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Josamycin
Josamycin is a macrolide antibiotic. It was isolated by Hamao Umezawa was a Japanese scientist who discovered several antimicrobial agents and enzyme inhibitors. Umezawa was born in Obama City, Fukui Prefecture, as the second son in a family of seven children. After graduating from Musashi Junior and Senior High ... and his colleagues from strains of '' Streptomyces narbonensis'' var. ''josamyceticus'' var. ''nova'' in 1964. It is currently sold in various countries. Brand examples are: * Europe: Josalid, Josacine, Iosalide, Josamina * Russia: Wilprafen (Вильпрафен) * Japan: Josamy Adverse effects There has been a case report of edema of the feet. References {{Macrolides, lincosamides and streptogramins Macrolide antibiotics ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Macrolide
The Macrolides are a class of natural products that consist of a large macrocyclic lactone ring to which one or more deoxy sugars, usually cladinose and desosamine, may be attached. The lactone rings are usually 14-, 15-, or 16-membered. Macrolides belong to the polyketide class of natural products. Some macrolides have antibiotic or antifungal activity and are used as pharmaceutical drugs. Rapamycin is also a macrolide and was originally developed as an antifungal, but is now used as an immunosuppressant drug and is being investigated as a potential longevity therapeutic. Macrolides are bacteriostatic in that they suppress or inhibit bacterial growth rather than killing bacteria completely. Definition In general, any macrocyclic lactone having greater than 8-membered rings are candidates for this class. The macrocycle may contain amino nitrogen, amide nitrogen (but should be differentiated from cyclopeptides), an oxazole ring, or a thiazole ring. Benzene rings are e ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Antibiotic
An antibiotic is a type of antimicrobial substance active against bacteria. It is the most important type of antibacterial agent for fighting bacterial infections, and antibiotic medications are widely used in the treatment and prevention of such infections. They may either kill or inhibit the growth of bacteria. A limited number of antibiotics also possess antiprotozoal activity. Antibiotics are not effective against viruses such as the common cold or influenza; drugs which inhibit viruses are termed antiviral drugs or antivirals rather than antibiotics. Sometimes, the term ''antibiotic''—literally "opposing life", from the Greek roots ἀντι ''anti'', "against" and βίος ''bios'', "life"—is broadly used to refer to any substance used against microbes, but in the usual medical usage, antibiotics (such as penicillin) are those produced naturally (by one microorganism fighting another), whereas non-antibiotic antibacterials (such as sulfonamides and antise ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hamao Umezawa
was a Japanese scientist who discovered several antimicrobial agents and enzyme inhibitors. Umezawa was born in Obama City, Fukui Prefecture, as the second son in a family of seven children. After graduating from Musashi Junior and Senior High School, he entered the University of Tokyo Graduate School of Medicine in 1933, and completed his medical degree in 1937. After serving in the Japanese army during World War II, Umezawa did work on tuberculosis which led to his discovery, in 1955, of the aminoglycoside antibiotic kanamycin. By this stage Umezawa was heading the Institute of Microbial Chemistry in Tokyo where his main focus was antimicrobial agents manufactured through fermentation processes. In 1963, he discovered the anticancer drug bleomycin, and in 1965 he discovered kasugamycin, a compound useful in combating rice molds. His elder brother, Sumio Umezawa, was a chemist who had sometimes assisted in his work. He was married to Mieko Ishizaki on December 2, 1944; they h ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Streptomyces Narbonensis
''Streptomyces narbonensis'' is a bacterium species from the genus of '' Streptomyces'' which has been isolated from soil in France.Deutsche Sammlung von Mikroorganismen und Zellkulturenbr>/ref> ''Streptomyces narbonensis'' produces narbomycin and josamycin. See also * List of Streptomyces species References Further reading * * * External linksType strain of ''Streptomyces narbonensis'' at Bac''Dive'' - the Bacterial Diversity Metadatabase {{Taxonbar, from=Q26291405 narbonensis Gallia Narbonensis (Latin for "Gaul of Narbonne", from its chief settlement) was a Roman province located in what is now Languedoc and Provence, in Southern France. It was also known as Provincia Nostra ("Our Province"), because it was the ... Bacteria described in 1955 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Edema
Edema, also spelled oedema, and also known as fluid retention, dropsy, hydropsy and swelling, is the build-up of fluid in the body's tissue. Most commonly, the legs or arms are affected. Symptoms may include skin which feels tight, the area may feel heavy, and joint stiffness. Other symptoms depend on the underlying cause. Causes may include venous insufficiency, heart failure, kidney problems, low protein levels, liver problems, deep vein thrombosis, infections, angioedema, certain medications, and lymphedema. It may also occur after prolonged sitting or standing and during menstruation or pregnancy. The condition is more concerning if it starts suddenly, or pain or shortness of breath is present. Treatment depends on the underlying cause. If the underlying mechanism involves sodium retention, decreased salt intake and a diuretic may be used. Elevating the legs and support stockings may be useful for edema of the legs. Older people are more commonly affected. The ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
