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Ivermectin During The COVID-19 Pandemic
Ivermectin is an antiparasitic drug that is well established for use in animals and people. The World Health Organization (WHO), the European Medicines Agency (EMA), the United States Food and Drug Administration (FDA), and the Infectious Diseases Society of America (IDSA) all advise against using ivermectin in an attempt to treat or prevent COVID-19. Early in the COVID-19 pandemic, laboratory research suggested ivermectin might have a role in preventing or treating COVID-19. Online misinformation campaigns and advocacy boosted the drug's profile among the public. While scientists and physicians largely remained skeptical, some nations adopted ivermectin as part of their pandemic-control efforts. Some people, desperate to use ivermectin without a prescription, took veterinary preparations, which led to shortages of supplies of ivermectin for animal treatment. The FDA responded to this situation by saying "You are not a horse" in a Tweet to draw attention to the issue, which the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Antiviral Drug
Antiviral drugs are a class of medication used for treating viral infections. Most antivirals target specific viruses, while a broad-spectrum antiviral is effective against a wide range of viruses. Unlike most antibiotics, antiviral drugs do not destroy their target pathogen; instead they inhibit its development. Antiviral drugs are one class of antimicrobials, a larger group which also includes antibiotic (also termed antibacterial), antifungal and antiparasitic drugs, or antiviral drugs based on monoclonal antibodies. Most antivirals are considered relatively harmless to the host, and therefore can be used to treat infections. They should be distinguished from viricides, which are not medication but deactivate or destroy virus particles, either inside or outside the body. Natural viricides are produced by some plants such as eucalyptus and Australian tea trees. Medical uses Most of the antiviral drugs now available are designed to help deal with HIV, herpes viruses, th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mexico City
Mexico City ( es, link=no, Ciudad de México, ; abbr.: CDMX; Nahuatl: ''Altepetl Mexico'') is the capital and largest city of Mexico, and the most populous city in North America. One of the world's alpha cities, it is located in the Valley of Mexico within the high Mexican central plateau, at an altitude of . The city has 16 boroughs or ''demarcaciones territoriales'', which are in turn divided into neighborhoods or ''colonias''. The 2020 population for the city proper was 9,209,944, with a land area of . According to the most recent definition agreed upon by the federal and state governments, the population of Greater Mexico City is 21,804,515, which makes it the sixth-largest metropolitan area in the world, the second-largest urban agglomeration in the Western Hemisphere (behind São Paulo, Brazil), and the largest Spanish language, Spanish-speaking city (city proper) in the world. Greater Mexico City has a gross domestic product, GDP of $411 billion in 2011, which makes ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Systematic Reviews
A systematic review is a scholarly synthesis of the evidence on a clearly presented topic using critical methods to identify, define and assess research on the topic. A systematic review extracts and interprets data from published studies on the topic, then analyzes, describes, and summarizes interpretations into a refined conclusion. For example, a systematic review of randomized controlled trials is a way of summarizing and implementing evidence-based medicine. While a systematic review may be applied in the biomedical or health care context, it may also be used where an assessment of a precisely defined subject can advance understanding in a field of research. A systematic review may examine clinical tests, public health interventions, environmental interventions, social interventions, adverse effects, qualitative evidence syntheses, methodological reviews, policy reviews, and economic evaluations. An understanding of systematic reviews and how to implement them in pract ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Expression Of Concern
In academic publishing, an expression of concern is a notice issued by a publisher against a particular publication, warning that it may contain errors or be otherwise untrustworthy. Definitions Practice for issuing expressions of concern is not standardized across the publishing industry. The International Committee of Medical Journal Editors says in its 2019 recommendations that a publisher may choose to issue an expression of concern while an investigation of alleged scientific misconduct is ongoing, and pending its outcome.. See also * Erratum * Post-publication peer review * Retractions in academic publishing Notes References *COPE Notes. *ICMJE. * Scientific misconduct Academic publishing Publishing Error {{Publish-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
American Journal Of Therapeutics
The ''American Journal of Therapeutics'' is a bimonthly medical journal covering advances in drug therapy, comparative effectiveness research, and post-marketing surveillance. The journal was established in 1994 by John Somberg MD and is published by Wolters Kluwer. The editor-in-chief since 2015 is Peter Manu MD, Professor of Medicine at the Zucker School of Medicine at Hofstra/Northwell, Hofstra University, Hempstead, NY. The journal has been part of the Web of Science Core Collection since 2010. According to the Journal Citation Reports, the journal has a 2020 impact factor of 2.688. The journal is included in the Index Medicus (MEDLINE MEDLINE (Medical Literature Analysis and Retrieval System Online, or MEDLARS Online) is a bibliographic database of life sciences and biomedical information. It includes bibliographic information for articles from academic journals covering medic ...). References External links * Pharmacology journals Wolters Kluwer academic journals ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Arkansas
