alternative splicing results in multiple transcript variants that encode the same isoform. Interactions Zyxin has been shown to interact with: * Actinin, alpha 1 * ENAH, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
British Expatriate Academics In The United States
British may refer to: Peoples, culture, and language * British people, nationals or natives of the United Kingdom, British Overseas Territories, and Crown Dependencies. ** Britishness, the British identity and common culture * British English, the English language as spoken and written in the United Kingdom or, more broadly, throughout the British Isles * Celtic Britons, an ancient ethno-linguistic group * Brittonic languages, a branch of the Insular Celtic language family (formerly called British) ** Common Brittonic, an ancient language Other uses *''Brit(ish)'', a 2018 memoir by Afua Hirsch *People or things associated with: ** Great Britain, an island ** United Kingdom, a sovereign state ** Kingdom of Great Britain (1707–1800) ** United Kingdom of Great Britain and Ireland (1801–1922) See also * Terminology of the British Isles * Alternative names for the British * English (other) * Britannic (other) * British Isles * Brit (other) * B ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Living People
Related categories * :Year of birth missing (living people) / :Year of birth unknown * :Date of birth missing (living people) / :Date of birth unknown * :Place of birth missing (living people) / :Place of birth unknown * :Year of death missing / :Year of death unknown * :Date of death missing / :Date of death unknown * :Place of death missing / :Place of death unknown * :Missing middle or first names See also * :Dead people * :Template:L, which generates this category or death years, and birth year and sort keys. : {{DEFAULTSORT:Living people 21st-century people People by status ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
1950 Births
Year 195 ( CXCV) was a common year starting on Wednesday (link will display the full calendar) of the Julian calendar. At the time, it was known as the Year of the Consulship of Scrapula and Clemens (or, less frequently, year 948 '' Ab urbe condita''). The denomination 195 for this year has been used since the early medieval period, when the Anno Domini calendar era became the prevalent method in Europe for naming years. Events By place Roman Empire * Emperor Septimius Severus has the Roman Senate deify the previous emperor Commodus, in an attempt to gain favor with the family of Marcus Aurelius. * King Vologases V and other eastern princes support the claims of Pescennius Niger. The Roman province of Mesopotamia rises in revolt with Parthian support. Severus marches to Mesopotamia to battle the Parthians. * The Roman province of Syria is divided and the role of Antioch is diminished. The Romans annexed the Syrian cities of Edessa and Nisibis. Severus re-establ ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Woodrow Wilson
Thomas Woodrow Wilson (December 28, 1856February 3, 1924) was an American politician and academic who served as the 28th president of the United States from 1913 to 1921. A member of the Democratic Party, Wilson served as the president of Princeton University and as the governor of New Jersey before winning the 1912 presidential election. As president, Wilson changed the nation's economic policies and led the United States into World War I in 1917. He was the leading architect of the League of Nations, and his progressive stance on foreign policy came to be known as Wilsonianism. Wilson grew up in the American South, mainly in Augusta, Georgia, during the Civil War and Reconstruction. After earning a Ph.D. in political science from Johns Hopkins University, Wilson taught at various colleges before becoming the president of Princeton University and a spokesman for progressivism in higher education. As governor of New Jersey from 1911 to 1913, Wilson broke with party bosse ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Edith Wilson
Edith Wilson ( Bolling, formerly Galt; October 15, 1872 – December 28, 1961) was the first lady of the United States from 1915 to 1921 and the second wife of President Woodrow Wilson. She married the widower Wilson in December 1915, during his first term as president. Edith Wilson played an influential role in President Wilson's administration following the severe stroke he suffered in October 1919. For the remainder of her husband's presidency, she managed the office of the president, a role she later described as a "stewardship," and determined which communications and matters of state were important enough to bring to the attention of the bedridden president. Early life Edith Bolling was born October 15, 1872, in Wytheville, Virginia, to circuit court judge William Holcombe Bolling and his wife Sarah "Sallie" Spears (née White). Her birthplace, the Bolling Home, is now a museum located in Wytheville's Historic District. Bolling was a descendant of the first settlers ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Han Van Meegeren
