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Gladys Lounsbury Hobby
Gladys Lounsbury Hobby (November 19, 1910 – July 4, 1993), born in New York City, was an American microbiologist whose research played a key role in the development and understanding of antibiotics. Her work took penicillin from a laboratory experiment to a mass-produced drug during World War II. Life and career Hobby was born in the Washington Heights neighbourhood in New York City, one of two daughters of Theodore Y. Hobby and Flora R. Lounsbury. Her mother taught in the New York public schools system, and her father was a close associate of the philanthropist and collector, Benjamin Altman. Theodore eventually oversaw the Benjamin Altman collection in the Metropolitan Museum of Art. After attending high school in White Plains, New York,9 Hobby graduated from Vassar College in 1931 with a degree in chemistry. She earned her and Ph.D. in bacteriology from Columbia University in 1935. She wrote her doctoral thesis on the medical uses of nonpathogenic organisms. Hobby worked fo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
New York City
New York, often called New York City or NYC, is the List of United States cities by population, most populous city in the United States. With a 2020 population of 8,804,190 distributed over , New York City is also the List of United States cities by population density, most densely populated major city in the United States, and is more than twice as populous as second-place Los Angeles. New York City lies at the southern tip of New York (state), New York State, and constitutes the geographical and demographic center of both the Northeast megalopolis and the New York metropolitan area, the largest metropolitan area in the world by urban area, urban landmass. With over 20.1 million people in its metropolitan statistical area and 23.5 million in its combined statistical area as of 2020, New York is one of the world's most populous Megacity, megacities, and over 58 million people live within of the city. New York City is a global city, global Culture of New ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pfizer Pharmaceuticals
Pfizer Inc. ( ) is an American multinational pharmaceutical and biotechnology corporation headquartered on 42nd Street in Manhattan, New York City. The company was established in 1849 in New York by two German entrepreneurs, Charles Pfizer (1824–1906) and his cousin Charles F. Erhart (1821–1891). Pfizer develops and produces medicines and vaccines for immunology, oncology, cardiology, endocrinology, and neurology. The company has several blockbuster drugs or products that each generate more than billion in annual revenues. In 2020, 52% of the company's revenues came from the United States, 6% came from each of China and Japan, and 36% came from other countries. Pfizer was a component of the Dow Jones Industrial Average stock market index from 2004 to August 2020. The company ranks 64th on the Fortune 500 and 49th on the Forbes Global 2000. History 1849–1950: Early history Pfizer was founded in 1849 by Charles Pfizer and Charles F. Erhart, two cousins who had immi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
1993 Deaths
File:1993 Events Collage.png, From left, clockwise: The Oslo I Accord is signed in an attempt to resolve the Israeli–Palestinian conflict; The Russian White House is shelled during the 1993 Russian constitutional crisis; Czechoslovakia is peacefully dissolved into the Czech Republic and Slovakia; In the United States, the ATF besieges a compound belonging to David Koresh and the Branch Davidians in a search for illegal weapons, which ends in the building being set alight and killing most inside; Eritrea gains independence; A major snow storm passes over the United States and Canada, leading to over 300 fatalities; Drug lord and narcoterrorist Pablo Escobar is killed by Colombian special forces; Ramzi Yousef and other Islamic terrorists detonate a truck bomb in the subterranean garage of the North Tower of the World Trade Center in the United States., 300x300px, thumb rect 0 0 200 200 Oslo I Accord rect 200 0 400 200 1993 Russian constitutional crisis rect 400 0 600 200 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
1910 Births
Year 191 ( CXCI) was a common year starting on Friday (link will display the full calendar) of the Julian calendar. At the time, it was known as the Year of the Consulship of Apronianus and Bradua (or, less frequently, year 944 ''Ab urbe condita''). The denomination 191 for this year has been used since the early medieval period, when the Anno Domini calendar era became the prevalent method in Europe for naming years. Events By place Parthia * King Vologases IV of Parthia dies after a 44-year reign, and is succeeded by his son Vologases V. China * A coalition of Chinese warlords from the east of Hangu Pass launches a punitive campaign against the warlord Dong Zhuo, who seized control of the central government in 189, and held the figurehead Emperor Xian hostage. After suffering some defeats against the coalition forces, Dong Zhuo forcefully relocates the imperial capital from Luoyang to Chang'an. Before leaving, Dong Zhuo orders his troops to loot the tombs of the Ha ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Viomycin
Viomycin is a member of the tuberactinomycin family, a group of nonribosomal peptide antibiotics exhibiting anti-tuberculosis activity. The tuberactinomycin family is an essential component in the drug cocktail currently used to fight infections of ''Mycobacterium tuberculosis''. Viomycin was the first member of the tuberactinomycins to be isolated and identified, and was used to treat TB until it was replaced by the less toxic, but structurally related compound, capreomycin. The tuberactinomycins target bacterial ribosomes, binding RNA and disrupting bacterial protein synthesis and certain forms of RNA splicing. Viomycin is produced by the actinomycete ''Streptomyces puniceus''. Biosynthesis The gene cluster for viomycin has been sequenced from ''Streptomyces sp.'' strain ATCC 11861, ''Streptomyces vinaceus'' and from ''Streptomyces lividans'' 1326. It consists of a central cyclic pentapeptide code assembled from nonribosomal peptide synthetase (NRPS). The NRPS contains 4 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Oxytetracycline
