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Jay Short
Jay M. Short is founder and CEO of the antibody drug company BioAtla, LLC. He was vice president of research and operations at Stratagene (now Agilent Technologies), president of the Stratagene antibody subsidiary Stratacyte, then founder and CEO of Diversa until 2005. While at Diversa, Short invented methods of protein and pathway discovery via metagenomics, in addition to evolution technologies gene site saturation mutagenesis (GSSM) and GeneReassembly, and was the first to combine these discovery and evolution technologies. On December 7, 2015, San Diego-based BioAtla signed a license and option deal with Pfizer, involving BioAtla's conditionally-active biologics (CAB) antibody platform and Pfizer's antibody-drug conjugate (ADC) payloads. BioAtla is eligible to receive more than $1.0 billion in up-front, regulatory and sales milestone commitments as well as tiered marginal royalties reaching double digits on potential future product sales. Short is also founder of the E. O. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Jay Short
Jay M. Short is founder and CEO of the antibody drug company BioAtla, LLC. He was vice president of research and operations at Stratagene (now Agilent Technologies), president of the Stratagene antibody subsidiary Stratacyte, then founder and CEO of Diversa until 2005. While at Diversa, Short invented methods of protein and pathway discovery via metagenomics, in addition to evolution technologies gene site saturation mutagenesis (GSSM) and GeneReassembly, and was the first to combine these discovery and evolution technologies. On December 7, 2015, San Diego-based BioAtla signed a license and option deal with Pfizer, involving BioAtla's conditionally-active biologics (CAB) antibody platform and Pfizer's antibody-drug conjugate (ADC) payloads. BioAtla is eligible to receive more than $1.0 billion in up-front, regulatory and sales milestone commitments as well as tiered marginal royalties reaching double digits on potential future product sales. Short is also founder of the E. O. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Agilent Technologies
Agilent Technologies, Inc. is an American life sciences company that provides instruments, software, services, and consumables for the entire laboratory workflow. Its global headquarters is located in Santa Clara, California. Agilent was established in 1999 as a spin-off from Hewlett-Packard. The resulting IPO of Agilent stock was the largest in the history of Silicon Valley at the time. Agilent focuses its products and services on six markets: food, environmental and forensics, pharmaceutical, diagnostics, chemicals and advanced materials, and research. From 1999 to 2014, the company also produced test and measurement equipment for electronics; that division was spun off to form Keysight. Products and services Agilent serves analytical laboratories and the clinical and routine diagnostics markets with a full suite of technology platforms. These include: automation, bioreagents, FISH probes, gas and liquid chromatography, immunohistochemistry, informatics, mass spectrometry ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Diversa
Verenium Corporation was a San Diego, California-based industrial biotechnology company founded in 2007 as the result of a merger between Diversa (San Diego) and Celunol (Cambridge, MA). The company specialized in research and development for the production of high performance enzymes used in industrial applications, including biofuel generation, hydraulic fracturing. Verenium was acquired by BASF corporation in 2013. The company's tailored enzymes are environmentally friendly, making products and processes greener and more cost-effective for industries including the global food and fuel markets. Using proprietary and patented genomic technologies, BASF extracts microbial DNA directly from collected samples to avoid the slow and often impossible task of growing microbes in the laboratory. BASF then mines its collection of microbial genes, numbering in the billions, using high-throughput screening technologies designed to identify unique enzymes as product candidates. As required, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
The San Diego Union-Tribune
''The San Diego Union-Tribune'' is a metropolitan daily newspaper published in San Diego, California, that has run since 1868. Its name derives from a 1992 merger between the two major daily newspapers at the time, ''The San Diego Union'' and the ''San Diego Evening Tribune''. The name changed to ''U-T San Diego'' in 2012 but was changed again to ''The San Diego Union-Tribune'' in 2015. In 2015, it was acquired by Tribune Publishing. In February 2018 it was announced to be sold, along with the ''Los Angeles Times'', to Patrick Soon-Shiong's investment firm Nant Capital LLC for $500 million plus $90 million in pension liabilities. The sale was completed on June 18, 2018. History Predecessors The predecessor newspapers of the ''Union-Tribune'' were: * ''San Diego Herald'', founded 1851 and closed April 7, 1860; John Judson Ames was its first editor and proprietor. * ''San Diego Sun'', founded 1861 and merged with the ''Evening Tribune'' in 1939. * ''San Diego Union'', fou ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Metagenomics
Metagenomics is the study of genetic material recovered directly from environmental or clinical samples by a method called sequencing. The broad field may also be referred to as environmental genomics, ecogenomics, community genomics or microbiomics. While traditional microbiology and microbial genome sequencing and genomics rely upon cultivated clonal cultures, early environmental gene sequencing cloned specific genes (often the 16S rRNA gene) to produce a profile of diversity in a natural sample. Such work revealed that the vast majority of microbial biodiversity had been missed by cultivation-based methods. Because of its ability to reveal the previously hidden diversity of microscopic life, metagenomics offers a powerful lens for viewing the microbial world that has the potential to revolutionize understanding of the entire living world. As the price of DNA sequencing continues to fall, metagenomics now allows microbial ecology to be investigated at a much greater scale ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pfizer
