GNA15
Guanine nucleotide-binding protein subunit alpha-15 is a protein that in humans is encoded by the ''GNA15'' gene.GUANINE NUCLEOTIDE-BINDING PROTEIN, ALPHA-15; GNA15
at OMIM. Retrieved JULY 25, 2019. G₁₅α is a member of the Gq alpha subunit family, and functions as a constituent of a heterotrimeric G protein in cell signal transduction. It was also previously known as G₁₆α.

See also

* Gq alpha subunit * Heterotrimeric G protein

References

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Gq Alpha Subunit
Gq protein alpha subunit is a family of heterotrimeric G protein alpha subunits. This family is also commonly called the Gq/11 (Gq/G11) family or Gq/11/14/15 family to include closely related family members. G alpha subunits may be referred to as Gq alpha, Gαq, or Gqα. Gq proteins couple to G protein-coupled receptors to activate beta-type phospholipase C (PLC-β) enzymes. PLC-β in turn hydrolyzes phosphatidylinositol 4,5-bisphosphate (PIP2) to diacyl glycerol (DAG) and inositol trisphosphate (IP3). IP3 acts as a second messenger to release stored calcium into the cytoplasm, while DAG acts as a second messenger that activates protein kinase C (PKC). Family members In humans, there are four distinct proteins in the Gq alpha subunit family: * Gαq is encoded by the gene GNAQ. * Gα11 is encoded by the gene GNA11. * Gα14 is encoded by the gene GNA14. * Gα15 is encoded by the gene GNA15. Function The general function of Gq is to activate intracellular signaling p ...
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