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GDF7
Growth differentiation factor 7 (GDF7) is a protein that in humans is encoded by the ''GDF7'' gene. GDF7 belongs to the transforming growth factor beta superfamily that is specifically found in a signaling center known as the roof plate that is located in the developing nervous system of embryos. The roof plate is required for the generation of several classes of spinal cord dorsal interneurons; GDF7 specifically induces the formation of sensory neurons in the dorsal spinal cord from neural crest cell Neural crest cells are a temporary group of cells unique to vertebrates that arise from the embryonic ectoderm germ layer, and in turn give rise to a diverse cell lineage—including melanocytes, craniofacial cartilage and bone, smooth muscle, ...s by generating signals within the roof plate. GDF7 is also known as bone morphogenic protein 12 ( BMP-12). References Further reading * * * * Developmental genes and proteins TGFβ domain {{Gene-2-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Transforming Growth Factor Beta Superfamily
The transforming growth factor beta (TGF-β) superfamily is a large group of structurally related cell regulatory proteins that was named after its first member, TGF-β1, originally described in 1983. They interact with TGF-beta receptors. Many proteins have since been described as members of the TGF-β superfamily in a variety of species, including invertebrates as well as vertebrates and categorized into 23 distinct gene types that fall into four major subfamilies: * The TGF-β subfamily * The bone morphogenetic proteins and the growth differentiation factors * The activin and inhibin subfamilies * The left-right determination factors * A group encompassing various divergent members Transforming growth factor-beta (TGF-beta) is a multifunctional peptide that controls proliferation, differentiation and other functions in many cell types. TGF-beta-1 is a peptide of 112 amino acid residues derived by proteolytic cleavage from the C-terminal of a precursor protein. These pro ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |