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Helix (genomics Company)
Helix is an American population genomics company. History Helix focuses on personal genomics and citizen science. Helix has a marketplace that offers applications created by approved partners. Helix handles sample collection, DNA sequencing, and secure data storage and partners develop on-demand products. Helix is headquartered in the San Francisco Bay Area and operates a sequencing laboratory in San Diego. In 2016, Helix partnered with the National Geographic Society to sequence DNA for the Genographic Project. In 2018, Helix partnered with the Desert Research Institute and Renown Institute of Health Innovation in support of the Healthy Nevada project, which offers free access to genomic sequencing to 40,000 residents of northern Nevada for health research. Sequencing methodology Helix uses NGS to sequence a proprietary assay called Exome+, a version of Exome sequencing the company claims to provide 100 times more data than was previously available. Exome+ includes all 22, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
San Mateo, California
San Mateo ( ; ) is a city in San Mateo County, California, on the San Francisco Peninsula. About 20 miles (32 km) south of San Francisco, the city borders Burlingame to the north, Hillsborough to the west, San Francisco Bay and Foster City to the east and Belmont to the south. The population was 105,661 at the 2020 census. San Mateo has a Mediterranean climate and is known for its rich history at the center of the San Francisco Bay Area. Some of the biggest economic drivers for the city include technology, health care and education. History The Ramaytush people lived in the land, prior to its becoming the city of San Mateo. In 1789, the Spanish missionaries had named a Native American village along Laurel Creek as ''Los Laureles'' or the Laurels (Mission Dolores, 1789). At the time of Mexican Independence, 30 native Californians were at San Mateo, most likely from the Salson tribelet. Naming of the city Captain Frederick William Beechey in 1827 traveling with t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Genetic Testing
Genetic testing, also known as DNA testing, is used to identify changes in DNA sequence or chromosome structure. Genetic testing can also include measuring the results of genetic changes, such as RNA analysis as an output of gene expression, or through biochemical analysis to measure specific protein output. In a medical setting, genetic testing can be used to diagnose or rule out suspected genetic disorders, predict risks for specific conditions, or gain information that can be used to customize medical treatments based on an individual's genetic makeup. Genetic testing can also be used to determine biological relatives, such as a child's biological parentage (genetic mother and father) through DNA paternity testing, or be used to broadly predict an individual's ancestry. Genetic testing of plants and animals can be used for similar reasons as in humans (e.g. to assess relatedness/ancestry or predict/diagnose genetic disorders), to gain information used for selective breeding, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Genetic Testing
Genetic testing, also known as DNA testing, is used to identify changes in DNA sequence or chromosome structure. Genetic testing can also include measuring the results of genetic changes, such as RNA analysis as an output of gene expression, or through biochemical analysis to measure specific protein output. In a medical setting, genetic testing can be used to diagnose or rule out suspected genetic disorders, predict risks for specific conditions, or gain information that can be used to customize medical treatments based on an individual's genetic makeup. Genetic testing can also be used to determine biological relatives, such as a child's biological parentage (genetic mother and father) through DNA paternity testing, or be used to broadly predict an individual's ancestry. Genetic testing of plants and animals can be used for similar reasons as in humans (e.g. to assess relatedness/ancestry or predict/diagnose genetic disorders), to gain information used for selective breeding, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
DNA Sequencing
DNA sequencing is the process of determining the nucleic acid sequence – the order of nucleotides in DNA. It includes any method or technology that is used to determine the order of the four bases: adenine, guanine, cytosine, and thymine. The advent of rapid DNA sequencing methods has greatly accelerated biological and medical research and discovery. Knowledge of DNA sequences has become indispensable for basic biological research, DNA Genographic Projects and in numerous applied fields such as medical diagnosis, biotechnology, forensic biology, virology and biological systematics. Comparing healthy and mutated DNA sequences can diagnose different diseases including various cancers, characterize antibody repertoire, and can be used to guide patient treatment. Having a quick way to sequence DNA allows for faster and more individualized medical care to be administered, and for more organisms to be identified and cataloged. The rapid speed of sequencing attained with modern D ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
National Geographic Society
The National Geographic Society (NGS), headquartered in Washington, D.C., United States, is one of the largest non-profit scientific and educational organizations in the world. Founded in 1888, its interests include geography, archaeology, and natural science, the promotion of environmental and historical conservation, and the study of world culture and history. The National Geographic Society's logo is a yellow portrait frame—rectangular in shape—which appears on the margins surrounding the front covers of its magazines and as its television channel logo. Through National Geographic Partners (a joint venture with The Walt Disney Company), the Society operates the magazine, TV channels, a website, worldwide events, and other media operations. Overview The National Geographic Society was founded on 13 January 1888 "to increase and diffuse geographic knowledge". It is governed by a board of trustees whose 33 members include distinguished educators, business executives, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Genographic Project
The Genographic Project, launched on 13 April 2005 by the National Geographic Society and IBM, was a genetic anthropological study (sales discontinued on 31 May 2019) that aimed to map historical human migrations patterns by collecting and analyzing DNA samples. The final phase of the project was Geno 2.0 Next Generation. Upon retirement of the site, 1,006,542 participants in over 140 countries had joined the project. Project history Beginnings Created and led by project director Spencer Wells in 2005, The Genographic Project was a privately funded, not-for-profit collaboration between the National Geographic Society, IBM and the Waitt Foundation. Field researchers at eleven regional centers around the world began by collecting DNA samples from indigenous populations. Since the fall of 2015, the Project was led by Miguel Vilar. In fall 2012, the Genographic Project announced the completion of a new genotyping array, dedicated to genetic anthropology, called GenoChi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Desert Research Institute
