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Jacques Benveniste
Jacques Benveniste (; 12 March 1935 – 3 October 2004) was a French immunology, immunologist born in Paris. In 1979, he published a well-known paper on the structure of platelet-activating factor and its relationship with histamine. He was head of allergy and inflammation immunology at the French biomedical research agency INSERM. In 1988, Benveniste Benveniste affair, published a paper in ''Nature (journal), Nature'' describing the action of very high dilutions of anti-IgE antibody on the degranulation of human basophils, findings that seemed to support the concept of homeopathy. After the article was published, a follow-up investigation was set up by a team including John Maddox, James Randi and Walter Stewart (chemist), Walter Stewart. With the cooperation of Benveniste's own team, the group failed to replicate the original results, and subsequent investigations did not support Benveniste's findings. Benveniste refused to retract, damaging his reputation and forcing him to fund ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Immunology
Immunology is a branch of medicineImmunology for Medical Students, Roderick Nairn, Matthew Helbert, Mosby, 2007 and biology that covers the medical study of immune systems in humans, animals, plants and sapient species. In such we can see there is a difference of human immunology and comparative immunology in veterinary medicine and animal biosciences. Immunology measures, uses charts and differentiate in context in medicine the studies of immunity on cell and molecular level, and the immune system as part of the physiological level as its functioning is of major importance. In the different states of both health, occurring symptoms and diseases; the functioning of the immune system and immunological responses such as autoimmune diseases, allergic hypersensitivities, or in some cases malfunctioning of immune system as for example in immunological disorders or in immune deficiency, and the specific transplant rejection) Immunology has applications in numerous disciplines ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
A23187
A23187 is a mobile ion-carrier that forms stable complexes with divalent cations ( ions with a charge of +2). A23187 is also known as Calcimycin, Calcium Ionophore, Antibiotic A23187 and Calcium Ionophore A23187. It is produced at fermentation of ''Streptomyces'' '' chartreusensis''. Actions and uses A23187 has antibiotic properties against gram positive bacteria and fungi. It also acts as a divalent cation ionophore, allowing these ions to cross cell membranes, which are usually impermeable to them. A23187 is most selective for Mn2+, somewhat less selective for Ca2+ and Mg2+, much less selective for Sr2+, and even less selective for Ba2+. The ionophore is used in laboratories to increase intracellular Ca2+ levels in intact cells. It also uncouples oxidative phosphorylation, the process cells use to synthesize Adenosine triphosphate which they use for energy. In addition, A23187 inhibits mitochondrial ATPase activity. A23187 also induces apoptosis in some cells (e.g. mouse ly ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Eric Fottorino
The given name Eric, Erich, Erikk, Erik, Erick, or Eirik is derived from the Old Norse name ''Eiríkr'' (or ''Eríkr'' in Old East Norse due to monophthongization). The first element, ''ei-'' may be derived from the older Proto-Norse ''* aina(z)'', meaning "one, alone, unique", ''as in the form'' ''Æ∆inrikr'' explicitly, but it could also be from ''* aiwa(z)'' "everlasting, eternity", as in the Gothic form ''Euric''. The second element ''- ríkr'' stems either from Proto-Germanic ''* ríks'' "king, ruler" (cf. Gothic ''reiks'') or the therefrom derived ''* ríkijaz'' "kingly, powerful, rich, prince"; from the common Proto-Indo-European root * h₃rḗǵs. The name is thus usually taken to mean "sole ruler, autocrat" or "eternal ruler, ever powerful". ''Eric'' used in the sense of a proper noun meaning "one ruler" may be the origin of '' Eriksgata'', and if so it would have meant "one ruler's journey". The tour was the medieval Swedish king's journey, when newly elected, to ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Jonathan Miller
Sir Jonathan Wolfe Miller CBE (21 July 1934 – 27 November 2019) was an English theatre and opera director, actor, author, television presenter, humourist and physician. After training in medicine and specialising in neurology in the late 1950s, he came to prominence in the early 1960s in the comedy revue '' Beyond the Fringe'' with Peter Cook, Dudley Moore and Alan Bennett. Miller began directing operas in the 1970s. His 1982 production of a "Mafia"-styled ''Rigoletto'' was set in 1950s Little Italy, Manhattan. In its early days, he was an associate director at the National Theatre. He later ran the Old Vic Theatre. As a writer and presenter of more than a dozen BBC documentaries, Miller became a television personality and public intellectual in Britain and the United States. Life and career Early life Miller grew up in St John's Wood, London, in a well-connected Jewish family. His father Emanuel (1892–1970), who was of Lithuanian descent and suffered from severe ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
After Dark (TV Series)
''After Dark'' was a British late-night live television discussion programme broadcast weekly on Channel 4 between 1987 and 1991, and which returned for specials between 1993 and 1997; it was later revived by the BBC for a single season broadcast on BBC Four in 2003. Roly Keating of the BBC described it as "one of the great television talk formats of all time". In 2010 the television trade magazine ''Broadcast'' wrote "''After Dark'' defined the first 10 years of Channel 4, just as '' Big Brother'' did for the second" and in 2018 the programme was cited in an editorial in ''The Times'' as an example of high-quality television. Broadcast live and with no scheduled end time, the series, inspired by an Austrian programme called ''Club 2'', was considered to be a groundbreaking reinvention of the discussion programme format. The programme was hosted by a variety of presenters, and each episode had around half a dozen guests, often including a member of the public. Program ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Channel 4
