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John Brereton Barlow
John Brereton Barlow (24 October 1924 – 10 December 2008) was a world-renowned South African cardiologist. He qualified as a doctor in 1951, gained experience as a registrar in Hammersmith Hospital and the Royal Postgraduate Medical School in London. In the late 1950s he returned to South Africa to Johannesburg Hospital where he became Professor of Cardiology in the research unit and carried out significant studies on cardiac disorders as well as discovering the cause of a well known mitral valve disorder. He gives his name to Barlow's Syndrome. Professional life Barlow commenced medical studies at the University of the Witwatersrand. However, shortly afterwards, in 1940 when South Africa became involved in World War II he enlisted in the military and spent time attached to British forces in North Africa and later the Fifth US Army in Italy. He returned to medical school in 1946 and graduated with MBBCh. in November 1951. Barlow served his internship and registrar posts ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Johannesburg
Johannesburg ( , , ; Zulu and xh, eGoli ), colloquially known as Jozi, Joburg, or "The City of Gold", is the largest city in South Africa, classified as a megacity, and is one of the 100 largest urban areas in the world. According to Demographia, the Johannesburg–Pretoria urban area (combined because of strong transport links that make commuting feasible) is the 26th-largest in the world in terms of population, with 14,167,000 inhabitants. It is the provincial capital and largest city of Gauteng, which is the wealthiest province in South Africa. Johannesburg is the seat of the Constitutional Court, the highest court in South Africa. Most of the major South African companies and banks have their head offices in Johannesburg. The city is located in the mineral-rich Witwatersrand range of hills and is the centre of large-scale gold and diamond trade. The city was established in 1886 following the discovery of gold on what had been a farm. Due to the extremely large gold de ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Royal College Of Physicians
The Royal College of Physicians (RCP) is a British professional membership body dedicated to improving the practice of medicine, chiefly through the accreditation of physicians by examination. Founded by royal charter from King Henry VIII in 1518, the RCP is the oldest medical college in England. It set the first international standard in the classification of diseases, and its library contains medical texts of great historical interest. The college is sometimes referred to as the Royal College of Physicians of London to differentiate it from other similarly named bodies. The RCP drives improvements in health and healthcare through advocacy, education and research. Its 40,000 members work in hospitals and communities across over 30 medical specialties with around a fifth based in over 80 countries worldwide. The college hosts six training faculties: the Faculty of Forensic and Legal Medicine, the Faculty for Pharmaceutical Medicine, the Faculty of Occupational Medicine the Fac ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Aneurysm
An aneurysm is an outward bulging, likened to a bubble or balloon, caused by a localized, abnormal, weak spot on a blood vessel wall. Aneurysms may be a result of a hereditary condition or an acquired disease. Aneurysms can also be a nidus (starting point) for clot formation (thrombosis) and embolization. As an aneurysm increases in size, the risk of rupture, which leads to uncontrolled bleeding, increases. Although they may occur in any blood vessel, particularly lethal examples include aneurysms of the Circle of Willis in the brain, aortic aneurysms affecting the thoracic aorta, and abdominal aortic aneurysms. Aneurysms can arise in the heart itself following a heart attack, including both ventricular and atrial septal aneurysms. There are congenital atrial septal aneurysms, a rare heart defect. Etymology The word is from Greek: ἀνεύρυσμα, aneurysma, "dilation", from ἀνευρύνειν, aneurynein, "to dilate". Classification Aneurysms are classified by type, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Carditis
Carditis (pl. carditides) is the inflammation of the heart. It is usually studied and treated by specifying it as: * Pericarditis is the inflammation of the pericardium * Myocarditis is the inflammation of the heart muscle * Endocarditis is the inflammation of the endocardium * Pancarditis, also called perimyoendocarditis, is the inflammation of the entire heart: the pericardium, the myocardium and the endocardium * Reflux carditis refers to a possible outcome of esophageal reflux (also known as GERD Gerd or GERD may refer to: * Gerd (given name), a list of people with the given name or nickname * Gerd (moon), a moon of Saturn * Gerd Island, South Orkney Islands, Antarctica * Gastroesophageal reflux disease, a chronic symptom of mucosal damage ...), and involves inflammation of the esophagus/stomach mucosa References Heart diseases {{circulatory-disease-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hemodynamics
Hemodynamics or haemodynamics are the dynamics of blood flow. The circulatory system is controlled by homeostatic mechanisms of autoregulation, just as hydraulic circuits are controlled by control systems. The hemodynamic response continuously monitors and adjusts to conditions in the body and its environment. Hemodynamics explains the physical laws that govern the flow of blood in the blood vessels. Blood flow ensures the transportation of nutrients, hormones, metabolic waste products, oxygen, and carbon dioxide throughout the body to maintain cell-level metabolism, the regulation of the pH, osmotic pressure and temperature of the whole body, and the protection from microbial and mechanical harm. Blood is a non-Newtonian fluid, and is most efficiently studied using rheology rather than hydrodynamics. Because blood vessels are not rigid tubes, classic hydrodynamics and fluids mechanics based on the use of classical viscometers are not capable of explaining haemodynamics. The st ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tricuspid Valve
