IgA Protease
IgA protease may refer to: * IgA specific serine endopeptidase, an enzyme * IgA-specific metalloendopeptidase, an enzyme {{Short pages monitor ...
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IgA Specific Serine Endopeptidase
IgA protease (, ''IgA-specific serine endopeptidase'', ''IgA proteinase'', ''IgA-specific proteinase'', ''immunoglobulin A protease'', ''immunoglobulin A proteinase'') is an enzyme. This enzyme catalyses the following chemical reaction eaction equation needed/sup> It performs cleavage of immunoglobulin A molecules at certain Pro- bonds in the hinge region. No small molecule substrates are known This enzyme is secreted by Gram-negative bacteria ''Neisseria gonorrhoeae'', ''Neisseria meningitidis'', ''Haemophilus influenzae'', and Gram-positive ''Streptococcus pneumoniae''. The action of IgA protease allows the above mentioned bacteria to adhere to mucous membranes. An IgA protease is a highly specific 106kDa enzyme that cleaves amino acid sequences of certain proteins. The natural substrate of IgA proteases is immunoglobulin A, hence its name. The enzyme is in fact capable of cleavage of proteins with the amino acid sequence Cleaves N-X-Z-Pro-Pro/-Y-Pro-C, where the X in the seq ...
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