Channel 4 is a British free-to-air public broadcast television network operated by the state-owned Channel Four Television Corporation. It began its transmission on 2 November 1982 and was established to provide a fourth television service in the United Kingdom. At the time, the only other channels were the licence-funded BBC One and BBC Two, and a single commercial broadcasting network ITV. The network's headquarters are based in London and Leeds, with creative hubs in Glasgow and Bristol. It is publicly owned and advertising-funded; originally a subsidiary of the Independent Broadcasting Authority (IBA), the station is now owned and operated by Channel Four Television Corporation, a public corporation of the Department for Digital, Culture, Media and Sport, which was established in 1990 and came into operation in 1993. Until 2010, Channel 4 did not broadcast in Wales, but many of its programmes were re-broadcast there by the Welsh fourth channel S4C. In 2010, Cha ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Double Blind
In a blind or blinded experiment, information which may influence the participants of the experiment is withheld until after the experiment is complete. Good blinding can reduce or eliminate experimental biases that arise from a participants' expectations, observer's effect on the participants, observer bias, confirmation bias, and other sources. A blind can be imposed on any participant of an experiment, including subjects, researchers, technicians, data analysts, and evaluators. In some cases, while blinding would be useful, it is impossible or unethical. For example, it is not possible to blind a patient to their treatment in a physical therapy intervention. A good clinical protocol ensures that blinding is as effective as possible within ethical and practical constraints. During the course of an experiment, a participant becomes unblinded if they deduce or otherwise obtain information that has been masked to them. For example, a patient who experiences a side effect may correc ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Scientific Skepticism
Scientific skepticism or rational skepticism (also spelled scepticism), sometimes referred to as skeptical inquiry, is a position in which one questions the veracity of claims lacking empirical evidence. In practice, the term most commonly references the examination of claims and theories that appear to be beyond mainstream science, rather than the routine discussions and challenges among scientists. Scientific skepticism differs from philosophical skepticism, which questions humans' ability to claim any knowledge about the nature of the world and how they perceive it, and the similar but distinct methodological skepticism, which is a systematic process of being skeptical about (or doubting) the truth of one's beliefs. in The skeptical movement ( British spelling: sceptical movement) is a contemporary social movement based on the idea of scientific skepticism. The movement has the goal of investigating claims made on fringe topics and determining whether they are supported ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Uri Geller
Uri Geller ( ; he, אורי גלר; born 20 December 1946) is an Israeli-British illusionist, magician, television personality, and self-proclaimed psychic. He is known for his trademark television performances of spoon bending and other illusions. Geller uses conjuring tricks to simulate the effects of psychokinesis and telepathy. Geller's career as an entertainer has spanned more than four decades, with television shows and appearances in many countries. Magicians have called Geller a fraud due to his claims of possessing psychic powers. Early life Geller was born on 20 December 1946 in Tel Aviv, which was then part of British Mandate of Palestine (now Israel). His mother and father were of Austrian-Jewish and Hungarian-Jewish background respectively. Geller is the son of Itzhaak Geller (Gellér Izsák), a retired army sergeant major, and Margaret "Manzy" Freud (Freud Manci). Geller claims that he is a distant relative of Sigmund Freud on his mother's side. At the a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Peer Review
Peer review is the evaluation of work by one or more people with similar competencies as the producers of the work ( peers). It functions as a form of self-regulation by qualified members of a profession within the relevant field. Peer review methods are used to maintain quality standards, improve performance, and provide credibility. In academia, scholarly peer review is often used to determine an academic paper's suitability for publication. Peer review can be categorized by the type of activity and by the field or profession in which the activity occurs, e.g., medical peer review. It can also be used as a teaching tool to help students improve writing assignments. Henry Oldenburg (1619–1677) was a German-born British philosopher who is seen as the 'father' of modern scientific peer review. Professional Professional peer review focuses on the performance of professionals, with a view to improving quality, upholding standards, or providing certification. In academia, p ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Water Memory
Water memory is the purported ability of water to retain a memory of substances previously dissolved in it even after an arbitrary number of serial dilutions. It has been claimed to be a mechanism by which homeopathic remedies work, even when they are diluted to the point that no molecule of the original substance remains, but there is no evidence for it. Water memory contradicts current scientific understanding of physical chemistry and is generally not accepted by the scientific community. In 1988, Jacques Benveniste published a study supporting a water memory effect amid controversy in ''Nature'', accompanied by an editorial by ''Natures'' editor John Maddox urging readers to "suspend judgement" until the results could be replicated. In the years after publication, multiple supervised experiments were made by Benveniste's team, the United States Department of Defense, BBC's ''Horizon'' programme, and other researchers, but no one has ever reproduced Benveniste's results unde ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Immunoglobulin E
Immunoglobulin E (IgE) is a type of antibody (or immunoglobulin (Ig) " isotype") that has been found only in mammals. IgE is synthesised by plasma cells. Monomers of IgE consist of two heavy chains (ε chain) and two light chains, with the ε chain containing four Ig-like constant domains (Cε1–Cε4). IgE is thought to be an important part of the immune response against infection by certain parasitic worms, including '' Schistosoma mansoni'', '' Trichinella spiralis'', and '' Fasciola hepatica''. IgE is also utilized during immune defense against certain protozoan parasites such as '' Plasmodium falciparum''. IgE may have evolved as a defense to protect against venoms. IgE also has an essential role in type I hypersensitivity, which manifests in various allergic diseases, such as allergic asthma, most types of sinusitis, allergic rhinitis, food allergies, and specific types of chronic urticaria and atopic dermatitis. IgE also plays a pivotal role in responses to aller ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
