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James D. Brenton
Professor James D Brenton is a clinician scientist and Senior Group Leader at the Cancer Research UK Cambridge Institute and Professor of Ovarian Cancer Medicine in the Department of Oncology, University of Cambridge. He is an Honorary Consultant in Medical Oncology at Addenbrooke's Hospital, Cambridge University Hospitals, Ovarian Cancer Domain Lead for the 100,000 Genomes Project by Genomics England, and co-founder and Clinical Advisor to Inivata Ltd, a clinical cancer genomics company. Education and career Dr Brenton studied Medicine at University College London, graduating in 1988, and trained in Medical Oncology at the Royal Marsden Hospital and Princess Margaret Cancer Centre, Toronto. He completed his PhD at the Gurdon Institute before attaining a Senior Clinical Research Fellowship for his work at the MRC Cancer Unit. In 2007 he became a Senior Group Leader at the Cancer Research UK Cambridge Institute, leading the Functional Genomics of Ovarian Cancer laboratory. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of Cambridge
, mottoeng = Literal: From here, light and sacred draughts. Non literal: From this place, we gain enlightenment and precious knowledge. , established = , other_name = The Chancellor, Masters and Scholars of the University of Cambridge , type = Public research university , endowment = £7.121 billion (including colleges) , budget = £2.308 billion (excluding colleges) , chancellor = The Lord Sainsbury of Turville , vice_chancellor = Anthony Freeling , students = 24,450 (2020) , undergrad = 12,850 (2020) , postgrad = 11,600 (2020) , city = Cambridge , country = England , campus_type = , sporting_affiliations = The Sporting Blue , colours = Cambridge Blue , website = , logo = University of Cambridge logo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
MRC Cancer Unit
The Medical Research Council Cancer Unit was located in Cambridge and was established in 2001. It was based within the Hutchison/MRC Research Centre, which in turn is situated on the Cambridge Biomedical Campus. History The MRC Cancer Unit was established in 2001 (as the MRC Cancer Cell Unit) by Professor Ron Laskey CBE, who was also appointed as the unit's first director. Professor Laskey retired from the unit in 2010. His successor was Professor Ashok Venkitaraman, who had co-directed the unit from 2006 with Professor Laskey. As well as his position as director of the MRC Cancer Unit, Professor Venkitaraman was also the Ursula Zoellner Professor of Cancer Research within the University of Cambridge. In October 2013, the unit joined the University of Cambridge and changed its name to the MRC Cancer Unit. Professor Venkitaraman stepped down from the directorship in November 2019 to take up a new role as director of the Cancer Science Institute of Singapore. He was succeeded by ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Academics Of The University Of Cambridge
An academy (Attic Greek: Ἀκαδήμεια; Koine Greek Ἀκαδημία) is an institution of secondary or tertiary higher learning (and generally also research or honorary membership). The name traces back to Plato's school of philosophy, founded approximately 385 BC at Akademia, a sanctuary of Athena, the goddess of wisdom and skill, north of Athens, Greece. Etymology The word comes from the ''Academy'' in ancient Greece, which derives from the Athenian hero, ''Akademos''. Outside the city walls of Athens, the gymnasium was made famous by Plato as a center of learning. The sacred space, dedicated to the goddess of wisdom, Athena, had formerly been an olive grove, hence the expression "the groves of Academe". In these gardens, the philosopher Plato conversed with followers. Plato developed his sessions into a method of teaching philosophy and in 387 BC, established what is known today as the Old Academy. By extension, ''academia'' has come to mean the accumulation, de ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Living People
Related categories * :Year of birth missing (living people) / :Year of birth unknown * :Date of birth missing (living people) / :Date of birth unknown * :Place of birth missing (living people) / :Place of birth unknown * :Year of death missing / :Year of death unknown * :Date of death missing / :Date of death unknown * :Place of death missing / :Place of death unknown * :Missing middle or first names See also * :Dead people * :Template:L, which generates this category or death years, and birth year and sort keys. : {{DEFAULTSORT:Living people 21st-century people People by status ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Year Of Birth Missing (living People)
A year or annus is the orbital period of a planetary body, for example, the Earth, moving in its orbit around the Sun. Due to the Earth's axial tilt, the course of a year sees the passing of the seasons, marked by change in weather, the hours of daylight, and, consequently, vegetation and soil fertility. In temperate and subpolar regions around the planet, four seasons are generally recognized: spring, summer, autumn and winter. In tropical and subtropical regions, several geographical sectors do not present defined seasons; but in the seasonal tropics, the annual wet and dry seasons are recognized and tracked. A calendar year is an approximation of the number of days of the Earth's orbital period, as counted in a given calendar. The Gregorian calendar, or modern calendar, presents its calendar year to be either a common year of 365 days or a leap year of 366 days, as do the Julian calendars. For the Gregorian calendar, the average length of the calendar year (the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ovarian Cancer Action
Ovarian Cancer Action is a charity based in the United Kingdom that funds scientific research both nationally and internationally. Nationally, the organisation funds the Ovarian Cancer Action Research Centre, based in the Institute of Reproductive and Developmental Biology (IRDB) on the Hammersmith Campus, and is one of the largest clusters of ovarian cancer research in Europe. International funding is made available through competitive research funding calls. The charity also promotes public awareness of ovarian cancer. On 8 May 2019 the charity carried out a symptoms awareness campaign for World Ovarian Cancer Day, which saw volunteers distributing 33,000 white roses with symptoms tags attached in locations throughout the United Kingdom. Cross-party MPs, including Theresa May and Jeremy Corbyn, also wore a white rose to PMQs to show their support for the campaign. The charity's headquarters are located in London. The Ovarian Cancer Action Research Centre is located at Hammersmith ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tumour Heterogeneity
