|
HLA-B
HLA-B (major histocompatibility complex, class I, B) is a human gene that provides instructions for making a protein that plays a critical role in the immune system. HLA-B is part of a family of genes called the human leukocyte antigen (HLA) complex. The HLA complex helps the immune system distinguish the body's own proteins from proteins made by foreign invaders such as viruses and bacteria. HLA is the human version of the major histocompatibility complex (MHC), a gene family that occurs in many species. Genes in this complex are separated into three basic groups: class I, class II, and class III. In humans, the HLA-B gene and two related genes, HLA-A and HLA-C, are the major genes in MHC class I. MHC class I genes provide instructions for making proteins that are present on the surface of almost all cells. On the cell surface, these proteins are bound to protein fragments (peptides) that have been exported from within the cell. MHC class I proteins display these peptides to t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
HLA-B54
HLA-B54 (B54) is an HLA- B serotype. B54 is a split antigen Split(s) or The Split may refer to: Places * Split, Croatia, the largest coastal city in Croatia * Split Island, Canada, an island in the Hudson Bay * Split Island, Falkland Islands * Split Island, Fiji, better known as Hạfliua Arts, entert ... from the B22 broad antigen, sister serotypes are B55 and B56. The serotype identifies the more common HLA-B*55 gene products. Serotype Allele distribution See also * HLA-serotype tutorial References {{DEFAULTSORT:Hla-B54 5 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
HLA-B55
HLA-B55 (B55) is an HLA- B serotype. B55 is a split antigen from the B22 broad antigen Broad(s) or The Broad(s) may refer to: People * A slang term for a woman. * Broad (surname), a surname Places * Broad Peak, on the border between Pakistan and China, the 12th highest mountain on Earth * The Broads, a network of mostly nav ..., sister serotypes are B54 and B56. The serotype identifies the more common HLA-B*55 gene products. (For terminology help see: HLA-serotype tutorial) Serotype B*55:03 is one of the four B alleles that reacts with neither Bw4 nor Bw6. The others are B*18:06, B*46:01, and B*73:01. Allele distribution References {{DEFAULTSORT:Hla-B55 5 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
HLA-B56
HLA-B56 (B56) is an HLA- B serotype. B56 is a split antigen from the B22 broad antigen Broad(s) or The Broad(s) may refer to: People * A slang term for a woman. * Broad (surname), a surname Places * Broad Peak, on the border between Pakistan and China, the 12th highest mountain on Earth * The Broads, a network of mostly nav ..., sister serotypes are B54 and B55. The serotype identifies the more common HLA-B*56 gene products. (For terminology help see: HLA-serotype tutorial) Serotype Allele distribution References {{DEFAULTSORT:Hla-B56 5 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Human Leukocyte Antigen
The human leukocyte antigen (HLA) system or complex is a complex of genes on chromosome 6 in humans which encode cell-surface proteins responsible for the regulation of the immune system. The HLA system is also known as the human version of the major histocompatibility complex (MHC) found in many animals. Mutations in HLA genes may be linked to autoimmune disease such as type I diabetes, and celiac disease. The HLA gene complex resides on a 3 Mbp stretch within chromosome 6, p-arm at 21.3. HLA genes are highly polymorphic, which means that they have many different alleles, allowing them to fine-tune the adaptive immune system. The proteins encoded by certain genes are also known as ''antigens'', as a result of their historic discovery as factors in organ transplants. HLAs corresponding to MHC class I ( A, B, and C), all of which are the HLA Class1 group, present peptides from inside the cell. For example, if the cell is infected by a virus, the HLA system brings fragme ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Serotype
A serotype or serovar is a distinct variation within a species of bacteria or virus or among immune cells of different individuals. These microorganisms, viruses, or cells are classified together based on their surface antigens, allowing the epidemiologic classification of organisms to the subspecies level. A group of serovars with common antigens is called a serogroup or sometimes ''serocomplex''. Serotyping often plays an essential role in determining species and subspecies. The ''Salmonella'' genus of bacteria, for example, has been determined to have over 2600 serotypes. ''Vibrio cholerae'', the species of bacteria that causes cholera, has over 200 serotypes, based on cell antigens. Only two of them have been observed to produce the potent enterotoxin that results in cholera: O1 and O139. Serotypes were discovered by the American microbiologist Rebecca Lancefield in 1933. Role in organ transplantation The immune system is capable of discerning a cell as being 'self' or 'n ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
