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Hans Thoenen
Hans Thoenen (5 May 1928 in Zweisimmen, Switzerland – 23 June 2012 in Munich, Germany) was a Swiss neurobiologist best known for his work on neurotrophins. Biography Thoenen studied medicine at the Universities of Bern and Innsbruck, graduating in 1953 and receiving his doctorate from Bern in 1957. In 1961 he joined the research laboratories of the Swiss pharmaceutical company Hoffmann LaRoche, leaving in 1968 to spend a year working with the Axelrod group at NIMH. In 1971 he joined the newly-formed Biocentre at the University of Basel as research group leader in Neurobiology. In 1977 he relocated to Munich where the Max Planck Institute for Psychiatry had offered him the directorship of a new institute – what is now the Max Planck Institute for Neurobiology – which he led until his retirement in 1996. Research While testing dopamine analogues at Hoffman-LaRoche, he was surprised by the toxicity of 6-hydroxydopamine on sympathetic nerves and investigated its mechanisms of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Zweisimmen
Zweisimmen is a municipality in the Obersimmental-Saanen administrative district in the canton of Bern in Switzerland. History Zweisimmen is first mentioned in 1228 as ''Duessimenes''. In 1257 it was mentioned as ''Zweinlixhenun''. The oldest trace of a settlement in the area are some scattered mesolithic artifacts from Mannenberg-Riedli. The remains of a Roman era settlement were found at Mannried. During the Middle Ages a significant trade route over the Alps to Valais and Lake Geneva passed through the Zweisimmen region. A number of farming villages probably existed in the area during the Middle Ages. In the 13th and 14th centuries, local nobles built several castles, Upper Mannenberg and Lower Mannenberg, Reichenstein-Terenstein, Blankenburg and Steinegg Castles, to protect and collect taxes from the roads. The villages and castles passed through several noble families until 1378 when the Lord of Düdingen sold the lands to Fribourg following an uprising. After the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hoffmann LaRoche
F. Hoffmann-La Roche AG, commonly known as Roche, is a Swiss multinational healthcare company that operates worldwide under two divisions: Pharmaceuticals and Diagnostics. Its holding company, Roche Holding AG, has shares listed on the SIX Swiss Exchange. The company headquarters are located in Basel. Roche is the fifth largest pharmaceutical company in the world by revenue, and the leading provider of cancer treatments globally. The company controls the American biotechnology company Genentech, which is a wholly owned affiliate, and the Japanese biotechnology company Chugai Pharmaceuticals, as well as the United States-based companies Ventana and Foundation Medicine. Roche's revenues during fiscal year 2020 were 58.32 billion Swiss francs. Descendants of the founding Hoffmann and Oeri families own slightly over half of the bearer shares with voting rights (a pool of family shareholders 45%, and Maja Oeri a further 5% apart), with Swiss pharma firm Novartis owning a furthe ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
National Academy Of Sciences
The National Academy of Sciences (NAS) is a United States nonprofit, non-governmental organization. NAS is part of the National Academies of Sciences, Engineering, and Medicine, along with the National Academy of Engineering (NAE) and the National Academy of Medicine (NAM). As a national academy, new members of the organization are elected annually by current members, based on their distinguished and continuing achievements in original research. Election to the National Academy is one of the highest honors in the scientific field. Members of the National Academy of Sciences serve '' pro bono'' as "advisers to the nation" on science, engineering, and medicine. The group holds a congressional charter under Title 36 of the United States Code. Founded in 1863 as a result of an Act of Congress that was approved by Abraham Lincoln, the NAS is charged with "providing independent, objective advice to the nation on matters related to science and technology. ... to provide scien ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
German Academy Of Sciences Leopoldina
