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His452Tyr
In genetics, rs6314, also called His452Tyr or H452Y, is a gene variation, a single nucleotide polymorphism (SNP), in the ''HTR2A'' gene that codes for the 5-HT2A receptor. The SNP is located in exon 3 of the gene and the change between C and T results in a change between histidine (His) and tyrosine (Tyr) at the 452nd amino acid, i.e., it is a missense substitution. As 5-HT2A is a neuroreceptor the SNP has been investigated in connection with neuropsychiatric disorders and other brain-related variables. A 2003 study looked at memory performance and found that His/His subjects performed better. Another study reported that the SNP had an effect on the memory performance in young adults. This has been replicated by another group. The His452Tyr variant may influence cell signaling. rs6311, rs6313 and rs7997012 In genetics, rs7997012 is a gene variation—a single nucleotide polymorphism (SNP)—in intron 2 of the human HTR2A gene that codes for the 5-HT2A receptor. The SNP varies b ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Rs7997012
In genetics, rs7997012 is a gene variation—a single nucleotide polymorphism (SNP)—in intron 2 of the human HTR2A gene that codes for the 5-HT2A receptor. The SNP varies between adenine (A) and guanine (G) DNA bases with the G-allele being most frequent. A research study found it to be related to antidepressant treatment. The research group reported that a polymorphism (rs1954787) on another gene, the GRIK4, has also shown a treatment-response-association in this kind of treatment. In a Japanese study rs7997012 was not associated with either major depressive disorder or bipolar disorder. Rs6311, rs6313 In genetics, rs6313 also called T102C or C102T is a gene variation—a single nucleotide polymorphism (SNP)—in the human ''HTR2A'' gene that codes for the 5-HT2A receptor. The SNP is a synonymous substitution located in exon 1 of the ge ... and His452Tyr (rs6314) are other SNPs in the HTR2A gene. There are many more, even in intron 2 alone. References SNPs on c ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
HTR2A
The 5-HT2A receptor is a subtype of the 5-HT2 receptor that belongs to the serotonin receptor family and is a G protein-coupled receptor (GPCR). The 5-HT2A receptor is a cell surface receptor, but has several intracellular locations. 5-HT is short for 5-hydroxy-tryptamine or serotonin. This is the main excitatory receptor subtype among the GPCRs for serotonin, although 5-HT2A may also have an inhibitory effect on certain areas such as the visual cortex and the orbitofrontal cortex. This receptor was first noted for its importance as a target of serotonergic psychedelic drugs such as LSD and psilocybin mushrooms. Later it came back to prominence because it was also found to be mediating, at least partly, the action of many antipsychotic drugs, especially the atypical ones. Downregulation of post-synaptic 5-HT2A receptor is an adaptive process provoked by chronic administration of selective serotonin reuptake inhibitors (SSRIs) and atypical antipsychotics. Suicidal and otherwise ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
5-HT2A Receptor
The 5-HT2A receptor is a subtype of the 5-HT2 receptor that belongs to the serotonin receptor family and is a G protein-coupled receptor (GPCR). The 5-HT2A receptor is a cell surface receptor, but has several intracellular locations. 5-HT is short for 5-hydroxy-tryptamine or serotonin. This is the main excitatory receptor subtype among the GPCRs for serotonin, although 5-HT2A may also have an inhibitory effect on certain areas such as the visual cortex and the orbitofrontal cortex. This receptor was first noted for its importance as a target of serotonergic psychedelic drugs such as LSD and psilocybin mushrooms. Later it came back to prominence because it was also found to be mediating, at least partly, the action of many antipsychotic drugs, especially the atypical ones. Downregulation of post-synaptic 5-HT2A receptor is an adaptive process provoked by chronic administration of selective serotonin reuptake inhibitors (SSRIs) and atypical antipsychotics. Suicidal and otherwis ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Rs6313
