|
High-definition Fiber Tracking
High definition fiber tracking (HDFT) is a tractography technique where data from MRI scanners is processed through computer algorithms to reveal the detailed wiring of the brain and to pinpoint fiber tracts. Each tract contains millions of neuronal connections. HDFT is based on data acquired from diffusion spectrum imaging and processed by generalized q-sampling imaging. The technique makes it possible to virtually dissect 40 major fiber tracts in the brain. The HDFT scan is consistent with brain anatomy unlike diffusion tensor imaging ( DTI). Thus, the use of HDFT is essential in pinpointing damaged neural connections. History Traditional DTI uses six diffusivity characteristics to model how water molecules diffuse in brain tissues and makes axonal fiber tracking possible. However, DTI had a major limitation in resolving axons from different tracts intersected and crossed en route to their target. In 2009, Learning Research & Development Center (LRDC) at University of Pittsburgh ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
High-definition Fiber Tracking
High definition fiber tracking (HDFT) is a tractography technique where data from MRI scanners is processed through computer algorithms to reveal the detailed wiring of the brain and to pinpoint fiber tracts. Each tract contains millions of neuronal connections. HDFT is based on data acquired from diffusion spectrum imaging and processed by generalized q-sampling imaging. The technique makes it possible to virtually dissect 40 major fiber tracts in the brain. The HDFT scan is consistent with brain anatomy unlike diffusion tensor imaging ( DTI). Thus, the use of HDFT is essential in pinpointing damaged neural connections. History Traditional DTI uses six diffusivity characteristics to model how water molecules diffuse in brain tissues and makes axonal fiber tracking possible. However, DTI had a major limitation in resolving axons from different tracts intersected and crossed en route to their target. In 2009, Learning Research & Development Center (LRDC) at University of Pittsburgh ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tractography
In neuroscience Neuroscience is the scientific study of the nervous system (the brain, spinal cord, and peripheral nervous system), its functions and disorders. It is a multidisciplinary science that combines physiology, anatomy, molecular biology, development ..., tractography is a 3D modeling technique used to visually represent nerve tracts using data collected by diffusion MRI. It uses special techniques of magnetic resonance imaging (MRI) and computer-based diffusion MRI. The results are presented in two- and three-dimensional images called tractograms. In addition to the long tracts that connect the brain to the rest of the body, there are complicated neural circuits formed by short connections among different Cerebral cortex, cortical and subcortical regions. The existence of these tracts and circuits has been revealed by histochemistry and biology, biological techniques on post-mortem specimens. Nerve tracts are not identifiable by direct exam, computed tomography, CT ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Magnetic Resonance Imaging
Magnetic resonance imaging (MRI) is a medical imaging technique used in radiology to form pictures of the anatomy and the physiological processes of the body. MRI scanners use strong magnetic fields, magnetic field gradients, and radio waves to generate images of the organs in the body. MRI does not involve X-rays or the use of ionizing radiation, which distinguishes it from CT and PET scans. MRI is a medical application of nuclear magnetic resonance (NMR) which can also be used for imaging in other NMR applications, such as NMR spectroscopy. MRI is widely used in hospitals and clinics for medical diagnosis, staging and follow-up of disease. Compared to CT, MRI provides better contrast in images of soft-tissues, e.g. in the brain or abdomen. However, it may be perceived as less comfortable by patients, due to the usually longer and louder measurements with the subject in a long, confining tube, though "Open" MRI designs mostly relieve this. Additionally, implants and oth ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Neuron
A neuron, neurone, or nerve cell is an electrically excitable cell that communicates with other cells via specialized connections called synapses. The neuron is the main component of nervous tissue in all animals except sponges and placozoa. Non-animals like plants and fungi do not have nerve cells. Neurons are typically classified into three types based on their function. Sensory neurons respond to stimuli such as touch, sound, or light that affect the cells of the sensory organs, and they send signals to the spinal cord or brain. Motor neurons receive signals from the brain and spinal cord to control everything from muscle contractions to glandular output. Interneurons connect neurons to other neurons within the same region of the brain or spinal cord. When multiple neurons are connected together, they form what is called a neural circuit. A typical neuron consists of a cell body (soma), dendrites, and a single axon. The soma is a compact structure, and the axon and dend ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Diffusion MRI