A neoplasm () is a type of abnormal and excessive growth of tissue. The process that occurs to form or produce a neoplasm is called neoplasia. The growth of a neoplasm is uncoordinated with that of the normal surrounding tissue, and persists in growing abnormally, even if the original trigger is removed. This abnormal growth usually forms a mass, when it may be called a tumor. ICD-10 classifies neoplasms into four main groups: benign neoplasms, in situ neoplasms, malignant neoplasms, and neoplasms of uncertain or unknown behavior. Malignant neoplasms are also simply known as cancers and are the focus of oncology. Prior to the abnormal growth of tissue, as neoplasia, cells often undergo an abnormal pattern of growth, such as metaplasia or dysplasia. However, metaplasia or dysplasia does not always progress to neoplasia and can occur in other conditions as well. The word is from Ancient Greek 'new' and 'formation, creation'. Types A neoplasm can be benign, potentially ma ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Circulating Tumor DNA
Circulating tumor DNA (ctDNA) is tumor-derived fragmented DNA in the bloodstream that is not associated with cells. ctDNA should not be confused with cell-free DNA (cfDNA), a broader term which describes DNA that is freely circulating in the bloodstream, but is not necessarily of tumor origin. Because ctDNA may reflect the entire tumor genome, it has gained traction for its potential clinical utility; "liquid biopsies" in the form of blood draws may be taken at various time points to monitor tumor progression throughout the treatment regimen. ctDNA originates directly from the tumor or from circulating tumor cells (CTCs), which describes viable, intact tumor cells that shed from primary tumors and enter the bloodstream or lymphatic system. The precise mechanism of ctDNA release is unclear. The biological processes postulated to be involved in ctDNA release include apoptosis and necrosis from dying cells, or active release from viable tumor cells. Studies in both human (healthy and ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
World Health Organization
The World Health Organization (WHO) is a specialized agency of the United Nations responsible for international public health. The WHO Constitution states its main objective as "the attainment by all peoples of the highest possible level of health". Headquartered in Geneva, Switzerland, it has six regional offices and 150 field offices worldwide. The WHO was established on 7 April 1948. The first meeting of the World Health Assembly (WHA), the agency's governing body, took place on 24 July of that year. The WHO incorporated the assets, personnel, and duties of the League of Nations' Health Organization and the , including the International Classification of Diseases (ICD). Its work began in earnest in 1951 after a significant infusion of financial and technical resources. The WHO's mandate seeks and includes: working worldwide to promote health, keeping the world safe, and serve the vulnerable. It advocates that a billion more people should have: universal health care coverag ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
TP53
p53, also known as Tumor protein P53, cellular tumor antigen p53 (UniProt name), or transformation-related protein 53 (TRP53) is a regulatory protein that is often mutated in human cancers. The p53 proteins (originally thought to be, and often spoken of as, a single protein) are crucial in vertebrates, where they prevent cancer formation. As such, p53 has been described as "the guardian of the genome" because of its role in conserving stability by preventing genome mutation. Hence ''TP53'' ''italics'' are used to denote the ''TP53'' gene name and distinguish it from the protein it encodes is classified as a tumor suppressor gene. The name p53 was given in 1979 describing the apparent molecular mass; SDS-PAGE analysis indicates that it is a 53-kilodalton (kDa) protein. However, the actual mass of the full-length p53 protein (p53α) based on the sum of masses of the amino acid residues is only 43.7 kDa. This difference is due to the high number of proline residues in the protein, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ovarian Cancer
Ovarian cancer is a cancerous tumor of an ovary. It may originate from the ovary itself or more commonly from communicating nearby structures such as fallopian tubes or the inner lining of the abdomen. The ovary is made up of three different cell types including epithelial cells, germ cells, and stromal cells. When these cells become abnormal, they have the ability to divide and form tumors. These cells can also invade or spread to other parts of the body. When this process begins, there may be no or only vague symptoms. Symptoms become more noticeable as the cancer progresses. These symptoms may include bloating, vaginal bleeding, pelvic pain, abdominal swelling, constipation, and loss of appetite, among others. Common areas to which the cancer may spread include the lining of the abdomen, lymph nodes, lungs, and liver. The risk of ovarian cancer increases with age. Most cases of ovarian cancer develop after menopause. It is also more common in women who have ovulated m ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gurdon Institute
The Gurdon Institute (officially the Wellcome/Cancer Research UK Gurdon Institute) is a research facility at the University of Cambridge, specialising in developmental biology and cancer biology. History The Institute was founded in 1989 to provide a rich, collaborative environment for scientists working in diverse but complementary specialities in the fields of developmental biology and cancer biology. It receives its primary funding from the Wellcome Trust and Cancer Research UK. In 2004 it was renamed in honour of John Gurdon, joint winner of the 2012 Nobel Prize for medicine. the director is Julie Ahringer and the deputy director is Eric Miska. Faculty there are 15 Group Leaders and 2 Associate Group Leaders. Group Leaders: # Julie Ahringer #Andrea Brand #Jenny Gallop #John Gurdon # Steve Jackson #Tony Kouzarides #Hansong Ma #Eric Miska #Emma Rawlins # Ben Simons #Daniel St Johnston #Azim Surani #Iva Tchasovnikarova (beginning Summer 2020) #Fengzhu Xiong #Philip Zegerman ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
