Jacob Augustus Lockhart Clarke
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Jacob Augustus Lockhart Clarke
Jacob Augustus Lockhart Clarke (1817 – 25 January 1880) was a British physiologist and neurologist who is primarily known for his studies of the brain and the spinal cord. Life Because his father died early, young Clarke was brought up by his mother in France. On returning to England he chose the medical profession, to which his elder brother and grandfather belonged, and studied at Guy’s Hospital, and St Thomas' Hospital. Having obtained the diploma of the Worshipful Society of Apothecaries, he began practice at Pimlico, living with his mother. He became devoted to microscopical research on the brain and nervous system, and applying a new method, and proceeding with extreme care and thoroughness, he established many new facts of structure which had important bearings on the physiology and pathology of the nervous system. His first paper, ‘Researches into the Structure of the Spinal Cord,’ was received by the Royal Society on 15 October 1850, and published in their ‘Tra ...
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Physiologist
Physiology (; ) is the scientific study of functions and mechanisms in a living system. As a sub-discipline of biology, physiology focuses on how organisms, organ systems, individual organs, cells, and biomolecules carry out the chemical and physical functions in a living system. According to the classes of organisms, the field can be divided into medical physiology, animal physiology, plant physiology, cell physiology, and comparative physiology. Central to physiological functioning are biophysical and biochemical processes, homeostatic control mechanisms, and communication between cells. ''Physiological state'' is the condition of normal function. In contrast, ''pathological state'' refers to abnormal conditions, including human diseases. The Nobel Prize in Physiology or Medicine is awarded by the Royal Swedish Academy of Sciences for exceptional scientific achievements in physiology related to the field of medicine. Foundations Cells Although there are difference ...
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Fellows Of The Royal Society
Fellowship of the Royal Society (FRS, ForMemRS and HonFRS) is an award granted by the judges of the Royal Society of London to individuals who have made a "substantial contribution to the improvement of natural knowledge, including mathematics, engineering science, and medical science". Fellowship of the Society, the oldest known scientific academy in continuous existence, is a significant honour. It has been awarded to many eminent scientists throughout history, including Isaac Newton (1672), Michael Faraday (1824), Charles Darwin (1839), Ernest Rutherford (1903), Srinivasa Ramanujan (1918), Albert Einstein (1921), Paul Dirac (1930), Winston Churchill (1941), Subrahmanyan Chandrasekhar (1944), Dorothy Hodgkin (1947), Alan Turing (1951), Lise Meitner (1955) and Francis Crick (1959). More recently, fellowship has been awarded to Stephen Hawking (1974), David Attenborough (1983), Tim Hunt (1991), Elizabeth Blackburn (1992), Tim Berners-Lee (2001), Venki Ramakrishnan ...
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Royal Medal Winners
Royal may refer to: People * Royal (name), a list of people with either the surname or given name * A member of a royal family Places United States * Royal, Arkansas, an unincorporated community * Royal, Illinois, a village * Royal, Iowa, a city * Royal, Missouri, an unincorporated community * Royal, Nebraska, a village * Royal, Franklin County, North Carolina, an unincorporated area * Royal, Utah, a ghost town * Royal, West Virginia, an unincorporated community * Royal Gorge, on the Arkansas River in Colorado * Royal Township (other) Elsewhere * Mount Royal, a hill in Montreal, Canada * Royal Canal, Dublin, Ireland * Royal National Park, New South Wales, Australia Arts, entertainment, and media * Royal (Jesse Royal album), ''Royal'' (Jesse Royal album), a 2021 reggae album * ''The Royal'', a British medical drama television series * ''The Royal Magazine'', a monthly British literary magazine published between 1898 and 1939 * Royal (Indian magazine), ''Royal'' (Indian ...
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1880 Deaths
Year 188 (CLXXXVIII) was a leap year starting on Monday of the Julian calendar. At the time, it was known in the Roman Empire as the Year of the Consulship of Fuscianus and Silanus (or, less frequently, year 941 ''Ab urbe condita''). The denomination 188 for this year has been used since the early medieval period, when the Anno Domini calendar era became the prevalent method in Europe for naming years. Events By place Roman Empire * Publius Helvius Pertinax becomes pro-consul of Africa from 188 to 189. Japan * Queen Himiko (or Shingi Waō) begins her reign in Japan (until 248). Births * April 4 – Caracalla (or Antoninus), Roman emperor (d. 217) * Lu Ji (or Gongji), Chinese official and politician (d. 219) * Sun Shao, Chinese general of the Eastern Wu state (d. 241) Deaths * March 17 – Julian, pope and patriarch of Alexandria * Fa Zhen (or Gaoqing), Chinese scholar (b. AD 100) * Lucius Antistius Burrus, Roman politician (executed) * Ma Xiang, Ch ...
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1817 Births
Events January–March * January 1 – Sailing through the Sandwich Islands, Otto von Kotzebue discovers New Year Island. * January 19 – An army of 5,423 soldiers, led by General José de San Martín, starts crossing the Andes from Argentina, to liberate Chile and then Peru. * January 20 – Ram Mohan Roy and David Hare found Hindu College, Calcutta, offering instructions in Western languages and subjects. * February 12 – Battle of Chacabuco: The Argentine–Chilean patriotic army defeats the Spanish. * March 3 ** President James Madison vetoes John C. Calhoun's Bonus Bill. ** The U.S. Congress passes a law to split the Mississippi Territory, after Mississippi drafts a constitution, creating the Alabama Territory, effective in August. * March 4 – James Monroe is sworn in as the fifth President of the United States. * March 21 – The flag of the Pernambucan Revolt is publicly blessed by the dean of Recife Cathedral, Brazil ...
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British Physiologists
British may refer to: Peoples, culture, and language * British people, nationals or natives of the United Kingdom, British Overseas Territories, and Crown Dependencies. ** Britishness, the British identity and common culture * British English, the English language as spoken and written in the United Kingdom or, more broadly, throughout the British Isles * Celtic Britons, an ancient ethno-linguistic group * Brittonic languages, a branch of the Insular Celtic language family (formerly called British) ** Common Brittonic, an ancient language Other uses *''Brit(ish)'', a 2018 memoir by Afua Hirsch *People or things associated with: ** Great Britain, an island ** United Kingdom, a sovereign state ** Kingdom of Great Britain (1707–1800) ** United Kingdom of Great Britain and Ireland (1801–1922) See also * Terminology of the British Isles * Alternative names for the British * English (other) * Britannic (other) * British Isles * Brit (other) * Briton (d ...
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British Neurologists
British may refer to: Peoples, culture, and language * British people, nationals or natives of the United Kingdom, British Overseas Territories, and Crown Dependencies. ** Britishness, the British identity and common culture * British English, the English language as spoken and written in the United Kingdom or, more broadly, throughout the British Isles * Celtic Britons, an ancient ethno-linguistic group * Brittonic languages, a branch of the Insular Celtic language family (formerly called British) ** Common Brittonic, an ancient language Other uses *''Brit(ish)'', a 2018 memoir by Afua Hirsch *People or things associated with: ** Great Britain, an island ** United Kingdom, a sovereign state ** Kingdom of Great Britain (1707–1800) ** United Kingdom of Great Britain and Ireland (1801–1922) See also * Terminology of the British Isles * Alternative names for the British * English (other) * Britannic (other) * British Isles * Brit (other) * Briton (d ...
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Column Of Clarke
The posterior thoracic nucleus, (Clarke's column, column of Clarke, dorsal nucleus, nucleus dorsalis of Clarke) is a group of interneurons found in the medial part of lamina VII, also known as the intermediate zone, of the spinal cord. It is mainly located from the cervical vertebra C7 to lumbar L3–L4 levels and is an important structure for proprioception of the lower limb. Anatomy It occupies the medial part of the base of the posterior grey column and appears on the transverse section as a well-defined oval area. It begins caudally at the level of the second or third lumbar nerve, and reaches its maximum size opposite the twelfth thoracic nerve. Above the level of the eight thoracic nerve its size diminishes, and the column ends opposite the last cervical or first thoracic nerve. It is represented, however, in the other regions by scattered cells, which become aggregated to form a cervical nucleus opposite the third cervical nerve, and a sacral nucleus in the middle and low ...
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Clarke's Nucleus
The posterior thoracic nucleus, (Clarke's column, column of Clarke, dorsal nucleus, nucleus dorsalis of Clarke) is a group of interneurons found in the medial part of lamina VII, also known as the intermediate zone, of the spinal cord. It is mainly located from the cervical vertebra C7 to lumbar L3–L4 levels and is an important structure for proprioception of the lower limb. Anatomy It occupies the medial part of the base of the posterior grey column and appears on the transverse section as a well-defined oval area. It begins caudally at the level of the second or third lumbar nerve, and reaches its maximum size opposite the twelfth thoracic nerve. Above the level of the eight thoracic nerve its size diminishes, and the column ends opposite the last cervical or first thoracic nerve. It is represented, however, in the other regions by scattered cells, which become aggregated to form a cervical nucleus opposite the third cervical nerve, and a sacral nucleus in the middle and low ...
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Muscular Atrophy
Muscle atrophy is the loss of skeletal muscle mass. It can be caused by immobility, aging, malnutrition, medications, or a wide range of injuries or diseases that impact the musculoskeletal or nervous system. Muscle atrophy leads to muscle weakness and causes disability. Disuse causes rapid muscle atrophy and often occurs during injury or illness that requires immobilization of a limb or bed rest. Depending on the duration of disuse and the health of the individual, this may be fully reversed with activity. Malnutrition first causes fat loss but may progress to muscle atrophy in prolonged starvation and can be reversed with nutritional therapy. In contrast, cachexia is a wasting syndrome caused by an underlying disease such as cancer that causes dramatic muscle atrophy and cannot be completely reversed with nutritional therapy. Sarcopenia is age-related muscle atrophy and can be slowed by exercise. Finally, diseases of the muscles such as muscular dystrophy or myopathies can caus ...
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Paraplegia
Paraplegia, or paraparesis, is an impairment in motor or sensory function of the lower extremities. The word comes from Ionic Greek () "half-stricken". It is usually caused by spinal cord injury or a congenital condition that affects the neural (brain) elements of the spinal canal. The area of the spinal canal that is affected in paraplegia is either the thoracic, lumbar, or sacral regions. If four limbs are affected by paralysis, tetraplegia or quadriplegia is the correct term. If only one limb is affected, the correct term is monoplegia. Spastic paraplegia is a form of paraplegia defined by spasticity of the affected muscles, rather than flaccid paralysis. The American Spinal Injury Association classifies spinal cord injury severity in the following manner. ASIA A is the complete loss of sensory function and motor skills below the injury. ASIA B is having some sensory function below the injury, but no motor function. In ASIA C, there is some motor function below the level of ...
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