Hans Gerhard Creutzfeldt
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Hans Gerhard Creutzfeldt
Hans Gerhard Creutzfeldt (June 2, 1885 – December 30, 1964) was a German neurologist and neuropathologist. Although he is typically credited as the physician to first describe the Creutzfeldt–Jakob disease, this has been disputed. He was born in Harburg upon Elbe and died in Munich. Biography Creutzfeldt was born into a medical family in Harburg, which was incorporated into Hamburg in 1937. In 1903, at the age of 18, he was drafted into the German army and spent his service stationed in Kiel. Afterwards, he attended the School of Medicine of the University of Jena and the University of Rostock, receiving his doctorate at the latter in 1909. Part of his practical training was undertaken at ''St. Georg'' – Hospital in Hamburg. After qualification he sought adventure as a ship's surgeon, voyaging the Pacific Ocean, taking the opportunity to study local crafts, linguistics, and tropical plants. After returning to Germany in 1912, Creutzfeldt worked at the Neurological Insti ...
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Harburg (quarter)
Harburg () is a quarter (''Stadtteil'') in the Harburg borough (''Bezirk'') of Hamburg, Germany. It used to be the capital of the Harburg district in Lower Saxony. In 2020, the population was 25,979. History A castle named Horeburg, meaning swamp castle, was probably erected by the counts of Stade, to secure the eastern border of the county. The oldest records mentioning the castle date back to 1133 and 1137. Outside the castle a settlement developed. As to religion Harburg belonged to the Diocese of Verden (till 1648). In 1257 the area became part of the Duchy of Brunswick and Lunenburg. After its dynastic partition in 1267 Harburg was part of the Brunswick-Lunenburgian Principality of Lunenburg (Celle). In 1288 the settlement outside the castle was granted municipal rights and in 1297 town privileges. The town was then the centre of the Bailiwick of Harburg (Vogtei Harburg). After Duke Otto (1495–1549), who co-ruled Lunenburg-Celle with his brother Duke Ernest I ''the Co ...
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Deutsche Forschungsanstalt Für Psychiatrie
The Max Planck Institute of Psychiatry (german: Max-Planck-Institut für Psychiatrie) is a scientific institute based in the city of Munich in Germany specializing in psychiatry. Currently directed by Elisabeth Binder and Alon Chen, it is one of the 81 institutes in the Max Planck Society. History The institute was founded as the German Institute for Psychiatric Research (german: Deutsche Forschungsanstalt für Psychiatrie) by King Ludwig III of Bavaria in Munich on February 13, 1917. The main force behind the institute was the psychiatrist Emil Kraepelin. Substantial funding was received from the Jewish-American banker James Loeb, as well as from the Rockefeller Foundation, well into the 1930s. The institute became affiliated with the K. W. Society for the Advancement of Science (german: Kaiser-Wilhelm-Gesellschaft zur Förderung der Wissenschaften) in 1924. In 1928 a new building of the institute was opened at 2 Kraepelinstrasse. The building was financed primarily by a donat ...
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Schutzstaffel
The ''Schutzstaffel'' (SS; also stylized as ''ᛋᛋ'' with Armanen runes; ; "Protection Squadron") was a major paramilitary organization under Adolf Hitler and the Nazi Party in Nazi Germany, and later throughout German-occupied Europe during World War II. It began with a small guard unit known as the ''Saal-Schutz'' ("Hall Security") made up of party volunteers to provide security for party meetings in Munich. In 1925, Heinrich Himmler joined the unit, which had by then been reformed and given its final name. Under his direction (1929–1945) it grew from a small paramilitary formation during the Weimar Republic to one of the most powerful organizations in Nazi Germany. From the time of the Nazi Party's rise to power until the regime's collapse in 1945, the SS was the foremost agency of security, surveillance, and terror within Germany and German-occupied Europe. The two main constituent groups were the '' Allgemeine SS'' (General SS) and ''Waffen-SS'' (Armed SS). The ' ...
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Heinrich Himmler
Heinrich Luitpold Himmler (; 7 October 1900 – 23 May 1945) was of the (Protection Squadron; SS), and a leading member of the Nazi Party of Germany. Himmler was one of the most powerful men in Nazi Germany and a main architect of the Holocaust. As a member of a reserve battalion during World War I, Himmler did not see active service, and did not fight. He studied agriculture in university, and joined the Nazi Party in 1923 and the SS in 1925. In 1929, he was appointed by Adolf Hitler. Over the next 16 years, he developed the SS from a 290-man battalion into a million-strong paramilitary group, and set up and controlled the Nazi concentration camps. He was known for good organisational skills and for selecting highly competent subordinates, such as Reinhard Heydrich in 1931. From 1943 onwards, he was both Chief of German Police and Minister of the Interior, overseeing all internal and external police and security forces, including the Gestapo (Secret State Police). H ...
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Förderndes Mitglied Der SS
A Förderndes Mitglied der SS (SS-FM; SS Patron Members) was a member of the Allgemeine SS (General SS) who did not take part in active duty, but instead contributed financially to the SS. The SS-FM was organised by the SS Main Economic and Administrative Office The SS Main Economic and Administrative Office (german: SS-Wirtschafts- und Verwaltungshauptamt; SS-WVHA) was a Nazi organization responsible for managing the finances, supply systems and business projects of the (a main branch of the ; SS). It ..., and started in 1926. Members of the SS-FM made monthly payments towards the work of the SS at their local SS headquarters. For people with low income, contributions were low; no minimum contribution was prescribed. Each member was issued with a lapel pin and a receipt book. From April 1934, members also received a monthly magazine - ''FM-Zeitschrift-'' which was produced by the SS High Command. By 1939, circulation of ''FM-Zeitschrift'' was approximately 365,000, but few c ...