Pfizer Inc. ( ) is an American multinational pharmaceutical and biotechnology corporation headquartered on 42nd Street in Manhattan, New York City. The company was established in 1849 in New York by two German entrepreneurs, Charles Pfizer (1824–1906) and his cousin Charles F. Erhart (1821–1891). Pfizer develops and produces medicines and vaccines for immunology, oncology, cardiology, endocrinology, and neurology. The company has several blockbuster drugs or products that each generate more than billion in annual revenues. In 2020, 52% of the company's revenues came from the United States, 6% came from each of China and Japan, and 36% came from other countries. Pfizer was a component of the Dow Jones Industrial Average stock market index from 2004 to August 2020. The company ranks 64th on the Fortune 500 and 49th on the Forbes Global 2000. History 1849–1950: Early history Pfizer was founded in 1849 by Charles Pfizer and Charles F. Erhart, two cousins who had i ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Antibody-drug Conjugate
Antibody-drug conjugates or ADCs are a class of biopharmaceutical drugs designed as a targeted therapy for treating cancer. Unlike chemotherapy, ADCs are intended to target and kill tumor cells while sparing healthy cells. As of 2019, some 56 pharmaceutical companies were developing ADCs. ADCs are complex molecules composed of an antibody linked to a biologically active cytotoxic (anticancer) payload or drug. Antibody-drug conjugates are an example of bioconjugates and immunoconjugates. ADCs combine the targeting properties of Monoclonal antibody, monoclonal antibodies with the cancer-killing capabilities of cytotoxic drugs, designed to discriminate between healthy and diseased tissue. Mechanism of action An anticancer drug is coupled to an antibody that targets a specific tumor antigen (or protein) that, ideally, is only found in or on tumor cells. Antibodies attach themselves to the antigens on the surface of cancerous cells. The biochemical reaction that occurs upon attaching ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
PR Newswire
PR Newswire is a distributor of press releases headquartered in Chicago. The service was created in 1954 to allow companies to electronically send press releases to news organizations, using teleprinters at first. The founder, Herbert Muschel, operated the service from his house in Manhattan for approximately 15 years. The business was eventually sold to Western Union and then United Newspapers of London. In December 2015, Cision Inc. announced it would acquire the company. On January 1, 2021, Cision formally merged PR Newswire into the company, ending its status as a legal entity after 66 years. Cision plans to continue utilizing the brand name for the foreseeable future in the United States, as well as in Europe and the Asia-Pacific regions. History PR Newswire was founded in March 1954 by Herbert Muschel, who ran the business from his town house in New York City for the first 15 years of its operation. The company used telecommunications lines and teleprinters owned by Weste ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Senomyx
Senomyx was an American biotechnology company that developed food additives. The company claimed to have "Reverse engineering, reverse engineered" human taste and aroma Receptor (biochemistry), receptors. It was founded by Lubert Stryer and Paul Nevsky in 1998. On 17 Sept 2018, private Swiss company Firmenich completed the acquisition of Senomyx. History Prominent biochemist Lubert Stryer founded Senomyx in 1999. In May 2001, Stryer returned to his professorship at Stanford University and resigned from Senomyx, but continued to be the Chairman of the Scientific Advisory Board. Around the year 2001, Senomyx patented several flavor enhancers by using "proprietary taste receptor-based assay systems", which have been previously expressed in human cell culture, in HEK cell, HEK293 cells. HEK293 cells are a Immortalised cell line, cell line widely used in biological and medical research, immortalized through a Genetic Modification, genetic modification removed from the original human ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Case Western Reserve University
Case Western Reserve University (CWRU) is a private research university in Cleveland, Ohio. Case Western Reserve was established in 1967, when Western Reserve University, founded in 1826 and named for its location in the Connecticut Western Reserve, and Case Institute of Technology, founded in 1880 through the endowment of Leonard Case Jr., formally federated. Case Western Reserve University is a member of the Association of American Universities and is classified among "R1: Doctoral Universities – Very high research activity". According to the National Science Foundation, in 2019 the university had research and development (R&D) expenditures of $439 million, ranking it 20th among private institutions and 58th in the nation. The university has eight schools that offer more than 100 undergraduate programs and about 160 graduate and professional options. Seventeen Nobel laureates have been affiliated with Case Western Reserve's faculty and alumni or one of its two predecessors ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Taylor University
Taylor University is a private, interdenominational, evangelical Christian university in Upland, Indiana. Founded in 1846, it is one of the oldest evangelical Christian universities in the country. The university is named after Bishop William Taylor (1821–1902). The university sits on an approximately campus on the south side of Upland. It also preserves a arboretum and an additional of undeveloped land northeast of campus which has more of arboretum space. Taylor University has 1,798 undergraduate students, 33 graduate students, and 395 distance learning students. The student body hails from 38 states and 26 foreign countries, with 44 percent from Indiana. Taylor is a member of NAIA with 16 men's and women's sports teams. The university is accredited by the Higher Learning Commission and is a member of the Council for Christian Colleges and Universities and the Christian College Consortium. In August 2021, Dr. Michael Lindsay was named as the current president. His ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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