The German National Academy of Sciences Leopoldina (german: Deutsche Akademie der Naturforscher Leopoldina – Nationale Akademie der Wissenschaften), short Leopoldina, is the national academy of Germany, and is located in Halle (Saale). Founded on January 1, 1652, based on academic models in Italy, it was originally named the ''Academia Naturae Curiosorum'' until 1687 when Emperor Leopold I raised it to an academy and named it after himself. It was since known under the German name ''Deutsche Akademie der Naturforscher Leopoldina'' until 2007, when it was declared to be Germany's National Academy of Sciences. History ' The Leopoldina was founded in the imperial city of Schweinfurt on 1 January 1652 under the Latin name sometimes translated into English as "Academy of the Curious as to Nature." It was founded by four local physicians- Johann Laurentius Bausch, the first president of the society, Johann Michael Fehr, Georg Balthasar Metzger, and Georg Balthasar Wohlfarth; and ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Eric M
The given name Eric, Erich, Erikk, Erik, Erick, or Eirik is derived from the Old Norse name ''Eiríkr'' (or ''Eríkr'' in Old East Norse due to monophthongization). The first element, ''ei-'' may be derived from the older Proto-Norse ''* aina(z)'', meaning "one, alone, unique", ''as in the form'' ''Æ∆inrikr'' explicitly, but it could also be from ''* aiwa(z)'' "everlasting, eternity", as in the Gothic form ''Euric''. The second element ''- ríkr'' stems either from Proto-Germanic ''* ríks'' "king, ruler" (cf. Gothic ''reiks'') or the therefrom derived ''* ríkijaz'' "kingly, powerful, rich, prince"; from the common Proto-Indo-European root * h₃rḗǵs. The name is thus usually taken to mean "sole ruler, autocrat" or "eternal ruler, ever powerful". ''Eric'' used in the sense of a proper noun meaning "one ruler" may be the origin of ''Eriksgata'', and if so it would have meant "one ruler's journey". The tour was the medieval Swedish king's journey, when newly elected, to s ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Society For Neuroscience
The Society for Neuroscience (SfN) is a professional society, headquartered in Washington, DC, for basic scientists and physicians around the world whose research is focused on the study of the brain and nervous system. It is especially well known for its annual meeting, consistently one of the largest scientific conferences in the world. History SfN was founded in 1969 by Ralph W. Gerard and, at nearly 37,000 members, has grown to be the largest neuroscience society in the world. The stated mission of the society is to: #Advance the understanding of the brain and the nervous system. #Provide professional development activities, information, and educational resources. #Promote public information and general education about science and neuroscience. #Inform legislators and other policy makers about the implications of research for public policy, societal benefit, and continued scientific progress. Annual meeting The Society holds an annual meeting that is attended by scien ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Dana Foundation
The Dana Foundation (Charles A. Dana Foundation) is a private philanthropic organization based in New York dedicated to advancing neuroscience and society by supporting cross-disciplinary intersections such as neuroscience and ethics, law, policy, humanities, and arts. Leadership The foundation was founded in 1950 by Charles A. Dana, a legislator and businessman from New York State, and president of the Dana Corporation. He presided over the organization until 1960, but continued to participate until his death in 1975. Steven E. Hyman, M.D., is chairman of the board of directors of the foundation. Caroline Montojo, Ph.D., is the current president of the foundation. Burton M. Mirsky is president emeritus; he served as vice president, finance, before being elected president and chairman in 2019. He succeeded Edward F. Rover, who served as vice-chairman of the board of directors of the foundation before being elected president in 2000 and then chairman in 2010. Rover was a se ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ciliary Neurotrophic Factor
Ciliary neurotrophic factor is a protein that in humans is encoded by the ''CNTF'' gene. The protein encoded by this gene is a polypeptide hormone and neurotrophic factor whose actions have mainly been studied in the nervous system where it promotes neurotransmitter synthesis and neurite outgrowth in certain neural populations including astrocytes. It is a hypothalamic neuropeptide that is a potent survival factor for neurons and oligodendrocytes and may be relevant in reducing tissue destruction during inflammatory attacks. A mutation in this gene, which results in aberrant splicing, leads to ciliary neurotrophic factor deficiency, but this phenotype is not causally related to neurologic disease. In addition to the predominant monocistronic transcript originating from this locus, the gene is also cotranscribed with the upstream ZFP91 gene. Cotranscription from the two loci results in a transcript that contains a complete coding region for the zinc finger protein but lacks a co ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Brain Derived Neurotrophic Factor
