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John A. Pollock (professor)
John A. Pollock, is a Full Professor of Biological Science at Duquesne University Bayer School of Natural and Environmental Sciences, where he researches and teaches molecular neurobiology. He is Principal Investigator for The Partnership in Education, a non-profit multidisciplinary health literacy and informal science education project at Duquesne University funded primarily through Science Education Partnership AwardSEPA) from the National Institute of General Medical Sciences, a component of the National Institutes of Health. Pollock holds the additional title of co-director for the Chronic Pain Research Consortium at Duquesne University. He serves as a faculty affiliate at thBrainHubat Carnegie Mellon University and separately at the McGowan Institute for Regenerative Medicine, University of Pittsburgh/ UPMC. Education After receiving a B.S. and M.S. in physics from Syracuse University, Pollock earned his Ph.D. in biophysics in 1984 under the guidance of Dr. Edward Lipson. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Duquesne University
Duquesne University of the Holy Spirit ( or ; Duquesne University or Duquesne) is a private Catholic research university in Pittsburgh, Pennsylvania. Founded by members of the Congregation of the Holy Spirit, Duquesne first opened as the Pittsburgh Catholic College of the Holy Ghost in October 1878 with an enrollment of 40 students and a faculty of six. In 1911, the college became the first Catholic university-level institution in Pennsylvania. It is the only Spiritan institution of higher education in the world. It is named for an 18th-century governor of New France, Michel-Ange Duquesne de Menneville. Duquesne has since expanded to over 9,300 graduate and undergraduate students within a self-contained hilltop campus in Pittsburgh's Bluff neighborhood. The school maintains an associate campus in Rome and encompasses ten schools of study. The university hosts international students from more than 80 countries although most students—about 80%—are from Pennsylvania or the surr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Neurobiology
Neuroscience is the scientific study of the nervous system (the brain, spinal cord, and peripheral nervous system), its functions and disorders. It is a multidisciplinary science that combines physiology, anatomy, molecular biology, developmental biology, cytology, psychology, physics, computer science, chemistry, medicine, statistics, and mathematical modeling to understand the fundamental and emergent properties of neurons, glia and neural circuits. The understanding of the biological basis of learning, memory, behavior, perception, and consciousness has been described by Eric Kandel as the "epic challenge" of the biological sciences. The scope of neuroscience has broadened over time to include different approaches used to study the nervous system at different scales. The techniques used by neuroscientists have expanded enormously, from molecular and cellular studies of individual neurons to imaging of sensory, motor and cognitive tasks in the brain. History The earliest ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Drug Therapy
Pharmacotherapy is therapy using pharmaceutical drugs, as distinguished from therapy using surgery (surgical therapy), radiation (radiation therapy), movement (physical therapy), or other modes. Among physicians, sometimes the term ''medical therapy'' refers specifically to pharmacotherapy as opposed to surgical or other therapy; for example, in oncology, medical oncology is thus distinguished from surgical oncology. Pharmacists are experts in pharmacotherapy and are responsible for ensuring the safe, appropriate, and economical use of pharmaceutical drugs. The skills required to function as a pharmacist require knowledge, training and experience in biomedical, pharmaceutical and clinical sciences. Pharmacology is the science that aims to continually improve pharmacotherapy. The pharmaceutical industry and academia use basic science, applied science, and translational science to create new pharmaceutical drugs. As pharmacotherapy specialists and pharmacists have responsibilit ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
TRPV1
The transient receptor potential cation channel subfamily V member 1 (TrpV1), also known as the capsaicin receptor and the vanilloid receptor 1, is a protein that, in humans, is encoded by the ''TRPV1'' gene. It was the first isolated member of the transient receptor potential vanilloid receptor proteins that in turn are a sub-family of the transient receptor potential protein group. This protein is a member of the TRPV group of transient receptor potential family of ion channels. The function of TRPV1 is detection and regulation of body temperature. In addition, TRPV1 provides a sensation of scalding heat and pain (nociception). In primary afferent sensory neurons, it cooperates with TRPA1 (a chemical irritant receptor) to mediate the detection of noxious environmental stimuli. Function TRPV1 is an element of or mechanism used by the mammalian somatosensory system. It is a nonselective cation channel that may be activated by a wide variety of exogenous and endogenous physical ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Neuroinflammation
Neuroinflammation is inflammation of the nervous tissue. It may be initiated in response to a variety of cues, including infection, traumatic brain injury,Ebert SE, Jensen P, Ozenne B, Armand S, Svarer C, Stenbaek DS ''et al.'' Molecular imaging of neuroinflammation in patients after mild traumatic brain injury: a longitudinal 123 I-CLINDE SPECT study. ''Eur J Neurol'' 2019. doi:10.1111/ene.13971. toxic metabolites, or autoimmunity. In the central nervous system (CNS), including the brain and spinal cord, microglia are the resident innate immune cells that are activated in response to these cues. The CNS is typically an immunologically privileged site because peripheral immune cells are generally blocked by the blood–brain barrier (BBB), a specialized structure composed of astrocytes and endothelial cells. However, circulating peripheral immune cells may surpass a compromised BBB and encounter neurons and glial cells expressing major histocompatibility complex molecules, perpetuat ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Rangos School Of Health Sciences
