Functional Imaging Laboratory
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Functional Imaging Laboratory
The 'Wellcome Centre for Human Neuroimaging'' at University College London is a world-leading interdisciplinary centre for neuroimaging research based in London, United Kingdom. Researchers at the Centre use expertise to investigate how the human brain generates behaviour, thoughts and feelings and how to use this knowledge to help patients with neurological and psychiatric disorders. Human neuroimaging allows scientists to non-invasively investigate the brain structure and functions including Action, Decision Making, Emotion, Hearing, Language, Memory, Navigation, Seeing, Self awareness, Social Behaviour and the Bayesian Brain The Wellcome Centre for Human Neuroimaging is part of UCL'Department for Imaging Neuroscience alongsidThe Max Planck UCL Centre for Computational Psychiatry and Ageingand Affiliated Principal Investigators (PIs). The current team of researchers and support staff use their diverse and interdisciplinary skills to work collaboratively towards one shared go ...
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Cathy Price
Catherine J. "Cathy" Price is a British neuroscientist and academic. She is a professor of cognitive neuroscience and director of the Wellcome Trust Centre for Neuroimaging at University College London. Her overarching research goal is to provide a model of the neural basis of language that predicts and explains speech and language difficulties and their recovery after brain damage ( stroke or neurosurgery). She is a world-leading, renowned neuroscientist. Education Price obtained her bachelor's degree in 1984, and her PhD in 1990, both from Birkbeck College. Professor Kia Nobre, who nominated Price for the 5th Suffrage award for Life Sciences, said: "She blossomed through the trenches of a very macho world with gentle words, generous deeds, scientific commitment and rigour, genuine translation of research to clinical benefit, and humour." Price originally trained as a neuropsychologist studying reading and object recognition in patients with brain damage. In 1991, she j ...
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Richard Frackowiak
Richard Stanislaus Joseph Frackowiak, born 26 March 1950 in London, is a British and French neurologist and neuroscientist. He is best known for his role in the development of neuroimaging, as the founding director of the Functional Imaging Laboratory (FIL) at University College London (UCL) and as one of the initiators, in 2013, of the Human Brain Project (HBP), a ten-year European project coordinated by the École Polytechnique Fédérale de Lausanne (EPFL) with the goal of advancing knowledge in the fields of neuroscience, computing and brain-related medicine. Biography Youth and education During World War II, his father fought on different fronts in the ranks of the Polish 1st Armoured Division (''1 Dywizja Pancerna''), his wartime engagements culminating in the Normandy theatre of operations (6 June – 12 September 1944). His mother took part in the Warsaw uprising (1 August – 2 October 1944), during which she was captured and interned at a series of Nazi concentrat ...
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Neuroscience Research Centres In The United Kingdom
Neuroscience is the scientific study of the nervous system (the brain, spinal cord, and peripheral nervous system), its functions and disorders. It is a multidisciplinary science that combines physiology, anatomy, molecular biology, developmental biology, cytology, psychology, physics, computer science, chemistry, medicine, statistics, and mathematical modeling to understand the fundamental and emergent properties of neurons, glia and neural circuits. The understanding of the biological basis of learning, memory, behavior, perception, and consciousness has been described by Eric Kandel as the "epic challenge" of the biological sciences. The scope of neuroscience has broadened over time to include different approaches used to study the nervous system at different scales. The techniques used by neuroscientists have expanded enormously, from molecular and cellular studies of individual neurons to imaging of sensory, motor and cognitive tasks in the brain. History The earlies ...
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Neuroimaging
Neuroimaging is the use of quantitative (computational) techniques to study the structure and function of the central nervous system, developed as an objective way of scientifically studying the healthy human brain in a non-invasive manner. Increasingly it is also being used for quantitative studies of brain disease and psychiatric illness. Neuroimaging is a highly multidisciplinary research field and is not a medical specialty. Neuroimaging differs from neuroradiology which is a medical specialty and uses brain imaging in a clinical setting. Neuroradiology is practiced by radiologists who are medical practitioners. Neuroradiology primarily focuses on identifying brain lesions, such as vascular disease, strokes, tumors and inflammatory disease. In contrast to neuroimaging, neuroradiology is qualitative (based on subjective impressions and extensive clinical training) but sometimes uses basic quantitative methods. Functional brain imaging techniques, such as functional magnet ...
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Medical Imaging Organizations
Medicine is the science and practice of caring for a patient, managing the diagnosis, prognosis, prevention, treatment, palliation of their injury or disease, and promoting their health. Medicine encompasses a variety of health care practices evolved to maintain and restore health by the prevention and treatment of illness. Contemporary medicine applies biomedical sciences, biomedical research, genetics, and medical technology to diagnose, treat, and prevent injury and disease, typically through pharmaceuticals or surgery, but also through therapies as diverse as psychotherapy, external splints and traction, medical devices, biologics, and ionizing radiation, amongst others. Medicine has been practiced since prehistoric times, and for most of this time it was an art (an area of skill and knowledge), frequently having connections to the religious and philosophical beliefs of local culture. For example, a medicine man would apply herbs and say prayers for healing, ...
