Frank's Sign
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Frank's Sign
Frank's sign is a diagonal crease in the ear lobe extending from the Tragus (ear), tragus across the lobule to the rear edge of the Auricle (anatomy), auricle. The sign is named after Sanders T. Frank. It has been hypothesised that Frank's sign is indicative of cardiovascular disease and/or diabetes. Some studies have described Frank's sign as a marker of cardiovascular disease but not linked to the severity of the condition. In contrast, other studies have rebutted any association between Frank's sign and coronary artery disease in diabetics. There have also been reported cases of Frank's sign being a predictor of Cerebral infarction, cerebral infarctions. A link between Frank's sign and premature aging and the loss of Dermis, dermal and blood vessel, vascular elastic fiber, fibers has also been hypothesized. Some studies have focused on association between bilateral earlobe crease and coronary artery disease. It is probably prudent to consider Frank's Sign alongside other clinica ...
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Blood Vessel
The blood vessels are the components of the circulatory system that transport blood throughout the human body. These vessels transport blood cells, nutrients, and oxygen to the tissues of the body. They also take waste and carbon dioxide away from the tissues. Blood vessels are needed to sustain life, because all of the body's tissues rely on their functionality. There are five types of blood vessels: the arteries, which carry the blood away from the heart; the arterioles; the capillaries, where the exchange of water and chemicals between the blood and the tissues occurs; the venules; and the veins, which carry blood from the capillaries back towards the heart. The word ''vascular'', meaning relating to the blood vessels, is derived from the Latin ''vas'', meaning vessel. Some structures – such as cartilage, the epithelium, and the lens and cornea of the eye – do not contain blood vessels and are labeled ''avascular''. Etymology * artery: late Middle English; from Latin ...
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KDWN
KDWN (720 AM) is a commercial radio station in Las Vegas, Nevada, owned and operated by Audacy, Inc.. The station pronounces its call letters as "K-Dawn." The station's studios are located in the unincorporated Clark County area of Spring Valley. Programming is simulcast on 250-watt FM translator station K268CS at 101.5 MHz. KDWN airs a talk radio format. It runs several nationally syndicated conservative talk hosts, along with local shows, most of which are brokered programming. National hosts include Brian Kilmeade, Sean Hannity and Mark Levin. Other hours are devoted to money, health, real estate and sports. In most cases, the local hosts pay for their time on the air and are permitted to run their own advertising. Most hours on weekdays begin with world and national news from Fox News Radio. A local staff provides Nevada news, weather and traffic. Weather coverage is supplied by National Broadcasting Company, NBC Network affiliate KSNV. KDWN's original 50,000-watt The ...
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Mel Gibson
Mel Columcille Gerard Gibson (born January 3, 1956) is an American actor, film director, and producer. He is best known for his action hero roles, particularly his breakout role as Max Rockatansky in the first three films of the post-apocalyptic action series ''Mad Max'' and as Martin Riggs in the buddy cop action-comedy film series ''Lethal Weapon''. Born in Peekskill, New York, Gibson moved with his parents to Sydney, Australia, when he was 12 years old. He studied acting at the National Institute of Dramatic Art, where he starred opposite Judy Davis in a production of ''Romeo and Juliet''. During the 1980s, he founded Icon Entertainment, a production company, which independent film director Atom Egoyan has called "an alternative to the studio system". Director Peter Weir cast him as one of the leads in the World War I drama ''Gallipoli'' (1981), which earned Gibson a Best Actor Award from the Australian Film Institute,The Australian Film InstitutPast Winners as well as a ...
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George W
George Walker Bush (born July 6, 1946) is an American politician who served as the 43rd president of the United States from 2001 to 2009. A member of the Republican Party, Bush family, and son of the 41st president George H. W. Bush, he previously served as the 46th governor of Texas from 1995 to 2000. While in his twenties, Bush flew warplanes in the Texas Air National Guard. After graduating from Harvard Business School in 1975, he worked in the oil industry. In 1978, Bush unsuccessfully ran for the House of Representatives. He later co-owned the Texas Rangers of Major League Baseball before he was elected governor of Texas in 1994. As governor, Bush successfully sponsored legislation for tort reform, increased education funding, set higher standards for schools, and reformed the criminal justice system. He also helped make Texas the leading producer of wind powered electricity in the nation. In the 2000 presidential election, Bush defeated Democratic incum ...
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Dick Van Dyke
Richard Wayne Van Dyke (born December 13, 1925) is an American actor, entertainer and comedian. His award-winning career has spanned seven decades in film, television, and stage. Van Dyke began his career as an entertainer on radio and television, in nightclubs, and on the Broadway stage. In 1961, he starred in the original production of ''Bye Bye Birdie'' alongside Chita Rivera, a role which earned him the Tony Award for Best Actor in a Musical. Carl Reiner then cast him as Rob Petrie on the CBS television sitcom ''The Dick Van Dyke Show'' (1961–1966), which made him a household name. He went on to star in the motion picture musicals ''Bye Bye Birdie'' (1963), ''Mary Poppins'' (1964), and '' Chitty Chitty Bang Bang'' (1968), and in the comedy-drama ''The Comic'' (1969). He made guest appearances on television programs '' Columbo'' (1974) and ''The Carol Burnett Show'' (1977), and starred in ''The New Dick Van Dyke Show'' (1971–74), '' Diagnosis: Murder'' (1993–2001), an ...
