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HIST1H3C
Histone H3.1 is a protein that in humans is encoded by the ''HIST1H3C'' gene. Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes, and functions in the compaction of chromatin into higher order structures. This gene is intronless, and encodes a member of the histone H3 family. Transcripts from this gene lack polyA tails, instead containing a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6 Chromosome 6 is one of the 23 pairs of chromosomes in humans. People normally have two copies of this chromosome. Chromosome 6 spans more than 170 million base pairs (the building material of DNA) and represents between 5 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Histone H3
Histone H3 is one of the five main histones involved in the structure of chromatin in eukaryotic cells. Featuring a main globular domain and a long N-terminal tail, H3 is involved with the structure of the nucleosomes of the 'beads on a string' structure. Histone proteins are highly post-translationally modified however Histone H3 is the most extensively modified of the five histones. The term "Histone H3" alone is purposely ambiguous in that it does not distinguish between sequence variants or modification state. Histone H3 is an important protein in the emerging field of epigenetics, where its sequence variants and variable modification states are thought to play a role in the dynamic and long term regulation of genes. Epigenetics and post-translational modifications The N-terminus of H3 protrudes from the globular nucleosome core and is susceptible to post-translational modification that influence cellular processes. These modifications include the covalent attachment ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Histone
In biology, histones are highly basic proteins abundant in lysine and arginine residues that are found in eukaryotic cell nuclei. They act as spools around which DNA winds to create structural units called nucleosomes. Nucleosomes in turn are wrapped into 30-nanometer fibers that form tightly packed chromatin. Histones prevent DNA from becoming tangled and protect it from DNA damage. In addition, histones play important roles in gene regulation and DNA replication. Without histones, unwound DNA in chromosomes would be very long. For example, each human cell has about 1.8 meters of DNA if completely stretched out; however, when wound about histones, this length is reduced to about 90 micrometers (0.09 mm) of 30 nm diameter chromatin fibers. There are five families of histones which are designated H1/H5 (linker histones), H2, H3, and H4 (core histones). The nucleosome core is formed of two H2A-H2B dimers and a H3-H4 tetramer. The tight wrapping of DNA around histones ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, responding to stimuli, providing structure to cells and organisms, and transporting molecules from one location to another. Proteins differ from one another primarily in their sequence of amino acids, which is dictated by the nucleotide sequence of their genes, and which usually results in protein folding into a specific 3D structure that determines its activity. A linear chain of amino acid residues is called a polypeptide. A protein contains at least one long polypeptide. Short polypeptides, containing less than 20–30 residues, are rarely considered to be proteins and are commonly called peptides. The individual amino acid residues are bonded together by peptide bonds and adjacent amino acid residues. The sequence of amino acid residue ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Proceedings Of The National Academy Of Sciences Of The United States Of America
''Proceedings of the National Academy of Sciences of the United States of America'' (often abbreviated ''PNAS'' or ''PNAS USA'') is a peer-reviewed multidisciplinary scientific journal. It is the official journal of the National Academy of Sciences, published since 1915, and publishes original research, scientific reviews, commentaries, and letters. According to ''Journal Citation Reports'', the journal has a 2021 impact factor of 12.779. ''PNAS'' is the second most cited scientific journal, with more than 1.9 million cumulative citations from 2008 to 2018. In the mass media, ''PNAS'' has been described variously as "prestigious", "sedate", "renowned" and "high impact". ''PNAS'' is a delayed open access journal, with an embargo period of six months that can be bypassed for an author fee ( hybrid open access). Since September 2017, open access articles are published under a Creative Commons license. Since January 2019, ''PNAS'' has been online-only, although print issues are ava ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Oncogene (journal)
''Oncogene'' is a peer-reviewed scientific journal published by the Nature Publishing Group addressing cancer cell genetics and the structure and function of oncogenes. According to the ''Journal Citation Reports'', the journal received a 2019 impact factor of 7.971, ranking it 29th out of 297 journals (9.596%) in the category ''Biochemistry & Molecular Biology'', 26th out of 244 journals (10.451%) in the category ''Oncology'', 31st out of 190 journals (15.641%) in the category ''Cell Biology'', and 14th out of 177 journals (7.627%) in the category ''Genetics & Heredity''. Its 2021 impact factor is 8.756. The current editors-in-chief are George Miller and Justin Stebbing. The journal has editorial office in London, England. Abstracting and indexing The journal is abstracted and indexed in: EBSCO Discovery Service, Google Scholar, OCLC, Summon by ProQuest, BIOSIS, Current Contents/Life Sciences, Science Citation Index, Science Citation Index Expanded (SciSearch), SCOPUS, EBSCO Ac ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nature (journal)