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Statistical Parametric Mapping
Statistical parametric mapping (SPM) is a statistical technique for examining differences in brain activity recorded during functional neuroimaging experiments. It was created by Karl Friston. It may alternatively refer to software created by the Wellcome Department of Imaging Neuroscience at University College London to carry out such analyses. Approach Unit of measurement Functional neuroimaging is one type of 'brain scanning'. It involves the measurement of brain activity. The measurement technique depends on the imaging technology (e.g., fMRI and PET). The scanner produces a 'map' of the area that is represented as voxels. Each voxel represents the activity of a specific volume in three-dimensional space. The exact size of a voxel varies depending on the technology. fMRI voxels typically represent a volume of 27 mm3 in an equilateral cuboid. Experimental design Researchers examine brain activity linked to a specific mental process or processes. One approach involves aski ...
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Transcranial Magnetic Stimulation
Transcranial magnetic stimulation (TMS) is a noninvasive form of brain stimulation in which a changing magnetic field is used to induce an electric current at a specific area of the brain through electromagnetic induction. An electric pulse generator, or stimulator, is connected to a magnetic coil connected to the scalp. The stimulator generates a changing electric current within the coil which creates a varying magnetic field, inducing a current within a region in the brain itself.NICE. January 201Transcranial magnetic stimulation for treating and preventing migraine/ref>Michael Craig Miller for Harvard Health Publications. July 26, 201Magnetic stimulation: a new approach to treating depression?/ref> TMS has shown diagnostic and therapeutic potential in the central nervous system with a wide variety of disease states in neurology and mental health, with research still evolving. Adverse effects of TMS appear rare and include fainting and seizure. Other potential issues include ...
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Electroencephalography
Electroencephalography (EEG) is a method to record an electrogram of the spontaneous electrical activity of the brain. The biosignals detected by EEG have been shown to represent the postsynaptic potentials of pyramidal neurons in the neocortex and allocortex. It is typically non-invasive, with the EEG electrodes placed along the scalp (commonly called "scalp EEG") using the International 10-20 system, or variations of it. Electrocorticography, involving surgical placement of electrodes, is sometimes called " intracranial EEG". Clinical interpretation of EEG recordings is most often performed by visual inspection of the tracing or quantitative EEG analysis. Voltage fluctuations measured by the EEG bioamplifier and electrodes allow the evaluation of normal brain activity. As the electrical activity monitored by EEG originates in neurons in the underlying brain tissue, the recordings made by the electrodes on the surface of the scalp vary in accordance with their orientation and ...
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Magnetoencephalography
Magnetoencephalography (MEG) is a functional neuroimaging technique for mapping brain activity by recording magnetic fields produced by electrical currents occurring naturally in the brain, using very sensitive magnetometers. Arrays of SQUIDs (superconducting quantum interference devices) are currently the most common magnetometer, while the SERF (spin exchange relaxation-free) magnetometer is being investigated for future machines. Applications of MEG include basic research into perceptual and cognitive brain processes, localizing regions affected by pathology before surgical removal, determining the function of various parts of the brain, and neurofeedback. This can be applied in a clinical setting to find locations of abnormalities as well as in an experimental setting to simply measure brain activity. History MEG signals were first measured by University of Illinois physicist David Cohen in 1968, before the availability of the SQUID, using a copper induction coil as the d ...
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Magnetic Resonance Imaging
Magnetic resonance imaging (MRI) is a medical imaging technique used in radiology to form pictures of the anatomy and the physiological processes of the body. MRI scanners use strong magnetic fields, magnetic field gradients, and radio waves to generate images of the organs in the body. MRI does not involve X-rays or the use of ionizing radiation, which distinguishes it from CT and PET scans. MRI is a medical application of nuclear magnetic resonance (NMR) which can also be used for imaging in other NMR applications, such as NMR spectroscopy. MRI is widely used in hospitals and clinics for medical diagnosis, staging and follow-up of disease. Compared to CT, MRI provides better contrast in images of soft-tissues, e.g. in the brain or abdomen. However, it may be perceived as less comfortable by patients, due to the usually longer and louder measurements with the subject in a long, confining tube, though "Open" MRI designs mostly relieve this. Additionally, implants and oth ...
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Semir Zeki
Semir Zeki FMedSci FRS is a British and French neurobiologist who has specialised in studying the primate visual brain and more recently the neural correlates of affective states, such as the experience of love, desire and beauty that are generated by sensory inputs within the field of neuroesthetics. He was educated at University College London , mottoeng = Let all come who by merit deserve the most reward , established = , type = Public research university , endowment = £143 million (2020) , budget = ... (UCL) where he was Henry Head Research Fellow of the Royal Society before being appointed Professor of Neurobiology. Since 2008 he has been Professor of Neuroesthetics at UCL. Early work Zeki's early work was mainly anatomical in nature and consisted in charting visual areas in the primate (monkey) brain by studying their connections, leading him to define several visual areas lying an ...
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Geraint Rees
Geraint Ellis Rees is Vice- Provost of research, innovation & global engagement at University College London (UCL). Previously he served as Dean of the UCL Faculty of Life Sciences, UCL Pro-Provost (Academic Planning), Pro-Vice-Provost (AI) and a Professor of Cognitive Neurology at University College London. He is also a Director of UCL Business and a trustee of the Guarantors of Brain. Until 2021 he was a founding Trustee of the charity in2scienceUK; until 2016 he was a member of the Francis Crick Institute Executive Team; from 2012 - 2014 he was Deputy Head of the UCL Faculty of Brain Sciences, and from 2009 to 2014 the Director of the UCL Institute of Cognitive Neuroscience. He held a Wellcome Trust Senior Clinical Fellowship from 2003 to 2018. Education Rees received his Bachelor of Arts degree in the Medical Science Tripos in 1988 from the University of Cambridge where he was an undergraduate student of Gonville and Caius College, Cambridge. He moved to the University o ...
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