Diffusion-weighted magnetic resonance imaging (DWI or DW-MRI) is the use of specific MRI sequences as well as software that generates images from the resulting data that uses the diffusion of water molecules to generate contrast in MR images. It allows the mapping of the diffusion process of molecules, mainly water, in biological tissues, in vivo and non-invasively. Molecular diffusion in tissues is not random, but reflects interactions with many obstacles, such as macromolecules, fibers, and membranes. Water molecule diffusion patterns can therefore reveal microscopic details about tissue architecture, either normal or in a diseased state. A special kind of DWI, diffusion tensor imaging (DTI), has been used extensively to map white matter tractography in the brain. Introduction In diffusion weighted imaging (DWI), the intensity of each image element (voxel) reflects the best estimate of the rate of water diffusion at that location. Because the mobility of water is driven by th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Boston University
Boston University (BU) is a private research university in Boston, Massachusetts. The university is nonsectarian, but has a historical affiliation with the United Methodist Church. It was founded in 1839 by Methodists with its original campus in Newbury, Vermont, before moving to Boston in 1867. The university now has more than 4,000 faculty members and nearly 34,000 students, and is one of Boston's largest employers. It offers bachelor's degrees, master's degrees, doctorates, and medical, dental, business, and law degrees through 17 schools and colleges on three urban campuses. The main campus is situated along the Charles River in Boston's Fenway-Kenmore and Allston, Massachusetts, Allston neighborhoods, while the Boston University Medical Campus is located in Boston's South End, Boston, South End neighborhood. The Fenway campus houses the Wheelock College of Education and Human Development, formerly Wheelock College, which merged with BU in 2018. BU is a member of the Bo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Traumatic Brain Injury
A traumatic brain injury (TBI), also known as an intracranial injury, is an injury to the brain caused by an external force. TBI can be classified based on severity (ranging from mild traumatic brain injury TBI/concussionto severe traumatic brain injury), mechanism ( closed or penetrating head injury), or other features (e.g., occurring in a specific location or over a widespread area). Head injury is a broader category that may involve damage to other structures such as the scalp and skull. TBI can result in physical, cognitive, social, emotional and behavioral symptoms, and outcomes can range from complete recovery to permanent disability or death. Causes include falls, vehicle collisions and violence. Brain trauma occurs as a consequence of a sudden acceleration or deceleration within the cranium or by a complex combination of both movement and sudden impact. In addition to the damage caused at the moment of injury, a variety of events following the injury may result in ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of Pittsburgh
The University of Pittsburgh (Pitt) is a public state-related research university in Pittsburgh, Pennsylvania. The university is composed of 17 undergraduate and graduate schools and colleges at its urban Pittsburgh campus, home to the university's central administration and around 28,000 undergraduate and graduate students. The 132-acre Pittsburgh campus includes various historic buildings that are part of the Schenley Farms Historic District, most notably its 42-story Gothic revival centerpiece, the Cathedral of Learning. Pitt is a member of the Association of American Universities and is classified among "R1: Doctoral Universities – Very high research activity". It is the second-largest non-government employer in the Pittsburgh metropolitan area. Pitt traces its roots to the Pittsburgh Academy founded by Hugh Henry Brackenridge in 1787. While the city was still on the edge of the American frontier at the time, Pittsburgh's rapid growth meant that a proper university was so ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Functional Magnetic Resonance Imaging
Functional magnetic resonance imaging or functional MRI (fMRI) measures brain activity by detecting changes associated with blood flow. This technique relies on the fact that cerebral blood flow and neuronal activation are coupled. When an area of the brain is in use, blood flow to that region also increases. The primary form of fMRI uses the blood-oxygen-level dependent (BOLD) contrast, discovered by Seiji Ogawa in 1990. This is a type of specialized brain and body scan used to map neuron, neural activity in the brain or spinal cord of humans or other animals by imaging the change in blood flow (hemodynamic response) related to energy use by brain cells. Since the early 1990s, fMRI has come to dominate brain mapping research because it does not involve the use of injections, surgery, the ingestion of substances, or exposure to ionizing radiation. This measure is frequently corrupted by noise from various sources; hence, statistical procedures are used to extract the underlying si ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Inventions
An invention is a unique or novel device, method, composition, idea or process. An invention may be an improvement upon a machine, product, or process for increasing efficiency or lowering cost. It may also be an entirely new concept. If an idea is unique enough either as a stand alone invention or as a significant improvement over the work of others, it can be patented. A patent, if granted, gives the inventor a proprietary interest in the patent over a specific period of time, which can be licensed for financial gain. An inventor creates or discovers an invention. The word ''inventor'' comes from the Latin verb ''invenire'', ''invent-'', to find. Although inventing is closely associated with science and engineering, inventors are not necessarily engineers or scientists. Due to advances in artificial intelligence, the term "inventor" no longer exclusively applies to an occupation (see human computers). Some inventions can be patented. The system of patents was established ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