The tricuspid valve, or right atrioventricular valve, is on the right dorsal side of the mammalian heart, at the superior portion of the right ventricle. The function of the valve is to allow blood to flow from the right atrium to the right ventricle during diastole, and to close to prevent backflow ( regurgitation) from the right ventricle into the right atrium during right ventricular contraction ( systole). Structure The tricuspid valve usually has three cusps or leaflets, named the anterior, posterior, and septal cusps. Each leaflet is connected via chordae tendineae to the anterior, posterior, and septal papillary muscles of the right ventricle, respectively. Tricuspid valves may also occur with two or four leaflets; the number may change over a lifetime. Function The tricuspid valve functions as a one-way valve that closes during ventricular systole to prevent regurgitation of blood from the right ventricle back into the right atrium. It opens during ventricular diastol ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chordae Tendineae
The chordae tendineae (tendinous cords), colloquially known as the heart strings, are inelastic cords of fibrous connective tissue that connect the papillary muscles to the tricuspid valve and the mitral valve in the heart. Structure The chordae tendineae connect the atrioventricular valves (tricuspid and mitral), to the papillary muscles within the ventricles. Multiple chordae tendineae attach to each leaflet or cusp of the valves. Chordae tendineae contain elastin in a delicate structure notably at their periphery. Tendon of Todaro The ''tendon of Todaro'' is a continuation of the Eustachian valve of the inferior vena cava and the valve of the coronary sinus. Along with the opening of the coronary sinus and the septal cusp of the tricuspid valve, it makes up Koch's triangle. The apex of Koch's triangle is the location of the atrioventricular node. Function During atrial systole, blood flows from the atria to the ventricles down the pressure gradient. Chordae tendineae are ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Fibrosis
Fibrosis, also known as fibrotic scarring, is a pathological wound healing in which connective tissue replaces normal parenchymal tissue to the extent that it goes unchecked, leading to considerable tissue remodelling and the formation of permanent scar tissue. Repeated injuries, chronic inflammation and repair are susceptible to fibrosis where an accidental excessive accumulation of extracellular matrix components, such as the collagen is produced by fibroblasts, leading to the formation of a permanent fibrotic scar. In response to injury, this is called scarring, and if fibrosis arises from a single cell line, this is called a fibroma. Physiologically, fibrosis acts to deposit connective tissue, which can interfere with or totally inhibit the normal architecture and function of the underlying organ or tissue. Fibrosis can be used to describe the pathological state of excess deposition of fibrous tissue, as well as the process of connective tissue deposition in healing. Define ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Heart Murmur
Heart murmurs are unique heart sounds produced when blood flows across a heart valve or blood vessel. This occurs when turbulent blood flow creates a sound loud enough to hear with a stethoscope. Turbulent blood flow is not smooth. The sound differs from normal heart sounds by their characteristics. For example, heart murmurs may have a distinct pitch, duration and timing. The major way health care providers examine the heart on physical exam is heart auscultation; another clinical technique is palpation, which can detect by touch when such turbulence causes the vibrations called cardiac thrill. A murmur is a sign found during the cardiac exam. Murmurs are of various types and are important in the detection of cardiac and valvular pathologies (i.e. can be a sign of heart diseases or defects). There are two types of murmur. A functional murmur is a benign heart murmur that is primarily due to physiologic conditions outside the heart. The other type of heart murmur is due to a str ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Systole (medicine)
Systole ( ) is the part of the cardiac cycle during which some chambers of the heart contract after refilling with blood. The term originates, via New Latin, from Ancient Greek (''sustolē''), from (''sustéllein'' 'to contract'; from ''sun'' 'together' + ''stéllein'' 'to send'), and is similar to the use of the English term ''to squeeze''. The mammalian heart has four chambers: the left atrium above the left ventricle (lighter pink, see graphic), which two are connected through the mitral (or bicuspid) valve; and the right atrium above the right ventricle (lighter blue), connected through the tricuspid valve. The atria are the receiving blood chambers for the circulation of blood and the ventricles are the discharging chambers. In late ventricular diastole, the atrial chambers contract and send blood to the larger, lower ventricle chambers. This flow fills the ventricles with blood, and the resulting pressure closes the valves to the atria. The ventricles now perform i ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Non-ejection Click
With newer, non-invasive imaging techniques, the origin of other, so-called ''adventitial sounds'' or heart clicks has been appreciated. These are short, high-pitched sounds. * The mitral valve in cases of mitral stenosis may open with an ''opening snap'' on the beginning of diastole. * Patients with mitral valve prolapse may have a mid-systolic click along with a murmur, referred to as apical late systolic murmur. Early systolic clicks may also be present in some patients. * Aortic and pulmonary stenosis Pulmonic stenosis, is a dynamic or fixed obstruction of flow from the right ventricle of the heart to the pulmonary artery. It is usually first diagnosed in childhood. Signs and symptoms Cause Pulmonic stenosis is usually due to isolated valvula ... may cause an ejection click immediately after S1. References {{Cardiovascular system symptoms and signs Symptoms and signs: Cardiac Audible medical signs ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Phonocardiogram
A phonocardiogram (or PCG) is a plot of high-fidelity recording of the sounds and murmurs made by the heart with the help of the machine called the phonocardiograph; thus, phonocardiography is the recording of all the sounds made by the heart during a cardiac cycle. Medical use Heart sounds result from vibrations created by the closure of the heart valves. There are at least two; the first (S1) is produced when the atrioventricular valves (tricuspid and mitral) close at the beginning of systole and the second (S2) when the aortic valve and pulmonary valve (semilunar valves) close at the end of systole. Phonocardiography allows the detection of subaudible sounds and murmurs and makes a permanent record of these events. In contrast, the stethoscope cannot always detect all such sounds or murmurs and provides no record of their occurrence. The ability to quantitate the sounds made by the heart provides information not readily available from more sophisticated tests and provides ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