Brain-derived neurotrophic factor (BDNF), or abrineurin, is a protein found in the and the periphery. that, in humans, is encoded by the ''BDNF'' gene. BDNF is a member of the neurotrophin family of growth factors, which are related to the canonical nerve growth factor (NGF), a family which also includes NT-3 and NT-4/NT-5. Neurotrophic factors are found in the brain and the periphery. BDNF was first isolated from a pig brain in 1982 by Yves-Alain Barde and Hans Thoenen. BDNF activates the TrkB tyrosine kinase receptor. Function BDNF acts on certain neurons of the central nervous system and the peripheral nervous system expressing TrkB, helping to support survival of existing neurons, and encouraging growth and Cellular differentiation, differentiation of new neurons and synapses. In the brain it is active in the hippocampus, Cerebral cortex, cortex, and basal forebrain—areas vital to learning, memory, and higher thinking. BDNF is also expressed in the retina, kidneys, pro ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nerve Growth Factor
Nerve growth factor (NGF) is a neurotrophic factor and neuropeptide primarily involved in the regulation of growth, maintenance, proliferation, and survival of certain target neurons. It is perhaps the prototypical growth factor, in that it was one of the first to be described. Since it was first isolated by Nobel Laureates Rita Levi-Montalcini and Stanley Cohen in 1956, numerous biological processes involving NGF have been identified, two of them being the survival of pancreatic beta cells and the regulation of the immune system. Structure NGF is initially in a 7S, 130-kDa complex of 3 proteins – Alpha-NGF, Beta-NGF, and Gamma-NGF (2:1:2 ratio) when expressed. This form of NGF is also referred to as proNGF (NGF precursor). The gamma subunit of this complex acts as a serine protease, and cleaves the N-terminal of the beta subunit, thereby activating the protein into functional NGF. The term ''nerve growth factor'' usually refers to the 2.5S, 26-kDa beta subunit of the protein ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tyrosine Hydroxylase
Tyrosine hydroxylase or tyrosine 3-monooxygenase is the enzyme responsible for catalyzing the conversion of the amino acid L-tyrosine to L-3,4-dihydroxyphenylalanine (L-DOPA). It does so using molecular oxygen (O2), as well as iron (Fe2+) and tetrahydrobiopterin as cofactors. L-DOPA is a precursor for dopamine, which, in turn, is a precursor for the important neurotransmitters norepinephrine (noradrenaline) and epinephrine (adrenaline). Tyrosine hydroxylase catalyzes the rate limiting step in this synthesis of catecholamines. In humans, tyrosine hydroxylase is encoded by the ''TH'' gene, and the enzyme is present in the central nervous system (CNS), peripheral sympathetic neurons and the adrenal medulla. Tyrosine hydroxylase, phenylalanine hydroxylase and tryptophan hydroxylase together make up the family of aromatic amino acid hydroxylases (AAAHs). Reaction Tyrosine hydroxylase catalyzes the reaction in which L-tyrosine is hydroxylated in the meta position to obtain L- ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Parkinson's Disease
Parkinson's disease (PD), or simply Parkinson's, is a long-term degenerative disorder of the central nervous system that mainly affects the motor system. The symptoms usually emerge slowly, and as the disease worsens, non-motor symptoms become more common. The most obvious early symptoms are tremor, rigidity, slowness of movement, and difficulty with walking. Cognitive and behavioral problems may also occur with depression, anxiety, and apathy occurring in many people with PD. Parkinson's disease dementia becomes common in the advanced stages of the disease. Those with Parkinson's can also have problems with their sleep and sensory systems. The motor symptoms of the disease result from the death of cells in the substantia nigra, a region of the midbrain, leading to a dopamine deficit. The cause of this cell death is poorly understood, but involves the build-up of misfolded proteins into Lewy bodies in the neurons. Collectively, the main motor symptoms are also known as ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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