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Integra LifeSciences
Integra LifeSciences is a global medical device manufacturing company headquartered in Princeton, New Jersey. Founded in 1989, the company manufactures products for skin regeneration, neurosurgery, reconstructive and general surgery. Integra artificial skin became the first commercially reproducible skin tissue used to treat severe burns and other skin wounds. History Integra LifeSciences was founded by Richard Caruso in 1989 after Caruso licensed Integra artificial skin technology from Harvard-MIT and acquired Colla-tec, a subsidiary of Marion Laboratories. The company became publicly traded under the NASDAQ ticker name IART. In 1996, Integra artificial skin was approved by the U.S. Food and Drug Administration. The artificial skin, manufactured and patented as Integra, is now used on patients with extensive burns. In 1999, the FDA approved Integra LifeSciences’ DuraGen, an absorbable implant used in neurosurgical and spinal procedures. In 2001, the company received FDA ap ...
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Princeton, New Jersey
Princeton is a municipality with a borough form of government in Mercer County, in the U.S. state of New Jersey. It was established on January 1, 2013, through the consolidation of the Borough of Princeton and Princeton Township, both of which are now defunct. Centrally located within the Raritan Valley region, Princeton is a regional commercial hub for the Central New Jersey region and a commuter town in the New York metropolitan area.New York-Newark, NY-NJ-CT-PA Combined Statistical Area
. Accessed December 5, 2020.
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Surgical Instruments
A surgical instrument is a tool or device for performing specific actions or carrying out desired effects during a surgery or operation, such as modifying biological tissue, or to provide access for viewing it. Over time, many different kinds of surgical instruments and tools have been invented. Some surgical instruments are designed for general use in all sorts of surgeries, while others are designed for only certain specialties or specific procedures. Classification of surgical instruments helps surgeons to understand the functions and purposes of the instruments. With the goal of optimizing surgical results and performing more difficult operations, more instruments continue to be invented in the modern era. History Many different kinds of surgical instruments and tools have been invented and some have been repurposed as medical knowledge and surgical practices have developed. As surgery practice diversified, some tools are advanced for higher accuracy and stability while so ...
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Wound Care
The history of wound care spans from prehistory to modern medicine. Wounds naturally heal by themselves, but hunter-gatherers would have noticed several factors and certain herbal remedies would speed up or assist the process, especially if it was grievous. In ancient history, this was followed by the realisation of the necessity of hygiene and the halting of bleeding, where wound dressing techniques and surgery developed. Eventually the germ theory of disease also assisted in improving wound care. Ancient medical practice Over time, different civilizations began to create their own herbal medicinal treatments for wounds depending on the trees, shrubs, or any other type of plants located in their environment. These herbal treatments became the oldest form of wound therapy. It is logically assumed that this may not have been a very safe way of treating humans with wounds due to overdosing or choosing the wrong plants to treat a person until the right one was found. Nevertheless, mo ...
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Artificial Skin
Artificial skin is a collagen scaffold that induces regeneration of skin in mammals such as humans. The term was used in the late 1970s and early 1980s to describe a new treatment for massive burns. It was later discovered that treatment of deep skin wounds in adult animals and humans with this scaffold induces regeneration of the dermis. It has been developed commercially under the name Integra and is used in massively burned patients, during plastic surgery of the skin, and in treatment of chronic skin wounds. Alternatively, the term "artificial skin" sometimes is used to refer to skin-like tissue grown in a laboratory, although this technology is still quite a way away from being viable for use in the medical field. 'Artificial skin' can also refer to flexible semiconductor materials that can sense touch for those with prosthetic limbs (also experimental). Background The skin is the largest organ in the human body. Skin is made up of three layers, the epidermis, dermis and the ...
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Richard Caruso
Richard E. Caruso (1943 – August 12, 2022) was an American entrepreneur, who was the founder and chairman of Integra LifeSciences and other companies. In 2006, Caruso was named the Ernst and Young National Entrepreneur of the Year for the United States. Education Caruso received a Bachelor of Science degree from Susquehanna University, a Master of Science in Business Analytics degree from Bucknell University, and a PhD from the London School of Economics. Entrepreneurial successes After college, Caruso began his career with PriceWaterhouse & Co in Philadelphia as a certified public accountant. From there, he joined LFC Financial Corporation where he became the executive vice president and a director. In 1978, Caruso founded The Provco Group, which organizes and provides funding for a variety of entrepreneurs and complex business activities. According to the company’s website, it currently manages more than a half a billion dollars in assets. In 1982, Caruso founded Tenl ...
