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Joseph Edward Rall
Joseph Edward Rall (February 3, 1920 – February 28, 2008) was an American endocrinologist and research director at the National Institutes of Health. He was an expert on the thyroid gland, particularly its proteins and its relationship with radioactive iodine. Early life and education Rall was born in 1920 in Naperville, Illinois. He obtained a B.A. from North Central College in 1941 before enrolling at Northwestern University. At Northwestern, he served as a teaching assistant and a research fellow in pharmacology while completing his studies; he received a Master's degree in 1944 and an M.D. in 1945. His residency and fellowship at Mayo Clinic in Rochester, Minnesota, which began in 1945, was interrupted by two years of military service in Germany with the Medical Corps following the Second World War. He eventually completed his fellowship at Mayo Clinic in 1950. He developed an interest in endocrinology, the thyroid and radioactive iodine at Mayo, and in 1952 he was awarded a Ph ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
National Institutes Of Health
The National Institutes of Health, commonly referred to as NIH (with each letter pronounced individually), is the primary agency of the United States government responsible for biomedical and public health research. It was founded in the late 1880s and is now part of the United States Department of Health and Human Services. The majority of NIH facilities are located in Bethesda, Maryland, and other nearby suburbs of the Washington metropolitan area, with other primary facilities in the Research Triangle Park in North Carolina and smaller satellite facilities located around the United States. The NIH conducts its own scientific research through the NIH Intramural Research Program (IRP) and provides major biomedical research funding to non-NIH research facilities through its Extramural Research Program. , the IRP had 1,200 principal investigators and more than 4,000 postdoctoral fellows in basic, translational, and clinical research, being the largest biomedical research instit ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
New York City
New York, often called New York City or NYC, is the List of United States cities by population, most populous city in the United States. With a 2020 population of 8,804,190 distributed over , New York City is also the List of United States cities by population density, most densely populated major city in the United States, and is more than twice as populous as second-place Los Angeles. New York City lies at the southern tip of New York (state), New York State, and constitutes the geographical and demographic center of both the Northeast megalopolis and the New York metropolitan area, the largest metropolitan area in the world by urban area, urban landmass. With over 20.1 million people in its metropolitan statistical area and 23.5 million in its combined statistical area as of 2020, New York is one of the world's most populous Megacity, megacities, and over 58 million people live within of the city. New York City is a global city, global Culture of New ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nino Salvatore
Gaetano "Nino" Salvatore (28 July 1932 – 25 June 1997) was an Italian endocrinologist known for his extensive research on the thyroid gland. He spent the majority of his career in Naples' Stazione Zoologica and the University of Naples Federico II, while also spending periods at the American National Institutes of Health and in France. Life and career Salvatore studied medicine at the University of Naples Federico II and, after graduating, travelled to Paris to work at the Collège de France with the endocrinologist Jean Roche. During his time in Paris from 1956 to 1958, he developed an interest in endocrinology and particularly the thyroid gland. He returned to Naples in 1959 and continued to collaborate with Roche on research into thyroid diseases at the Stazione Zoologica. In 1961, he moved to Marseille before relocating again in 1962 to the United States, where he worked in Jacob Robbins and Joseph Edward Rall's laboratory at the National Institutes of Health (NIH) in Bethes ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Growth Hormone
Growth hormone (GH) or somatotropin, also known as human growth hormone (hGH or HGH) in its human form, is a peptide hormone that stimulates growth, cell reproduction, and cell regeneration in humans and other animals. It is thus important in human development. GH also stimulates production of IGF-1 and increases the concentration of glucose and free fatty acids. It is a type of mitogen which is specific only to the receptors on certain types of cells. GH is a 191-amino acid, single-chain polypeptide that is synthesized, stored and secreted by somatotropic cells within the lateral wings of the anterior pituitary gland. A recombinant form of hGH called somatropin (INN) is used as a prescription drug to treat children's growth disorders and adult growth hormone deficiency. In the United States, it is only available legally from pharmacies by prescription from a licensed health care provider. In recent years in the United States, some health care providers are prescribing growth ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Diabetes
Diabetes, also known as diabetes mellitus, is a group of metabolic disorders characterized by a high blood sugar level ( hyperglycemia) over a prolonged period of time. Symptoms often include frequent urination, increased thirst and increased appetite. If left untreated, diabetes can cause many health complications. Acute complications can include diabetic ketoacidosis, hyperosmolar hyperglycemic state, or death. Serious long-term complications include cardiovascular disease, stroke, chronic kidney disease, foot ulcers, damage to the nerves, damage to the eyes, and cognitive impairment. Diabetes is due to either the pancreas not producing enough insulin, or the cells of the body not responding properly to the insulin produced. Insulin is a hormone which is responsible for helping glucose from food get into cells to be used for energy. There are three main types of diabetes mellitus: * Type 1 diabetes results from failure of the pancreas to produce enough insulin due to lo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bethesda, Maryland
Bethesda () is an unincorporated, census-designated place in southern Montgomery County, Maryland. It is located just northwest of Washington, D.C. It takes its name from a local church, the Bethesda Meeting House (1820, rebuilt 1849), which in turn took its name from Jerusalem's Pool of Bethesda. The National Institutes of Health's main campus and the Walter Reed National Military Medical Center are in Bethesda, in addition to a number of corporate and government headquarters. As an unincorporated community, Bethesda has no official boundaries. According to the 2020 U.S. census, the community had a total population of 68,056. History Bethesda is located in a region that was populated by the Piscataway and Nacotchtank tribes at the time of European colonization. Fur trader Henry Fleet became the first European to visit the area, reaching it by sailing up the Potomac River. He stayed with the Piscataway tribe from 1623 to 1627, either as a guest or prisoner (historical accounts ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Thyroglobulin
