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Growth Hormone In Sports
Growth hormones in sports refers to the use of growth hormones (GH or HGH) for athletic enhancement, as opposed to growth hormone treatment for medical therapy. Human Growth Hormone is a prescription medication in the US, meaning that its distribution and use without a prescription is illegal. There is limited evidence that GH doping improves athletic performance, although the perception that it does is common in the sporting community. Potential side effects of long term GH doping could mirror the symptoms found in sufferers of acromegaly, a disease in which the anterior pituitary gland produces excess growth hormone. These symptoms include swelling of the hands and feet, joint pain, fluid retention, and excessive sweating. Overview Human growth hormone occurs naturally in the human body where it functions by stimulating growth of essentially all tissues, including bone. Use of exogenous human growth hormone (HGH), via injection, was originally for medical purposes until athlete ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Growth Hormone
Growth hormone (GH) or somatotropin, also known as human growth hormone (hGH or HGH) in its human form, is a peptide hormone that stimulates growth, cell reproduction, and cell regeneration in humans and other animals. It is thus important in human development. GH also stimulates production of IGF-1 and increases the concentration of glucose and free fatty acids. It is a type of mitogen which is specific only to the receptors on certain types of cells. GH is a 191-amino acid, single-chain polypeptide that is synthesized, stored and secreted by somatotropic cells within the lateral wings of the anterior pituitary gland. A recombinant form of hGH called somatropin (INN) is used as a prescription drug to treat children's growth disorders and adult growth hormone deficiency. In the United States, it is only available legally from pharmacies by prescription from a licensed health care provider. In recent years in the United States, some health care providers are prescribing growth ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Adverse Drug Reaction
An adverse drug reaction (ADR) is a harmful, unintended result caused by taking medication. ADRs may occur following a single dose or prolonged administration of a drug or result from the combination of two or more drugs. The meaning of this term differs from the term "side effect" because side effects can be beneficial as well as detrimental. The study of ADRs is the concern of the field known as ''pharmacovigilance''. An adverse drug event (ADE) refers to any unexpected and inappropriate occurrence at the time a drug is used, whether or not associated with the administration of the drug. An ADR is a special type of ADE in which a causative relationship can be shown. ADRs are only one type of medication-related harm, as harm can also be caused by omitting to take indicated medications. Classification ADRs may be classified by e.g. cause and severity. Cause *Type A: Augmented pharmacologic effects - dose dependent and predictable :Type A reactions, which constitute approximate ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Lionel Messi
Lionel Andrés Messi (; born 24 June 1987), also known as Leo Messi, is an Argentine professional footballer who plays as a forward for club Paris Saint-Germain and captains the Argentina national team. Widely regarded as one of the greatest players of all time, Messi has won a record seven Ballon d'Or awards, a record six European Golden Shoes, and in 2020 was named to the Ballon d'Or Dream Team. Until leaving the club in 2021, he had spent his entire professional career with Barcelona, where he won a club-record 35 trophies, including 10 La Liga titles, seven Copa del Rey titles and four UEFA Champions Leagues. With his country, he won the 2021 Copa América and the 2022 FIFA World Cup. A prolific goalscorer and creative playmaker, Messi holds the records for most goals in La Liga (474), most hat-tricks in La Liga (36) and the UEFA Champions League (8), and most assists in La Liga (192) and the Copa América (17). He has also the most international goal ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
HGH Controversies
Controversies regarding the use of human growth hormone (HGH) as treatment method have centered on the claims, products, and businesses related to the use of growth hormone as an anti-aging therapy. Most of these controversies fall into two categories: # Claims of exaggerated, misleading, or unfounded assertions that growth hormone treatment safely and effectively slows or reverses the effects of aging. # The sale of products that fraudulently or misleadingly purport to be growth hormone or to increase the user's own secretion of natural human growth hormone to a beneficial degree. History A study was published in ''The New England Journal of Medicine'' in 1990 by Rudman ''et al.'', which showed fat loss, muscle mass increase and maintenance of healthy skin from the administration of growth hormone in twelve elderly men. Despite the fact the authors at no time claimed that GH had reversed the aging process itself, their results were misinterpreted as indicating that GH is an eff ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Growth Hormone Treatment
Growth hormone therapy refers to the use of growth hormone (GH) as a prescription medication—it is one form of hormone therapy. Growth hormone is a peptide hormone secreted by the pituitary gland that stimulates growth and cell reproduction. In the past, growth hormone was extracted from human pituitary glands. Growth hormone is now produced by recombinant DNA technology and is prescribed for a variety of reasons. GH therapy has been a focus of social and ethical controversies for 50 years. This article describes the history of GH treatment and the current uses and risks arising from GH use. Other articles describe GH physiology, diseases of GH excess ( acromegaly and pituitary gigantism), deficiency, the recent phenomenon of HGH controversies, growth hormone in sports, and growth hormone for cows. Medical uses HGH deficiency in children Growth hormone deficiency is treated by replacing growth hormone. Lonapegsomatropin was approved for medical use in the United States i ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Biogenesis Scandal
The Biogenesis scandal broke in 2013 when several Major League Baseball (MLB) players were accused of obtaining performance-enhancing drugs ("PEDs"), specifically human growth hormone, from the now-defunct rejuvenation clinic Biogenesis of America. After an ex-employee, annoyed over missing back-pay, revealed clinic records that were "clear in describing the firm's real business: selling performance-enhancing drugs", MLB sued six people connected to Biogenesis, accusing them of damaging the sport by providing banned substances to its players. In July, thirteen involved players received lengthy suspensions of fifty or more games (nearly a third of a season). Clinic history Biogenesis of America was a health clinic briefly operating in Coral Gables, Florida, specializing in weight loss and hormone replacement therapy. It was first registered in state corporation records in March 2012, and was founded by Anthony Bosch (also listed as the program director). His father, Dr. Pedro Bos ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mitchell Report
