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Golgi Cell
In neuroscience, Golgi cells are inhibitory interneurons found within the granular layer of the cerebellum. They were first identified as inhibitory in 1964. It was also the first example of an inhibitory feedback network, where the inhibitory interneuron was identified anatomically. These cells synapse onto the dendrite of granule cells and unipolar brush cells. They receive excitatory input from mossy fibres, also synapsing on granule cells, and parallel fibers, which are long granule cell axons. Thereby this circuitry allows for feed-forward and feed-back inhibition of granule cells. The main synapse made by these cells is a synapse onto the mossy fibre - granule cell excitatory synapse in a glomerulus. The glomerulus is made up of the mossy fibre terminal, granule cell dendrites, the Golgi terminal and is enclosed by a glial coat. The Golgi cell acts by altering the mossy fibre - granule cell synapse. The Golgi cells use GABA as their neurotransmitter. The basal level of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Excitatory Synapses
An excitatory synapse is a synapse in which an action potential in a presynaptic neuron increases the probability of an action potential occurring in a postsynaptic cell. Neurons form networks through which nerve impulses travel, each neuron often making numerous connections with other cells. These electrical signals may be excitatory or inhibitory, and, if the total of excitatory influences exceeds that of the inhibitory influences, the neuron will generate a new action potential at its axon hillock, thus transmitting the information to yet another cell. This phenomenon is known as an excitatory postsynaptic potential (EPSP). It may occur via direct contact between cells (i.e., via gap junctions), as in an electrical synapse, but most commonly occurs via the vesicular release of neurotransmitters from the presynaptic axon terminal into the synaptic cleft, as in a chemical synapse. The excitatory neurotransmitters, the most common of which is glutamate, then migrate via di ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nature (journal)
''Nature'' is a British weekly scientific journal founded and based in London, England. As a multidisciplinary publication, ''Nature'' features peer-reviewed research from a variety of academic disciplines, mainly in science and technology. It has core editorial offices across the United States, continental Europe, and Asia under the international scientific publishing company Springer Nature. ''Nature'' was one of the world's most cited scientific journals by the Science Edition of the 2019 ''Journal Citation Reports'' (with an ascribed impact factor of 42.778), making it one of the world's most-read and most prestigious academic journals. , it claimed an online readership of about three million unique readers per month. Founded in autumn 1869, ''Nature'' was first circulated by Norman Lockyer and Alexander Macmillan as a public forum for scientific innovations. The mid-20th century facilitated an editorial expansion for the journal; ''Nature'' redoubled its efforts in exp ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Journal Of Neuroscience
A journal, from the Old French ''journal'' (meaning "daily"), may refer to: *Bullet journal, a method of personal organization *Diary, a record of what happened over the course of a day or other period *Daybook, also known as a general journal, a daily record of financial transactions *Logbook, a record of events important to the operation of a vehicle, facility, or otherwise *Record (other) *Transaction log, a chronological record of data processing *Travel journal In publishing, ''journal'' can refer to various periodicals or serials: *Academic journal, an academic or scholarly periodical **Scientific journal, an academic journal focusing on science **Medical journal, an academic journal focusing on medicine **Law review, a professional journal focusing on legal interpretation *Magazine, non-academic or scholarly periodicals in general **Trade magazine, a magazine of interest to those of a particular profession or trade **Literary magazine, a magazine devoted to literat ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Anatomy And Embryology
''Brain Structure and Function'' is a bimonthly peer-reviewed scientific journal covering research on brain structure-function relationships. It was established in 1891 as ''Anatomische Hefte'', renamed first ''Zeitschrift für Anatomie und Entwicklungsgeschichte'' in 1921 and then ''Anatomy and Embryology'' in 1974, before obtaining its current name in 2007. It is published by Springer Science+Business Media and the editors-in-chief are Michel Thiebaut de Schotten and Susan R. Sesack. Abstracting and indexing The journal is abstracted and indexed in: According to the ''Journal Citation Reports'', the journal has a 2020 impact factor The impact factor (IF) or journal impact factor (JIF) of an academic journal is a scientometric index calculated by Clarivate that reflects the yearly mean number of citations of articles published in the last two years in a given journal, as i ... of 3.270. References External links * {{DEFAULTSORT:Brain Structure and Function Neuroscienc ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Dendrite
Dendrites (from Greek δένδρον ''déndron'', "tree"), also dendrons, are branched protoplasmic extensions of a nerve cell that propagate the electrochemical stimulation received from other neural cells to the cell body, or soma, of the neuron from which the dendrites project. Electrical stimulation is transmitted onto dendrites by upstream neurons (usually via their axons) via synapses which are located at various points throughout the dendritic tree. Dendrites play a critical role in integrating these synaptic inputs and in determining the extent to which action potentials are produced by the neuron. Dendritic arborization, also known as dendritic branching, is a multi-step biological process by which neurons form new dendritic trees and branches to create new synapses. The morphology of dendrites such as branch density and grouping patterns are highly correlated to the function of the neuron. Malformation of dendrites is also tightly correlated to impaired nervous syste ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Glomerulus (cerebellum)
