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Gerd Ulrich Nienhaus
Gerd Ulrich "Uli" Nienhaus (born 1959) is a German physicist who is a professor and director of the Institute of Applied Physics, Karlsruhe Institute of Technology (KIT). At the KIT, he is also affiliated with the Institute of Nanotechnology, Institute of Biological and Chemical Systems, and Institute of Physical Chemistry, and he is an adjunct professor at the University of Illinois at Urbana-Champaign. He is known for his research on the molecular machinery of life. Over the years, he has employed and advanced a wide range of biophysical techniques, including protein crystallography with x-rays and γ-rays, various spectroscopic methods ( Mössbauer, XAS, UV-VIS, infrared) and optical fluorescence spectroscopy and microscopy ( single-molecule studies, FRET, FLIM, super-resolution microscopy) to elucidate the structure, dynamics and function of biological molecules. He has also been engaged in the development and characterization of nanoscale luminescent markers for bioim ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Germany
Germany,, officially the Federal Republic of Germany, is a country in Central Europe. It is the second most populous country in Europe after Russia, and the most populous member state of the European Union. Germany is situated between the Baltic and North seas to the north, and the Alps to the south; it covers an area of , with a population of almost 84 million within its 16 constituent states. Germany borders Denmark to the north, Poland and the Czech Republic to the east, Austria and Switzerland to the south, and France, Luxembourg, Belgium, and the Netherlands to the west. The nation's capital and most populous city is Berlin and its financial centre is Frankfurt; the largest urban area is the Ruhr. Various Germanic tribes have inhabited the northern parts of modern Germany since classical antiquity. A region named Germania was documented before AD 100. In 962, the Kingdom of Germany formed the bulk of the Holy Roman Empire. During the 16th ce ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Super-resolution Microscopy
Super-resolution microscopy is a series of techniques in optical microscopy that allow such images to have resolutions higher than those imposed by the diffraction limit, which is due to the diffraction of light. Super-resolution imaging techniques rely on the near-field (photon-tunneling microscopy as well as those that utilize the Pendry Superlens and near field scanning optical microscopy) or on the far-field. Among techniques that rely on the latter are those that improve the resolution only modestly (up to about a factor of two) beyond the diffraction-limit, such as confocal microscopy with closed pinhole or aided by computational methods such as deconvolution or detector-based pixel reassignment (e.g. re-scan microscopy, pixel reassignment), the 4Pi microscope, and structured-illumination microscopy technologies such as SIM and SMI. There are two major groups of methods for super-resolution microscopy in the far-field that can improve the resolution by a much larger fa ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of Karlsruhe (TH)
The Karlsruhe Institute of Technology (KIT; german: Karlsruher Institut für Technologie) is a public research university in Karlsruhe, Germany. The institute is a national research center of the Helmholtz Association. KIT was created in 2009 when the University of Karlsruhe (), founded in 1825 as a public research university and also known as the "Fridericiana", merged with the Karlsruhe Research Center (), which had originally been established in 1956 as a national nuclear research center (, or KfK). KIT is a member of the TU9, an incorporated society of the largest and most notable German institutes of technology.TU9 As part of the German Universities Excellence Initiative KIT was one of three universities which were awarded excellence status in 2006. In the following "German Excellence Strategy" KIT was awarded as one of eleven "Excellence Universities" in 2019. KIT is among the leading technical universities in Germany and Europe. According to different bibliometric ranking ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Eos (protein)
EosFP is a photoactivatable green to red fluorescent protein. Its green fluorescence (516 nm) switches to red (581 nm) upon UV irradiation of ~390 nm (violet/blue light) due to a photo-induced modification resulting from a break in the peptide backbone near the chromophore. Eos was first discovered as a tetrameric protein in the stony coral '' Lobophyllia hemprichii''''.'' Like other fluorescent proteins, Eos allows for applications such as the tracking of fusion proteins, multicolour labelling and tracking of cell movement. Several variants of Eos have been engineered for use in specific study systems including mEos2, mEos4 and CaMPARI. History EosFP was first discovered in 2005 during a large scale screen for PAFPs (photoactivatable fluorescent proteins) within the stony coral '' Lobophyllia hemprichii.'' It has since been successfully cloned in ''Escherichia coli'' and fusion constructs have been developed for use in human cells. Eos was named after the Gr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Stanford University
Stanford University, officially Leland Stanford Junior University, is a private research university in Stanford, California. The campus occupies , among the largest in the United States, and enrolls over 17,000 students. Stanford is considered among the most prestigious universities in the world. Stanford was founded in 1885 by Leland and Jane Stanford in memory of their only child, Leland Stanford Jr., who had died of typhoid fever at age 15 the previous year. Leland Stanford was a U.S. senator and former governor of California who made his fortune as a railroad tycoon. The school admitted its first students on October 1, 1891, as a coeducational and non-denominational institution. Stanford University struggled financially after the death of Leland Stanford in 1893 and again after much of the campus was damaged by the 1906 San Francisco earthquake. Following World War II, provost of Stanford Frederick Terman inspired and supported faculty and graduates' entrepreneu ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Steven Chu