In genetics, rs6313 also called T102C or C102T is a gene variation—a single nucleotide polymorphism (SNP)—in the human ''HTR2A'' gene that codes for the 5-HT2A receptor. The SNP is a synonymous substitution located in exon 1 of the gene where it is involved in coding the 34th amino acid as serine. As 5-HT2A is a neuroreceptor the SNP has been investigated in connection with brain functions and neuropsychiatric disorders, and it is perhaps the most investigated SNP for its gene. Two other SNPs in HTR2A have also received much attention: rs6311 and His452Tyr (rs6314). The T102C polymorphism has been shown to be in complete linkage disequilibrium with the rs6311 (A-1438G). A less well investigated SNP of this gene is rs7997012. Meta-analyses seem to indicate that the SNP is not directly associated with schizophrenia, not with Alzheimer's disease, and two initial studies seem to indicate that it is not associated with Parkinson's disease. There have been multiple stud ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Anna Schuhmacher
Anna may refer to: People Surname and given name * Anna (name) Mononym * Anna the Prophetess, in the Gospel of Luke * Anna (wife of Artabasdos) (fl. 715–773) * Anna (daughter of Boris I) (9th–10th century) * Anna (Anisia) (fl. 1218 to 1221) * Anna of Poland, Countess of Celje (1366–1425) * Anna of Cilli (1386–1416) * Anna, Grand Duchess of Lithuania (died 1418) * Anne of Austria, Landgravine of Thuringia (1432–1462) * Anna of Nassau-Dillenburg (died 1514) * Anna, Duchess of Prussia (1576–1625) * Anna of Russia (1693–1740) * Anna, Lady Miller (1741–1781) * Anna Russell, Duchess of Bedford (1783–1857) * Anna, Lady Barlow (1873–1965) * Anna (feral child) (1932–1942) * Anna (singer) (born 1987) Places Australia * Hundred of Anna, a cadastral district in South Australia Iran * Anna, Fars, a village in Fars Province * Anna, Kohgiluyeh and Boyer-Ahmad, a village in Kohgiluyeh and Boyer-Ahmad Province Russia * Anna, Voronezh Oblast, an urban locality in Vorone ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Rs6311
In genetics, rs6311 is a gene variation—a single nucleotide polymorphism (SNP)—in the human ''HTR2A'' gene that codes for the 5-HT2A, 5-HT2A receptor (biology), receptor. 5-HT2A is a neuroreceptor, and several scientific studies have investigated the effect of the genetic variation on personality, e.g., personality traits measured with the Temperament and Character Inventory or with a psychological task measuring impulsive behavior. The SNP has also been investigated in rheumatology studies. Some research studies may refer to this gene variation as a C/T SNP, while others refer to it as a G/A polymorphism in the promoter region, thus writing it as, e.g., −1438 G/A or 1438G>A. , meta-analysis of research studies indicates that people with the A-allele may have slightly elevated risk of schizophrenia. rs6313, rs6314, and rs7997012 are other investigated SNPs in the HTR2A gene. References SNPs on chromosome 13 {{genetics-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Molecular Pharmacology
''Molecular Pharmacology'' is a peer-reviewed scientific journal published by the American Society for Pharmacology and Experimental Therapeutics since 1965. It is indexed in MEDLINE, Meta, Scopus, and other databases. According to the ''Journal Citation Reports'', the journal received a 2017 impact factor of 3.987. History The journal was established by Avram Goldstein in 1965. , the editor-in-chief is Kathryn E. Meier, (Washington State University Washington State University (Washington State, WSU, or informally Wazzu) is a public land-grant research university with its flagship, and oldest, campus in Pullman, Washington. Founded in 1890, WSU is also one of the oldest land-grant uni ...). References External links * {{Official, http://molpharm.aspetjournals.org/ Pharmacology journals Publications established in 1965 Monthly journals English-language journals ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Elaine Sanders-Bush