The cerebellar glomerulus is a small, intertwined mass of nerve fiber terminals in the granular layer of the cerebellar cortex. It consists of post-synaptic granule cell dendrites and pre-synaptic Golgi cell axon terminals surrounding the pre-synaptic terminals of mossy fibers. Function The cerebellar glomeruli are the first "processing station" for afferent nerve fibers entering the cerebellum. Input comes from the mossy fibers, which terminate there and synapse with the Golgi and granule cell fibers. The Golgi cells regulate the glomeruli with inhibitory signals, while information is passed on to the granule and Golgi cells from the mossy fiber. Structure A cerebellar glomerulus is about 2.5 um in diameter, and is wrapped by glial sheathing. Glomeruli are centered on the large axonal terminals of glutamatergic afferent mossy fibers. Each terminal comes into contact with dendrites from 50–60 different granule cells. The granule cells themselves each have a single or mul ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Parallel Fiber
Parallel is a geometric term of location which may refer to: Computing * Parallel algorithm * Parallel computing * Parallel metaheuristic * Parallel (software), a UNIX utility for running programs in parallel * Parallel Sysplex, a cluster of IBM mainframes * Parallel communication * Parallel port * Parallel ATA * Parallel Computers, Inc., an American computer manufacturer of the 1980s Mathematics and science * Parallel circuits, as opposed to series * Parallel (geometry) *Parallel (operator), mathematical function used in electrical engineering * Parallel postulate * Parallel evolution * Parallel transport * Parallel manipulator Navigation * Parallel (latitude), an imaginary east–west line circling a globe * Parallel of declination, used in astronomy Music and entertainment * ''Parallel'' (manga) * ''Parallel'' (2018 film), a Canadian science fiction thriller film * Parallel (2023 film) an upcoming American science fiction thriller film * Parallel key, the minor (o ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Granule Cells
A granule is a large particle or grain. It can refer to: * Granule (cell biology), any of several submicroscopic structures, some with explicable origins, others noted only as cell type-specific features of unknown function ** Azurophilic granule, a structure characteristic of the azurophil eukaryotic cell type ** Chromaffin granule, a structure characteristic of the chromophil eukaryotic cell type. * Astrophysics and geology: ** Granule (solar physics), a visible structure in the photosphere of the Sun arising from activity in the Sun's convective zone ** Martian spherules, spherical granules of material found on the surface of the planet Mars ** Granule (geology), a specified particle size of 2–4 millimetres (-1 to -2 on the φ scale) * Granule, in pharmaceutical terms, small particles gathered into a larger, permanent aggregate in which the original particles can still be identified * Granule (Oracle DBMS), a unit of contiguously allocated virtual memory * Granular synthesis ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mossy Fiber (cerebellum)
Mossy fibers are one of the major inputs to cerebellum. There are many sources of this pathway, the largest of which is the cerebral cortex, which sends input to the cerebellum via the pontocerebellar pathway. Other contributors include the vestibular nerve and nuclei, the spinal cord, the reticular formation, and feedback from deep cerebellar nuclei. Axons enter the cerebellum via the middle and inferior cerebellar peduncles, where some branch to make contact with deep cerebellar nuclei. They ascend into the white matter of the cerebellum, where each axon branches to innervate granule cells in several cerebellar folia. In this case, the pathway is so named for a unique synapse formed by its projections, the ''mossy fiber rosette''. Fine branches of the mossy fiber axons twist through the granule cell layer, and slight enlargements giving a knotted appearance indicate synaptic contacts. These contacts have the appearance of a classic Gray's type 1 synapse, indicating they are ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Unipolar Brush Cell
Unipolar brush cells (UBCs) are a class of excitatory glutamatergic interneuron found in the granular layer of the cerebellar cortex and also in the granule cell domain of the cochlear nucleus. Structure The UBC has a round or oval cell body with usually a single short dendrite that ends in a brush-like tuft of short dendrioles (dendrites unique to UBCs). These brush dendrioles form very large synaptic junctions. The dendritic brush and the large endings of the axonal branches are involved in the formation of cerebellar glomeruli. The UBC has one short dendrite where the granule cell has four or five. The brush dendrioles emit numerous, thin evaginations called filopodia, unique to UBCs. The filopodia emanate from all over the neuron, even including the dendritic stem and the cell body in some cells. Although UBC filopodia do not bear synaptic junctions, they are nevertheless involved in cell signaling. Function UBCs are intrinsically firing neurons and considered as a cla ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Granule Cell
A granule is a large particle or grain. It can refer to: * Granule (cell biology), any of several submicroscopic structures, some with explicable origins, others noted only as cell type-specific features of unknown function ** Azurophilic granule, a structure characteristic of the azurophil eukaryotic cell type ** Chromaffin granule, a structure characteristic of the chromophil eukaryotic cell type. * Astrophysics and geology: ** Granule (solar physics), a visible structure in the photosphere of the Sun arising from activity in the Sun's convective zone ** Martian spherules, spherical granules of material found on the surface of the planet Mars ** Granule (geology), a specified particle size of 2–4 millimetres (-1 to -2 on the φ scale) * Granule, in pharmaceutical terms, small particles gathered into a larger, permanent aggregate in which the original particles can still be identified * Granule (Oracle DBMS), a unit of contiguously allocated virtual memory * Granular synthesis ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