''Nature'' is a British weekly scientific journal founded and based in London, England. As a multidisciplinary publication, ''Nature'' features peer-reviewed research from a variety of academic disciplines, mainly in science and technology. It has core editorial offices across the United States, continental Europe, and Asia under the international scientific publishing company Springer Nature. ''Nature'' was one of the world's most cited scientific journals by the Science Edition of the 2019 ''Journal Citation Reports'' (with an ascribed impact factor of 42.778), making it one of the world's most-read and most prestigious academic journals. , it claimed an online readership of about three million unique readers per month. Founded in autumn 1869, ''Nature'' was first circulated by Norman Lockyer and Alexander Macmillan as a public forum for scientific innovations. The mid-20th century facilitated an editorial expansion for the journal; ''Nature'' redoubled its efforts in exp ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Virology (journal)
''Virology'' is a peer-reviewed scientific journal in virology. Established in 1955 by George Hirst, Lindsay Black and Salvador Luria, it is the earliest English-only journal to specialize in the field. The journal covers basic research into viruses affecting animals, plants, bacteria and fungi, including their molecular biology, structure, assembly, pathogenesis, immunity, interactions with the host cell, evolution and ecology. Molecular aspects of control and prevention are also covered, as well as viral vectors and gene therapy, but clinical virology is excluded. As of 2013, the journal is published fortnightly by Elsevier. History The field of virology began in the 1890s, with the discovery of infectious agents small enough to pass through filters sufficiently fine to catch bacteria. The first specialist journal in the field, ''Archiv für die gesamte Virusforschung'', appeared in 1939. Published by Springer-Verlag out of its Vienna office, its papers were in a mixture of lan ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cell (journal)
''Cell'' is a peer-reviewed scientific journal publishing research papers across a broad range of disciplines within the life sciences. Areas covered include molecular biology, cell biology, systems biology, stem cells, developmental biology, genetics and genomics, proteomics, cancer research, immunology, neuroscience, structural biology, microbiology, virology, physiology, biophysics, and computational biology. The journal was established in 1974 by Benjamin LewinElsevier: ''Cell'': Home (accessed 12 December 2008) and is published twice monthly by , an imprint of |
Genes To Cells
''Genes to Cells'' is a peer-reviewed scientific journal that publishes original research on the molecular mechanisms of biological events. The journal has been published since 1996 by Wiley-Blackwell Wiley-Blackwell is an international scientific, technical, medical, and scholarly publishing business of John Wiley & Sons. It was formed by the merger of John Wiley & Sons Global Scientific, Technical, and Medical business with Blackwell Publish ... on behalf of the Molecular Biology Society of Japan. Indexing ''Genes to Cells'' is indexed in: References External linksJournal homepage at publisher site Biology journals [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Molecular And Cellular Biology
''Molecular and Cellular Biology'' is a biweekly peer-reviewed scientific journal covering all aspects of molecular and cellular biology. It is published by the American Society for Microbiology and the editor-in-chief is Peter Tontonoz (University of California, Los Angeles). It was established in 1981. The h-index (1981-2021) is 338. Abstracting and indexing The journal is abstracted and indexed in: According to the ''Journal Citation Reports'', the journal has a 2021 impact factor The impact factor (IF) or journal impact factor (JIF) of an academic journal is a scientometric index calculated by Clarivate that reflects the yearly mean number of citations of articles published in the last two years in a given journal, as i ... of 5.069. References External links * Molecular and cellular biology journals Delayed open access journals Publications established in 1981 English-language journals Biweekly journals American Society for Microbiology academic journals [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Human Genetics (journal)
''Human Genetics'' is a peer-reviewed medical journal covering all aspects of human genetics, including legal and social issues. It was established in 1964 by Arno Motulsky and Friedrich Vogel as the German-language ''Humangenetik'', obtaining its current title in 1976. It is published by Springer Science+Business Media. Its editors-in-chief are David N. Cooper (Cardiff University) and Thomas J. Hudson (Ontario Institute for Cancer Research). According to the ''Journal Citation Reports'', the journal has a 2018 impact factor of 5.20. Ethics scandal The journal published findings exploring the DNA of physical appearance traits of Uighur men from Tumxuk TumxukThe official spelling according to , (Beijing, ''SinoMaps Press'' 1997); is a sub-prefecture-level city in the western part of Xinjiang, China. The eastern part of Tumxuk is surrounded by Maralbexi County, Kashgar Prefecture. The smaller ... in 2019. One of the authors of the paper on DNA phenotyping said he had been ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chromosome 6
Chromosome 6 is one of the 23 pairs of chromosomes in humans. People normally have two copies of this chromosome. Chromosome 6 spans more than 170 million base pairs (the building material of DNA) and represents between 5.5 and 6% of the total DNA in cells. It contains the major histocompatibility complex, which contains over 100 genes related to the immune response, and plays a vital role in organ transplantation. Genes The human leukocyte antigen lies on chromosome 6, with the exception of the gene for β2-microglobulin (which is located on chromosome 15), and encodes cell-surface antigen-presenting proteins among other functions. Number of genes In 2003, the entirety of chromosome 6 was manually annotated for proteins, resulting in the identification of 1,557 genes, and 633 pseudogenes. The following are some of the newer gene count estimates. Because researchers use different approaches to genome annotation their predictions of the number of genes on each chromosome var ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
