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Gene Transfer Agent
Gene transfer agents (GTAs) are DNA-containing virus-like particles that are produced by some bacteria and archaea and mediate horizontal gene transfer. Different GTA types have originated independently from viruses in several bacterial and archaeal lineages. These cells produce GTA particles containing short segments of the DNA present in the cell. After the particles are released from the producer cell, they can attach to related cells and inject their DNA into the cytoplasm. The DNA can then become part of the recipient cells' genome. Discovery of gene transfer agents The first GTA system was discovered in 1974, when mixed cultures of ''Rhodobacter capsulatus'' strains produced a high frequency of cells with new combinations of genes. The factor responsible was distinct from known gene-transfer mechanisms in being independent of cell contact, insensitive to deoxyribonuclease, and not associated with phage production. Because of its presumed function it was named gene tran ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Phage And GTA
A bacteriophage (), also known informally as a ''phage'' (), is a duplodnaviria virus that infects and replicates within bacteria and archaea. The term was derived from "bacteria" and the Greek φαγεῖν ('), meaning "to devour". Bacteriophages are composed of proteins that encapsulate a DNA or RNA genome, and may have structures that are either simple or elaborate. Their genomes may encode as few as four genes (e.g. MS2) and as many as hundreds of genes. Phages replicate within the bacterium following the injection of their genome into its cytoplasm. Bacteriophages are among the most common and diverse entities in the biosphere. Bacteriophages are ubiquitous viruses, found wherever bacteria exist. It is estimated there are more than 1031 bacteriophages on the planet, more than every other organism on Earth, including bacteria, combined. Viruses are the most abundant biological entity in the water column of the world's oceans, and the second largest component of biom ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
GTA Transduction
GTA may refer to: Arts and entertainment * ''Grand Theft Auto'', series of video games by Rockstar Games ** ''Grand Theft Auto'' (video game), the original 1997 game ** ''Grand Theft Auto Advance'', also known simply as ''Grand Theft Auto'', 2004 * ''Grand Theft Auto'' (film), a 1977 film directed by Ron Howard * Grand Text Auto, a game studies blog by Nick Montfort * Good Times Ahead (GTA), an American electronic music duo Vehicles Alfa Romeo * Alfa Romeo GTA, a succession of Italian sport coupés (1965–1975) based on the Giulia * 147 GTA, a high-performance version of the Alfa Romeo 147 * 156 GTA, a high-performance version of the Alfa Romeo 156 * MiTo GTA, a concept version of the Alfa Romeo MiTo Other uses * Grand theft auto, a type of crime, see motor vehicle theft * GTA Motor, a Spanish automobile designer and manufacturer * GTA Motor Competición, a Spanish racing team * Pontiac Firebird Trans Am GTA, a U.S. sport coupé (1987–1992) * Renault Alpine GTA/A610, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Horizontal Gene Transfer
Horizontal gene transfer (HGT) or lateral gene transfer (LGT) is the movement of genetic material between unicellular and/or multicellular organisms other than by the ("vertical") transmission of DNA from parent to offspring (reproduction). HGT is an important factor in the evolution of many organisms. HGT is influencing scientific understanding of higher order evolution while more significantly shifting perspectives on bacterial evolution. Horizontal gene transfer is the primary mechanism for the spread of antibiotic resistance in bacteria, and plays an important role in the evolution of bacteria that can degrade novel compounds such as human-created pesticides and in the evolution, maintenance, and transmission of virulence. It often involves temperate bacteriophages and plasmids. Genes responsible for antibiotic resistance in one species of bacteria can be transferred to another species of bacteria through various mechanisms of HGT such as transformation, transduction and ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gene Transfer Agent-release Holin Family
Gene transfer agent-release holins (GTA-HolTC# 1.E.54 are holins which are believed to facilitate the lysis-dependent release of a gene transfer agent. Particularly the gene transfer agent of ''Rhodobacter capsulatus'' (RcGTA), which is known to be a bacteriophage-like genetic element that induces horizontal gene transfer. The promoter of the RcGTA gene was identified by Westbye ''et al''. in 2013. A representative list of members belonging to the GTA-Hol family can be found in the Transporter Classification Database with homologues found in Pseudomonadota (formerly proteobacteria) and caudovirales. See also * Gene transfer agent * Lysin Lysins, also known as endolysins or murein hydrolases, are hydrolytic enzymes produced by bacteriophages in order to cleave the host's cell wall during the final stage of the lytic cycle. Lysins are highly evolved enzymes that are able to targ ... References Further reading * * * * * Holins {{membrane-protein-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Homology (biology)
In biology, homology is similarity due to shared ancestry between a pair of structures or genes in different taxa. A common example of homologous structures is the forelimbs of vertebrates, where the wings of bats and birds, the arms of primates, the front flippers of whales and the forelegs of four-legged vertebrates like dogs and crocodiles are all derived from the same ancestral tetrapod structure. Evolutionary biology explains homologous structures adapted to different purposes as the result of descent with modification from a common ancestor. The term was first applied to biology in a non-evolutionary context by the anatomist Richard Owen in 1843. Homology was later explained by Charles Darwin's theory of evolution in 1859, but had been observed before this, from Aristotle onwards, and it was explicitly analysed by Pierre Belon in 1555. In developmental biology, organs that developed in the embryo in the same manner and from similar origins, such as from matching prim ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Rhodobacterales
