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Jesús Manzano
Jesús María Manzano Ruano (San Lorenzo de El Escorial, 12 May 1978) is a former Spanish professional road racing cyclist. He is famous as the whistleblower of systematic doping within his cycling team and his statements led the Guardia Civil to conduct the Operación Puerto investigation around the sport doctor Eufemiano Fuentes. Cycling career Manzano turned professional in 2000 with the Kelme-Costa Blanca team that he would stay with until late 2003. Manzano's first professional win came in 2001 at the Vuelta a La Rioja. That same year he rode the 2001 Giro d'Italia where he had to retire after colliding with a course motorbike. The following year he rode in both the 2002 Giro d'Italia and the 2002 Vuelta a España. Manzano did not finish the Giro nor the Vuelta but his team Kelme were successful in the latter with the overall win by Aitor González. At that time Kelme was one of the strongest Spanish teams in the Vuelta a España and won the race with Roberto Heras in 2000 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
San Lorenzo De El Escorial
San Lorenzo de El Escorial, also known as El Escorial de Arriba, is a town and municipality in the Community of Madrid, Spain, located to the northwest of the region in the southeastern side of the Sierra de Guadarrama, at the foot of Mount Abantos and , from Madrid. It is head of the eponymous judicial party. The settlement is popularly called El Escorial de Arriba, to differentiate it from the neighbouring village of El Escorial, also known as El Escorial de Abajo. The Monastery of El Escorial is the most prominent building in the town and is one of the main Spanish Renaissance monuments. Especially remarkable is the Royal Library, inside the Monastery. The monastery and its historic surroundings were declared a World Heritage Site UNESCO on November 2, 1984, under the name of "El Escorial, monastery and site". The site also enjoys protection on Spain's heritage register; since June 21, 2006, it has been protected by the Community of Madrid as a Property of Cultural Int ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Blood Doping
Blood doping is a form of doping in which the number of red blood cells in the bloodstream is boosted in order to enhance athletic performance. Because such blood cells carry oxygen from the lungs to the muscles, a higher concentration in the blood can improve an athlete's aerobic capacity (VO2 max) and endurance. Blood doping can be achieved by making the body produce more red blood cells itself using drugs, giving blood transfusions either from another person or back to the same individual, or by using blood substitutes. Many methods of blood doping are illegal, particularly in professional sports where it is considered to give an artificial advantage to the competitor. Anti-doping agencies use tests to try to identify individuals who have been blood doping using a number of methods, typically by analysing blood samples from the competitors. History Blood doping is defined as the use of illicit products (e.g. erythropoietin (EPO), darbepoetin-alfa, hypoxia-inducible factor (H ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cortisone
Cortisone is a pregnene (21-carbon) steroid hormone. It is a naturally-occurring corticosteroid metabolite that is also used as a pharmaceutical prodrug; it is not synthesized in the adrenal glands. Cortisol is converted by the action of the enzyme corticosteroid 11-beta-dehydrogenase isozyme 2 into the inactive metabolite cortisone, particularly in the kidneys. Cortisone is converted back to the active steroid cortisol by the action of the enzyme 11β-Hydroxysteroid dehydrogenase type 1, particularly in the liver. The term "cortisone" is frequently misused to mean either any corticosteroid or hydrocortisone, which is actually another name for cortisol. Many who speak of receiving a "cortisone shot" or taking "cortisone" are actually receiving hydrocortisone or one of many other, much more potent synthetic corticosteroids; it is unlikely that the drug administered is actually cortisone. Cortisone can be administered as a prodrug, meaning it has to be converted by the body (speci ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Human Growth Hormone
Growth hormone (GH) or somatotropin, also known as human growth hormone (hGH or HGH) in its human form, is a peptide hormone that stimulates growth, cell reproduction, and cell regeneration in humans and other animals. It is thus important in human development. GH also stimulates production of IGF-1 and increases the concentration of glucose and free fatty acids. It is a type of mitogen which is specific only to the receptors on certain types of cells. GH is a 191-amino acid, single-chain polypeptide that is synthesized, stored and secreted by somatotropic cells within the lateral wings of the anterior pituitary gland. A recombinant form of hGH called somatropin (INN) is used as a prescription drug to treat children's growth disorders and adult growth hormone deficiency. In the United States, it is only available legally from pharmacies by prescription from a licensed health care provider. In recent years in the United States, some health care providers are prescribing growth h ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Neorecormon
Epoetin beta (rINN) is a synthetic, recombinant form of erythropoietin, a protein that promotes the production of red blood cells. It is an erythropoiesis-stimulating agent (ESA) that is used to treat anemia, commonly associated with chronic kidney failure and cancer chemotherapy. Epoetin beta is sold under the brand name NeoRecormon, among others.Amgen - Products. URLhttp://www.amgen.com/patients/prca.html. Accessed 21 October 2007. It is on the World Health Organization's List of Essential Medicines. Chemistry Epoetin beta is a recombinant form of human erythropoietin which is produced in Chinese hamster ovary cells. It has the same protein sequence as natural human erythropoietin, being composed of 165 amino acids with about 30 KDa molecular weight.MedsafeNeoRecormon Datasheet/ref> History Erythropoietin (EPO) is a hormone produced in the kidneys. The existence of this hormone has been known since 1906, when scientists first started isolating it, and since the 1980s, a rec ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Erythropoietin
