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Immunoglobulin V-set Domain
V-set domains are Ig-like domains resembling the antibody variable domain. V-set domains are found in diverse protein families, including immunoglobulin light and heavy chains; in several T-cell receptors such as CD2 (Cluster of Differentiation 2), CD4, CD80, and CD86; in myelin membrane adhesion molecules; in junctional adhesion molecules (JAM); in tyrosine-protein kinase receptors; and in the programmed cell death protein 1 (PD1). Subfamilies * Immunoglobulin V-set, subgroup * T-cell surface antigen CD2 Human proteins containing this domain ACAM; ACAN; ADAMTSL1; AGC1; AMICA1; BCAM; BCAN; BGP; BGPc; BT3.3; BTN1A1; BTN2A1; BTN2A2; BTN2A3; BTN3A1; BTN3A2; BTN3A3; BTNL2; BTNL3; BTNL8; BTNL9; C10orf54; C1orf32; C9orf94; CADM1; CADM2; CADM3; CADM4; CD2; CD226; CD274; CD276; CD300A; CD300C; CD300D; CD300E; CD300LB; CD300LF; CD300LG; ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
CD80
The Cluster of differentiation 80 (also CD80 and B7-1) is a B7, type I membrane protein in the immunoglobulin superfamily, with an extracellular immunoglobulin constant-like domain and a variable-like domain required for receptor binding. It is closely related to CD86, another B7 protein (B7-2), and often works in tandem. Both CD80 and CD86 interact with costimulatory receptors CD28 and CTLA-4 (CD152). Structure CD80 is a member of the B7 family, which consists of molecules present at APCs and their receptors present on the T-cells. CD80 is present specifically on DC, activated B-cells, and macrophages, but also T-cells CD80 is also a transmembrane glycoprotein and a member of the Ig superfamily. It is composed of 288 amino acids, and its mass is 33 kDa. It consists of two Ig-like extracellular domains (208 AA), a transmembrane helical segment (21 AA), and a short cytoplasmic tail (25 AA). The Ig-like extracellular domains are formed by single V-type and C2-type domains. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
BTN1A1
Butyrophilin subfamily 1 member A1 is a protein that in humans is encoded by the ''BTN1A1'' gene. Butyrophilin (BTN) is the major protein associated with fat droplets in the milk. It is a member of the immunoglobulin superfamily. It may have a cell surface receptor function. The human butyrophilin gene is localized in the major histocompatibility complex (MHC) class I region of 6p and may have arisen relatively recently in evolution by the shuffling of exons between 2 ancestral gene families Function Btn1a1 regulates the amount of lipids and size of droplets expressed in milk. When the gene is compromised in laboratory mice, approximately half the pups died within the first 20 days and the remainder were significantly under-weight. Link to multiple sclerosis Butyrophilin has been presented as a potential antigen which may be similar enough to myelin oligodendrocyte glycoprotein (MOG) to spur the immune system to attack myelin in a process known as molecular or epitopic mim ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
C10orf54
V-domain Ig suppressor of T cell activation (VISTA) is a type I transmembrane protein that functions as an immune checkpoint and is encoded by the ''C10orf54'' gene. Structure and function VISTA is approximately 50k Da and belongs to the immunoglobulin superfamily and has one IgV domain. VISTA is part of the B7 family, is primarily expressed in white blood cells and its transcription is partially controlled by p53. There is evidence that VISTA can act as both a ligand and a receptor on T cells to inhibit T cell effector function and maintain peripheral tolerance. Clinical significance VISTA is produced at high levels in tumor-infiltrating lymphocytes, such as myeloid-derived suppressor cells and regulatory T cells, and its blockade with an antibody results in delayed tumor growth in mouse models of melanoma and squamous cell carcinoma. Monocytes from HIV-infected patients produce higher levels of VISTA compared to uninfected individuals. The increased VI ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
BTNL2
Butyrophilin-like protein 2 is a protein that in humans is encoded by the ''BTNL2'' gene. Because it is associated with the immune system and the major histocompatibility complex, it has been implicated in many diseases (see further reading list below). A large scale study found it to be the protein under the most stringent selection in the human genome The human genome is a complete set of nucleic acid sequences for humans, encoded as DNA within the 23 chromosome pairs in cell nuclei and in a small DNA molecule found within individual mitochondria. These are usually treated separately as the ... in 8 out of 12 geographic regions using the HKA test. References External links * Further reading * * * * * * * * * * * * {{gene-6-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
BTN3A3
Butyrophilin subfamily 3 member A3 is a protein that in humans is encoded by the ''BTN3A3'' gene. References Further reading * * * * External links * * * * {{gene-6-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |