|
Immune-related Response Criteria
The immune-related response criteria (irRC) is a set of published rules that define when tumors in cancer patients improve ("respond"), stay the same ("stabilize"), or worsen ("progress") during treatment, where the compound being evaluated is an immuno-oncology drug. Immuno-oncology, part of the broader field of cancer immunotherapy, involves agents which harness the body's own immune system to fight cancer. Traditionally, patient responses to new cancer treatments have been evaluated using two sets of criteria, the WHO criteria and the response evaluation criteria in solid tumors (RECIST). The immune-related response criteria, first published in 2009, arose out of observations that immuno-oncology drugs would fail in clinical trials that measured responses using the WHO or RECIST Criteria, because these criteria could not account for the time gap in many patients between initial treatment and the apparent action of the immune system to reduce the tumor burden. Background Part o ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cancer
Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body. These contrast with benign tumors, which do not spread. Possible signs and symptoms include a lump, abnormal bleeding, prolonged cough, unexplained weight loss, and a change in bowel movements. While these symptoms may indicate cancer, they can also have other causes. Over 100 types of cancers affect humans. Tobacco use is the cause of about 22% of cancer deaths. Another 10% are due to obesity, poor diet, lack of physical activity or excessive drinking of alcohol. Other factors include certain infections, exposure to ionizing radiation, and environmental pollutants. In the developing world, 15% of cancers are due to infections such as ''Helicobacter pylori'', hepatitis B, hepatitis C, human papillomavirus infection, Epstein–Barr virus and human immunodeficiency virus (HIV). These factors act, at least partly, by changing the genes of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pfizer
Pfizer Inc. ( ) is an American multinational pharmaceutical and biotechnology corporation headquartered on 42nd Street in Manhattan, New York City. The company was established in 1849 in New York by two German entrepreneurs, Charles Pfizer (1824–1906) and his cousin Charles F. Erhart (1821–1891). Pfizer develops and produces medicines and vaccines for immunology, oncology, cardiology, endocrinology, and neurology. The company has several blockbuster drugs or products that each generate more than billion in annual revenues. In 2020, 52% of the company's revenues came from the United States, 6% came from each of China and Japan, and 36% came from other countries. Pfizer was a component of the Dow Jones Industrial Average stock market index from 2004 to August 2020. The company ranks 64th on the Fortune 500 and 49th on the Forbes Global 2000. History 1849–1950: Early history Pfizer was founded in 1849 by Charles Pfizer and Charles F. Erhart, two cousins who had i ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Boston
Boston (), officially the City of Boston, is the state capital and most populous city of the Commonwealth of Massachusetts, as well as the cultural and financial center of the New England region of the United States. It is the 24th- most populous city in the country. The city boundaries encompass an area of about and a population of 675,647 as of 2020. It is the seat of Suffolk County (although the county government was disbanded on July 1, 1999). The city is the economic and cultural anchor of a substantially larger metropolitan area known as Greater Boston, a metropolitan statistical area (MSA) home to a census-estimated 4.8 million people in 2016 and ranking as the tenth-largest MSA in the country. A broader combined statistical area (CSA), generally corresponding to the commuting area and including Providence, Rhode Island, is home to approximately 8.2 million people, making it the sixth most populous in the United States. Boston is one of the oldest ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Dana–Farber Cancer Institute
Dana–Farber Cancer Institute is a comprehensive cancer treatment and research institution in Boston, Massachusetts. Dana–Farber is the founding member of Dana–Farber/Harvard Cancer Center, Harvard's Comprehensive Cancer Center designated by the National Cancer Institute, and one of the 15 clinical affiliates and research institutes of Harvard Medical School. As of 2021, Dana–Farber is ranked the #3 cancer hospital in the world. Two Nobel laureates in Physiology or Medicine are among its past and present faculty. Dana–Farber's research discoveries include the development of the highly successful Gleevec to treat chronic myeloid leukemia. Overview Dana–Farber employs more than 4,855 full-time and part-time people, 529 faculty, and has annual gross revenues of about $1,733,386,000. All faculty and postdoctoral research fellows at Dana–Farber hold the equivalent academic positions concurrently at Harvard University. There are more than 523,425 adult and pediatric patie ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Medarex
Medarex (former NASDAQ symbol: MEDX ) was an American biopharmaceutical company based in Princeton, New Jersey, with manufacturing facilities in Bloomsbury and Annandale, New Jersey, and research facilities in Milpitas and Sunnyvale, California. In 2009, Medarex was purchased by Bristol Myers Squibb. Medarex developed monoclonal antibodies to CTLA-4 and PD-1, which are proteins on the surface of T cells. T cells attack cancer cells, but CTLA-4 and PD-1 act as "brakes" on the T cell's anti-cancer activities. The monoclonal antibodies bind to these proteins and block them, releasing the T cell to attack cancer cells. References {{reflist External links medarex.com is now BMS.comCorporate website Companies formerly listed on the Nasdaq Bristol Myers Squibb Biotechnology companies of the United States Companies based in Princeton, New Jersey Pharmaceutical companies based in New Jersey 2009 mergers and acquisitions Pharmaceutical companies disestablished in 2009 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Informatics
Informatics is the study of computational systems, especially those for data storage and retrieval. According to ACM ''Europe and'' ''Informatics Europe'', informatics is synonymous with computer science and computing as a profession, in which the central notion is transformation of information. In other countries, the term "informatics" is used with a different meaning in the context of library science. Different meanings In some countries, depending on local interpretations, the term "informatics" is used synonymously to mean information systems, information science, information theory, information engineering, information technology, information processing, or other theoretical or practical fields. In Germany, the term ''informatics'' almost exactly corresponds to modern computer science. Accordingly, universities in continental Europe usually translate "informatics" as computer science, or sometimes information and computer science, although technical universities may t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Berlin
