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Kendall Smith
Kendall A. Smith is an American medical scientist best known for his work on interleukins, the regulatory molecules of the immune system, which has led to many of the new present-day therapies for immunological disorders, transplant rejection, infectious diseases and cancer. Smith is a Professor Emeritus of Medicine at Weill Cornell Medicine. Early life Kendall Arthur Smith was born in Akron, Ohio, where he grew up as the second child of Robert Lyman Smith and Juanita Murphy Smith. He attended Fairlawn Primary School, Simon Perkins Junior High School followed by Buchtel High School in Akron, graduating in 1960. Medical and scientific training Smith graduated from Denison University, Granville, Ohio with a B.S. in biology (1964). He graduated ''summa cum laude'' from the Ohio State University College of Medicine in 1968, then trained in Internal Medicine at Yale-New Haven Hospital (1968–1970). Smith then trained at the National Cancer Institute, Dartmouth Medical School ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Akron, Ohio
Akron () is the fifth-largest city in the U.S. state of Ohio and is the county seat of Summit County, Ohio, Summit County. It is located on the western edge of the Glaciated Allegheny Plateau, about south of downtown Cleveland. As of the 2020 Census, the city proper had a total population of 190,469, making it the 125th largest city in the United States. The Akron Metropolitan Statistical Area, Akron metropolitan area, covering Summit and Portage County, Ohio, Portage counties, had an estimated population of 703,505. The city was founded in 1825 by Simon Perkins and Paul Williams, along the Cuyahoga River, Little Cuyahoga River at the summit of the developing Ohio and Erie Canal. The name is derived from the Ancient Greek word ''ἄκρον : ákron'' signifying a summit or high point. It was briefly renamed South Akron after Eliakim Crosby founded nearby North Akron in 1833, until both merged into an incorporated village in 1836. In the 1910s, Akron doubled in population, makin ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Interleukin 2
Interleukin-2 (IL-2) is an interleukin, a type of cytokine signaling molecule in the immune system. It is a 15.5–16 kDa protein that regulates the activities of white blood cells (leukocytes, often lymphocytes) that are responsible for immunity. IL-2 is part of the body's natural response to microbial infection, and in discriminating between foreign ("non-self") and "self". IL-2 mediates its effects by binding to IL-2 receptors, which are expressed by lymphocytes. The major sources of IL-2 are activated CD4+ T cells and activated CD8+ T cells. IL-2 receptor IL-2 is a member of a cytokine family, each member of which has a four alpha helix bundle; the family also includes IL-4, IL-7, IL-9, IL-15 and IL-21. IL-2 signals through the IL-2 receptor, a complex consisting of three chains, termed alpha (CD25), beta (CD122) and gamma ( CD132). The gamma chain is shared by all family members. The IL-2 receptor (IL-2R) α subunit binds IL-2 with low affinity (Kd~ 10 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nature (journal)
''Nature'' is a British weekly scientific journal founded and based in London, England. As a multidisciplinary publication, ''Nature'' features peer-reviewed research from a variety of academic disciplines, mainly in science and technology. It has core editorial offices across the United States, continental Europe, and Asia under the international scientific publishing company Springer Nature. ''Nature'' was one of the world's most cited scientific journals by the Science Edition of the 2019 ''Journal Citation Reports'' (with an ascribed impact factor of 42.778), making it one of the world's most-read and most prestigious academic journals. , it claimed an online readership of about three million unique readers per month. Founded in autumn 1869, ''Nature'' was first circulated by Norman Lockyer and Alexander Macmillan as a public forum for scientific innovations. The mid-20th century facilitated an editorial expansion for the journal; ''Nature'' redoubled its efforts in exp ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Alpha Omega Alpha
Alpha Omega Alpha Honor Medical Society () is an honor society in the field of medicine. Alpha Omega Alpha currently has active Chapters in 132 LCME- accredited medical schools in the United States and Lebanon. It annually elects over 4,000 new members. The majority of new members are elected in their final year of medical school, but distinguished teachers, faculty members, residents, and alumni can also be inducted into the society. All elections are held at local Chapters. No elections are held nationally. History ΑΩΑ was founded in 1902 by William Webster Root and five other medical students at the College of Physicians and Surgeons, which later became the University of Illinois College of Medicine. The impetus for its formation was the generally poor quality of American medical schools and students at the time; Root and his colleagues wished to promote excellence in these groups. They decided that membership in ΑΩΑ was to be based on both scholarly achievement and pro ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Kirkus Reviews
''Kirkus Reviews'' (or ''Kirkus Media'') is an American book review magazine founded in 1933 by Virginia Kirkus (1893–1980). The magazine is headquartered in New York City. ''Kirkus Reviews'' confers the annual Kirkus Prize to authors of fiction, nonfiction, and young readers' literature. ''Kirkus Reviews'', published on the first and 15th of each month; previews books before their publication. ''Kirkus'' reviews over 10,000 titles per year. History Virginia Kirkus was hired by Harper & Brothers to establish a children's book department in 1926. The department was eliminated as an economic measure in 1932 (for about a year), so Kirkus left and soon established her own book review service. Initially, she arranged to get galley proofs of "20 or so" books in advance of their publication; almost 80 years later, the service was receiving hundreds of books weekly and reviewing about 100. Initially titled ''Bulletin'' by Kirkus' Bookshop Service from 1933 to 1954, the title was ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Rockefeller University
