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Human Monocytic Ehrlichiosis
Human monocytotropic ehrlichiosis is a form of ehrlichiosis associated with ''Ehrlichia chaffeensis''. This bacterium is an obligate intracellular pathogen affecting monocytes and macrophages. Symptom and signs The most common symptoms are fever, headache, malaise, and muscle aches ( myalgia). Compared to human granulocytic anaplasmosis, rash is more common. Laboratory abnormalities include thrombocytopenia, leukopenia, and elevated liver tests. The severity of the illness can range from minor or asymptomatic to life-threatening. CNS involvement may occur. A serious septic or toxic shock-like picture can also develop, especially in patients with impaired immunity. Cause This disease is known to be caused by tick bites. Diagnosis Tick exposure is often overlooked. For patients living in high-prevalence areas who spend time outdoors, a high degree of clinical suspicion should be employed. Ehrlichia serologies can be negative in the acute period. Polymerase chain reaction i ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ehrlichiosis
Ehrlichiosis is a Tick-borne disease, tick-borne bacterial infection, caused by bacteria of the family Anaplasmataceae, genera ''Ehrlichia'' and ''Anaplasma''. These Obligate intracellular parasite, obligate intracellular bacteria infect and kill white blood cells. The average reported annual incidence is on the order of 2.3 cases per million people. Types Six (see note below) species have been shown to cause human infection: * ''Anaplasma phagocytophilum'' causes human granulocytic anaplasmosis. ''A. phagocytophilum'' is endemic to New England and the north-central and Pacific regions of the United States. * ''Ehrlichia ewingii'' causes human ewingii ehrlichiosis. ''E. ewingii'' primarily infects deer and dogs (see Ehrlichiosis (canine)). ''E. ewingii'' is most common in the south-central and southeastern states. * ''Ehrlichia chaffeensis'' causes human monocytic ehrlichiosis. ''E. chaffeensis'' is most common in the south-central and southeastern states. * ''Ehrlichia canis'' ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Rifampin
Rifampicin, also known as rifampin, is an ansamycin antibiotic used to treat several types of bacterial infections, including tuberculosis (TB), ''Mycobacterium avium'' complex, leprosy, and Legionnaires’ disease. It is almost always used together with other antibiotics with two notable exceptions: when given as a "preferred treatment that is strongly recommended" for latent TB infection; and when used as post-exposure prophylaxis to prevent ''Haemophilus influenzae'' type b and meningococcal disease in people who have been exposed to those bacteria. Before treating a person for a long period of time, measurements of liver enzymes and blood counts are recommended. Rifampicin may be given either by mouth or intravenously. Common side effects include nausea, vomiting, diarrhea, and loss of appetite. It often turns urine, sweat, and tears a red or orange color. Liver problems or allergic reactions may occur. It is part of the recommended treatment of active tuberculosis during ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bacterial Diseases
Pathogenic bacteria are bacteria that can cause disease. This article focuses on the bacteria that are pathogenic to humans. Most species of bacteria are harmless and are often Probiotic, beneficial but others can cause infectious diseases. The number of these pathogenic species in humans is estimated to be fewer than a hundred. By contrast, several thousand species are part of the gut flora present in the digestive tract. The body is continually exposed to many species of bacteria, including beneficial commensals, which grow on the skin and mucous membranes, and saprophytes, which grow mainly in the soil and in decomposition, decaying matter. The blood and tissue fluids contain nutrients sufficient to sustain the growth of many bacteria. The body has defence mechanisms that enable it to resist microbial invasion of its tissues and give it a natural immune system, immunity or innate immunity, innate resistance against many microorganisms. Pathogenic bacteria are specially adapt ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Monocyte
Monocytes are a type of leukocyte or white blood cell. They are the largest type of leukocyte in blood and can differentiate into macrophages and conventional dendritic cells. As a part of the vertebrate innate immune system monocytes also influence adaptive immune responses and exert tissue repair functions. There are at least three subclasses of monocytes in human blood based on their phenotypic receptors. Structure Monocytes are amoeboid in appearance, and have nongranulated cytoplasm. Thus they are classified as agranulocytes, although they might occasionally display some azurophil granules and/or vacuoles. With a diameter of 15–22 μm, monocytes are the largest cell type in peripheral blood. Monocytes are mononuclear cells and the ellipsoidal nucleus is often lobulated/indented, causing a bean-shaped or kidney-shaped appearance. Monocytes compose 2% to 10% of all leukocytes in the human body. Development Monocytes are produced by the bone marrow from precursors ca ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Human Granulocytic Anaplasmosis
Human granulocytic anaplasmosis (HGA) is a tick-borne, infectious disease caused by ''Anaplasma phagocytophilum'', an obligate intracellular bacterium that is typically transmitted to humans by ticks of the ''Ixodes ricinus'' species complex, including ''Ixodes scapularis'' and ''Ixodes pacificus'' in North America. These ticks also transmit Lyme disease and other tick-borne diseases. The bacteria infect white blood cells called neutrophils, causing changes in gene expression that prolong the life of these otherwise short-lived cells. Signs and symptoms Signs and symptoms may include: * fever * severe headache * muscle aches (myalgia) * chills and shaking, similar to the symptoms of influenza * nausea * vomiting * loss of appetite * unintentional weight loss * abdominal pain * cough * diarrhea, * aching joints * sensitivity to light * weakness * fatigue * change in mental status (extreme confusion, memory loss, inability to comprehend environment- interaction, reading, etc.) * te ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Human Ewingii Ehrlichiosis