Berlin ( , ) is the capital and largest city of Germany by both area and population. Its 3.7 million inhabitants make it the European Union's most populous city, according to population within city limits. One of Germany's sixteen constituent states, Berlin is surrounded by the State of Brandenburg and contiguous with Potsdam, Brandenburg's capital. Berlin's urban area, which has a population of around 4.5 million, is the second most populous urban area in Germany after the Ruhr. The Berlin-Brandenburg capital region has around 6.2 million inhabitants and is Germany's third-largest metropolitan region after the Rhine-Ruhr and Rhine-Main regions. Berlin straddles the banks of the Spree, which flows into the Havel (a tributary of the Elbe) in the western borough of Spandau. Among the city's main topographical features are the many lakes in the western and southeastern boroughs formed by the Spree, Havel and Dahme, the largest of which is Lake Müggelsee. Due to its l ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Medical University Of Vienna
The Medical University of Vienna (German: ''Medizinische Universität Wien'') is a public university located in Vienna, Austria. It is the direct successor to the faculty of medicine at the University of Vienna, founded in 1365 by Rudolf IV, Duke of Austria. As one of the oldest medical schools in the world, it is the oldest in the German-speaking countries, and was the second medical faculty in the Holy Roman Empire, after the Charles University of Prague. The Medical University of Vienna is the largest medical organisation in Austria, as well as one of the top-level research institutions in Europe and provides Europe's largest hospital, the Vienna General Hospital, with all of its medical staff. It consists of 31 university clinics and clinical institutes, and 12 medical-theoretical departments, which perform around 48,000 operations each year. The Vienna General Hospital has about 100,000 patients treated as inpatients and 605,000 treated as outpatients each year. There hav ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hôpital Saint-Louis
Hôpital Saint-Louis is a hospital in Paris, France. It was built in 1611 by architect Claude Vellefaux at the request of Henry IV of France. It is part of the Assistance publique - Hôpitaux de Paris hospital system, and it is located at 1 avenue Claude-Vellefaux, in the 10th arrondissement near the metro station Goncourt. It was founded by King Henry IV (1553–1610) (King of France and Navarre) on May 17, 1607 to relieve the Hôtel-Dieu de Paris during the plague. It was named ''St. Louis'' in memory of Louis IX, who died of the dysentery that devastated Tunis in 1270. Today, Hôpital Saint-Louis uses its historical premises (parts of which are classified as historical monuments) for administrative functions. Following the 1980s new modern additions were made to house the current hospital and teaching hospital. Its primary specialties are dermatology and hematology, as well as oncology. The dermatology library was founded by Dr Henri Feulard. The hospital employs 2,500 peop ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of South Florida
The University of South Florida (USF) is a public research university with its main campus located in Tampa, Florida, and other campuses in St. Petersburg and Sarasota. It is one of 12 members of the State University System of Florida. USF is home to 14 colleges, offering more than 240 undergraduate, graduate, specialist, and doctoral-level degree programs. USF is classified among "R1: Doctoral Universities – Very high research activity" and is accredited by the Commission on Colleges of the Southern Association of Colleges and Schools. USF is designated by the Florida Board of Governors as one of three Preeminent State Research Universities. Founded in 1956, USF is the fourth largest university in Florida by enrollment, with 49,766 students from over 145 countries, all 50 states, all five U.S. Territories, and the District of Columbia as of the 2022–2023 academic year. In 2022, the university reported an annual budget of $2.31 billion and an annual economic impact of ove ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Santa Monica, California
Santa Monica (; Spanish language, Spanish: ''Santa Mónica'') is a city in Los Angeles County, California, Los Angeles County, situated along Santa Monica Bay on California's South Coast (California), South Coast. Santa Monica's 2020 United States Census Bureau, U.S. Census population was 93,076. Santa Monica is a popular resort town, owing to its climate, beaches, and hospitality industry. It has a diverse economy, hosting headquarters of companies such as Hulu, Universal Music Group, Lionsgate Films, and The Recording Academy. Santa Monica traces its history to Rancho San Vicente y Santa Monica, granted in 1839 to the Sepúlveda family of California. The rancho was later sold to John Percival Jones, John P. Jones and Robert Symington Baker, Robert Baker, who in 1875, along with his Californio heiress wife Arcadia Bandini de Stearns Baker, founded Santa Monica, which incorporated as a city in 1886. The city developed into a seaside resort during the late 19th and early 20th cen ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tremelimumab
Tremelimumab, sold under the brand name Imjudo, is a fully human monoclonal antibody against CTLA-4. It is an immune checkpoint blocker. Tremelimumab was approved for unresectable hepatocellular carcinoma medical use in the United States in October 2022. Medical uses Tremelimumab is indicated, in combination with durvalumab, for the treatment of adults with unresectable hepatocellular carcinoma. Mechanism of action Tremelimumab aims to stimulate an immune system attack on tumors. Cytotoxic T lymphocytes (CTLs) can recognize and destroy cancer cells. However, there is also an inhibitory mechanism (immune checkpoint) that interrupts this destruction. Tremelimumab turns off this inhibitory mechanism and allows CTLs to continue to destroy the cancer cells. Tremelimumab binds to the protein CTLA-4, which is expressed on the surface of activated T lymphocytes and inhibits the killing of cancer cells. Tremelimumab blocks the binding of the antigen-presenting cell ligands B7.1 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
.png "Click for more on -> Santa Monica, California")