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Gluten-free, Casein-free Diet
A gluten-free casein-free diet (GFCF diet), also known as a gluten-free dairy-free diet (GFDF diet), is a diet that does not include gluten (found most often in wheat, barley, and rye), and casein (found most often in milk and dairy products). Despite an absence of scientific evidence, there have been advocates for the use of this diet as a treatment for autism and related conditions. Uses Autism The majority of the available evidence does not support the use of this diet in the treatment of autism. * American Academy of Pediatrics – Clinical Report (2007) In their report, the AAP did not recommend the use of special diets for children with autism spectrum disorder because of inadequate evidence. * Cochrane Library – Gluten and Casein-free diets in autism spectrum disorder (2008) The Cochrane review found that while relatively commonly used the evidence to support the diets use in children with autism was poor. All studies as of 2006 had issues with them. * '' Research in ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gluten
Gluten is a structural protein naturally found in certain cereal grains. Although "gluten" often only refers to wheat proteins, in medical literature it refers to the combination of prolamin and glutelin proteins naturally occurring in all grains that have been proved capable of triggering celiac disease. These include any species of wheat (such as common wheat, durum, spelt, khorasan, emmer and einkorn), barley, rye and some oat cultivars, as well as any cross hybrids of these grains (such as triticale). Gluten makes up 75–85% of the total protein in bread wheat. Glutens, especially Triticeae glutens, have unique viscoelastic and adhesive properties, which give dough its elasticity, helping it rise and keep its shape and often leaving the final product with a chewy texture. These properties, and its relatively low cost, make gluten valuable to both food and non-food industries. Wheat gluten is composed of mainly two types of proteins: the glutenins and the gliadins, which i ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pacific Islands
Collectively called the Pacific Islands, the islands in the Pacific Ocean are further categorized into three major island groups: Melanesia, Micronesia, and Polynesia. Depending on the context, the term ''Pacific Islands'' may refer to one of several different concepts: (1) those countries and islands with common Austronesian origins, (2) the islands once (or currently) colonized, or (3) the geographical region of Oceania. This list of islands in the Pacific Ocean is organized by archipelago or border, political boundary. In order to keep this list of moderate size, the more complete lists for countries with large numbers of small or uninhabited islands have been hyperlinked. Name ambiguity and groupings The umbrella term ''Pacific Islands'' has taken on several meanings. Sometimes it is used to refer only to the islands defined as lying within Oceania Oceania (, , ) is a region, geographical region that includes Australasia, Melanesia, Micronesia, and Polynesia. Spann ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gliadorphin
Gliadorphin (also known as gluteomorphin) is an opioid peptide that is formed during digestion of the gliadin component of the gluten protein. It is usually broken down into amino acids by digestion enzymes. It has been hypothesized that children with autism have abnormal leakage from the gut of this compound. This is partly the basis for the gluten-free, casein-free diet A gluten-free casein-free diet (GFCF diet), also known as a gluten-free dairy-free diet (GFDF diet), is a diet that does not include gluten (found most often in wheat, barley, and rye), and casein (found most often in milk and dairy products). De .... Abnormally high levels of gliadorphin have been found in the urine of autistic children via mass spectrometry testing. References Opioid peptides {{organic-compound-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gluten Exorphine
Gluten exorphins are a group of opioid peptides formed during the digestion of the gluten Gluten is a structural protein naturally found in certain cereal grains. Although "gluten" often only refers to wheat proteins, in medical literature it refers to the combination of prolamin and glutelin proteins naturally occurring in all grai ... protein. These peptides work as external regulators for gastrointestinal movement and hormonal release. The breakdown of gliadin, a polymer of wheat proteins, creates amino acids that stop the gluten epitopes from entering the immune system to activate inflammatory reactions. During this process, gluten does not fully break down, thus increasing the presence of gluten exorphins. Because of this, researchers think this is what might lead to various diseases. Research shows the benefits of gluten- and casein-free diets for people with diseases and disorders connected to gluten exorphins. The mechanism behind this is still unknown. There is a possi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Casomorphine
Casomorphin is an opioid peptide (protein fragment) derived from the digestion of the milk protein casein. Health Digestive enzymes can break casein down into peptides that have some biological activity in cells and in laboratory animals though conclusive causal effects on humans have not been established.European Food Safety Authority. 1 February 200Review of the potential health impact of β-casomorphins and related peptides/ref> Although research has shown high rates of use of complementary and alternative therapies for children with autism, including gluten and/or casein exclusion diets, there was a lack of evidence that these diets had any effect. If opioid peptides breach the intestinal barrier, typically linked to permeability and constrained biosynthesis of dipeptidyl peptidase-4 (DPP4), they can attach to opioid receptors. Elucidation requires a systemic framework that acknowledges that public-health effects of food-derived opioids are complex with varying genetic s ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Opioid Peptide
Opioid peptides are peptides that bind to opioid receptors in the brain; opiates and opioids mimic the effect of these peptides. Such peptides may be produced by the body itself, for example endorphins. The effects of these peptides vary, but they all resemble those of opiates. Brain opioid peptide systems are known to play an important role in motivation, emotion, attachment behaviour, the response to stress and pain, control of food intake, and the rewarding effects of alcohol and nicotine. Opioid-like peptides may also be absorbed from partially digested food (casomorphins, exorphins, and rubiscolins). The opioid food peptides have lengths of typically 4–8 amino acids. The body's own opioids are generally much longer. Opioid peptides are released by post-translational proteolytic cleavage of precursor proteins. The precursors consist of the following components: a signal sequence that precedes a conserved region of about 50 residues; a variable-length region; and the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Paul Shattock
