Heart Transplantation
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Heart Transplantation
A heart transplant, or a cardiac transplant, is a surgical transplant procedure performed on patients with end-stage heart failure or severe coronary artery disease when other medical or surgical treatments have failed. , the most common procedure is to take a functioning heart, with or without both lungs, from a recently deceased organ donor (brain death is the standard) and implant it into the patient. The patient's own heart is either removed and replaced with the donor heart ( orthotopic procedure) or, much less commonly, the recipient's diseased heart is left in place to support the donor heart (heterotopic, or "piggyback", transplant procedure). Approximately 3,500 heart transplants are performed each year worldwide, more than half of which are in the US. Post-operative survival periods average 15 years. Heart transplantation is not considered to be a cure for heart disease; rather it is a life-saving treatment intended to improve the quality and duration of life for a reci ...
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Heart
The heart is a muscular organ in most animals. This organ pumps blood through the blood vessels of the circulatory system. The pumped blood carries oxygen and nutrients to the body, while carrying metabolic waste such as carbon dioxide to the lungs. In humans, the heart is approximately the size of a closed fist and is located between the lungs, in the middle compartment of the chest. In humans, other mammals, and birds, the heart is divided into four chambers: upper left and right atria and lower left and right ventricles. Commonly the right atrium and ventricle are referred together as the right heart and their left counterparts as the left heart. Fish, in contrast, have two chambers, an atrium and a ventricle, while most reptiles have three chambers. In a healthy heart blood flows one way through the heart due to heart valves, which prevent backflow. The heart is enclosed in a protective sac, the pericardium, which also contains a small amount of fluid. The wall ...
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University Of Mississippi Medical Center
University of Mississippi Medical Center (UMMC) is the health sciences campus of the University of Mississippi (Ole Miss) and is located in Jackson, Mississippi, United States. UMMC, also referred to as the Medical Center, is the state's only academic medical center. UMMC houses seven health science schools: Medicine, Dentistry, Nursing, Health Related Professions, Graduate Studies in the Health Sciences, Population Health and Pharmacy. (The main School of Pharmacy is headquartered on the University of Mississippi (UM) campus in Oxford, Mississippi.) The 164-acre campus also includes University Hospital, Wiser Hospital for Women and Infants, Conerly Critical Care Hospital, Children's of Mississippi (including the Blair E. Batson Tower and the Kathy and Joe Sanderson Tower), the state's only children's hospital, and Rowland Medical Library. History The University of Mississippi Medical Center opened in 1955, but its beginnings date to 1903 when a two-year medical school was establ ...
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Louis Washkansky
Louis Joshua Washkansky (12 April 1912 – 21 December 1967) was a South African man who was the recipient of the world's first human-to-human heart transplant, and the first patient to regain consciousness following the operation. Washkansky lived for 18 days and was able to speak with his wife and reporters.''S Afr Med J'',A human cardiac transplant: an interim report of a successful operation performed at Groote Schuur Hospital, Cape Town, Barnard CN, 1967 Dec 30; ''41''(48): 1271–74.Louis Washkansky (1913 – 1967)
Science Museum. Louis was born in Lithuania in 1913 and moved to South Africa in 1922.
Washkansky was actually the second human recipient of a heart transplant overall, in that
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Donald McRae (author)
Donald McRae (born 1961) is a South African writer. Born in Germiston in 1961, he moved to the United Kingdom in 1984. McRae is noted as the only two-time winner of the William Hill Sports Book of the Year award with '' Dark Trade: Lost in Boxing'' in 1996 (2nd ed. Hamilcar Publications Hamilcar Publications is a Boston-based book publisher and a division of Hannibal Boxing Media LLC. Founded in 2018 by Kyle Sarofeen and Andy Komack, Hamilcar's titles focus on professional boxing, true crime, and hip-hop. Hamilcar Publications i ..., 2019) and '' In Black and White: The Untold Story of Joe Louis and Jesse Owens'' in 2002. His other works include ''Every Second Counts: the Race to Transplant the First Human Heart'' (New York: G. P. Putnam's Sons, 2006), ''The Great Trials of Clarence Darrow: The Landmark Cases of Leopold and Loeb, John T. Scopes, and Ossian Sweet'', published in 2009, '' A Man’s World: The Double Life of Emile Griffith'' (Simon & Schuster, 2015), ''Steven Gerr ...
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Richard Lower (surgeon)
Richard Rowland Lower (August 15, 1929 – May 17, 2008) was an American pioneer of cardiac surgery, particularly in the field of heart transplantation.Pincock, S. (2008)"Richard Rowland Lower" ''The Lancet'', 372(9640), 712 EP–. doi:10.1016/S0140-6736(08)61294-5. Retrieved May 25, 2013 Lower was born in Detroit, attended Amherst College, and received his medical degree from Cornell University in 1955.Pearce, J. (May 31, 2008)"Richard Lower Dies at 78; Transplanted Animal and Human Hearts" ''The New York Times''. Retrieved May 25, 2013. Lower and Norman Shumway developed many of the techniques required to conduct successful heart transplantation, including the use of hypothermia and the orthotopic technique, McRae, D. (2007). ''Every Second Counts''. New York. which became the standard technique for cardiac transplantation. Initially experimenting on dogs, Lower and Shumway conducted their research at Stanford. Lower left Stanford to head the cardiac program at the Medical Coll ...