Elaine may refer to: * Elaine (legend), name shared by several different female characters in Arthurian legend, especially: ** Elaine of Astolat ** Elaine of Corbenic * "Elaine" (short story), 1945 short story by J. D. Salinger * Elaine (singer), South African singer Business * Elaine's, a New York City restaurant Entertainment * '' The Exploits of Elaine'', 1914 film serial in the genre of ''The Perils of Pauline'' * "Elaine" (song) by ABBA, the B-side of the single ''The Winner Takes It All'' and a bonus track on the CD re-issues of ''Super Trouper'' * "Miss Elaine", song by Run–D.M.C. from the album '' Tougher Than Leather'' * Elaine Marley, heroine of the video series ''Monkey Island'' * ''Elaine'' (opera), composed by Herman Bemberg * Elaine Benes (Seinfeld character) Places * Elaine, Victoria, a town in Australia * Elaine, Arkansas, a US city People * Elaine (given name) Elaine is a given name, a variant of Elaina, Elayne and Helen. It may refer to: ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Lisa A
Lisa or LISA may refer to: People People with the mononym * Lisa Lisa (born 1967), American actress and lead singer of the Cult Jam * Lisa (Japanese musician, born 1974), stylized "LISA", Japanese singer and producer * Lisa Komine (born 1978), Japanese singer formerly known as Lisa, stylized "lisa" * Lisa (South Korean singer) (born 1980), South Korean singer and musical theatre actress * LiSA (Japanese musician, born 1987), Japanese singer * Lisa (rapper) (born 1997), Thai rapper, member of K-pop group Blackpink * Lisa (French musician) (born 1997), French singer and actress People with the name *Lisa (given name), a feminine given name * Lisa (surname), a list of notable people with the surname Places Romania * Lisa, Brașov * Lisa, Teleorman * Lisa, a village in Schitu, Olt * Lisa River United States * Fort Lisa (Nebraska) (1812–1823), a trading post in the US * Fort Lisa (North Dakota) (1809-1812), a trading post in the US Elsewhere * Lisa, Ivanjica, a municipality i ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cell Signaling
In biology, cell signaling (cell signalling in British English) or cell communication is the ability of a cell to receive, process, and transmit signals with its environment and with itself. Cell signaling is a fundamental property of all cellular life in prokaryotes and eukaryotes. Signals that originate from outside a cell (or extracellular signals) can be physical agents like mechanical pressure, voltage, temperature, light, or chemical signals (e.g., small molecules, peptides, or gas). Cell signaling can occur over short or long distances, and as a result can be classified as autocrine, juxtacrine, intracrine, paracrine, or endocrine. Signaling molecules can be synthesized from various biosynthetic pathways and released through passive or active transports, or even from cell damage. Receptors play a key role in cell signaling as they are able to detect chemical signals or physical stimuli. Receptors are generally proteins located on the cell surface or within the interio ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
The International Journal Of Neuropsychopharmacology
The ''International Journal of Neuropsychopharmacology'' is a peer-reviewed scientific journal published by Oxford University Press. It is an official journal of the Collegium Internationale Neuro-Psychopharmacologicum (CINP) (International College of Neuro-Psychopharmacology) and covers basic and clinical topics in neuropharmacology and psychopharmacology. It was established in 1998 by Bernard Lerer, who served as editor-in-chief An editor-in-chief (EIC), also known as lead editor or chief editor, is a publication's editorial leader who has final responsibility for its operations and policies. The highest-ranking editor of a publication may also be titled editor, managing ... until 2008. References External links * Collegium Internationale Neuro-Psychopharmacologicum Publications established in 1998 Oxford University Press academic journals English-language journals Pharmacology journals {{pharma-journal-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Wolfgang Maier
Wolfgang Maier (born 13 January 1949)CV Prof. Maier (Leopoldina) is a German psychiatrist and . Academic and professional career Wolfgang Maier first studied mathematics and economics at the of , graduating with diplomas in 1973. That same year he started studying medicine, also at the University of Munich. In 1980 he rec ...[...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
