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Haptoglobin-related Protein
Haptoglobin-related protein is a protein that in humans is encoded by the ''HPR'' gene. The HPR gene affects hereditary immunity to a non-pathogenic species of African trypanosomes. See also * Haptoglobin Haptoglobin (abbreviated as Hp) is the protein that in humans is encoded by the ''HP'' gene. In blood plasma, haptoglobin binds with high affinity to ''free'' hemoglobin released from erythrocytes, and thereby inhibits its deleterious oxidat ... * ''Trypanosoma brucei'': Killing by human serum and resistance to human serum killing References Further reading * * * * * * * * * * * * {{gene-16-stub African trypanosomiasis ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, responding to stimuli, providing structure to cells and organisms, and transporting molecules from one location to another. Proteins differ from one another primarily in their sequence of amino acids, which is dictated by the nucleotide sequence of their genes, and which usually results in protein folding into a specific 3D structure that determines its activity. A linear chain of amino acid residues is called a polypeptide. A protein contains at least one long polypeptide. Short polypeptides, containing less than 20–30 residues, are rarely considered to be proteins and are commonly called peptides. The individual amino acid residues are bonded together by peptide bonds and adjacent amino acid residues. The sequence of amino acid ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gene
In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a basic unit of heredity and the molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protein-coding genes and noncoding genes. During gene expression, the DNA is first copied into RNA. The RNA can be directly functional or be the intermediate template for a protein that performs a function. The transmission of genes to an organism's offspring is the basis of the inheritance of phenotypic traits. These genes make up different DNA sequences called genotypes. Genotypes along with environmental and developmental factors determine what the phenotypes will be. Most biological traits are under the influence of polygenes (many different genes) as well as ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Trypanosoma
''Trypanosoma'' is a genus of kinetoplastids (class Trypanosomatidae), a monophyletic group of unicellular parasitic flagellate protozoa. Trypanosoma is part of the phylum Sarcomastigophora. The name is derived from the Greek ''trypano-'' (borer) and ''soma'' (body) because of their corkscrew-like motion. Most trypanosomes are heteroxenous (requiring more than one obligatory host to complete life cycle) and most are transmitted via a vector. The majority of species are transmitted by blood-feeding invertebrates, but there are different mechanisms among the varying species. Some, such as ''Trypanosoma equiperdum'', are spread by direct contact. In an invertebrate host they are generally found in the intestine, but normally occupy the bloodstream or an intracellular environment in the vertebrate host. Trypanosomes infect a variety of hosts and cause various diseases, including the fatal human diseases sleeping sickness, caused by '' Trypanosoma brucei'', and Chagas disease, c ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Haptoglobin
Haptoglobin (abbreviated as Hp) is the protein that in humans is encoded by the ''HP'' gene. In blood plasma, haptoglobin binds with high affinity to ''free'' hemoglobin released from erythrocytes, and thereby inhibits its deleterious oxidative activity. Compared to Hp, hemopexin binds to ''free'' heme. The haptoglobin-hemoglobin complex will then be removed by the reticuloendothelial system (mostly the spleen). In clinical settings, the haptoglobin assay is used to screen for and monitor intravascular hemolytic anemia. In intravascular hemolysis, free hemoglobin will be released into circulation and hence haptoglobin will bind the hemoglobin. This causes a decline in haptoglobin levels. Function Hemoglobin that has been released into the blood plasma by damaged red blood cells has harmful effects. The ''HP'' gene encodes a preproprotein that is processed to yield both alpha and beta chains, which subsequently combines as a tetramer to produce haptoglobin. Haptoglobin func ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Killing By Human Serum And Resistance To Human Serum Killing
Killing, Killings, or The Killing may refer to: Arts, entertainment, and media Films * ''Killing'' (film), a 2018 Japanese film * ''The Killing'' (film), a 1956 film noir directed by Stanley Kubrick Television * ''The Killing'' (Danish TV series), a police procedural drama first broadcast in 2007 * ''The Killing'' (U.S. TV series), a crime drama based on the Danish television series, first broadcast in 2011 Literature * ''Killing'' (comics), Italian photo comic series about a vicious vigilante-criminal * ''Killing'', a series of historical nonfiction books by Bill O'Reilly and Martin Dugard * "Killings" (short story), a short story by Andre Dubus * ''The Killing'' (Muchamore novel), a CHERUB series installment by Robert Muchamore * ''The Killing'', a 2012 novelization of the Danish TV series by David Hewson Music * "Killing", a song on the album ''Echoes'' by The Rapture * "Killing", a song from an untitled Korn album released in 2007 * ''The Killing'' (EP), by Hatesph ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
