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Geoffrey Barrow Dowling
Geoffrey Barrow Dowling (9 August 1891-1 June1976), was a consultant dermatologist at St Thomas's Hospital and St John's Hospital for Diseases of the Skin, who encouraged the study of histopathology and demonstrated the beneficial effects of large doses of calciferol in the treatment of lupus vulgaris in 1945. In addition, he worked with Walter Freudenthal Walter Freudenthal (6 May 1893 – 27 March 1952) was a German-Jewish dermatologist who gave the earliest clear histopathological description of keratoma senile (actinic keratosis) in 1926 in Breslau. In 1933, he moved to London to escape the N ... on dermatomyositis and scleroderma. He established The Dowling Club in the 1940s. References 1891 births 1976 deaths British dermatologists {{England-med-bio-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Calciferol
Vitamin D is a group of Lipophilicity, fat-soluble secosteroids responsible for increasing intestinal absorption of calcium, magnesium, and phosphate, and many other biological effects. In humans, the most important compounds in this group are vitamin D3 (cholecalciferol) and vitamin D2 (ergocalciferol). The major natural source of the vitamin is Chemical synthesis, synthesis of cholecalciferol in the Epidermis#Layers, lower layers of epidermis of the skin through a chemical reaction that is dependent on Health effects of sunlight exposure, sun exposure (specifically Ultraviolet#Subtypes, UVB radiation). Cholecalciferol and ergocalciferol can be ingested from the diet and dietary supplement, supplements. Only a few foods, such as the flesh of fatty fish, naturally contain significant amounts of vitamin D. In the U.S. and other countries, cow's milk and plant-derived milk substitutes are fortified with vitamin D, as are many breakfast cereals. Mushrooms exposed to ultraviolet l ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Lupus Vulgaris
Lupus vulgaris (also known as tuberculosis luposa) are painful cutaneous tuberculosis skin lesions with nodular appearance, most often on the face around the nose, eyelids, lips, cheeks, ears and neck. It is the most common ''Mycobacterium tuberculosis'' skin infection. The lesions may ultimately develop into disfiguring skin ulcers if left untreated. Signs and symptoms It begins as painless reddish-brown nodules which slowly enlarge to form irregularly shaped red plaque. File:Lupus vulgaris.jpg, Lupus vulgaris, changes in skin in hyperkeratotic forms File:Lupus vulgaris 2.jpg, Lupus vulgaris in a woman in 19th century Cause Lupus vulgaris often develops due to inadequately treated pre-existing tuberculosis. It may also develop at site of BCG vaccination. Rarely, it has been shown to be associated with tattoo marks. Histopathology Histologically, it shows presence of epithelioid cell granulomas with Langhans giant cells with or without central caseation necrosis in the derm ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Walter Freudenthal
Walter Freudenthal (6 May 1893 – 27 March 1952) was a German-Jewish dermatologist who gave the earliest clear histopathological description of keratoma senile (actinic keratosis) in 1926 in Breslau. In 1933, he moved to London to escape the Nazi regime and worked as a dermatopathologist at University College Hospital (UCH) in London where he coined the term keratoacanthoma in the 1940s. He worked with dermatologist Geoffrey Dowling on the connection between dermatomyositis and scleroderma and was later appointed to the first readership in dermatological histology by London University. In addition to lecturing, demonstrating specimens at the Royal Society of Medicine and postgraduate training, Freudenthal wrote many papers on his histopathological findings, and chapters in dermatology textbooks. Early life Walter Freudenthal was born on 6 May 1893 in Breslau (later Wroclaw, Poland) in the Silesia region of Germany, into a Jewish family of physicians. In 1913 he began to stu ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Dermatomyositis
Dermatomyositis (DM) is a long-term inflammatory disorder which affects skin and the muscles. Its symptoms are generally a skin rash and worsening muscle weakness over time. These may occur suddenly or develop over months. Other symptoms may include weight loss, fever, lung inflammation, or light sensitivity. Complications may include calcium deposits in muscles or skin. The cause is unknown. Theories include that it is an autoimmune disease or a result of a viral infection. Dermatomyositis may develop as a paraneoplastic syndrome associated with several forms of malignancy. It is a type of inflammatory myopathy. Diagnosis is typically based on some combination of symptoms, blood tests, electromyography, and muscle biopsies. While no cure for the condition is known, treatments generally improve symptoms. Treatments may include medication, physical therapy, exercise, heat therapy, orthotics and assistive devices, and rest. Medications in the corticosteroids family are typic ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Scleroderma
Scleroderma is a group of autoimmune diseases that may result in changes to the skin, blood vessels, muscles, and internal organs. The disease can be either localized to the skin or involve other organs, as well. Symptoms may include areas of thickened skin, stiffness, feeling tired, and poor blood flow to the fingers or toes with cold exposure. One form of the condition, known as CREST syndrome, classically results in calcium deposits, Raynaud's syndrome, esophageal problems, thickening of the skin of the fingers and toes, and areas of small, dilated blood vessels. The cause is unknown, but it may be due to an abnormal immune response. Risk factors include family history, certain genetic factors, and exposure to silica. The underlying mechanism involves the abnormal growth of connective tissue, which is believed to be the result of the immune system attacking healthy tissues. Diagnosis is based on symptoms, supported by a skin biopsy or blood tests. While no cure is ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
1891 Births
Events January–March * January 1 ** Paying of old age pensions begins in Germany. ** A strike of 500 Hungarian steel workers occurs; 3,000 men are out of work as a consequence. **Germany takes formal possession of its new African territories. * January 2 – A. L. Drummond of New York is appointed Chief of the Treasury Secret Service. * January 4 – The Earl of Zetland issues a declaration regarding the famine in the western counties of Ireland. * January 5 **The Australian shearers' strike, that leads indirectly to the foundation of the Australian Labor Party, begins. **A fight between the United States and Indians breaks out near Pine Ridge agency. ** Henry B. Brown, of Michigan, is sworn in as an Associate Justice of the Supreme Court. **A fight between railway strikers and police breaks out at Motherwell, Scotland. * January 6 – Encounters continue, between strikers and the authorities at Glasgow. * January 7 ** General Miles' force ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
1976 Deaths
Events January * January 3 – The International Covenant on Economic, Social and Cultural Rights enters into force. * January 5 – The Pol Pot regime proclaims a new constitution for Democratic Kampuchea. * January 11 – The 1976 Philadelphia Flyers–Red Army game results in a 4–1 victory for the National Hockey League's Philadelphia Flyers over HC CSKA Moscow of the Soviet Union. * January 16 – The trial against jailed members of the Red Army Faction (the West German extreme-left militant Baader–Meinhof Group) begins in Stuttgart. * January 18 ** Full diplomatic relations are established between Bangladesh and Pakistan 5 years after the Bangladesh Liberation War. ** The Scottish Labour Party is formed as a breakaway from the UK-wide party. ** Super Bowl X in American football: The Pittsburgh Steelers defeat the Dallas Cowboys, 21–17, in Miami. * January 21 – First commercial Concorde flight, from London to Bahrain. * January 27 ** The United States v ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