Thyroglobulin (Tg) is a 660 kDa, dimeric glycoprotein produced by the follicular cells of the thyroid and used entirely within the thyroid gland. Tg is secreted and accumulated at hundreds of grams per litre in the extracellular compartment of the thyroid follicles, accounting for approximately half of the protein content of the thyroid gland. Human TG (hTG) is a homodimer of subunits each containing 2768 amino acids as synthesized (a short signal peptide of 19 aminoacids may be removed from the N-terminus in the mature protein). Thyroglobulin is in all vertebrates the main precursor to thyroid hormones, which are produced when thyroglobulin's tyrosine residues are combined with iodine and the protein is subsequently cleaved. Each thyroglobulin molecule contains approximately 100–120 tyrosine residues, but only a small number (20) of these are subject to iodination by thyroperoxidase in the follicular colloid. Therefore, each Tg molecule forms approximately 10 thyroid hormo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Jacob Robbins
Jacob Robbins (September 1, 1922May 12, 2008) was an American endocrinologist known for his research on the thyroid gland. He established the "free thyroxine hypothesis", which holds that thyroxine is only active when not bound to protein, and performed long-term research on the incidence of thyroid cancer caused by radiation in survivors of nuclear fallout. Biography Robbins was born in 1922 in Yonkers, New York. He attended Cornell University, completing an undergraduate degree in chemistry in 1944 and graduating from Cornell Medical College in 1947. He began working at Memorial Sloan Kettering Cancer Center in 1948 before moving to the National Institutes of Health in Bethesda, Maryland, in 1954 as an investigator. At NIH, he was chief of the Clinical Endocrinology Branch (part of the National Institute of Diabetes and Digestive and Kidney Diseases) from 1963 to 1991. Robbins worked alongside Joseph E. Rall, another endocrinologist, during much of his career at NIH. Robbins an ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Marshall Islands
The Marshall Islands ( mh, Ṃajeḷ), officially the Republic of the Marshall Islands ( mh, Aolepān Aorōkin Ṃajeḷ),'' () is an independent island country and microstate near the Equator in the Pacific Ocean, slightly west of the International Date Line. Geographically, the country is part of the larger island group of Micronesia. The country's population of 58,413 people (at the 2018 World Bank Census) is spread out over five islands and 29 coral atolls, comprising 1,156 individual islands and islets. The capital and largest city is Majuro. It has the largest portion of its territory composed of water of any sovereign state, at 97.87%. The islands share maritime boundaries with Wake Island to the north, Kiribati to the southeast, Nauru to the south, and Federated States of Micronesia to the west. About 52.3% of Marshall Islanders (27,797 at the 2011 Census) live on Majuro. In 2016, 73.3% of the population were defined as being "urban". The UN also indicates a population d ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hydrogen Bomb
A thermonuclear weapon, fusion weapon or hydrogen bomb (H bomb) is a second-generation nuclear weapon design. Its greater sophistication affords it vastly greater destructive power than first-generation nuclear bombs, a more compact size, a lower mass, or a combination of these benefits. Characteristics of nuclear fusion reactions make possible the use of non-fissile depleted uranium as the weapon's main fuel, thus allowing more efficient use of scarce fissile material such as uranium-235 () or plutonium-239 (). The Ivy Mike, first full-scale thermonuclear test was carried out by the United States in 1952; the concept has since been employed by most of the world's List of states with nuclear weapons, nuclear powers in the design of their weapons. Modern fusion weapons consist essentially of two main components: a nuclear fission primary stage (fueled by or ) and a separate nuclear fusion secondary stage containing thermonuclear fuel: the heavy hydrogen isotopes deuterium and tri ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cornell University Medical College
The Joan & Sanford I. Weill Medical College of Cornell University is Cornell University's biomedical research unit and medical school located in Upper East Side, Manhattan, New York City, New York. Weill Cornell Medicine is affiliated with NewYork-Presbyterian Hospital, Weill Cornell Medical Center, Hospital for Special Surgery, Memorial Sloan Kettering Cancer Center, and Rockefeller University, all of which are located nearby on York Avenue. Weill Cornell's clinical affiliates rank highly, with the NewYork-Presbyterian Hospital ranked #1 in the region and #4 in the nation, the Hospital for Special Surgery ranked #1 in the nation for orthopedics and the Memorial Sloan Kettering Center #2 for cancer. Memorial Sloan Kettering Cancer Center and Rockefeller University joined Weill Cornell to establish the Tri-Institutional MD–PhD Program in 1991. In 2001, the school opened a campus in Qatar. Weill Cornell has also been affiliated with Houston Methodist Hospital since 2004. On S ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nature Clinical Practice Endocrinology & Metabolism
''Nature Reviews Endocrinology'' is a monthly peer-reviewed medical journal published by Nature Portfolio. It covers all aspects of endocrinology. The journal was established in 2005 as ''Nature Clinical Practice Endocrinology & Metabolism'' and obtained its current title in April 2009. The editor-in-chief is Claire Greenhill. According to the ''Journal Citation Reports'', the journal has a 2021 impact factor The impact factor (IF) or journal impact factor (JIF) of an academic journal is a scientometric index calculated by Clarivate that reflects the yearly mean number of citations of articles published in the last two years in a given journal, as i ... of 47.564, ranking it 1st out of 146 journals in the category "Endocrinology & Metabolism". References External links * Nature Research academic journals Monthly journals Endocrinology journals Publications established in 2005 English-language journals Review journals {{Georg von Holtzbrinck Publishing Group ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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