Rhodobacterales are an order of the Alphaproteobacteria. Gene transfer agents are viruslike elements produced by Rhodobacterales which transfer DNA and may be an important factor in their evolution. Etymology From Greek ''rhodon'', the rose A rose is either a woody perennial flowering plant of the genus ''Rosa'' (), in the family Rosaceae (), or the flower it bears. There are over three hundred species and tens of thousands of cultivars. They form a group of plants that can be ..., and ''bakterion'', a rod. This refers to the colour of aerobic phototrophic cultures of this order of bacteria which can be pink or red due to the production of carotenoids. References Further reading Scientific journals * * Scientific books * External links Alphaproteobacteria {{Rhodobacterales-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cell Lysis
Lysis ( ) is the breaking down of the membrane of a cell, often by viral, enzymic, or osmotic (that is, "lytic" ) mechanisms that compromise its integrity. A fluid containing the contents of lysed cells is called a ''lysate''. In molecular biology, biochemistry, and cell biology laboratories, cell cultures may be subjected to lysis in the process of purifying their components, as in protein purification, DNA extraction, RNA extraction, or in purifying organelles. Many species of bacteria are subject to lysis by the enzyme lysozyme, found in animal saliva, egg white, and other secretions. Phage lytic enzymes (lysins) produced during bacteriophage infection are responsible for the ability of these viruses to lyse bacterial cells. Penicillin and related β-lactam antibiotics cause the death of bacteria through enzyme-mediated lysis that occurs after the drug causes the bacterium to form a defective cell wall. If the cell wall is completely lost and the penicillin was used on gr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Alphaproteobacteria
Alphaproteobacteria is a class of bacteria in the phylum Pseudomonadota (formerly Proteobacteria). The Magnetococcales and Mariprofundales are considered basal or sister to the Alphaproteobacteria. The Alphaproteobacteria are highly diverse and possess few commonalities, but nevertheless share a common ancestor. Like all ''Proteobacteria'', its members are gram-negative and some of its intracellular parasitic members lack peptidoglycan and are consequently gram variable. Characteristics The Alphaproteobacteria are a diverse taxon and comprises several phototrophic genera, several genera metabolising C1-compounds (''e.g.'', ''Methylobacterium'' spp.), symbionts of plants (''e.g.'', ''Rhizobium'' spp.), endosymbionts of arthropods (''Wolbachia'') and intracellular pathogens (''e.g. Rickettsia''). Moreover, the class is sister to the protomitochondrion, the bacterium that was engulfed by the eukaryotic ancestor and gave rise to the mitochondria, which are organelles in eukaryotic ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Regulation Of RcGTA
Regulation is the management of complex systems according to a set of rules and trends. In systems theory, these types of rules exist in various fields of biology and society, but the term has slightly different meanings according to context. For example: * in biology, gene regulation and metabolic regulation allow living organisms to adapt to their environment and maintain homeostasis; * in government, typically regulation means stipulations of the delegated legislation which is drafted by subject-matter experts to enforce primary legislation; * in business, industry self-regulation occurs through self-regulatory organizations and trade associations which allow industries to set and enforce rules with less government involvement; and, * in psychology, self-regulation theory is the study of how individuals regulate their thoughts and behaviors to reach goals. Social Regulation in the social, political, psychological, and economic domains can take many forms: legal restrictio ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
RecA
RecA is a 38 kilodalton protein essential for the repair and maintenance of DNA. A RecA structural and functional homolog has been found in every species in which one has been seriously sought and serves as an archetype for this class of homologous DNA repair proteins. The homologous protein is called RAD51 in eukaryotes and RadA in archaea. RecA has multiple activities, all related to DNA repair. In the bacterial SOS response, it has a co-protease function in the autocatalytic cleavage of the LexA repressor and the λ repressor. RecA's association with DNA repair is based on its central role in homologous recombination. The RecA protein binds strongly and in long clusters to ssDNA to form a nucleoprotein filament. The protein has more than one DNA binding site, and thus can hold a single strand and double strand together. This feature makes it possible to catalyze a DNA synapsis reaction between a DNA double helix and a complementary region of single-stranded DNA. The Rec ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Natural Competence
In microbiology, genetics, cell biology, and molecular biology, competence is the ability of a cell to alter its genetics by taking up extracellular ("naked") DNA from its environment in the process called transformation. Competence may be differentiated between ''natural competence'', a genetically specified ability of bacteria which is thought to occur under natural conditions as well as in the laboratory, and ''induced'' or ''artificial competence'', which arises when cells in laboratory cultures are treated to make them transiently permeable to DNA. Competence allows for rapid adaptation and DNA repair of the cell. This article primarily deals with natural competence in bacteria, although information about artificial competence is also provided. History Natural competence was discovered by Frederick Griffith in 1928, when he showed that a preparation of killed cells of a pathogenic bacterium contained something that could transform related non-pathogenic cells into the path ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
GTA Production
GTA may refer to: Arts and entertainment * ''Grand Theft Auto'', series of video games by Rockstar Games ** ''Grand Theft Auto'' (video game), the original 1997 game ** ''Grand Theft Auto Advance'', also known simply as ''Grand Theft Auto'', 2004 * ''Grand Theft Auto'' (film), a 1977 film directed by Ron Howard * Grand Text Auto, a game studies blog by Nick Montfort * Good Times Ahead (GTA), an American electronic music duo Vehicles Alfa Romeo * Alfa Romeo GTA, a succession of Italian sport coupés (1965–1975) based on the Giulia * 147 GTA, a high-performance version of the Alfa Romeo 147 * 156 GTA, a high-performance version of the Alfa Romeo 156 * MiTo GTA, a concept version of the Alfa Romeo MiTo Other uses * Grand theft auto, a type of crime, see motor vehicle theft * GTA Motor, a Spanish automobile designer and manufacturer * GTA Motor Competición, a Spanish racing team * Pontiac Firebird Trans Am GTA, a U.S. sport coupé (1987–1992) * Renault Alpine GTA/A610, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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