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Marion Laboratories
Marion Merrell Dow and its predecessor Marion Laboratories was a U.S. pharmaceutical company based in Kansas City, Missouri from 1950 until 1996. The company specialized in bringing to market drugs that had been discovered but unmarketed by other companies including Cardizem which treats arrhythmias and high blood pressure, Carafate (an ulcer treatment), Gaviscon (an antacid), Seldane (a withdrawn antihistamine), Nicorette (anti-smoking gum) and Cepacol mouthwash.Marion Merrell Dow, Inc., International Directory of Company Histories, Vol. 9. St. James Press, 1994
(reprinted on fundinguniverse.com)
The company operating out of its headquarters at 9300 Ward Parkway was a springboard for its founder

Fortune (magazine)
''Fortune'' is an American multinational corporation, multinational business magazine headquartered in New York City. It is published by Fortune Media Group Holdings, owned by Thai businessman Chatchaval Jiaravanon. The publication was founded by Henry Luce in 1929. The magazine competes with ''Forbes'' and ''Bloomberg Businessweek'' in the national business magazine category and distinguishes itself with long, in-depth feature articles. The magazine regularly publishes ranked lists, including the Fortune 500, ''Fortune'' 500, a ranking of companies by revenue that it has published annually since 1955. The magazine is also known for its annual ''Fortune Investor's Guide''. History ''Fortune'' was founded by ''Time (magazine), Time'' magazine co-founder Henry Luce in 1929 as "the Ideal Super-Class Magazine", a "distinguished and de luxe" publication "vividly portraying, interpreting and recording the Industrial Civilization". Briton Hadden, Luce's business partner, was not enthu ...
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John F
John is a common English name and surname: * John (given name) * John (surname) John may also refer to: New Testament Works * Gospel of John, a title often shortened to John * First Epistle of John, often shortened to 1 John * Second Epistle of John, often shortened to 2 John * Third Epistle of John, often shortened to 3 John People * John the Baptist (died c. AD 30), regarded as a prophet and the forerunner of Jesus Christ * John the Apostle (lived c. AD 30), one of the twelve apostles of Jesus * John the Evangelist, assigned author of the Fourth Gospel, once identified with the Apostle * John of Patmos, also known as John the Divine or John the Revelator, the author of the Book of Revelation, once identified with the Apostle * John the Presbyter, a figure either identified with or distinguished from the Apostle, the Evangelist and John of Patmos Other people with the given name Religious figures * John, father of Andrew the Apostle and Saint Peter * Pope Jo ...
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Medtronic
Medtronic plc is an American medical device company. The company's operational and executive headquarters are in Minneapolis, Minnesota, and its legal headquarters are in Ireland due to its acquisition of Irish-based Covidien in 2015. While it primarily operates in the United States, it operates in more than 150 countries and employs over 90,000 people. It develops and manufactures healthcare technologies and therapies. History Medtronic was founded in 1949 in Minneapolis by Earl Bakken and his brother-in-law, Palmer Hermundslie, as a medical equipment repair shop. Bakken invented several medical technology devices that continue to be used around the world today. Through his repair business, Bakken came to know C. Walton Lillehei, a doctor of heart surgery at the University of Minnesota Medical School. The deficiencies of the Artificial cardiac pacemaker, artificial pacemakers of the day were made painfully obvious following a power outage over Halloween in 1957, which affecte ...
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Covidien
Covidien was an Irish-headquartered global health care products company and manufacturer of medical devices and supplies. Covidien became an independent publicly traded company after being spun off from Tyco International in 2007. It was purchased by Medtronic in a transaction that closed in 2015. The now-merged company is headquartered in Ireland, where Covidien was based. History In 2007, Covidien was formed when Tyco International spun off its health care business. In 2012, Covidien acquired Newport Medical Instruments, a small ventilator manufacturer supplier. Newport Medical Instruments had been contracted in 2006 by the U.S. Department of Health and Human Services' Biomedical Advanced Research and Development Authority to design a cheap, portable ventilator. At the time, Newport Medical Instruments had three working prototypes produced, and was on schedule to file for market approval late 2013. Covidien then effectively halted the project, subsequently exiting the cont ...
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Total Contact Casting
Total contact casting (TCC) is a specially designed cast designed to take weight off of the foot (off-loading) in patients with diabetic foot ulcers (DFUs). Reducing pressure on the wound by taking weight off the foot has proven to be very effective in DFU treatment. DFUs are a major factor leading to lower leg amputations among the diabetic population in the US with 85% of amputations in diabetics being preceded by a DFU. Furthermore, the five-year post-amputation mortality rate among diabetics is estimated at 45% for those with neuropathic DFUs. TCC has been used for off-loading DFUs in the US since the mid-1960s and is regarded by many practitioners as the "reference standard" for off-loading the bottom surface (sole) of the foot. TCC involves encasing the patient's complete foot, including toes, and the lower leg in a specialist cast that redistributes weight and pressure in the lower leg and foot during everyday movements. This redistributes pressure from the foot into the leg, ...
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ACell
ACell is a Columbia, Maryland-based biotechnology company. The company works in regenerative medicine, in which it owns several extracellular matrix patents. ACell develops, manufactures and markets products for medical and veterinary applications. The company was founded by Alan R. Spievack, a former associate professor at Harvard Medical School and is currently run by Patrick A. McBrayer. ACell's extracellular matrix (ECM) is derived from the lamina propria and basement membrane of a porcine Urinary Bladder Matrix (UBM). The lamina propria acts as a scaffold for cell infiltration while the basement membrane encourages the growth of site-specific tissue as the UBM resorbs. The UBM is offered in both sheet and powder form. The powder form is sold under the brand name of MicroMatrix. The company offers products for wound management (Cytal and MicroMatrix), hernia repair (Gentrix) and Pelvic Organ Prolapse repair (Pelvic Floor Matrix). Over 100 papers have been published related to ...
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