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Ageing
Ageing ( BE) or aging ( AE) is the process of becoming older. The term refers mainly to humans, many other animals, and fungi, whereas for example, bacteria, perennial plants and some simple animals are potentially biologically immortal. In a broader sense, ageing can refer to single cells within an organism which have ceased dividing, or to the population of a species. In humans, ageing represents the accumulation of changes in a human being over time and can encompass physical, psychological, and social changes. Reaction time, for example, may slow with age, while memories and general knowledge typically increase. Ageing increases the risk of human diseases such as cancer, Alzheimer's disease, diabetes, cardiovascular disease, stroke and many more. Of the roughly 150,000 people who die each day across the globe, about two-thirds die from age-related causes. Current ageing theories are assigned to the damage concept, whereby the accumulation of damage (such as DNA ox ...
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Coronary Artery Disease
Coronary artery disease (CAD), also called coronary heart disease (CHD), ischemic heart disease (IHD), myocardial ischemia, or simply heart disease, involves the reduction of blood flow to the heart muscle due to build-up of atherosclerotic plaque An atheroma, or atheromatous plaque, is an abnormal and reversible accumulation of material in the inner layer of an arterial wall. The material consists of mostly macrophage cells, or debris, containing lipids, calcium and a variable amount ... in the arteries of the heart. It is the most common of the cardiovascular diseases. Types include stable angina, unstable angina, myocardial infarction, and sudden cardiac death. A common symptom is chest pain or discomfort which may travel into the shoulder, arm, back, neck, or jaw. Occasionally it may feel like heartburn. Usually symptoms occur with exercise or emotional Stress (psychological), stress, last less than a few minutes, and improve with rest. Shortness of breath may also o ...
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Elastic Fiber
Elastic fibers (or yellow fibers) are an essential component of the extracellular matrix composed of bundles of proteins (elastin) which are produced by a number of different cell types including fibroblasts, endothelial, smooth muscle, and airway epithelial cells. These fibers are able to stretch many times their length, and snap back to their original length when relaxed without loss of energy. Elastic fibers include elastin, elaunin and oxytalan. Elastic tissue is classified as "connective tissue proper". Elastic fibers are formed via elastogenesis, a highly complex process involving several key proteins including fibulin-4, fibulin-5, latent transforming growth factor β binding protein 4, and microfibril associated protein 4. In this process tropoelastin, the soluble monomeric precursor to elastic fibers is produced by elastogenic cells and chaperoned to the cell surface. Following excretion from the cell, tropoelastin self associates into ~200 nm particles by coacer ...
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Dermis
The dermis or corium is a layer of skin between the epidermis (with which it makes up the cutis) and subcutaneous tissues, that primarily consists of dense irregular connective tissue and cushions the body from stress and strain. It is divided into two layers, the superficial area adjacent to the epidermis called the papillary region and a deep thicker area known as the reticular dermis.James, William; Berger, Timothy; Elston, Dirk (2005). ''Andrews' Diseases of the Skin: Clinical Dermatology'' (10th ed.). Saunders. Pages 1, 11–12. . The dermis is tightly connected to the epidermis through a basement membrane. Structural components of the dermis are collagen, elastic fibers, and extrafibrillar matrix.Marks, James G; Miller, Jeffery (2006). ''Lookingbill and Marks' Principles of Dermatology'' (4th ed.). Elsevier Inc. Page 8–9. . It also contains mechanoreceptors that provide the sense of touch and thermoreceptors that provide the sense of heat. In addition, hair follicles, ...
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Frank S Sign
Frank or Franks may refer to: People * Frank (given name) * Frank (surname) * Franks (surname) * Franks, a medieval Germanic people * Frank, a term in the Muslim world for all western Europeans, particularly during the Crusades - see Farang Currency * Liechtenstein franc or frank, the currency of Liechtenstein since 1920 * Swiss franc or frank, the currency of Switzerland since 1850 * Westphalian frank, currency of the Kingdom of Westphalia between 1808 and 1813 * The currencies of the German-speaking cantons of Switzerland (1803–1814): ** Appenzell frank ** Argovia frank ** Basel frank ** Berne frank ** Fribourg frank ** Glarus frank ** Graubünden frank ** Luzern frank ** Schaffhausen frank ** Schwyz frank ** Solothurn frank ** St. Gallen frank ** Thurgau frank ** Unterwalden frank ** Uri frank ** Zürich frank Places * Frank, Alberta, Canada, an urban community, formerly a village * Franks, Illinois, United States, an unincorporated community * Franks, Missouri, United Stat ...
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