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Nazi Germany
Nazi Germany (lit. "National Socialist State"), ' (lit. "Nazi State") for short; also ' (lit. "National Socialist Germany") (officially known as the German Reich from 1933 until 1943, and the Greater German Reich from 1943 to 1945) was the German state between 1933 and 1945, when Adolf Hitler and the Nazi Party controlled the country, transforming it into a dictatorship. Under Hitler's rule, Germany quickly became a totalitarian state where nearly all aspects of life were controlled by the government. The Third Reich, meaning "Third Realm" or "Third Empire", alluded to the Nazi claim that Nazi Germany was the successor to the earlier Holy Roman Empire (800–1806) and German Empire (1871–1918). The Third Reich, which Hitler and the Nazis referred to as the Thousand-Year Reich, ended in May 1945 after just 12 years when the Allies defeated Germany, ending World War II in Europe. On 30 January 1933, Hitler was appointed chancellor of Germany, the head of gove ...
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Prion
Prions are misfolded proteins that have the ability to transmit their misfolded shape onto normal variants of the same protein. They characterize several fatal and transmissible neurodegenerative diseases in humans and many other animals. It is not known what causes a normal protein to misfold, but the resulting abnormal three-dimensional structure confers infectious properties by collapsing nearby protein molecules into the same shape. The word ''prion'' is derived from the term, "proteinaceous infectious particle". In comparison to all other known infectious agents such as viroids, viruses, bacteria, fungi, and parasites, all of which contain nucleic acids ( DNA, RNA, or both), the hypothesized role of a protein as an infectious agent stands in contrast. Prion isoforms of the prion protein (PrP), whose specific function is uncertain, are hypothesized as the cause of transmissible spongiform encephalopathies (TSEs), including scrapie in sheep, chronic wasting disease (CWD) ...
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Protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, responding to stimuli, providing structure to cells and organisms, and transporting molecules from one location to another. Proteins differ from one another primarily in their sequence of amino acids, which is dictated by the nucleotide sequence of their genes, and which usually results in protein folding into a specific 3D structure that determines its activity. A linear chain of amino acid residues is called a polypeptide. A protein contains at least one long polypeptide. Short polypeptides, containing less than 20–30 residues, are rarely considered to be proteins and are commonly called peptides. The individual amino acid residues are bonded together by peptide bonds and adjacent amino acid residues. The sequence of amino acid residue ...
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Brain Tissue
The human brain is the central organ of the human nervous system, and with the spinal cord makes up the central nervous system. The brain consists of the cerebrum, the brainstem and the cerebellum. It controls most of the activities of the body, processing, integrating, and coordinating the information it receives from the sense organs, and making decisions as to the instructions sent to the rest of the body. The brain is contained in, and protected by, the skull bones of the head. The cerebrum, the largest part of the human brain, consists of two cerebral hemispheres. Each hemisphere has an inner core composed of white matter, and an outer surface – the cerebral cortex – composed of grey matter. The cortex has an outer layer, the neocortex, and an inner allocortex. The neocortex is made up of six neuronal layers, while the allocortex has three or four. Each hemisphere is conventionally divided into four lobes – the frontal, temporal, parietal, and occipital lo ...
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Alfons Maria Jakob
Alfons Maria Jakob (2 July 1884 – 17 October 1931) was a German neurologist who worked in the field of neuropathology. He was born in Aschaffenburg, Bavaria and educated in medicine at the universities of Munich, Berlin, and Strasbourg, where he received his doctorate in 1908. During the following year, he began clinical work under the psychiatrist Emil Kraepelin and did laboratory work with Franz Nissl and Alois Alzheimer in Munich.Alfons Maria Jakob
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In 1911, by way of an invitation from ,
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Neurology
Neurology (from el, wikt:νεῦρον, νεῦρον (neûron), "string, nerve" and the suffix wikt:-logia, -logia, "study of") is the branch of specialty (medicine), medicine dealing with the diagnosis and treatment of all categories of conditions and disease involving the brain, the spinal cord and the peripheral nerves. Neurological practice relies heavily on the field of neuroscience, the scientific study of the nervous system. A neurologist is a physician specializing in neurology and trained to investigate, diagnose and treat neurological disorders. Neurologists treat a myriad of neurologic conditions, including stroke, seizures, movement disorders such as Parkinson's disease, autoimmune neurologic disorders such as multiple sclerosis, headache disorders like migraine and dementias such as Alzheimer's disease. Neurologists may also be involved in clinical research, clinical trials, and basic research, basic or translational research. While neurology is a nonsurgical sp ...
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Psychiatry
Psychiatry is the medical specialty devoted to the diagnosis, prevention, and treatment of mental disorders. These include various maladaptations related to mood, behaviour, cognition, and perceptions. See glossary of psychiatry. Initial psychiatric assessment of a person typically begins with a case history and mental status examination. Physical examinations and psychological tests may be conducted. On occasion, neuroimaging or other neurophysiological techniques are used. Mental disorders are often diagnosed in accordance with clinical concepts listed in diagnostic manuals such as the ''International Classification of Diseases'' (ICD), edited and used by the World Health Organization (WHO) and the widely used '' Diagnostic and Statistical Manual of Mental Disorders'' (DSM), published by the American Psychiatric Association (APA). The fifth edition of the DSM (DSM-5) was published in May 2013 which re-organized the larger categories of various diseases and expanded upon the p ...
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