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Giuseppe Guarnieri
Giuseppe Guarnieri (April 20, 1856 - August 15, 1918) was an Italian physician. Dr. Guarnieri made his most famous discovery in 1892 while examining thin tissue cells damaged by smallpox. He discovered small bodies of protein clusters that he mistook for bacteria, but were actually clusters of viral proteins crucial in the replication of Poxviridae, pox viruses. He named these protein masses ''Cytorrhyctes variolae'' ("the cell destroyer of smallpox") but they were eventually properly identified and named Guarnieri bodies. References 1856 births 1918 deaths 19th-century Italian physicians {{Italy-med-bio-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Offida
Offida () is a ''comune'' (municipality) in the Province of Ascoli Piceno in the Italian region Marche, located about south of Ancona and about northeast of Ascoli Piceno, on a rocky spur between the valleys of the Tesino (from north) and Tronto (south) rivers. History The origins of Offida are debated. In its territory have been found tombs of the Piceni (7th–5th century BC) and Roman remains; however, the town is known only from 578 AD when the population, fleeing the Lombard invasion, founded several castles in the area, included that of Offida. The true first historical mention dates to 1039, when the Abbey of Farfa received the castle of ''Ophida'', being confirmed in 1261 by Pope Urban IV. During the war between the communes of Ascoli and Fermo, Offida sided for the latter. In the early 16th century Offida signed a truce with Ascoli while, in the same period, all the lands of the Farfa Abbey went to the Papal States. From the late 19th century the economy, from a w ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Italy
Italy ( it, Italia ), officially the Italian Republic, ) or the Republic of Italy, is a country in Southern Europe. It is located in the middle of the Mediterranean Sea, and its territory largely coincides with the homonymous geographical region. Italy is also considered part of Western Europe, and shares land borders with France, Switzerland, Austria, Slovenia and the enclaved microstates of Vatican City and San Marino. It has a territorial exclave in Switzerland, Campione. Italy covers an area of , with a population of over 60 million. It is the third-most populous member state of the European Union, the sixth-most populous country in Europe, and the tenth-largest country in the continent by land area. Italy's capital and largest city is Rome. Italy was the native place of many civilizations such as the Italic peoples and the Etruscans, while due to its central geographic location in Southern Europe and the Mediterranean, the country has also historically been home ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Guarnieri Bodies
Orthopoxvirus inclusion bodies are aggregates of stainable protein produced by poxvirus virions in the cell nuclei and/or cytoplasm of epithelial cells in humans. They are important as sites of viral replication. Morphology Morphologically there are two types of Orthopoxvirus inclusion bodies, Type-A inclusion bodies and Guarnieri bodies. Type-A inclusion bodies are found only in certain poxviruses like cowpox. The Guarnieri bodies are found in all poxvirus infections and their presence is diagnostic. The diagnosis of an orthopoxvirus infection can also be made rapidly by electron microscopic examination of pustular fluid or scabs. However, all orthopoxviruses exhibit identical brick-shaped virions A virus is a submicroscopic infectious agent that replicates only inside the living cells of an organism. Viruses infect all life forms, from animals and plants to microorganisms, including bacteria and archaea. Since Dmitri Ivanovsky's ... by electron microscopy. Guarnie ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Giuseppe Guarneri
Bartolomeo Giuseppe "del Gesù" Guarneri (, , ; 21 August 1698 – 17 October 1744) was an Italian luthier from the Guarneri family of Cremona. He rivals Antonio Stradivari (1644–1737) with regard to the respect and reverence accorded his instruments, and for many prominent players and collectors his instruments are the most coveted of all. Instruments made by Guarneri are often referred to as ''Del Gesùs''. Guarneri is known as ''del Gesù'' (literally "of Jesus") because his labels after 1731 incorporated the ''nomen sacrum'', IHS (''iota-eta-sigma'') and a cross fleury. His instruments diverged significantly from family tradition, becoming uniquely his own style. They are considered equal in quality to those of Stradivari, and claimed by some to be superior. Guarneri's violins often have a darker, more robust, more sonorous tone than Stradivari's. Fewer than 200 of Guarneri's instruments survive. They are all violins, although one cello bearing his father's label, dated 173 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
1892