''Ehrlichiosis ewingii'' infection is an infectious disease caused by an intracellular bacteria, ''Ehrlichia ewingii''. The infection is transmitted to humans by the tick, ''Amblyomma americanum''. This tick can also transmit ''Ehrlichia chaffeensis'', the bacteria that causes human monocytic ehrlichiosis (HME). Symptoms and signs Patients can present with fever, headache, myalgias, and malaise. Laboratory tests may reveal thrombocytopenia, leukopenia, and evidence of liver damage. Mechanism Humans contract the disease after a bite by an infected tick of the species ''Amblyomma americanum''. Those with an underlying immunodeficiency (such as HIV) appear to be at greater risk of contracting the disease. Compared to HME, ewingii ehrlichiosis has a decreased incidence of complications. Like ''Anaplasma phagocytophilum'', the causative agent of human granulocytic ehrlichiosis, ''Ehrlichia ewingii'' infects neutrophils. Infection with ''E. ewingii'' may delay neutrophil apoptosis. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Dermacentor Variabilis
''Dermacentor variabilis'', also known as the American dog tick or wood tick, is a species of tick that is known to carry bacteria responsible for several diseases in humans, including Rocky Mountain spotted fever and tularemia (''Francisella tularensis''). It is one of the best-known hard ticks. Diseases are spread when it sucks blood from the host. It may take several days for the host to experience symptoms. Though ''D. variabilis'' may be exposed to ''Borrelia burgdorferi'', the causative agent of Lyme disease, these ticks are not competent vectors for the transmission of this disease. The primary vectors for ''B. burgdorferi'' are the deer ticks ''Ixodes scapularis'' in eastern parts of the United States, ''Ixodes pacificus'' in California and Oregon, and ''Ixodes ricinus'' in Europe. ''D. variabilis'' may also carry ''Anaplasma phagocytophilum'', the causative agent of human granulocytic anaplasmosis, and ''Ehrlichia chaffeensis'', the causative agent of human monocytic eh ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ixodes Pacificus
''Ixodes pacificus'', the western black-legged tick, is a species of parasitic tick found on the western coast of North America. ''I. pacificus'' is a member of the ''Ixodidae'' (hard-bodied) family. It is the principal vector of Lyme disease in that region. ''I. pacificus'' typically feeds on lizards and small mammals therefore its rate of transmission of Lyme disease to humans is around 1% of adults. It is an ectoparasite that attaches itself to the outside of its host and feeds on the host's blood. It can have a heteroxenous lifestyle or monoxenous life cycle depending on how many hosts it feeds on in each cycle. ''I. pacificus'' has a four stage life cycle that takes around 3 years to complete. These stages include egg, larva, nymph, and adult. They prefer dense woodland habitats or areas of brush and tall grass. Description Belonging to the family ''Ixodidae'', the western black-legged tick is considered a slow-feeding hard tick which possesses a plated body armor.Lyme Disea ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Amblyomma Americanum
''Amblyomma americanum'', also known as the lone star tick, the northeastern water tick, or the turkey tick, or the "Cricker Tick", is a type of tick indigenous to much of the eastern United States and Mexico, that bites painlessly and commonly goes unnoticed, remaining attached to its host for as long as seven days until it is fully engorged with blood. It is a member of the phylum Arthropoda, class Arachnida. The adult lone star tick is sexually dimorphic, named for a silvery-white, star-shaped spot or "lone star" present near the center of the posterior portion of the adult female shield (scutum); adult males conversely have varied white streaks or spots around the margins of their shields. ''A. americanum'' is also referred to as the turkey tick in some Midwestern U.S. states, where wild turkeys are a common host for immature ticks. It is the primary vector of ''Ehrlichia chaffeensis'', which causes human monocytic ehrlichiosis, and ''Ehrlichia ewingii'', which causes human a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
White-tailed Deer
The white-tailed deer (''Odocoileus virginianus''), also known as the whitetail or Virginia deer, is a medium-sized deer native to North America, Central America, and South America as far south as Peru and Bolivia. It has also been introduced to New Zealand, all the Greater Antilles in the Caribbean (Cuba, Jamaica Jamaica (; ) is an island country situated in the Caribbean Sea. Spanning in area, it is the third-largest island of the Greater Antilles and the Caribbean (after Cuba and Hispaniola). Jamaica lies about south of Cuba, and west of His ..., Hispaniola, and Puerto Rico), and some countries in Europe, such as the Czech Republic, Finland, France, Germany, Romania and Serbia. In the Americas, it is the most widely distributed wild ungulate. In North America, the species is widely distributed east of the Rocky Mountains as well as in southwestern Arizona and most of Mexico, except Baja California peninsula, Lower California. It is mostly displaced by the black ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Doxycycline
Doxycycline is a broad-spectrum tetracycline class antibiotic used in the treatment of infections caused by bacteria and certain parasites. It is used to treat bacterial pneumonia, acne, chlamydia infections, Lyme disease, cholera, typhus, and syphilis. It is also used to prevent malaria in combination with quinine. Doxycycline may be taken by mouth or by injection into a vein. Common side effects include diarrhea, nausea, vomiting, abdominal pain, and an increased risk of sunburn. Use during pregnancy is not recommended. Like other agents of the tetracycline class, it either slows or kills bacteria by inhibiting protein production. It kills malaria by targeting a plastid organelle, the apicoplast. Doxycycline was patented in 1957 and came into commercial use in 1967. It is on the World Health Organization's List of Essential Medicines. Doxycycline is available as a generic medicine. In 2020, it was the 79th most commonly prescribed medication in the United States, with m ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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