Henricus Antonius "Han" van Meegeren (; 10 October 1889 – 30 December 1947) was a Dutch painter and portraitist, considered one of the most ingenious art forgers of the 20th century. Van Meegeren became a national hero after World War II when it was revealed that he had sold a forged painting to ''Reichsmarschall'' Hermann Göring during the Nazi occupation of the Netherlands. As a child, Van Meegeren developed an enthusiasm for the paintings of the Dutch Golden Age, and he set out to become an artist. Art critics, however, decried his work as tired and derivative, and Van Meegeren felt that they had destroyed his career. He decided to prove his talent by forging paintings by 17th-century artists including Frans Hals, Pieter de Hooch, Gerard ter Borch and Johannes Vermeer. The best art critics and experts of the time accepted the paintings as genuine and sometimes exquisite. His most successful forgery was ''Supper at Emmaus'', created in 1937 while he was living in the south ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Knutsford Little Theatre
Knutsford Little Theatre is an amateur theatre group based in Knutsford, United Kingdom. They were formed in 1925, as ''Knutsford Amateur Drama Society'' and changed their name, after acquiring their own premises on Queen Street. They perform up to seven productions a year including a very popular family pantomime and a youth production. The society is run by its members who are entitled to vote at the annual award ceremony held as part of the AGM. The Society is part of the Cheshire Theatre Guild, and the National Operatic and Dramatic Association. History The society was formed after a meeting in the Cranford Cafe on a date in March 1925 when a group of local residents met to discuss the formation of Knutsford Amateur Dramatic Society. There had been theatrical productions in Knutsford for a number of years prior to the meeting: the Y.M.C.A. had performed Thread of Scarlett, a play about a murder in Ashley that resulted in execution at Knutsford Prison, and the Young Liberals ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
RhoA
Transforming protein RhoA, also known as Ras homolog family member A (RhoA), is a small GTPase protein in the Rho family of GTPases that in humans is encoded by the ''RHOA'' gene. While the effects of RhoA activity are not all well known, it is primarily associated with cytoskeleton regulation, mostly actin stress fibers formation and actomyosin contractility. It acts upon several effectors. Among them, ROCK1 (Rho-associated, coiled-coil containing protein kinase 1) and DIAPH1 (Diaphanous Homologue 1, a.k.a. hDia1, homologue to mDia1 in mouse, diaphanous in ''Drosophila'') are the best described. RhoA, and the other Rho GTPases, are part of a larger family of related proteins known as the Ras superfamily, a family of proteins involved in the regulation and timing of cell division. RhoA is one of the oldest Rho GTPases, with homologues present in the genomes since 1.5 billion years. As a consequence, RhoA is somehow involved in many cellular processes which emerged throughout evol ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Palladin
Palladin is a protein that in humans is encoded by the ''PALLD'' gene. Palladin is a component of actin-containing microfilaments that control cell shape, adhesion, and contraction. Discovery Palladin was characterised independently by two research groups, first in the lab of Carol Otey (in 2000) and then in the lab of Olli Carpén (in 2001). It is a part of the myotilin-myopalladin-palladin family and may play an important role in modulating the actin cytoskeleton. Palladin, in contrast to myotilin and myopalladin, which are expressed only in striated muscle, is expressed ubiquitously in cells of mesenchymal origin. Palladin was named after the Italian Renaissance architect Andrea Palladio, reflecting its localization to architectural elements of the cell. Isoforms In humans, it appears that seven different isoforms exist, some of which arise through alternative splicing. In mice, three major isoforms of palladin arise from a single gene. These isoforms contain between ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Integrins
Integrins are transmembrane receptors that facilitate cell-cell and cell-extracellular matrix (ECM) adhesion. Upon ligand binding, integrins activate signal transduction pathways that mediate cellular signals such as regulation of the cell cycle, organization of the intracellular cytoskeleton, and movement of new receptors to the cell membrane. The presence of integrins allows rapid and flexible responses to events at the cell surface (''e.g''. signal platelets to initiate an interaction with coagulation factors). Several types of integrins exist, and one cell generally has multiple different types on its surface. Integrins are found in all animals while integrin-like receptors are found in plant cells. Integrins work alongside other proteins such as cadherins, the immunoglobulin superfamily cell adhesion molecules, selectins and syndecans, to mediate cell–cell and cell–matrix interaction. Ligands for integrins include fibronectin, vitronectin, collagen and laminin. Structur ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