Steven Chu''Chu, Steven'' was elected a fellow of the American Physical Society in 1986 for his contributions in atomic physics and laser spectroscopy, including the first observation of parity non-conservation in atoms, excitation and precision spectroscopy of positronium, and the optical confinement and cooling of atoms. (born February 28, 1948) is an American Experimental physics, physicist and former government official. He is a Nobel laureate and was the 12th United States Secretary of Energy. He is currently the William R. Kenan Jr. Professor of Physics and Professor of Molecular and Cellular Physiology at Stanford University. He is known for his research at the University of California, Berkel ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Fluorescence Correlation Spectroscopy
Fluorescence correlation spectroscopy (FCS) is a statistical analysis, via time correlation, of stationary fluctuations of the fluorescence intensity. Its theoretical underpinning originated from L. Onsager's regression hypothesis. The analysis provides kinetic parameters of the physical processes underlying the fluctuations. One of the interesting applications of this is an analysis of the concentration fluctuations of fluorescent particles (molecules) in solution. In this application, the fluorescence emitted from a very tiny space in solution containing a small number of fluorescent particles (molecules) is observed. The fluorescence intensity is fluctuating due to Brownian motion of the particles. In other words, the number of the particles in the sub-space defined by the optical system is randomly changing around the average number. The analysis gives the average number of fluorescent particles and average diffusion time, when the particle is passing through the space. Eventua ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hemoprotein
A hemeprotein (or haemprotein; also hemoprotein or haemoprotein), or heme protein, is a protein that contains a heme prosthetic group. They are a very large class of metalloproteins. The heme group confers functionality, which can include oxygen carrying, oxygen reduction, electron transfer, and other processes. Heme is bound to the protein either covalently or noncovalently or both. The heme consists of iron cation bound at the center of the conjugate base of the porphyrin, as well as other ligands attached to the "axial sites" of the iron. The porphyrin ring is a planar dianionic, tetradentate ligand. The iron is typically Fe2+ or Fe3+. One or two ligands are attached at the axial sites. The porphyrin ring has 4 nitrogen atoms that bind to the iron, leaving two other coordination positions of the iron available for bonding to the histidine of the protein and a divalent atom. Hemeproteins probably evolved to incorporate the iron atom contained within the protoporphyrin IX rin ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, responding to stimuli, providing structure to cells and organisms, and transporting molecules from one location to another. Proteins differ from one another primarily in their sequence of amino acids, which is dictated by the nucleotide sequence of their genes, and which usually results in protein folding into a specific 3D structure that determines its activity. A linear chain of amino acid residues is called a polypeptide. A protein contains at least one long polypeptide. Short polypeptides, containing less than 20–30 residues, are rarely considered to be proteins and are commonly called peptides. The individual amino acid residues are bonded together by peptide bonds and adjacent amino acid residues. The sequence of amino acid residue ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hans Frauenfelder
Hans Frauenfelder (July 28, 1922 – July 10, 2022) was an American physicist and biophysicist notable for his discovery of perturbed angular correlation (PAC) in 1951. In the modern day, PAC spectroscopy is widely used in the study of condensed matter physics. Within biophysics, he is known for his experimental and theoretical research on the dynamical behavior of protein tertiary structure. Education Frauenfelder received his Dr. sc. nat. in physics in 1950 at the Swiss Federal Institute of Technology (ETH) in Zurich under Paul Scherrer, his thesis being on the study of radioactive surfaces. At ETH, he was also taught by Gregor Wentzel and Wolfgang Pauli. Through Pauli, he also got to know many of the leading scientists such as Hendrik Kramers, Werner Heisenberg, Hans Jensen, and Wolfgang Paul. Career Frauenfelder migrated to the United States in 1952, joining the Department of Physics at the University of Illinois at Urbana-Champaign as a research associate. He stayed at t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Alexander Von Humboldt Foundation
The Alexander von Humboldt Foundation (german: Alexander von Humboldt-Stiftung) is a foundation established by the government of the Federal Republic of Germany and funded by the Federal Foreign Office, the Federal Ministry of Education and Research, the Federal Ministry for Economic Cooperation and Development as well as other national and international partners; it promotes international academic cooperation between excellent scientists and scholars from Germany and from abroad. Description Every year, the Foundation grants more than 700 competitive research fellowships and awards, primarily going to academics from natural sciences (mathematics included) and the humanities. It allows scientists and scholars from all over the world to come to Germany to work on a research project they have chosen themselves together with a host and collaborative partner. Additionally it funds German scholars' via the Feodor Lynen Fellowships to go anywhere in the world to work on a research proj ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Wire Chamber
A wire chamber or multi-wire proportional chamber is a type of proportional counter that detects charged particles and photons and can give positional information on their trajectory, by tracking the trails of gaseous ionization. was located via Dr. C.N. BootPHY304 Particle Physics Sheffield University/ref> Description The multi-wire chamber uses an array of wires at high voltage (anode), which run through a chamber with conductive walls held at ground potential (cathode). Alternatively, the wires may be at ground potential and the cathode held at a high negative voltage; the important thing is that a uniform electric field draws extra electrons or negative ions to the anode wires with little lateral motion. The chamber is filled with carefully chosen gas, such as an argon/methane mix, such that any ionizing particle that passes through the tube will ionize surrounding gaseous atoms. The resulting ions and electrons are accelerated by the electric field across the chamber, causi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