The Rockefeller University is a private biomedical research and graduate-only university in New York City, New York. It focuses primarily on the biological and medical sciences and provides doctoral and postdoctoral education. It is classified among "R2: Doctoral Universities – High research activity." Rockefeller is the oldest biomedical research institute in the United States. In 2018, the faculty included 82 tenured and tenure-track members, including 37 members of the National Academy of Sciences, 17 members of the National Academy of Medicine, seven Lasker Award recipients, and five Nobel laureates. As of March 2022, a total of 26 Nobel laureates have been affiliated with Rockefeller University. The university is located on the Upper East Side of Manhattan, between 63rd and 68th streets on York Avenue. Richard P. Lifton became the university's eleventh president on September 1, 2016. The Rockefeller University Press publishes the ''Journal of Experimental Medicine' ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sloan-Kettering Institute
Memorial Sloan Kettering Cancer Center (MSK or MSKCC) is a cancer treatment and research institution in the borough of Manhattan in New York City, founded in 1884 as the New York Cancer Hospital. MSKCC is one of 52 National Cancer Institute–designated Comprehensive Cancer Centers. Its main campus is located at 1275 York Avenue, between 67th and 68th streets, in Manhattan. According to U.S. News & World Report 2021-2022 Best Hospitals, Memorial Sloan Kettering Cancer Center (MSK) has been ranked as the number two hospital for cancer care in the nation. History New York Cancer Hospital (1884–1934) Memorial Hospital was founded on the Upper West Side of Manhattan in 1884 as the New York Cancer Hospital by a group that included John Jacob Astor III and his wife Charlotte. The hospital appointed as an attending surgeon William B. Coley, who pioneered an early form of immunotherapy to eradicate tumors. Rose Hawthorne, daughter of author Nathaniel Hawthorne, trained there in ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
HIV/AIDS
Human immunodeficiency virus infection and acquired immunodeficiency syndrome (HIV/AIDS) is a spectrum of conditions caused by infection with the human immunodeficiency virus (HIV), a retrovirus. Following initial infection an individual may not notice any symptoms, or may experience a brief period of influenza-like illness. Typically, this is followed by a prolonged incubation period with no symptoms. If the infection progresses, it interferes more with the immune system, increasing the risk of developing common infections such as tuberculosis, as well as other opportunistic infections, and tumors which are rare in people who have normal immune function. These late symptoms of infection are referred to as acquired immunodeficiency syndrome (AIDS). This stage is often also associated with unintended weight loss. HIV is spread primarily by unprotected sex (including anal and vaginal sex), contaminated blood transfusions, hypodermic needles, and from mother to ch ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cytokine Receptor
Cytokine receptors are receptors that bind to cytokines. In recent years, the cytokine receptors have come to demand the attention of more investigators than cytokines themselves, partly because of their remarkable characteristics, and partly because a deficiency of cytokine receptors has now been directly linked to certain debilitating immunodeficiency states. In this regard, and also because the redundancy and pleiotropy of cytokines are a consequence of their homologous receptors, many authorities are now of the opinion that a classification of cytokine receptors would be more clinically and experimentally useful. Classification A classification of cytokine receptors based on their three-dimensional structure has been attempted. (Such a classification, though seemingly cumbersome, provides several unique perspectives for attractive pharmacotherapeutic targets.) * Type I cytokine receptors, whose members have certain conserved motifs in their extracellular amino-acid domain. Th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Radioactive Tracer
A radioactive tracer, radiotracer, or radioactive label is a chemical compound in which one or more atoms have been replaced by a radionuclide so by virtue of its radioactive decay it can be used to explore the mechanism of chemical reactions by tracing the path that the radioisotope follows from reactants to products. Radiolabeling or radiotracing is thus the radioactive form of isotopic labeling. In biological contexts, use of radioisotope tracers are sometimes called radioisotope feeding experiments. Radioisotopes of hydrogen, carbon, phosphorus, sulfur, and iodine have been used extensively to trace the path of biochemical reactions. A radioactive tracer can also be used to track the distribution of a substance within a natural system such as a cell or tissue, or as a flow tracer to track fluid flow. Radioactive tracers are also used to determine the location of fractures created by hydraulic fracturing in natural gas production.Reis, John C. (1976). ''Environmental Cont ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bioactive Compound
A bioactive compound is a compound that has an effect on a living organism, tissue or cell, usually demonstrated by basic research in vitro or in vivo in the laboratory. While dietary nutrients are essential to life, bioactive compounds have not been proved to be essential as the body can function without them or because their actions are obscured by nutrients fulfilling the function. Bioactive compounds lack sufficient evidence of effect or safety, and consequently they are usually unregulated and may be sold as dietary supplements. Origin and examples Bioactive compounds are commonly derived from plants, animal products, or can be synthetically produced. Examples of plant bioactive compounds are carotenoids, polyphenols, or phytosterols. Examples in animal products are fatty acids found in milk and fish. Other examples are flavonoids, caffeine, choline, coenzyme Q, creatine, dithiolthiones, polysaccharides, phytoestrogens, glucosinolates, and prebiotics. In the diet The ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Annual Review Of Immunology
The ''Annual Review of Immunology'' is a peer-reviewed scientific journal published by Annual Reviews. It releases an annual volume of review articles relevant to the field of immunology. It was first published in 1983 with inaugural editor William E. Paul; Paul remained editor for the journal's first thirty years. As of 2022, its editor is Wayne M. Yokoyama and its 2021 impact factor is 32.481, ranking it third of 161 journals in the category "Immunology". History During the 1982 Midwinter Conference of Immunologists at the Asilomar Conference Grounds, a meeting of prominent immunologists was convened to discuss the need for a new journal that published review articles about immunological topics. Interest was high, with many meeting attendees agreeing that such a journal would be useful and offering to write a review for the first volume. The ''Annual Review of Immunology'' was first published in 1983, making it the twenty-fifth journal title published by the nonprofit publishe ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
