Hexvix
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Hexvix
Hexyl aminolevulinate hydrochloride, sold under the brand names Cysview and Hexvix, is an imaging agent that lights up under Effects of blue light technology, blue light during a blue light cystoscopy. It is used to help detect non-muscle invasive bladder cancer (NMIBC), in particular papillary tumors and carcinoma in situ (CIS). In 2016, the American Urological Association (AUA) made the following statement with respect to NMIBC: * "In a patient with a history of NMIBC with normal cystoscopy and positive cytology, a clinician should consider prostatic urethral biopsies and upper tract imaging, as well as enhanced cystoscopic techniques (blue light cystoscopy, when available), ureteroscopy, or random bladder biopsies. (Expert Opinion)" * "In a patient with NMIBC, a clinician should offer blue light cystoscopy at the time of TURBT, if available, to increase detection and decrease recurrence. (Moderate Recommendation; Evidence Strength: Grade B)." It made by Photocure ASA, a Norw ...
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Photocure
Photocure ASA is a Norwegian specialty pharma company that develops and sells pharmaceuticals and medical devices based on proprietary photodynamic technology. Photocure's strategy in cancer is to continue the commercialization of Hexvix for bladder cancer diagnostics, and continue the development of the cancer portfolio and out-license prior to phase III studies. This strategy is based on a strong platform of intellectual property in photodynamic therapy. Pharmaceuticals Hexyl aminolevulinate hydrochloride for diagnosis of bladder cancer Bladder cancer is any of several types of cancer arising from the tissues of the urinary bladder. Symptoms include blood in the urine, pain with urination, and low back pain. It is caused when epithelial cells that line the bladder become ma .... References External links * {{Authority control Companies established in 1993 Pharmaceutical companies of Norway Companies listed on the Oslo Stock Exchange ...
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Effects Of Blue Light Technology
High-energy visible light (HEV light) is high-frequency, high-energy light in the violet/blue band from 400 to 450  nm in the visible spectrum, which has a number of biological effects, including those on the eye. HEV light may be a cause of age-related macular degeneration. Some sunglasses and beauty creams specifically block HEV, for added marketing value. Currently, a 2019 report by France's Agency for Food, Environmental and Occupational Health & Safety (ANSES) supports the 2010 result on the adverse effect of blue LED light (400-450 nm spike) on the eye, which can lead to impaired vision. It highlights short-term effects on the retina linked to intense exposure to blue LED light, and long-term effects linked to the onset of age-related macular degeneration. Although few studies have examined occupational causes of macular degeneration, they show that long-term sunlight exposure, specifically its blue-light component, is associated with macular degeneration in outd ...
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Cystoscopy
Cystoscopy is endoscopy of the urinary bladder via the urethra. It is carried out with a cystoscope. The urethra is the tube that carries urine from the bladder to the outside of the body. The cystoscope has lenses like a telescope or microscope. These lenses let the physician focus on the inner surfaces of the urinary tract. Some cystoscopes use optical fibres (flexible glass fibres) that carry an image from the tip of the instrument to a viewing piece at the other end. Cystoscopes range from pediatric to adult and from the thickness of a pencil up to approximately 9 mm and have a light at the tip. Many cystoscopes have extra tubes to guide other instruments for surgical procedures to treat urinary problems. There are two main types of cystoscopy—flexible and rigid—differing in the flexibility of the cystoscope. Flexible cystoscopy is carried out with local anaesthesia on both sexes. Typically, a topical anesthetic, most often xylocaine gel (common brand names are Ane ...
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Bladder Cancer
Bladder cancer is any of several types of cancer arising from the tissues of the urinary bladder. Symptoms include blood in the urine, pain with urination, and low back pain. It is caused when epithelial cells that line the bladder become malignant. Risk factors for bladder cancer include smoking, family history, prior radiation therapy, frequent bladder infections, and exposure to certain chemicals. The most common type is transitional cell carcinoma. Other types include squamous cell carcinoma and adenocarcinoma. Diagnosis is typically by cystoscopy with tissue biopsies. Staging of the cancer is determined by transurethral resection and medical imaging. Treatment depends on the stage of the cancer. It may include some combination of surgery, radiation therapy, chemotherapy, or immunotherapy. Surgical options may include transurethral resection, partial or complete removal of the bladder, or urinary diversion. The typical five-year survival rates in the Unite ...
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Carcinoma In Situ
Carcinoma ''in situ'' (CIS) is a group of abnormal cells. While they are a form of neoplasm, there is disagreement over whether CIS should be classified as cancer. This controversy also depends on the exact CIS in question (i.e. cervical, skin, breast). Some authors do not classify them as cancer, however, recognizing that they can potentially become cancer. Others classify certain types as a non-invasive form of cancer. The term " pre-cancer" has also been used. These abnormal cells grow in their normal place, thus "''in situ''" (from Latin for "in its place"). For example, carcinoma ''in situ'' of the skin, also called Bowen's disease, is the accumulation of dysplastic epidermal cells within the epidermis only, that has failed to penetrate into the deeper dermis. For this reason, CIS will usually not form a tumor. Rather, the lesion is flat (in the skin, cervix, etc.) or follows the existing architecture of the organ (in the breast, lung, etc.). Exceptions include CIS of the colo ...
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American Urological Association
The American Urological Association (AUA) is a professional association in the United States for urology professionals. It has its headquarters at the William P. Didusch Center for Urologic History in Maryland. AUA works with many international organizations, representing urologists from across the world. These groups offer full or half day sessions, covering a variety of topics, during the annual meeting. Awards * Hugh Hampton Young Award: Presented annually to an individual for outstanding contributions to the study of genitourinary tract disease. This award is sponsored by Karl Storz Endoscopy-America, Inc. * Ramon Guiteras Award: Awarded annually to an individual who is deemed to have made outstanding contributions to the art and science of urology. This award is sponsored by Bard Urological Division. *Distinguished Contribution Award: Presented annually to individuals who have made outstanding contributions to the science and practice of urology, including contributions made ...
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