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Iniparib
Iniparib (International nonproprietary name, INN, previously known as BSI 201) was a drug candidate for cancer treatment. It was originally believed to act as an Enzyme inhibitor#Irreversible inhibitors, irreversible inhibitor of PARP1 (hence, a PARP inhibitor) and possibly other enzymes through covalent bond, covalent modification, but its effects against PARP were later disproven. It underwent clinical trials for treatment of some types of breast cancer, but was discontinued after disappointing phase III clinical trials. History Iniparib was the first putative PARP inhibitor to commence Phases_of_clinical_research#Phase_III, phase III clinical trials. The first was for breast cancer, another was for Squamous-cell carcinoma of the lung, squamous-cell lung cancer. Preliminary results in June 2009 on triple-negative breast cancer were promising. Later results showed increased median survival of triple-negative breast cancer patients from 7.7 to 12.2 months. In 2009, the Food an ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
PARP Inhibitor
PARP inhibitors are a group of pharmacological inhibitors of the enzyme poly ADP ribose polymerase (PARP). They are developed for multiple indications, including the treatment of heritable cancers. Several forms of cancer are more dependent on PARP than regular cells, making PARP (PARP1, PARP2 etc) an attractive target for cancer therapy. PARP inhibitors appear to improve progression-free survival in women with recurrent platinum-sensitive ovarian cancer, as evidenced mainly by olaparib added to conventional treatment. In addition to their use in cancer therapy, PARP inhibitors are considered a potential treatment for acute life-threatening diseases, such as stroke and myocardial infarction, as well as for long-term neurodegenerative diseases. Medical uses Approved for marketing * Olaparib: In December, 2014, the EMA and US FDA approved olaparib as monotherapy (at 400 mg taken twice per day) for patients with germline BRCA mutated (gBRCAm) advanced ovarian cancer wh ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
