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Hisss
The Handheld Isothermal Silver Standard Sensor (HISSS) project was sponsored by DARPA in the 2000s to develop a hand-held sensor that is capable of identifying biological weapon threats across the entire spectrum including bacteria, viruses and toxins. The program began in early part of the 21st century with the following goals: * DNA detection without polymerase chain reaction (PCR) * RNA detection without PCR or reverse transcription * antibody-based protein detection at sensitivities unachievable by traditional methods The final goal was to give field units the ability to detect threat agents across the complete spectrum of biological warfare weapons. The main contractor for this project was Northrop Grumman with subcontractors Ionian Technologies Ionian Technologies Inc. was a United States Biotechnology Company focused on molecular diagnostics development for the detection of infectious diseases and biothreat agents. It was established in 2000 in Upland, California as the ...
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DARPA
The Defense Advanced Research Projects Agency (DARPA) is a research and development agency of the United States Department of Defense responsible for the development of emerging technologies for use by the military. Originally known as the Advanced Research Projects Agency (ARPA), the agency was created on February 7, 1958, by President Dwight D. Eisenhower in response to the Soviet Union, Soviet launching of Sputnik 1 in 1957. By collaborating with academia, industry, and government partners, DARPA formulates and executes research and development projects to expand the frontiers of technology and science, often beyond immediate U.S. military requirements.Dwight D. Eisenhower and Science & Technology, (2008). Dwight D. Eisenhower Memorial CommissionSource ''The Economist'' has called DARPA the agency "that shaped the modern world," and pointed out that "Moderna COVID-19 vaccine, Moderna's COVID-19 vaccine sits alongside weather satellites, Global Positioning System, GPS, Unmann ...
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Polymerase Chain Reaction
The polymerase chain reaction (PCR) is a method widely used to rapidly make millions to billions of copies (complete or partial) of a specific DNA sample, allowing scientists to take a very small sample of DNA and amplify it (or a part of it) to a large enough amount to study in detail. PCR was invented in 1983 by the American biochemist Kary Mullis at Cetus Corporation; Mullis and biochemist Michael Smith (chemist), Michael Smith, who had developed other essential ways of manipulating DNA, were jointly awarded the Nobel Prize in Chemistry in 1993. PCR is fundamental to many of the procedures used in genetic testing and research, including analysis of Ancient DNA, ancient samples of DNA and identification of infectious agents. Using PCR, copies of very small amounts of DNA sequences are exponentially amplified in a series of cycles of temperature changes. PCR is now a common and often indispensable technique used in medical laboratory research for a broad variety of applications ...
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Northrop Grumman
Northrop Grumman Corporation is an American multinational aerospace and defense technology company. With 90,000 employees and an annual revenue in excess of $30 billion, it is one of the world's largest weapons manufacturers and military technology providers. The firm ranks on the 2022 ''Fortune'' 500 list of America's largest corporations. Northrop Grumman and its industry partners have won the Collier Trophy eight times, most recently for developing the X-47B, the first unmanned, autonomous air system to operate from an aircraft carrier. Northrop Grumman currently leads the development of the B-21 Raider, a long-range, stealth strategic bomber that can drop conventional and nuclear weapons; it will replace Northrop's own B-2 Spirit, the world's only known stealth bomber. Among its other current projects are development and production of the James Webb Space Telescope, an orbiting observatory launched in 2021, and production of the solid rocket boosters for NASA's Space ...
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Ionian Technologies
Ionian Technologies Inc. was a United States Biotechnology Company focused on molecular diagnostics development for the detection of infectious diseases and biothreat agents. It was established in 2000 in Upland, California as the first spin-off company to commercialize technology developed at the Keck Graduate Institute. Since its inception Ionian has expanded its isothermal amplification technology. Ionian was acquired in July 2010 by Alere Inc. History Ionian traces its origins to Dr. David Galas who was previously Chancellor, Chief Scientific Officer and Norris Professor of Applied Life Science at the Keck Graduate Institute of Applied Life Sciences. During his development of KGI he spun off Ionian Technologies from work done in his lab, based upon a 2003 PNAS paper. In 2001, Ionian was incorporated in Delaware. Corporate governance Current members of the board of directors of Ionian Technologies are: David Galas and Paul Tardif. Technology Ionian's proprietary isothermal te ...
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