Erythropoietin (; EPO), also known as erythropoetin, haematopoietin, or haemopoietin, is a glycoprotein cytokine secreted mainly by the kidneys in response to cellular hypoxia; it stimulates red blood cell production (erythropoiesis) in the bone marrow. Low levels of EPO (around 10 mU/mL) are constantly secreted in sufficient quantities to compensate for normal red blood cell turnover. Common causes of cellular hypoxia resulting in elevated levels of EPO (up to 10 000 mU/mL) include any anemia, and hypoxemia due to chronic lung disease. Erythropoietin is produced by interstitial fibroblasts in the kidney in close association with the peritubular capillary and proximal convoluted tubule. It is also produced in perisinusoidal cells in the liver. Liver production predominates in the fetal and perinatal period; renal production predominates in adulthood. It is homologous with thrombopoietin. Exogenous erythropoietin, recombinant human erythropoietin (rhEPO), ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cycling Team
A cycling team is a group of cycle sport, cyclists who join a team or are acquired and train together to compete in bicycle racing, bicycle races whether amateur or professional – and the supporting personnel. Cycling teams are most important in road bicycle racing, which is a team sport, but collaboration between team members is also important in track cycling and cyclo-cross. Composition While riders form the core of a team, a top team also has personnel who support the racing and training. These include *A manager, who oversees the team's commitments, sponsorships, and general operation. *Directeur sportif, Directeurs sportifs, who travel to races and dictate the racing strategy. In bigger teams they often drive team cars and have radio contact with the riders. *Coaches, who direct the team's training. *Doctors, responsible for riders' well-being and often making sure the riders meet regulations such as those related to Doping (sport), doping. *Therapists, who assist the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Jean-Marie Leblanc
Jean-Marie Leblanc (born 27 July 1944, in Nueil-sur-Argent, now Nueil-les-Aubiers, Deux-Sèvres) is a French retired professional road bicycle racer who was general director of the Tour de France from 1989 to 2007, when he reached pensionable age and was succeeded by Christian Prudhomme. Biography He became a professional in 1966 and rode until 1971. He gained his best results in criteriums, small tours, and single stage races, like the Grand Prix d'Aix-en-Provence (1968, 1st), the Circuit d'Armorique (1969, 1st), and the Four Days of Dunkirk (1970, 2nd). Afterwards, he became a sports journalist. Under his aegis, the Tour was modernised, most notably with the abandonment of the red and combination jerseys. Revenues were increased, as large numbers of sponsors were replaced by a limited number of larger ones - as well as increased income from television rights. In 1989, Leblanc cancelled further running of Tour de France Féminin Tour or Tours may refer to: Travel * Tour ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Volta A Portugal
The Volta a Portugal ( en, Tour of Portugal), also known as Volta a Portugal em Bicicleta ( en, Tour of Portugal on Bicycle), is an annual multi-stage road bicycle racing competition held in Portugal. The competition takes place during a two-week span. History The competition started in 1927, although its second edition only occurred in 1931. In 1936 and 1937 the tour did not take place. During World War II the race was cancelled between 1942 and 1945. In 1975 the competition was skipped due to the Carnation Revolution. In the period 1940-1980 the competition was staged over three weeks. Since the 1980s it was reduced to the period of two weeks. As of 2005 the race consisted only of ten stages. In the last years the race consisted of ten stages and a prologue (a short time trial that starts the race). It is still the longest competition in cycling after the three grand Tours. It is one of the oldest stage races in the world. Although not as important as the three Grand Tours, it ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Directeur Sportif
A ''directeur sportif'' ( French for sporting director, although the original French term is often used in English-language media; plural ''directeurs sportifs'') is a person directing a cycling team during a road bicycle racing event. It is seen as the equivalent to a field manager in baseball, or a head coach in football. At professional level, a directeur sportif follows the team in a car and communicates with riders, personnel and race officials by radio. The directeur sportif warns of obstacles or challenging terrain, updates the team on the situation in the race, and provides mechanical help. The car carrying the directeur sportif also usually carries a bicycle mechanic with spare bikes, wheels and parts. It also carries spare water bottles, food and medical equipment. Since the late 1990s, the role has increased, in keeping with better team cohesion, tactics and communication and telemetry equipment. The directeur sportif can have split times, find where riders from o ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Dehydration
In physiology, dehydration is a lack of total body water, with an accompanying disruption of metabolic processes. It occurs when free water loss exceeds free water intake, usually due to exercise, disease, or high environmental temperature. Mild dehydration can also be caused by immersion diuresis, which may increase risk of decompression sickness in divers. Most people can tolerate a 3-4% decrease in total body water without difficulty or adverse health effects. A 5-8% decrease can cause fatigue and dizziness. Loss of over ten percent of total body water can cause physical and mental deterioration, accompanied by severe thirst. Death occurs at a loss of between fifteen and twenty-five percent of the body water.Ashcroft F, Life Without Water in Life at the Extremes. Berkeley and Los Angeles, 2000, 134-138. Mild dehydration is characterized by thirst and general discomfort and is usually resolved with oral rehydration. Dehydration can cause hypernatremia (high levels of sodium ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Oxyglobin
A blood substitute (also called artificial blood or blood surrogate) is a substance used to mimic and fulfill some functions of biological blood. It aims to provide an alternative to blood transfusion, which is transferring blood or blood-based products from one person into another. Thus far, there are no well-accepted ''oxygen-carrying'' blood substitutes, which is the typical objective of a red blood cell transfusion; however, there are widely available non-blood volume expanders for cases where only volume restoration is required. These are helping doctors and surgeons avoid the risks of disease transmission and immune suppression, address the chronic blood donor shortage, and address the concerns of Jehovah's Witnesses and others who have religious objections to receiving transfused blood. The main categories of "oxygen-carrying" blood substitutes being pursued are hemoglobin-based oxygen carriers (HBOC) and perfluorocarbon emulsions. Oxygen therapeutics are in clinical trial ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