The John G. Rangos School of Health Sciences (RSHS) is one of the ten constituent colleges that comprise Duquesne University in Pittsburgh, Pennsylvania. History On January 29, 1990, Dr. John E. Murray Jr., then President of Duquesne University, announced the creation of a School of Health Sciences in order to "graduate professionals who will provide assistance to people in maintaining their physical well-being. It will make them more self-sufficient physically and provide great hope for their futures. It meets an overwhelming societal need, and it enlarges opportunities for students at Duquesne. In serving the citizens of Western Pennsylvania, and our students, this initiative is precisely in accordance with the purposes of Duquesne University." On March 18, 1991, Mr. John G. Rangos Sr. made a major gift to Duquesne University in support of the school, and so it was announced that the school would be named after him. Programs The Rangos School houses such programs as Athletic Trai ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Duquesne University School Of Pharmacy
The School of Pharmacy is one of the ten degree-granting divisions that comprise Duquesne University in Pittsburgh, Pennsylvania. The school's first pharmacy class matriculated in September 1925 under the leadership of the founding dean, Dr. Hugh C. Muldoon, and graduated in 1928. In May 2000, the School of Pharmacy graduated its first entry-level Doctor of Pharmacy class. The School of Pharmacy is housed in Duquesne University's Mellon Hall of Science, with new administrative, faculty, and student services offices located in the adjacent Bayer Learning Center. Curriculum The full-time on-campus Pharm.D. program is arranged in two phases: a two-year pre-professional stage and four-year professional curricular format. The School also offers a four-year weekend-only program for candidates with a Bachelor's degree who want to obtain a Pharm.D. Administration The Dean of the school is J. Kirk Drennen, Ph.D. References External links The School of Pharmacy website {{DEFAULTSOR ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Jelena Janjic
Jelena, also written Yelena and Elena, is a Slavic given name. It is a Slavicized form of the Greek name Helen, which is of uncertain origin. Diminutives of the name include Jelica, Jelka, Jele, Jela, Lena, Lenotschka, Jeca, Lenka, and Alena. Notable people Nobility *Jelena Anžujska, Serbian Queen (d. 1314) * Jelena of Bulgaria, Empress consort of Serbia (d. 1374) * Jelena Petrović Njegoš, Montenegrin princess and Queen of Italy * Jelena of Serbia, many Serbian consorts *Jelena Urošević Vukanović, Queen consort of Hungary *Jelena Zrinski, Princess Consort of Transylvania and Croatian noblewoman Other people *Jelena Agbaba, Serbian handball player *Elena Berezhnaya, Russian figure skater *Jelena Blagojević, Serbian volleyball player *Yelena Bonner, Russian writer *Jelena Brooks (Milovanović), Serbian basketball player *Jelena Dokić, Australian tennis player of Croatian and Serbian origin *Jelena Glebova, Estonian figure skater *Jelena 'Gigi' Hadid, American model *Jelena ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Transcription Factor
In molecular biology, a transcription factor (TF) (or sequence-specific DNA-binding factor) is a protein that controls the rate of transcription of genetic information from DNA to messenger RNA, by binding to a specific DNA sequence. The function of TFs is to regulate—turn on and off—genes in order to make sure that they are expressed in the desired cells at the right time and in the right amount throughout the life of the cell and the organism. Groups of TFs function in a coordinated fashion to direct cell division, cell growth, and cell death throughout life; cell migration and organization (body plan) during embryonic development; and intermittently in response to signals from outside the cell, such as a hormone. There are up to 1600 TFs in the human genome. Transcription factors are members of the proteome as well as regulome. TFs work alone or with other proteins in a complex, by promoting (as an activator), or blocking (as a repressor) the recruitment of RNA ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
RUNX1
Runt-related transcription factor 1 (RUNX1) also known as acute myeloid leukemia 1 protein (AML1) or core-binding factor subunit alpha-2 (CBFA2) is a protein that in humans is encoded by the ''RUNX1'' gene. RUNX1 is a transcription factor that regulates the differentiation of hematopoietic stem cells into mature blood cells. In addition it plays a major role in the development of the neurons that transmit pain. It belongs to the Runt-related transcription factor (RUNX) family of genes which are also called core binding factor-α (CBFα). RUNX proteins form a heterodimeric complex with CBFβ which confers increased DNA binding and stability to the complex. Chromosomal translocations involving the ''RUNX1'' gene are associated with several types of leukemia including M2 AML. Mutations in ''RUNX1'' are implicated in cases of breast cancer. Gene and protein In humans, the gene RUNX1 is 260 kilobases (kb) in length, and is located on chromosome 21 (21q22.12). The gene can be t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Arrestins
Arrestins (abbreviated Arr) are a small family of proteins important for regulating signal transduction at G protein-coupled receptors. Arrestins were first discovered as a part of a conserved two-step mechanism for regulating the activity of G protein-coupled receptors (GPCRs) in the visual rhodopsin system by Hermann Kühn, Scott Hall, and Ursula Wilden and in the β-adrenergic system by Martin J. Lohse and co-workers. Function In response to a stimulus, GPCRs activate heterotrimeric G proteins. In order to turn off this response, or adapt to a persistent stimulus, active receptors need to be desensitized. The first step in desensitization is phosphorylation of the receptor by a class of serine/threonine kinases called G protein coupled receptor kinases (GRKs). GRK phosphorylation specifically prepares the activated receptor for arrestin binding. Arrestin binding to the receptor blocks further G protein-mediated signaling and targets receptors for internalization, and re ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