Events January–March * January 1 – Ellis Island begins accommodating immigrants to the United States. * February 1 - The historic Enterprise Bar and Grill was established in Rico, Colorado. * February 27 – Rudolf Diesel applies for a patent, on his compression ignition engine (the Diesel engine). * February 29 – St. Petersburg, Florida is incorporated as a town. * March 1 – Theodoros Deligiannis ends his term as Prime Minister of Greece, and Konstantinos Konstantopoulos takes office. * March 6– 8 – "Exclusive Agreement": Rulers of the Trucial States (Abu Dhabi, Dubai, Sharjah, Ajman, Ras al-Khaimah and Umm al-Quwain) sign an agreement, by which they become ''de facto'' British protectorates. * March 11 – The first basketball game is played in public, between students and faculty at the Springfield YMCA before 200 spectators. The final score is 5–1 in favor of the students, with the only goal for the faculty being scored by Amos Alonzo Stagg. * March 13 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bacteria
Bacteria (; singular: bacterium) are ubiquitous, mostly free-living organisms often consisting of one biological cell. They constitute a large domain of prokaryotic microorganisms. Typically a few micrometres in length, bacteria were among the first life forms to appear on Earth, and are present in most of its habitats. Bacteria inhabit soil, water, acidic hot springs, radioactive waste, and the deep biosphere of Earth's crust. Bacteria are vital in many stages of the nutrient cycle by recycling nutrients such as the fixation of nitrogen from the atmosphere. The nutrient cycle includes the decomposition of dead bodies; bacteria are responsible for the putrefaction stage in this process. In the biological communities surrounding hydrothermal vents and cold seeps, extremophile bacteria provide the nutrients needed to sustain life by converting dissolved compounds, such as hydrogen sulphide and methane, to energy. Bacteria also live in symbiotic and parasitic relationsh ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Poxviridae
''Poxviridae'' is a family of double-stranded DNA viruses. Vertebrates and arthropods serve as natural hosts. There are currently 83 species in this family, divided among 22 genera, which are divided into two subfamilies. Diseases associated with this family include smallpox. Four genera of poxviruses may infect humans: ''Orthopoxvirus'', ''Parapoxvirus'', ''Yatapoxvirus'', ''Molluscipoxvirus''. ''Orthopoxvirus'': smallpox virus (variola), vaccinia virus, cowpox virus, monkeypox virus; ''Parapoxvirus'': orf virus, pseudocowpox, bovine papular stomatitis virus; ''Yatapoxvirus'': tanapox virus, yaba monkey tumor virus; ''Molluscipoxvirus'': molluscum contagiosum virus (MCV). The most common are vaccinia (seen on the Indian subcontinent) and molluscum contagiosum, but monkeypox infections are rising (seen in west and central African rainforest countries). The similarly named disease chickenpox is not a true poxvirus and is caused by the herpesvirus varicella zoster. Etymology ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
1856 Births
Events January–March * January 8 – Borax deposits are discovered in large quantities by John Veatch in California. * January 23 – American paddle steamer SS ''Pacific'' leaves Liverpool (England) for a transatlantic voyage on which she will be lost with all 186 on board. * January 24 – U.S. President Franklin Pierce declares the new Free-State Topeka government in "Bleeding Kansas" to be in rebellion. * January 26 – First Battle of Seattle: Marines from the suppress an indigenous uprising, in response to Governor Stevens' declaration of a "war of extermination" on Native communities. * January 29 ** The 223-mile North Carolina Railroad is completed from Goldsboro through Raleigh and Salisbury to Charlotte. ** Queen Victoria institutes the Victoria Cross as a British military decoration. * February ** The Tintic War breaks out in Utah. ** The National Dress Reform Association is founded in the United States to promote "rational" dress for ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
1918 Deaths
This year is noted for the end of the World War I, First World War, on the eleventh hour of the eleventh day of the eleventh month, as well as for the Spanish flu pandemic that killed 50–100 million people worldwide. Events Below, the events of World War I have the "WWI" prefix. January * January – 1918 flu pandemic: The "Spanish flu" (influenza) is first observed in Haskell County, Kansas. * January 4 – The Finnish Declaration of Independence is recognized by Russian Soviet Federative Socialist Republic, Soviet Russia, Sweden, German Empire, Germany and France. * January 9 – Battle of Bear Valley: U.S. troops engage Yaqui people, Yaqui Native American warriors in a minor skirmish in Arizona, and one of the last battles of the American Indian Wars between the United States and Native Americans. * January 15 ** The keel of is laid in Britain, the first purpose-designed aircraft carrier to be laid down. ** The Red Army (The Workers and Peasants Red Army) ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