Paul Shattock is a British autism researcher and scientific consultant to the charity Education and Services for People with Autism, of which he is also the founder. He was formerly the director of the Autism Research Unit at the University of Sunderland. He is well known for his disputed research into dietary therapy and autism, having claimed that autistic children may have a " leaky gut" which allows certain peptides to enter the bloodstream, and claimed that they excrete unusually high levels thereof. As a result of this speculation, he has promoted the use of a gluten-free, casein-free diet A gluten-free casein-free diet (GFCF diet), also known as a gluten-free dairy-free diet (GFDF diet), is a diet that does not include gluten (found most often in wheat, barley, and rye), and casein (found most often in milk and dairy products). De ... to ameliorate the symptoms of autism, a theory he developed along with Kalle Reichelt. In addition, he has claimed that a protein found ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Opioid Excess Theory
The opioid excess theory is a theory which postulates that autism is the result of a metabolic disorder in which opioid peptides produced through metabolism of gluten and casein pass through an abnormally permeable intestinal membrane and then proceed to exert an effect on neurotransmission through binding with opioid receptors. It is believed by advocates of this hypothesis that autistic children are unusually sensitive to gluten, which results in small bowel inflammation in these children, which in turn allows these opioid peptides to enter the brain. Early years This hypothesis was first proposed by Jaak Panksepp in a 1979 paper, in which he speculated that autism might be "an emotional disturbance arising from an upset in the opiate systems in the brain." Kalle Reichelt then emerged as one of the leading advocates of this theory, publishing papers alleging that "the patterns of peptides and associated proteins from urinary samples rom people with autismdiffer considerably fr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Opiate
An opiate, in classical pharmacology, is a substance derived from opium. In more modern usage, the term ''opioid'' is used to designate all substances, both natural and synthetic, that bind to opioid receptors in the brain (including antagonists). Opiates are alkaloid compounds naturally found in the opium poppy plant ''Papaver somniferum''. The psychoactive compounds found in the opium plant include morphine, codeine, and thebaine. Opiates have long been used for a variety of medical conditions with evidence of opiate trade and use for pain relief as early as the eighth century AD. Opiates are considered drugs with moderate to high abuse potential and are listed on various "Substance-Control Schedules" under the Uniform Controlled Substances Act of the United States of America. In 2014, between 13 and 20 million people used opiates recreationally (0.3% to 0.4% of the global population between the ages of 15 and 65). According to the CDC, from this population, there were 47,00 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Urine
Urine is a liquid by-product of metabolism in humans and in many other animals. Urine flows from the kidneys through the ureters to the urinary bladder. Urination results in urine being excretion, excreted from the body through the urethra. Cell (biology), Cellular metabolism generates many by-products that are rich in nitrogen and must be clearance (medicine), cleared from the Circulatory system, bloodstream, such as urea, uric acid, and creatinine. These by-products are expelled from the body during urination, which is the primary method for excreting water-soluble chemicals from the body. A urinalysis can detect nitrogenous wastes of the mammalian body. Urine plays an important role in the earth's nitrogen cycle. In balanced ecosystems, urine fertilizes the soil and thus helps plants to grow. Therefore, Reuse of excreta, urine can be used as a fertilizer. Some animals use it to territory (animal)#Scent marking, mark their territories. Historically, aged or fermented urine (kn ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Kalle Reichelt
Karl Ludvig "Kalle" Reichelt (28 November 1933 – 29 October 2016) was a Norwegian medical researcher. He was best known for his research on the opioid peptides in casein and gluten. He also did important work on cancer. In 1972, he delivered his PhD thesis at the University of Oslo: ''“An investigation into the nature and function of anionic acids, peptides, and acid-soluble proteins from brain tissue”''. The voluntary associationbr>Mat og Atferd (in English Food & Behaviour is established in Norway on the basis of Reichelt´s work. He worked daily at Rikshospitalet Oslo University Hospital, Rikshospitalet is one of the four main campuses of Oslo University Hospital in Oslo, Norway. It was an independent hospital, ''Rigshospitalet'', later spelled ''Rikshospitalet'' ("The National Hospital"), from 1826 to 200 ..., Norwegian for the National Hospital, in Oslo, Norway, until medio 2012 as a senior researcher and advisor. Karl Ludvig Reichelt received HM The King's Medal o ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Jaak Panksepp
Jaak Panksepp (June 5, 1943 – April 18, 2017) was an Estonian-American neuroscientist and psychobiologist who coined the term "affective neuroscience", the name for the field that studies the neural mechanisms of emotion. He was the Baily Endowed Chair of Animal Well-Being Science for the Department of Veterinary and Comparative Anatomy, Pharmacology, and Physiology at Washington State University's College of Veterinary Medicine, and Emeritus Professor of the Department of Psychology at Bowling Green State University. He was known in the popular press for his research on laughter in non-human animals. Early life and education Panksepp was born in Estonia on June 5, 1943. His family escaped the ravages of post-WWII Soviet occupation by moving to the United States when he was very young. He studied initially at University of Pittsburgh in 1964, and then completed a Ph.D. at the University of Massachusetts. Research Panksepp conducted many experiments; in one with rats, he foun ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