The ''Report to the Commissioner of Baseball of an Independent Investigation into the Illegal Use of Steroids and Other Performance Enhancing Substances by Players in Major League Baseball'', informally known as the Mitchell Report, is the result of former Democratic United States Senator from Maine George J. Mitchell's 20-month investigation into the use of anabolic steroids and human growth hormone (HGH) in Major League Baseball (MLB). The 409-page report, released on December 13, 2007, covers the history of the use of illegal performance-enhancing substances by players and the effectiveness of the MLB Joint Drug Prevention and Treatment Program. The report also advances certain recommendations regarding the handling of past illegal drug use and future prevention practices. In addition, the report names 89 MLB players who are alleged to have used steroids or other performance-enhancing drugs. Background A former Senate Majority Leader, federal prosecutor, and ex-chairma ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Placebo
A placebo ( ) is a substance or treatment which is designed to have no therapeutic value. Common placebos include inert tablets (like sugar pills), inert injections (like Saline (medicine), saline), sham surgery, and other procedures. In general, placebos can affect how patients perceive their condition and encourage the body's chemical processes for relieving pain and a few other symptoms, but have no impact on the disease itself. Improvements that patients experience after being treated with a placebo can also be due to unrelated factors, such as regression to the mean (a statistical effect where an unusually high or low measurement is likely to be followed by a less extreme one). The use of placebos in clinical medicine raises ethical concerns, especially if they are disguised as an active treatment, as this introduces dishonesty into the doctor–patient relationship and bypasses informed consent. While it was once assumed that this deception was necessary for placebos to have ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Protein Synthesis
Protein biosynthesis (or protein synthesis) is a core biological process, occurring inside Cell (biology), cells, homeostasis, balancing the loss of cellular proteins (via Proteolysis, degradation or Protein targeting, export) through the production of new proteins. Proteins perform a number of critical functions as enzymes, structural proteins or hormones. Protein synthesis is a very similar process for both prokaryotes and eukaryotes but there are some distinct differences. Protein synthesis can be divided broadly into two phases - Transcription (biology), transcription and Translation (biology), translation. During transcription, a section of DNA encoding a protein, known as a gene, is converted into a template molecule called messenger RNA (mRNA). This conversion is carried out by enzymes, known as RNA polymerases, in the cell nucleus, nucleus of the cell. In eukaryotes, this mRNA is initially produced in a premature form (Primary transcript, pre-mRNA) which undergoes post-tra ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ergogenic Use Of Anabolic Steroids
Since their discovery, anabolic steroids (AAS) have been widely used as performance-enhancing drugs to improve performance in sports, to improve one's physical appearance, as self-medication to recover from injury, and as an anti-aging aid. Use of anabolic steroids for purposes other than treating medical conditions is controversial and, in some cases, illegal. Major sports organizations have moved to ban the use of anabolic steroids. There is a wide range of health concerns for users. Legislation in many countries restricts and criminalizes AAS possession and trade. History Performance-enhancing substances have been used for thousands of years in traditional medicine by societies around the world, with the aim of promoting vitality and strength. The use of gonadal hormones pre-dates their identification and isolation. Medical use of testicle extract began in the late 19th century, while its effects on strength were still being studied. In 1889, the 72-year-old Mauritian neurol ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
United States House Committee On Oversight And Government Reform
The Committee on Oversight and Reform is the main investigative committee of the United States House of Representatives. The committee's broad jurisdiction and legislative authority make it one of the most influential and powerful panels in the House. Its chairman is one of only three in the House with the authority to issue subpoenas without a committee vote or consultation with the ranking member. However, in recent history, it has become practice to refrain from unilateral subpoenas. Carolyn Maloney ( D-New York) served as acting chair of the committee following the death of Elijah Cummings ( D-Maryland) on October 17, 2019; she was elected chair a month later. Representative Jim Jordan served as ranking member from January 3, 2019, until March 12, 2020. On March 31, 2020, Jordan started his second stint as ranking member. Representative Mark Meadows served as ranking member from March 13, 2020, until March 30, 2020, when he resigned his congressional seat to become White Ho ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Meta-analysis
A meta-analysis is a statistical analysis that combines the results of multiple scientific studies. Meta-analyses can be performed when there are multiple scientific studies addressing the same question, with each individual study reporting measurements that are expected to have some degree of error. The aim then is to use approaches from statistics to derive a pooled estimate closest to the unknown common truth based on how this error is perceived. Meta-analytic results are considered the most trustworthy source of evidence by the evidence-based medicine literature.Herrera Ortiz AF., Cadavid Camacho E, Cubillos Rojas J, Cadavid Camacho T, Zoe Guevara S, Tatiana Rincón Cuenca N, Vásquez Perdomo A, Del Castillo Herazo V, & Giraldo Malo R. A Practical Guide to Perform a Systematic Literature Review and Meta-analysis. Principles and Practice of Clinical Research. 2022;7(4):47–57. https://doi.org/10.21801/ppcrj.2021.74.6 Not only can meta-analyses provide an estimate of the un ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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