Arkansas ( ) is a landlocked state in the South Central United States. It is bordered by Missouri to the north, Tennessee and Mississippi to the east, Louisiana to the south, and Texas and Oklahoma to the west. Its name is from the Osage language, a Dhegiha Siouan language, and referred to their relatives, the Quapaw people. The state's diverse geography ranges from the mountainous regions of the Ozark and Ouachita Mountains, which make up the U.S. Interior Highlands, to the densely forested land in the south known as the Arkansas Timberlands, to the eastern lowlands along the Mississippi River and the Arkansas Delta. Arkansas is the 29th largest by area and the 34th most populous state, with a population of just over 3 million at the 2020 census. The capital and most populous city is Little Rock, in the central part of the state, a hub for transportation, business, culture, and government. The northwestern corner of the state, including the Fayetteville–Springdaleâ ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Washington County, Arkansas
Washington County is a regional economic, educational, and cultural hub in the Northwest Arkansas region. Created as Arkansas's 17th county on November 30, 1848, Washington County has 13 incorporated municipalities, including Fayetteville, Arkansas, Fayetteville, the county seat, and Springdale, Arkansas, Springdale. The county is also the site of small towns, bedroom community, bedroom communities, and unincorporated places. The county is named for George Washington, the first President of the United States. Located within the Ozark Mountains, the county is roughly divided into two halves: the rolling Springfield Plateau and the steeper, forested Boston Mountains. It contains three segments of the Ozark National Forest, two state parks, two List of Wildlife Management Areas in Arkansas, Wildlife Management Areas, the Garrett Hollow Natural Area, and dozens of city parks. Other historical features such as Civil War battlefields, log cabins, one-room school houses, community cent ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Randomised Controlled Trial
A randomized controlled trial (or randomized control trial; RCT) is a form of scientific experiment used to control factors not under direct experimental control. Examples of RCTs are clinical trials that compare the effects of drugs, surgical techniques, medical devices, diagnostic procedures or other medical treatments. Participants who enroll in RCTs differ from one another in known and unknown ways that can influence study outcomes, and yet cannot be directly controlled. By randomly allocating participants among compared treatments, an RCT enables ''statistical control'' over these influences. Provided it is designed well, conducted properly, and enrolls enough participants, an RCT may achieve sufficient control over these confounding factors to deliver a useful comparison of the treatments studied. Definition and examples An RCT in clinical research typically compares a proposed new treatment against an existing standard of care; these are then termed the 'experimental' ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Therapeutic Index
The therapeutic index (TI; also referred to as therapeutic ratio) is a quantitative measurement of the relative safety of a drug. It is a comparison of the amount of a therapeutic agent that causes the therapeutic effect to the amount that causes toxicity. The related terms therapeutic window or safety window refer to a range of doses which optimize between efficacy and toxicity, achieving the greatest therapeutic benefit without resulting in unacceptable side-effects or toxicity. Classically, in an established clinical indication setting of an approved drug, TI refers to the ratio of the dose of drug that causes adverse effects at an incidence/severity not compatible with the targeted indication (e.g. toxic dose in 50% of subjects, TD) to the dose that leads to the desired pharmacological effect (e.g. efficacious dose in 50% of subjects, ED). In contrast, in a drug development setting TI is calculated based on plasma exposure levels. In the early days of pharmaceutical toxico ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Importin
Importin is a type of karyopherin that transports protein molecules from the cell's cytoplasm to the nucleus. It does so by binding to specific recognition sequences, called nuclear localization sequences (NLS). Importin has two subunits, importin α and importin β. Members of the importin-β family can bind and transport cargo by themselves, or can form heterodimers with importin-α. As part of a heterodimer, importin-β mediates interactions with the pore complex, while importin-α acts as an adaptor protein to bind the nuclear localization signal (NLS) on the cargo. The NLS-Importin α-Importin β trimer dissociates after binding to Ran GTP inside the nucleus, with the two importin proteins being recycled to the cytoplasm for further use. Discovery Importin can exist as either a heterodimer of importin-α/β or as a monomer of Importin-β. Importin-α was first isolated in 1994 by a group includinEnno Hartmann based at the Max Delbrück Center for Molecular Medicine. The p ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nuclear Transport
Nuclear transport refers to the mechanisms by which molecules move across the nuclear membrane of a cell. The entry and exit of large molecules from the cell nucleus is tightly controlled by the nuclear pore complexes (NPCs). Although small molecules can enter the nucleus without regulation, macromolecules such as RNA and proteins require association with transport factors known as nuclear transport receptors, like karyopherins called importins to enter the nucleus and exportins to exit. Nuclear import Protein that must be imported to the nucleus from the cytoplasm carry nuclear localization signals (NLS) that are bound by importins. An NLS is a sequence of amino acids that acts as a tag. They are most commonly hydrophilic proteins containing lysine and arginine residues, although diverse NLS sequences have been documented. Proteins, transfer RNA, and assembled ribosomal subunits are exported from the nucleus due to association with exportins, which bind signaling sequences called ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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