Oxytetracycline is a broad-spectrum tetracycline antibiotic, the second of the group to be discovered. Oxytetracycline works by interfering with the ability of bacteria to produce essential proteins. Without these proteins, the bacteria cannot grow, multiply and increase in numbers. Oxytetracycline therefore stops the spread of the infection and the remaining bacteria are killed by the immune system or eventually die. Oxytetracycline is a broad-spectrum antibiotic, active against a wide variety of bacteria. However, some strains of bacteria have developed resistance to this antibiotic, which has reduced its effectiveness for treating some types of infections. Oxytetracycline is used to treat infections caused by ''Chlamydia'' (e.g. the chest infection psittacosis, the eye infection trachoma, and the genital infection urethritis) and infections caused by ''Mycoplasma'' organisms (e.g. pneumonia). Oxytetracycline is also used to treat acne, due to its activity against the bact ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ernst Chain
Sir Ernst Boris Chain (19 June 1906 – 12 August 1979) was a German-born British biochemist best known for being a co-recipient of the Nobel Prize in Physiology or Medicine for his work on penicillin. Life and career Chain was born in Berlin, the son of Margarete () and Michael Chain, a chemist and industrialist dealing in chemical products. His family was of both Sephardic and Ashkenazi Jewish descent. His father emigrated from Russia to study chemistry abroad and his mother was from Berlin. In 1930, he received his degree in chemistry from Friedrich Wilhelm University. His father descends from Zerahiah ben Shealtiel Ḥen who was a prominent figure among the Catalonian Jewry and whose ancestors were leading Jewish figures in Babylonia. He was a lifelong friend of Professor Albert Neuberger, whom he met in Berlin in the 1930s. After the Nazis came to power, Chain understood that, being Jewish, he would no longer be safe in Germany. He left Germany and moved to Eng ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Howard Florey
Howard Walter Florey, Baron Florey (24 September 189821 February 1968) was an Australian pharmacologist and pathologist who shared the Nobel Prize in Physiology or Medicine in 1945 with Sir Ernst Chain and Sir Alexander Fleming for his role in the development of penicillin. Although Fleming received most of the credit for the discovery of penicillin, it was Florey who carried out the first clinical trials of penicillin in 1941 at the Radcliffe Infirmary in Oxford on the first patient, a police constable from Oxford. The patient started to recover, but subsequently died because Florey was unable, at that time, to make enough penicillin. It was Florey and Chain who actually made a useful and effective drug out of penicillin, after the task had been abandoned as too difficult. Florey's discoveries, along with the discoveries of Fleming and Ernst Chain, are estimated to have saved over 200 million lives, and he is consequently regarded by the Australian scientific and medical comm ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Manhattan Project
The Manhattan Project was a research and development undertaking during World War II that produced the first nuclear weapons. It was led by the United States with the support of the United Kingdom and Canada. From 1942 to 1946, the project was under the direction of Major General Leslie Groves of the United States Army Corps of Engineers, U.S. Army Corps of Engineers. Nuclear physicist Robert Oppenheimer was the director of the Los Alamos Laboratory that designed the actual bombs. The Army component of the project was designated the Manhattan District as its first headquarters were in Manhattan; the placename gradually superseded the official codename, Development of Substitute Materials, for the entire project. Along the way, the project absorbed its earlier British counterpart, Tube Alloys. The Manhattan Project began modestly in 1939, but grew to employ more than 130,000 people and cost nearly US$2 billion (equivalent to about $ billion in ). Over 90 percent of th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Antimicrobial Agents And Chemotherapy
''Antimicrobial Agents and Chemotherapy'' is a peer-reviewed scientific journal published by the American Society for Microbiology. It covers antimicrobial, antiviral, antifungal, and antiparasitic agents and chemotherapy. The editor-in-chief is Cesar A. Arias (University of Texas Health Science Center at Houston). It was established in 1972 by Gladys Lounsbury Hobby. __TOC__ Abstracting and indexing The journal is abstracted and indexed in: According to the ''Journal Citation Reports'', its 2021 impact factor The impact factor (IF) or journal impact factor (JIF) of an academic journal is a scientometric index calculated by Clarivate that reflects the yearly mean number of citations of articles published in the last two years in a given journal, as i ... is 5.938, ranking it 51st out of 279 journals in the category ''Pharmacology & Pharmacy'' and 35th out of 137 journals in the category ''Microbiology''. References External links * Delayed open access journals Pu ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cornell University Medical College
The Joan & Sanford I. Weill Medical College of Cornell University is Cornell University's biomedical research unit and medical school located in Upper East Side, Manhattan, New York City, New York. Weill Cornell Medicine is affiliated with NewYork-Presbyterian Hospital, Weill Cornell Medical Center, Hospital for Special Surgery, Memorial Sloan Kettering Cancer Center, and Rockefeller University, all of which are located nearby on York Avenue. Weill Cornell's clinical affiliates rank highly, with the NewYork-Presbyterian Hospital ranked #1 in the region and #4 in the nation, the Hospital for Special Surgery ranked #1 in the nation for orthopedics and the Memorial Sloan Kettering Center #2 for cancer. Memorial Sloan Kettering Cancer Center and Rockefeller University joined Weill Cornell to establish the Tri-Institutional MD–PhD Program in 1991. In 2001, the school opened a campus in Qatar. Weill Cornell has also been affiliated with Houston Methodist Hospital since 2004. On S ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
East Orange, New Jersey
East Orange is a City (New Jersey), city in Essex County, New Jersey, Essex County, in the U.S. state of New Jersey. As of the 2020 United States census, 2020 U.S. census, the city's population was 69,612. The city was List of municipalities in New Jersey, the state's 20th most-populous municipality in 2010, after having been the state's 14th most-populous municipality in 2000.The Counties and Most Populous Cities and Townships in 2010 in New Jersey: 2000 and 2010 New Jersey Department of Labor and Workforce Development. Accessed November 3, 2019. The United States Census Bureau, Census Bureau's Population Estimates Program calculated that the city's population was 68,903 in 2021, ranking the city the List of United St ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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