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Norman Shumway
Norman Edward Shumway (February 9, 1923 – February 10, 2006) was a pioneer of heart surgery at Stanford University. He was the 67th president of the American Association for Thoracic Surgery and the first to perform an adult human to human heart transplantation in the United States. Early life Shumway was born in Kalamazoo, Michigan and brought up as an only child by his parents Norman Edward Shumway and Laura Irene Van der Vliet who ran the dairy in Jackson, Michigan. At school he was a key member of the debating team which won the state debating contest. In 1941, he entered the University of Michigan and remained there for one year as an undergraduate law student until he was drafted by the Army in 1943, which sent him to John Tarleton Agricultural College in Stephenville, Texas for engineering training. He then underwent Army Specialized Training, which included nine months of pre-medical training at Baylor University, followed by enrollment at Vanderbilt University f ...
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Christiaan Barnard
Christiaan Neethling Barnard (8 November 1922 – 2 September 2001) was a South African cardiac surgeon who performed the world's first human-to-human heart transplant operation. On 3 December 1967, Barnard transplanted the heart of accident-victim Denise Darvall into the chest of 54-year-old Louis Washkansky, with Washkansky regaining full consciousness and being able to talk easily with his wife, before dying eighteen days later of pneumonia, largely brought on by the anti-rejection drugs that suppressed his immune system. Barnard had told Mr. and Mrs. Washkansky that the operation had an 80% chance of success, an assessment which has been criticised as misleading. Barnard's second transplant patient, Philip Blaiberg, whose operation was performed at the beginning of 1968, returned home from the hospital and lived for a year and a half. Born in Beaufort West, Cape Province, Barnard studied medicine and practised for several years in his native South Africa. As a young docto ...
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South Africa
South Africa, officially the Republic of South Africa (RSA), is the southernmost country in Africa. It is bounded to the south by of coastline that stretch along the South Atlantic and Indian Oceans; to the north by the neighbouring countries of Namibia, Botswana, and Zimbabwe; and to the east and northeast by Mozambique and Eswatini. It also completely enclaves the country Lesotho. It is the southernmost country on the mainland of the Old World, and the second-most populous country located entirely south of the equator, after Tanzania. South Africa is a biodiversity hotspot, with unique biomes, plant and animal life. With over 60 million people, the country is the world's 24th-most populous nation and covers an area of . South Africa has three capital cities, with the executive, judicial and legislative branches of government based in Pretoria, Bloemfontein, and Cape Town respectively. The largest city is Johannesburg. About 80% of the population are Black South Afri ...
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Bartley P
Bartley is a family name and a given name. Notable people with the name include: Surname * Barrington Bartley (born 1980), Jamaican-American cricketer *Charles Bartley (1921–1996), American scientist * David M. Bartley (born 1935), American politician and educator *Dick Bartley (born 1951), American radio disc jockey active 1969–2016 *Edward Bartley (1839–1919), New Zealand architect * Ephesians Bartley (born 1969), American football player * Frank Bartley (born 1994), American basketball player for Ironi Ness Ziona of the Israeli Basketball Premier League Ligat HaAl ( he, ליגת העל, lit., ''Supreme League or Premier League''), or the Israeli Basketball Premier League, is the top-tier level league of professional sports, professional competition in Israeli sports club, club basketball, making ... *Geoff Bartley (born 1948), American singer/songwriter active 1969–present *George Bartley (comedian), George Bartley (1782?–1858), English comedic actor *Jonathan Bart ...
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Assam
Assam (; ) is a state in northeastern India, south of the eastern Himalayas along the Brahmaputra and Barak River valleys. Assam covers an area of . The state is bordered by Bhutan and Arunachal Pradesh to the north; Nagaland and Manipur to the east; Meghalaya, Tripura, Mizoram and Bangladesh to the south; and West Bengal to the west via the Siliguri Corridor, a wide strip of land that connects the state to the rest of India. Assamese and Boro are the official languages of Assam, while Bengali is an additional official language in the Barak Valley. Assam is known for Assam tea and Assam silk. The state was the first site for oil drilling in Asia. Assam is home to the one-horned Indian rhinoceros, along with the wild water buffalo, pygmy hog, tiger and various species of Asiatic birds, and provides one of the last wild habitats for the Asian elephant. The Assamese economy is aided by wildlife tourism to Kaziranga National Park and Manas National Park, which are ...
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Dhaniram Baruah
Dhaniram Baruah is an Assamese heart surgeon known for his work in the field of xenotransplantation. He is popularly known as India's ''Pig Heart Doctor''. On January 1, 1997, he became the first heart surgeon in the world to transplant a pig's heart in a human body. Although the recipient died subsequently, it was a precursor to the first successful pig-to-human heart transplant performed 25 years later by Bartley P. Griffith in January 2022. While Griffith used a genetically modified pig's heart, Barua had transplanted a normal pig heart. Barua is also the founder of Dr Dhaniram Baruah Heart Institute & Research Centre. Experiments, claims and controversies Throughout his career Barua has courted controversies due to his maverick ideas and unconventional methods. The pig heart transplanted by Barua in his patient Purna Saikia worked for seven days, after which there were infections, and the transplant was rejected by the recipient's body. Barua was sent to jail for 40 days for n ...
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Xenotransplantation
Xenotransplantation (''xenos-'' from the Greek meaning "foreign" or strange), or heterologous transplant, is the transplantation of living cells, tissues or organs from one species to another. Such cells, tissues or organs are called xenografts or xenotransplants. It is contrasted with allotransplantation (from other individual of same species), syngeneic transplantation or isotransplantation (grafts transplanted between two genetically identical individuals of the same species) and autotransplantation (from one part of the body to another in the same person). Xenotransplantation of human tumor cells into immunocompromised mice is a research technique frequently used in pre-clinical oncology research. Human xenotransplantation offers a potential treatment for end-stage organ failure, a significant health problem in parts of the industrialized world. It also raises many novel medical, legal and ethical issues. A continuing concern is that many animals, such as pigs, have a s ...
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