Desert Research Institute (DRI) is the nonprofit research campus of the Nevada System of Higher Education (NSHE), the organization that oversees all publicly supported higher education in the U.S. state of Nevada. At DRI, approximately 460 research faculty and support staff engage in $43 million in sponsored research each year. DRI's environmental research programs are divided into three core divisions (Atmospheric Sciences, Earth and Ecosystem Sciences, and Hydrologic Sciences) and a robust K-12 STEM education program. Established in 1988, the institute's Nevada Medal awards "outstanding achievement in science and engineering". Programs Atmospheric sciences The DRI Atmospheric Modeling group implements a full suite of numerical models of the atmosphere and climate including fine-scale computational fluid dynamics codes, Lagrangian particle models, chemical transport models, medium-resolution regional weather and climate models, and fully coupled ocean-atmospheric global climate ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Renown Regional Medical Center
Renown Regional Medical Center (formerly Washoe Medical Center) is part of Renown Health (formerly Washoe Health System), a non-profit hospital in Reno, Nevada. It is Renown Health's flagship hospital and the region's only level II trauma center. Renown Regional facilitates the area's only dedicated children's hospital, Renown Children's Hospital. The hospital was founded in 1876. History In 1862, the organization's roots was established with the formation of the Washoe Clinic. The clinic was founded to treat patients affected by a smallpox outbreak in Washoe Valley, Nevada Nevada ( ; ) is a U.S. state, state in the Western United States, Western region of the United States. It is bordered by Oregon to the northwest, Idaho to the northeast, California to the west, Arizona to the southeast, and Utah to the east. N .... The Washoe County Hospital opened in 1864, after Nevada became a state. The medical center and the healthcare organization were transferred to Washoe Health Sy ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Exome Sequencing
Exome sequencing, also known as whole exome sequencing (WES), is a genomic technique for sequencing all of the protein-coding regions of genes in a genome (known as the exome). It consists of two steps: the first step is to select only the subset of DNA that encodes proteins. These regions are known as exons—humans have about 180,000 exons, constituting about 1% of the human genome, or approximately 30 million base pairs. The second step is to sequence the exonic DNA using any high-throughput DNA sequencing technology. The goal of this approach is to identify genetic variants that alter protein sequences, and to do this at a much lower cost than whole-genome sequencing. Since these variants can be responsible for both Mendelian and common polygenic diseases, such as Alzheimer's disease, whole exome sequencing has been applied both in academic research and as a clinical diagnostic. Motivation and comparison to other approaches Exome sequencing is especially effective in the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Clinical Laboratory Improvement Amendments
The Clinical Laboratory Improvement Amendments (CLIA) of 1988 are United States federal regulatory standards that apply to all clinical laboratory testing performed on humans in the United States, except clinical trials and basic research. CLIA Program In accord with the CLIA, the CLIA Program sets standards and issues certificates for clinical laboratory testing. CLIA defines a clinical laboratory as any facility which performs laboratory testing on specimens derived from humans for the purpose of providing information for: * diagnosis, prevention, or treatment of disease or impairment * health assessments An objective of the CLIA is to ensure the accuracy, reliability and timeliness of test results regardless of where the test was performed. Most Laboratory Developed Tests have been regulated under this program. In 2014 the FDA started a public discussion about regulating some LDTs. Per CLIA, each specific laboratory system, assay, examination is graded for level of complexit ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
College Of American Pathologists
The College of American Pathologists (CAP) is a member-based physician organization founded in 1946 comprising approximately 18,000 board-certified pathologists. It serves patients, pathologists, and the public by fostering and advocating best practices in pathology and laboratory medicine. It is the world's largest association composed exclusively of pathologists certified by the American Board of Pathology, and is widely considered the leader in laboratory quality assurance. The CAP is an advocate for high-quality and cost-effective medical care. The CAP currently inspects and accredits medical laboratories under authority from the Centers for Medicare & Medicaid Services (CMS). Their standards have been called "the toughest and most exacting in the medical business." The CAP provides resources and guidance to laboratories seeking accreditation in programs for biorepositories, genomics, ISO 15189, and more. In November 2008, Piedmont Medical Laboratory of Winchester, Vir ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Illumina (company)
Illumina, Inc. is an American biotechnology company, headquartered in San Diego, California. Incorporated on April 1, 1998, Illumina develops, manufactures, and markets integrated systems for the analysis of genetic variation and biological function. The company provides a line of products and services that serves the sequencing, genotyping and gene expression, and proteomics markets. Illumina's technology had purportedly reduced the cost of sequencing a human genome to by 2014. Its customers include genomic research centers, pharmaceutical companies, academic institutions, clinical research organizations, and biotechnology companies. History Illumina was founded in April 1998 by David Walt, Larry Bock, John Stuelpnagel, Anthony Czarnik, and Mark Chee. While working with CW Group, a venture-capital firm, Bock and Stuelpnagel uncovered what would become Illumina's BeadArray technology at Tufts University and negotiated an exclusive license to that technology. In 1999, Illumin ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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